Clinical Trials Updated in 2025

NCT06132386 | COMPLETED

21 Participants

Analysis of Cellular Kinases and Aging in PBMCs and Colorectal Tissue

Study Type: OBSERVATIONAL

Last Updated: 2025-12-24

Start Date: 2023-08-07

Completion: 2024-05-20

Conditions

HIV Infections Aging

Interventions

OTHER

Results Available

NCT06129747 | RECRUITING | PHASE2

55 Participants

Repeat Breast Conserving Surgery Followed by Daily Partial Breast Irradiation in Ipsilateral Breast

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2023-11-30

Completion: 2029-08-09

Conditions

Breast Cancer Tumor, Breast

Interventions

RADIATION

No Results Yet

NCT06128564 | RECRUITING | PHASE2

21 Participants

A Gene Delivery Study to Evaluate the Safety and Expression of Delandistrogene Moxeparvovec in Participants Under the Age of Four With Duchenne Muscular Dystrophy (DMD)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2023-11-29

Completion: 2034-01-30

Conditions

Duchenne Muscular Dystrophy

Interventions

GENETIC

No Results Yet

NCT06119581 | RECRUITING | PHASE3

1016 Participants

A Study of First-Line Olomorasib (LY3537982) and Pembrolizumab With or Without Chemotherapy in Patients With Advanced KRAS G12C-Mutant Non-small Cell Lung Cancer

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2023-12-21

Completion: 2026-10-31

Conditions

Carcinoma, Non-Small-Cell Lung Neoplasm Metastasis

Interventions

DRUG

No Results Yet

NCT06113081 | COMPLETED

100 Participants

Real World Experience With Mogamulizumab in the Treatment of Cutaneous T-cell Lymphoma

Study Type: OBSERVATIONAL

Last Updated: 2025-12-24

Start Date: 2024-06-06

Completion: 2025-10-10

Conditions

Cutaneous T Cell Lymphoma Cutaneous T-Cell Lymphoma/Mycosis Fungoides Cutaneous T-Cell Lymphoma/Sezary Syndrome

No Results Yet

NCT06107426 | RECRUITING

450 Participants

Real-World Study of ABBV-951 Subcutaneous Infusion to Assess Change in Disease Activity in Adult Participants With Parkinson's Disease

Study Type: OBSERVATIONAL

Last Updated: 2025-12-24

Start Date: 2024-01-24

Completion: 2029-05-31

Conditions

Parkinson's Disease (PD)

No Results Yet

NCT06105736 | RECRUITING | NA

105 Participants

Regulating Together in Tuberous Sclerosis Complex

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2023-12-20

Completion: 2026-12-20

Conditions

TSC Behavioral Symptoms

Interventions

BEHAVIORAL

No Results Yet

NCT06098612 | RECRUITING | EARLY_PHASE1

40 Participants

PET Imaging Evaluation of [11C]SY08

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2024-05-01

Completion: 2026-11-30

Conditions

Parkinson's Disease Multiple System Atrophy Dementia With Lewy Bodies Healthy Controls

Interventions

DRUG

No Results Yet

NCT06098079 | RECRUITING | PHASE4

8600 Participants

Effect of Naltrexone Hydrochloride ER and Bupropion Hydrochloride ER Combination (Contrave®/Mysimba®) on Major Adverse Cardiovascular Events (MACE)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2024-01-03

Completion: 2029-01-31

Conditions

Obesity

Interventions

DRUG

No Results Yet

NCT06096337 | ACTIVE_NOT_RECRUITING | NA

484 Participants

Pulsed Field Ablation (PFA) vs Anti-Arrhythmic Drug (AAD) Therapy as a First Line Treatment for Persistent Atrial Fibrillation

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2023-12-28

Completion: 2026-02-03

Conditions

Persistent Atrial Fibrillation

Interventions

DEVICE DRUG

No Results Yet

NCT06091787 | COMPLETED | NA

90 Participants

Effect of Ursodeoxycholic Acid Supplementation on Liver Regeneration on Right Lobe Donor Hepatectomy

