Clinical Trials Updated in 2025

NCT05598970 | COMPLETED | NA

3585 Participants

Family and Childhood Development: The Next Generation ('Kizazi Kijacho')

Study Type: INTERVENTIONAL

Last Updated: 2025-12-23

Start Date: 2022-09-26

Completion: 2024-06-05

Conditions

Parenting Early Child Development

Interventions

OTHER

No Results Yet

NCT05598008 | COMPLETED

85 Participants

Effects of Glucagon-like-Peptide-1 Analogues on Sexuality

Study Type: OBSERVATIONAL

Last Updated: 2025-12-23

Start Date: 2022-11-25

Completion: 2025-10-24

Conditions

Sexual Desire

No Results Yet

NCT05595681 | TERMINATED | PHASE1

21 Participants

Effect of Mesenchymal Stem Cells on Healing of Foot Ulcers in Diabetes Patients.

Study Type: INTERVENTIONAL

Last Updated: 2025-12-23

Start Date: 2022-12-15

Completion: 2025-11-28

Conditions

Diabetic Foot Ulcer Mesenchymal Stromal Cells

Interventions

DRUG

No Results Yet

NCT05576051 | COMPLETED

9159 Participants

To Estimate the Efficacy of Treatment With TNFi as Monotherapy or Combination Therapy With MTX and Compare and Contrast Efficacy With Tofacitinib as Monotherapy and Combination Therapy in a Real World Setting.

Study Type: OBSERVATIONAL

Last Updated: 2025-12-23

Start Date: 2015-06-04

Completion: 2015-10-07

Conditions

Rheumatoid Arthritis

Interventions

OTHER

Results Available

NCT05570006 | COMPLETED | PHASE2

30 Participants

Study of ABBV-668 Oral Capsules to Assess Adverse Events and Change in Disease Activity in Adult Participants With Moderate to Severe Ulcerative Colitis

Study Type: INTERVENTIONAL

Last Updated: 2025-12-23

Start Date: 2023-03-16

Completion: 2024-12-23

Conditions

Ulcerative Colitis

Interventions

DRUG

Results Available

NCT05568095 | ACTIVE_NOT_RECRUITING | PHASE3

1040 Participants

A Clinical Trial of a New Combination Treatment, Domvanalimab and Zimberelimab, Plus Chemotherapy, for People With an Upper Gastrointestinal Tract Cancer That Cannot be Removed With Surgery That Has Spread to Other Parts of the Body

Study Type: INTERVENTIONAL

Last Updated: 2025-12-23

Start Date: 2022-11-21

Completion: 2026-06-30

Conditions

Advanced Upper Gastrointestinal Tract Adenocarcinoma

Interventions

DRUG

No Results Yet

NCT05555589 | RECRUITING | PHASE3

70 Participants

Assessment of the Safety and Efficacy of 0.1% RGN-259 Ophthalmic Solution for the Treatment of NK: SEER-2

Study Type: INTERVENTIONAL

Last Updated: 2025-12-23

Start Date: 2023-04-11

Completion: 2026-04-30

Conditions

Neurotrophic Keratopathy

Interventions

DRUG

No Results Yet

NCT05546515 | COMPLETED | PHASE2

20 Participants

Suvorexant for Opioid/Stimulant Co-use

Study Type: INTERVENTIONAL

Last Updated: 2025-12-23

Start Date: 2022-12-01

Completion: 2024-11-30

Conditions

Opioid Use Disorder Stimulant Use Disorder

Interventions

DRUG

Results Available

NCT05514054 | RECRUITING | PHASE3

8000 Participants

A Study of Imlunestrant Versus Standard Endocrine Therapy in Participants With Early Breast Cancer

Study Type: INTERVENTIONAL

Last Updated: 2025-12-23

Start Date: 2022-10-04

Completion: 2027-10-31

Conditions

Breast Neoplasms

Interventions

DRUG

No Results Yet

NCT05509777 | RECRUITING | PHASE3

90 Participants

A Study of Mirikizumab (LY3074828) in Pediatric Participants With Crohn's Disease

Study Type: INTERVENTIONAL

Last Updated: 2025-12-23

Start Date: 2024-03-13

Completion: 2027-12-31

Conditions

Crohn's Disease

Interventions

DRUG

No Results Yet

NCT05506423 | ENROLLING_BY_INVITATION

300 Participants

Study of the CycloPen Micro-Interventional System and Long-Term Clinical Outcomes

Study Type: OBSERVATIONAL

Last Updated: 2025-12-23

Start Date: 2022-08-17

Completion: 2026-08-31

Conditions

Open Angle Glaucoma

Interventions

DEVICE

No Results Yet

NCT05505630 | COMPLETED | EARLY_PHASE1

20 Participants

The Effects of Sedatives on Tobacco Use Disorder Version 2

Study Type: INTERVENTIONAL

Last Updated: 2025-12-23

Start Date: 2023-01-31

Completion: 2025-12-10

Conditions

Tobacco Smoking

Interventions

DRUG

No Results Yet

NCT05494723 | NOT_YET_RECRUITING | PHASE1

6 Participants

Safety and Efficacy of YB-1113 in Treatment of POI

Study Type: INTERVENTIONAL

Last Updated: 2025-12-23

Start Date: 2026-12-09

Completion: 2028-01-09

Conditions

POI

Interventions

DRUG

No Results Yet

NCT05483933 | COMPLETED | PHASE1

86 Participants

Phase 1b Study of SL-172154 Administered With Combination Agent(s) in Subjects With Ovarian Cancers

