Clinical Trials

Showing trials with last updates posted in 2025.

NCT05256745 | RECRUITING | PHASE1/PHASE2
48 Participants

RAGE Inhibition to Decrease Cardiotoxicity in Women With Early Breast Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2023-06-06
Completion: 2026-12-31
Conditions
Cancer Related Cognitive Decline Non-metastatic Breast Cancer
Interventions
DRUG
No Results Yet
NCT05254743 | RECRUITING | PHASE3
662 Participants

A Study of Pirtobrutinib (LOXO-305) Versus Ibrutinib in Participants With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2022-07-22
Completion: 2025-06-10
Conditions
Chronic Lymphocytic Leukemia Leukemia, Lymphocytic Leukemia, B-cell Small Lymphocytic Lymphoma
Interventions
DRUG
No Results Yet
NCT05225727 | COMPLETED | NA
123 Participants

Me & You-Tech: A Socio-Ecological Solution to Teen Dating Violence for the Digital Age

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2022-10-01
Completion: 2024-12-14
Conditions
Adolescent Behavior Interpersonal Relations Domestic Violence Physical Violence
Interventions
BEHAVIORAL
NCT05224323 | RECRUITING
50 Participants

Avalanche Phenomenon During Airways Opening in Acute Respiratory Distress Syndrome

Study Type: OBSERVATIONAL
Last Updated: 2025-12-24
Start Date: 2022-03-01
Completion: 2026-09-30
Conditions
Acute Respiratory Distress Syndrome
Interventions
OTHER
No Results Yet
NCT05220410 | COMPLETED | PHASE2
20 Participants

The Safety and Efficacy of Psilocybin in Patients With Treatment-resistant Depression and Chronic Suicidal Ideation

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2022-03-28
Completion: 2025-05-12
Conditions
Treatment Resistant Depression Suicidal Ideation
Interventions
DRUG
No Results Yet
NCT05182125 | COMPLETED | PHASE1
34 Participants

Phase 1 Clinical Trial to Evaluate the Safety and Immunogenicity of HIV-1 Chimp Adenovirus Vaccines Expressing Clade C gp140 & CH505TF gp120 Protein Boost in HIV-uninfected Adult.

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2021-11-25
Completion: 2023-08-21
Conditions
HIV Infections
Interventions
BIOLOGICAL
NCT05181722 | ACTIVE_NOT_RECRUITING | NA
196 Participants

Evaluating the Use of Patient Navigation to Promote Timely Diagnostic Evaluation During the COVID-19 Pandemic

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2022-07-18
Completion: 2026-12-31
Conditions
Breast Cancer
Interventions
OTHER
No Results Yet
NCT05179603 | TERMINATED | PHASE2
14 Participants

A Study of SAR444245 With or Without Other Anticancer Therapies for the Treatment of Adults and Adolescents With Relapsed or Refractory B Cell Lymphoma (Master Protocol) [Pegathor Lymphoma 205]

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2021-12-07
Completion: 2023-09-14
Conditions
Classic Hodgkin Lymphoma Diffuse Large B-cell Lymphoma
Interventions
DRUG
NCT05173818 | COMPLETED | PHASE2
20 Participants

Hyperbaric Oxygen Effects on Persistent Post-concussive Symptoms

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2022-06-28
Completion: 2025-08-01
Conditions
Persistent Post-concussive Syndrome Concussion Post Syndrome
Interventions
DRUG
No Results Yet
NCT05165940 | NOT_YET_RECRUITING | NA
40 Participants

Facilitating Transition to Recommended PTSD Treatment

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2026-02-01
Completion: 2027-05-03
Conditions
PTSD
Interventions
BEHAVIORAL
No Results Yet
NCT05162170 | COMPLETED
633 Participants

Primary Mediastinal Large B-cell Lymphoma (PMBCL): Multicenter Retrospective Study

Study Type: OBSERVATIONAL
Last Updated: 2025-12-24
Start Date: 2019-10-02
Completion: 2022-12-05
Conditions
Primary Mediastinal Large B-cell Lymphoma (PMBCL)
No Results Yet
NCT05160636 | ACTIVE_NOT_RECRUITING
999 Participants

A Study to Look at the Health Outcomes of Patients With COVID-19 and Influenza

Study Type: OBSERVATIONAL
Last Updated: 2025-12-24
Start Date: 2022-01-31
Completion: 2026-02-28
Conditions
COVID-19 Coronavirus Disease 2019 Influenza
Interventions
BIOLOGICAL
No Results Yet
NCT05160584 | RECRUITING
300 Participants

A Study of Real-Life Current Standards of Care in Participants With Relapsed and/or Refractory Multiple Myeloma

Study Type: OBSERVATIONAL
Last Updated: 2025-12-24
Start Date: 2021-11-18
Completion: 2028-04-30
Conditions
Relapsed/Refractory Multiple Myeloma
Interventions
OTHER
No Results Yet
NCT05141357 | TERMINATED | PHASE2
5 Participants