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2023-09-01

Completion: 2024-11-30

Conditions

Liver Regeneration Ursodeoxycholic Acid Partial Liver Resection

Interventions

DRUG OTHER

No Results Yet

NCT06080789 | RECRUITING | PHASE2

36 Participants

A Study to Evaluate the Safety and Efficacy of a Single Dose of RABI-767 in Participants With Acute Pancreatitis

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2024-06-28

Completion: 2026-06-30

Conditions

Acute Pancreatitis

Interventions

DRUG

No Results Yet

NCT06080425 | RECRUITING | NA

75 Participants

Promoting Intergenerational Health in Rural Kentuckians With Diabetes (PIHRK'D)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2023-09-01

Completion: 2025-12-31

Conditions

Diabetes Mellitus, Type 2

Interventions

BEHAVIORAL

No Results Yet

NCT06079879 | RECRUITING | PHASE3

340 Participants

A Study of Bomedemstat (IMG-7289/MK-3543) Compared to Best Available Therapy (BAT) in Participants With Essential Thrombocythemia and an Inadequate Response or Intolerance of Hydroxyurea (MK-3543-006)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2023-12-31

Completion: 2027-07-30

Conditions

Essential Thrombocythemia

Interventions

DRUG

No Results Yet

NCT06075576 | COMPLETED

23 Participants

Characterization of the Central and Peripheral Wavefront Aberration Profile in Pediatric Myopic Subjects

Study Type: OBSERVATIONAL

Last Updated: 2025-12-24

Start Date: 2023-11-16

Completion: 2025-08-11

Conditions

Myopia

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT06075537 | ENROLLING_BY_INVITATION | PHASE2/PHASE3

99 Participants

An Extension Study of the Long-Term Safety, Tolerability, and Efficacy of Tividenofusp Alfa (DNL310) in Participants With Mucopolysaccharidosis Type II (MPS II) From Study DNLI-E-0002 or Study DNLI-E-0007

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2023-09-20

Completion: 2027-06-30

Conditions

Mucopolysaccharidosis II

Interventions

DRUG

No Results Yet

NCT06074341 | ACTIVE_NOT_RECRUITING | NA

470 Participants

TeleHealth Resources for IndiVidualizEd Goals (THRIVE) in Alcohol Recovery Study

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2023-09-13

Completion: 2028-01-31

Conditions

Alcohol Use Disorder Alcohol Drinking Alcohol-Related Disorders

Interventions

BEHAVIORAL

No Results Yet

NCT06073041 | COMPLETED | NA

20 Participants

Implementing and Evaluating the Integration of Physical Activity Into a Major Health System and Connecting Patients to Physical Activity Programs.

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2023-08-03

Completion: 2023-09-05

Conditions

Chronic Disease Exercise Physical Activity

Interventions

OTHER BEHAVIORAL

No Results Yet

NCT06065462 | RECRUITING | PHASE1/PHASE2

21 Participants

Safety and Efficacy of Targeting PP2A in Ovarian Clear Cell Carcinoma Using Dostarlimab and LB-100

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2023-11-10

Completion: 2027-10-01

Conditions

Ovarian Clear Cell Carcinoma

Interventions

DRUG

No Results Yet

NCT06052306 | ACTIVE_NOT_RECRUITING | PHASE1

232 Participants

A Study to Learn How Safe the Study Treatment Actinium-225-macropa-pelgifatamab (BAY3546828) is, How it Affects the Body, How it Moves Into, Through and Out of the Body, and About Its Anticancer Activity in Participants With Advanced Metastatic Castration-resistant Prostate Cancer (mCRPC)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2023-09-20

Completion: 2027-06-08

Conditions

Metastatic Castration-resistant Prostate Cancer

Interventions

DRUG

No Results Yet

NCT06051617 | RECRUITING | PHASE3

318 Participants

Seladelpar in Subjects With Primary Biliary Cholangitis (PBC) and Compensated Cirrhosis

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2023-09-07

Completion: 2030-08-31

Conditions

Primary Biliary Cholangitis

Interventions

DRUG

No Results Yet

NCT06046170 | ACTIVE_NOT_RECRUITING | NA

60 Participants

Adaptation and Feasibility of the Community-Based Anxiety Program Tailored for Autism (CAPTA)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2024-02-16

Completion: 2026-04-30

Conditions

Anxiety Autism Spectrum Disorder Separation Anxiety Generalized Anxiety Disorder Social Anxiety Disorder of Childhood

Interventions

BEHAVIORAL OTHER

No Results Yet

NCT06044935 | RECRUITING | NA

100 Participants

Effect of Nicotinamide Riboside on Ketosis, Fat Oxidation & Metabolic Rate

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2024-01-08

Completion: 2026-01-31

Conditions

Overweight Obesity

Interventions

OTHER DIETARY_SUPPLEMENT

No Results Yet

NCT06042725 | RECRUITING | PHASE1

100 Participants

MC210808 Venetoclax in Combination With Lenalidomide and Dexamethasone (Ven-Rd), Daratumumab and Dexamethasone (Ven-Dd), or Daratumumab-Lenalidomide-Dexamethasone (Ven-DRd) for the Treatment of Multiple Myeloma

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2024-03-04

Completion: 2028-12-01

Conditions

Multiple Myeloma

Interventions

PROCEDURE BIOLOGICAL DRUG OTHER

No Results Yet

NCT06040190 | RECRUITING | PHASE4

150 Participants

Effect of Treatments on Pain and Quality of Life in Individual With Burning Mouth Syndrome

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2023-11-01

Completion: 2026-02-01

Conditions

Burning Mouth Syndrome

Interventions

DRUG DIETARY_SUPPLEMENT OTHER RADIATION

No Results Yet

NCT06029517 | ACTIVE_NOT_RECRUITING | NA

48 Participants

A Sugar-Sweetened Beverage Reduction Intervention for Native American Men

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2022-07-20

Completion: 2025-09-15

Conditions

Cardiovascular Disorder Coronary Artery Disease Diabetes Mellitus Obesity-Related Malignant Neoplasm

Interventions

OTHER PROCEDURE

No Results Yet

NCT06022081 | ACTIVE_NOT_RECRUITING | NA

60 Participants

Lung Ultrasound Versus Chest Radiography for Detection of Pneumothorax

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2023-09-27

Completion: 2024-07-23

Conditions

Pneumothorax

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT06022029 | RECRUITING | PHASE1

168 Participants

A Dose Escalation and Dose Expansion Study of Intratumoral ONM-501 Alone and in Combination With Cemiplimab in Patients With Advanced Solid Tumors and Lymphomas.

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2023-10-13

Completion: 2026-04-30

Conditions

Triple Negative Breast Cancer Diffuse Large B Cell Lymphoma Follicular Lymphoma Lymphoma, Non-Hodgkin Mantle Cell Lymphoma Bladder Cancer Uveal Melanoma, Recurrent Cervix Cancer Carcinoma in Situ Head and Neck Squamous Cell Carcinoma Skin Cancer Metastatic Cancer Tumor, Solid Tumor Recurrence

Interventions

DRUG

No Results Yet

NCT06014086 | ACTIVE_NOT_RECRUITING | PHASE1

30 Participants

Intratumoral PH-762 for Cutaneous Carcinoma

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2023-11-07

Completion: 2026-01-31

Conditions

Malignant Melanoma of Skin Squamous Cell Carcinoma of the Skin Merkel Cell Carcinoma of Skin

Interventions

DRUG

No Results Yet

NCT06009276 | RECRUITING

70 Participants

Associations Between the Microbiome, Skeletal Muscle Perfusion, and Fitness Status