A Study of HBI-8000 (Tucidinostat) With Pembrolizumab in Non-Small Cell Lung Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2022-02-15
Completion: 2023-04-19
Conditions
Non Small Cell Lung Cancer
Interventions
DRUG
NCT05133479 | ACTIVE_NOT_RECRUITING | NA
241 Participants

Let's Know!2: Language-focused Intervention for Children at Risk of Comprehension Difficulties

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2021-01-01
Completion: 2026-06-30
Conditions
Language Disorders in Children
Interventions
BEHAVIORAL
No Results Yet
NCT05130827 | ACTIVE_NOT_RECRUITING | PHASE2
17 Participants

Study of Plinabulin and Pegfilgrastim in People With Multiple Myeloma Undergoing an Autologous Hematopoietic Stem Cell Transplant (AHCT)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2021-12-21
Completion: 2026-11-30
Conditions
Multiple Myeloma
Interventions
DRUG
No Results Yet
NCT05130437 | RECRUITING | PHASE1/PHASE2
50 Participants

A Study to Assess the Long-term Safety and Clinical Activity of mRNA-3927 in Participants Previously Enrolled in the mRNA-3927-P101 Study

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2021-11-09
Completion: 2029-12-04
Conditions
Propionic Acidemia
Interventions
BIOLOGICAL
No Results Yet
NCT05128942 | TERMINATED | PHASE2
67 Participants

A Phase 2 Study to Evaluate the Safety, Efficacy and PK of Tildacerfont in Children Aged 2-17 Years With CAH

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2021-12-10
Completion: 2025-01-31
Conditions
Congenital Adrenal Hyperplasia 21-OHD
Interventions
DRUG
NCT05122988 | COMPLETED
2606 Participants

Facing Adverse Childhood Experiences

Study Type: OBSERVATIONAL
Last Updated: 2025-12-24
Start Date: 2021-10-28
Completion: 2024-05-01
Conditions
Adverse Childhood Experiences
No Results Yet
NCT05104723 | ENROLLING_BY_INVITATION | PHASE1/PHASE2
20 Participants

Safety and Efficacy of Tofacitinib for Chronic Granulomatous Disease With Inflammatory Complications

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2022-08-12
Completion: 2026-01-01
Conditions
Chronic Granulomatous Disease Inflammatory Gastrointestinal Disease Inflammatory Skin Disease Inflammatory Lung Disease
Interventions
DRUG
No Results Yet
NCT05098613 | RECRUITING | PHASE1
68 Participants

Preliminary Safety and Tolerability of CD19x22 CAR T Cells in Adolescent and Adult R/R B-NHL Patients

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2021-12-21
Completion: 2026-12-31
Conditions
Non-Hodgkin Lymphoma B-cell Non-Hodgkin Lymphoma (B-NHL) Mantle Cell Lymphoma (MCL) CNS Lymphoma
Interventions
DRUG
No Results Yet
NCT05097534 | ENROLLING_BY_INVITATION | NA
150 Participants

A Comprehensive Community Approach for Diabetes Prevention and Care for a Vulnerable Population in Galveston

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2021-12-07
Completion: 2025-10-31
Conditions
Diabetes Mellitus, Type 2
Interventions
OTHER
No Results Yet
NCT05090371 | ACTIVE_NOT_RECRUITING | PHASE4
136 Participants

A Multicenter Study of Continued Current Therapy vs Transition to Ofatumumab After Neurofilament (NfL) Elevation

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2022-03-02
Completion: 2026-12-31
Conditions
Relapsing-Remitting Multiple Sclerosis
Interventions
DRUG
No Results Yet
NCT05049798 | ACTIVE_NOT_RECRUITING
1314 Participants

A Study of Guselkumab and Interleukin-17 (IL-17) Inhibitor Therapies in Participants With Psoriatic Arthritis in Routine Clinical Practice

Study Type: OBSERVATIONAL
Last Updated: 2025-12-24
Start Date: 2021-08-25
Completion: 2027-08-01
Conditions
Arthritis, Psoriatic
Interventions
DRUG
No Results Yet
NCT05043922 | COMPLETED | PHASE2
93 Participants

A Study to Evaluate the Efficacy and Safety of CYH33 in Patients With Recurrent/Persistent Ovary Clear Cell Carcinoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2021-10-11
Completion: 2024-07-31
Conditions
Ovarian Cancer Recurrent Cancer
Interventions
DRUG
No Results Yet
NCT05040373 | RECRUITING
10 Participants

Patisiran-Lipid Nanoparticle (LNP) Pregnancy Surveillance Program

Study Type: OBSERVATIONAL
Last Updated: 2025-12-24
Start Date: 2020-08-01
Completion: 2030-10-12
Conditions
Hereditary Transthyretin-mediated (hATTR) Amyloidosis Polyneuropathy
No Results Yet
NCT05012618 | TERMINATED | PHASE1
128 Participants

A Dose-escalation Study of LUNA18 in Patients With Locally Advanced or Metastatic Solid Tumors (With Expansion).