Study Type: OBSERVATIONAL

Last Updated: 2025-12-24

Start Date: 2023-08-30

Completion: 2026-12-31

Conditions

Heart Failure, Diastolic Peripheral Arterial Disease Overweight and Obesity Heart Failure, Systolic

No Results Yet

NCT05996185 | RECRUITING | PHASE2

22 Participants

Study of Mogamulizumab With DA-EPOCH or CHOEP in Patients With Aggressive T-cell Lymphoma

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2024-10-09

Completion: 2026-11-30

Conditions

T Cell Lymphoma T-cell Lymphoma

Interventions

DRUG

No Results Yet

NCT05977322 | TERMINATED | PHASE1

24 Participants

A Phase I Study of [177Lu]Lu-FF58 in Patients With Advanced Solid Tumors.

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2023-10-06

Completion: 2024-12-13

Conditions

Pancreatic Ductal Adenocarcinoma Gastroesophageal Adenocarcinoma Glioblastoma Multiforme

Interventions

DRUG

No Results Yet

NCT05961956 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2

5 Participants

Study With NVDX3 for Treatment of Low Grade Degenerative Lumbar Spondylolisthesis

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2023-10-12

Completion: 2026-04-18

Conditions

Degenerative Lumbar Spondylolisthesis

Interventions

DRUG

No Results Yet

NCT05959304 | ACTIVE_NOT_RECRUITING | PHASE4

63 Participants

Post Marketing Study to Evaluate the Safety and Effectiveness of Brolucizumab in Patients With Diabetic Macular Edema.

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2024-12-11

Completion: 2026-02-28

Conditions

Diabetic Macular Edema

Interventions

DRUG

No Results Yet

NCT05958667 | NOT_YET_RECRUITING | NA

1200 Participants

Quitxt Mobile Text Messaging Cessation Research Study

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2026-01-31

Completion: 2028-08-31

Conditions

Smoking Cessation

Interventions

BEHAVIORAL OTHER

No Results Yet

NCT05947851 | RECRUITING | PHASE3

735 Participants

A Study of Nemtabrutinib Plus Venetoclax vs Venetoclax + Rituximab (VR) in Second-line (2L) + Relapsed/Refractory (R/R) Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) (MK-1026-010/BELLWAVE-010).

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2023-08-08

Completion: 2032-06-01

Conditions

Leukemia, Lymphocytic, Chronic, B-Cell Leukemia, Chronic Lymphocytic Small-Cell Lymphoma Lymphoma, Small Lymphocytic CLL SLL

Interventions

DRUG BIOLOGICAL

No Results Yet

NCT05943509 | ACTIVE_NOT_RECRUITING | NA

120 Participants

Hearing Program in Primary Care

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2024-02-15

Completion: 2026-01-15

Conditions

Deafness

Interventions

BEHAVIORAL

No Results Yet

NCT05938153 | COMPLETED

41 Participants

Evaluation of Metabolic Syndrome, Frailty, Locomotive Syndrome, Balance and Physical Fitness in Elderly Individuals

Study Type: OBSERVATIONAL

Last Updated: 2025-12-24

Start Date: 2023-06-01

Completion: 2024-11-01

Conditions

Geriatrics Fragility Locomotor Physical Fitness Balance

Interventions

OTHER

No Results Yet

NCT05937373 | TERMINATED | NA

22 Participants

Perioperative Continuous Glucose Monitoring

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2023-08-04

Completion: 2024-05-21

Conditions

Diabetes Mellitus

Interventions

DEVICE OTHER

Results Available

NCT05934773 | TERMINATED | NA

5 Participants

Post-Brain Injury Walking and Balance Recovery Program

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2022-08-18

Completion: 2025-04-04

Conditions

Acquired Brain Injury Stroke Traumatic Brain Injury

Interventions

DEVICE

No Results Yet