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2021-10-08
Completion: 2025-11-13
Conditions
Locally Advanced or Metastatic Solid Tumors
Interventions
DRUG
No Results Yet
NCT05009862 | ACTIVE_NOT_RECRUITING | PHASE4
75 Participants

The Impact of Factor Xa Inhibition on Thrombosis, Platelet Activation, and Endothelial Function in Peripheral Artery Disease

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2022-04-19
Completion: 2026-03-01
Conditions
Peripheral Arterial Disease
Interventions
DRUG
No Results Yet
NCT04995081 | COMPLETED | PHASE2
60 Participants

Clinical Trial for Parkinson's Disease Using Allogeneic HB-adMSCs (Early and Moderate PD)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2021-07-16
Completion: 2025-10-03
Conditions
Parkinson Disease
Interventions
BIOLOGICAL OTHER
No Results Yet
NCT04994756 | RECRUITING
40000 Participants

Stroke Thrombectomy and Aneurysm Registry

Study Type: OBSERVATIONAL
Last Updated: 2025-12-24
Start Date: 2019-09-17
Completion: 2055-01-01
Conditions
Stroke Thromboses, Intracranial Aneurysm, Brain
Interventions
PROCEDURE
No Results Yet
NCT04982393 | ACTIVE_NOT_RECRUITING
207 Participants

BONAPH1DE, A Prospective Observational Study of Patients With Primary Hyperoxaluria Type 1 (PH1)

Study Type: OBSERVATIONAL
Last Updated: 2025-12-24
Start Date: 2021-12-13
Completion: 2028-09-01
Conditions
Primary Hyperoxaluria Type 1
No Results Yet
NCT04968340 | COMPLETED | NA
600 Participants

External Pop Out cs vs Conventional Method for Fetal Head Extraction in Repeatedcaesarean Section.

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2021-06-16
Completion: 2022-07-24
Conditions
EPO Teqnique in Fetal Head Extraction
Interventions
PROCEDURE
No Results Yet
NCT04961697 | COMPLETED | NA
431 Participants

Family and Patient Outcomes After Pediatric Intensive Care (FOREVER)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2019-12-20
Completion: 2021-12-16
Conditions
Post-Intensive Care Syndrome Anxiety Depression Stress Disorders, Post-Traumatic Quality of Life Satisfaction, Patient
Interventions
BEHAVIORAL
No Results Yet
NCT04948463 | COMPLETED | PHASE4
55 Participants

Early Versus Late Stopping of Antibiotics in Children With Cancer and High-risk Febrile Neutropenia

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2021-11-15
Completion: 2025-12-17
Conditions
Febrile Neutropenia
Interventions
DRUG
No Results Yet
NCT04946201 | SUSPENDED
60 Participants

Premolar Extractions for Obstructive Sleep Apnea in Children With Overjet

Study Type: OBSERVATIONAL
Last Updated: 2025-12-24
Start Date: 2021-09-02
Completion: 2026-12-31
Conditions
Malocclusion Obstructive Sleep Apnea
No Results Yet
NCT04939454 | COMPLETED | NA
22 Participants

Involvement of Skeletal Muscle Fibrocytes in sarcOpenia in Patients With Chronic ObstRuctive Pulmonary Disease

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2022-11-29
Completion: 2025-11-21
Conditions
Pulmonary Disease, Chronic Obstructive
Interventions
PROCEDURE
No Results Yet
NCT04922814 | COMPLETED | NA
40 Participants

Comparison for the Effect of Neuromuscular Blocking Agents Versus Sedation Alone on Severe ARDS Patients Due to COVID-19

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2021-08-01
Completion: 2022-03-01
Conditions
COVID-19 Acute Respiratory Distress Syndrome Sedation Complication ICU Acquired Weakness
Interventions
DRUG
No Results Yet
NCT04916340 | RECRUITING | NA
240 Participants

Examining the Impact of Exercise Training on Vascular Dysfunction in Individuals With Mental Health Disorders - Study 3

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2022-01-24
Completion: 2026-02-28
Conditions
Peripheral Vascular Diseases
Interventions
BEHAVIORAL
No Results Yet
NCT04916132 | RECRUITING
300 Participants

Diabetic Nephropathy in People With Diabetes. Prevalence and Predictive Factors

Study Type: OBSERVATIONAL
Last Updated: 2025-12-24
Start Date: 2021-08-10
Completion: 2043-12-31
Conditions
Chronic Kidney Diseases Albuminuria Diabetic Kidney Disease Diabetic Nephropathies Diabetes type2 Molecular Sequence Variation Kidney Biopsy
Interventions
PROCEDURE
No Results Yet
NCT04915248 | RECRUITING | PHASE2
28 Participants

Study to Evaluate Combined Treatment of Daratumumab, Bortezomib and Dexamethasone in PBL Patients.

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2022-07-11
Completion: 2026-01-01
Conditions
Plasmablastic Lymphoma
Interventions
DRUG
No Results Yet
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