Study Type: INTERVENTIONAL

Last Updated: 2025-12-23

Start Date: 2022-08-18

Completion: 2025-02-07

Conditions

Platinum-resistant Ovarian Cancer Fallopian Tube Cancer Epithelial Ovarian Cancer Ovarian Cancer Platinum-Resistant Fallopian Tube Carcinoma Platinum-Resistant Primary Peritoneal Carcinoma Primary Peritoneal Carcinoma

Interventions

DRUG

Results Available

NCT05470023 | RECRUITING | NA

275 Participants

Imaging-based Assessment of Oral Biofilm and Gingival Health

Study Type: INTERVENTIONAL

Last Updated: 2025-12-23

Start Date: 2022-09-01

Completion: 2028-12-31

Conditions

Plaque, Dental Gingivitis

Interventions

OTHER

No Results Yet

NCT05469373 | RECRUITING

86 Participants

ESIS in Pediatric DRE

Study Type: OBSERVATIONAL

Last Updated: 2025-12-23

Start Date: 2022-02-17

Completion: 2026-06-30

Conditions

Epilepsy

No Results Yet

NCT05463120 | ENROLLING_BY_INVITATION

566 Participants

Minipuberty of Infancy and the Timing of Pubertal Development in Adolescence: a Follow-up of the Infant Feeding and Early Development (IFED) Cohort

Study Type: OBSERVATIONAL

Last Updated: 2025-12-23

Start Date: 2022-10-10

Completion: 2026-03-01

Conditions

Puberty

No Results Yet

NCT05445323 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2

8 Participants

Gene Therapy for Cardiomyopathy Associated With Friedreich's Ataxia

Study Type: INTERVENTIONAL

Last Updated: 2025-12-23

Start Date: 2022-08-24

Completion: 2029-09-30

Conditions

Friedreich Ataxia Cardiomyopathy, Secondary

Interventions

GENETIC

No Results Yet

NCT05418049 | ACTIVE_NOT_RECRUITING | PHASE2

45 Participants

Evaluating the Neurophysiologic and Clinical Effects of Single Dose Drug Challenge

Study Type: INTERVENTIONAL

Last Updated: 2025-12-23

Start Date: 2022-09-08

Completion: 2025-10-28

Conditions

Fragile X Syndrome

Interventions

DRUG

No Results Yet

NCT05417789 | ACTIVE_NOT_RECRUITING | PHASE3

128 Participants

Study of Emactuzumab for Tenosynovial Giant Cell Tumor (TGCT)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-23

Start Date: 2024-10-09

Completion: 2026-04-30

Conditions

TGCT

Interventions

DRUG

No Results Yet

NCT05414903 | RECRUITING | NA

90 Participants

Reading Outcomes in Children With Vestibular Loss

Study Type: INTERVENTIONAL

Last Updated: 2025-12-23

Start Date: 2022-06-06

Completion: 2026-06-30

Conditions

Vestibular Disorder Hearing Loss, Sensorineural

Interventions

BEHAVIORAL

No Results Yet

NCT05399498 | COMPLETED | PHASE2

9 Participants

Psilocybin in Co-occuring Major Depressive Disorder and Borderline Personality Disorder

Study Type: INTERVENTIONAL

Last Updated: 2025-12-23

Start Date: 2023-11-01

Completion: 2025-12-01

Conditions

Borderline Personality Disorder Major Depressive Disorder

Interventions

DRUG

No Results Yet

NCT05371210 | COMPLETED | NA

105 Participants

An End-to-end System for Assessment and Intervention of Frailty

Study Type: INTERVENTIONAL

Last Updated: 2025-12-23

Start Date: 2021-03-15

Completion: 2022-06-16

Conditions

Frailty

Interventions

OTHER

No Results Yet

NCT05367102 | COMPLETED | NA

1022 Participants

Supporting Healthy Relationships Program for FRAMEWorks (SHR FRAMEWorks)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-23

Start Date: 2021-04-01

Completion: 2025-06-10

Conditions

Parenting Family Relations Relationship, Family

Interventions

BEHAVIORAL

No Results Yet

NCT05337982 | RECRUITING | NA

49 Participants

Eccentric Muscle Training, Stimulation, and Biomarkers in SCI

Study Type: INTERVENTIONAL

Last Updated: 2025-12-23

Start Date: 2022-05-17

Completion: 2026-12-31

Conditions

Spinal Cord Injuries Healthy

Interventions

OTHER

No Results Yet

NCT05333263 | COMPLETED | NA

12 Participants

A Study to Validate Treadmill Parameters

Study Type: INTERVENTIONAL

Last Updated: 2025-12-23

Start Date: 2022-06-17

Completion: 2024-12-17

Conditions

Healthy

Interventions

DEVICE

Results Available

NCT05323630 | COMPLETED | NA

10 Participants

Evaluation of the Use of the Renuvion APR System in the Labia

Study Type: INTERVENTIONAL

Last Updated: 2025-12-23

Start Date: 2023-04-19

Completion: 2024-04-23

Conditions

Labia Enlarged Labium; Hypertrophy

Interventions

DEVICE

Results Available

NCT05321459 | RECRUITING

100 Participants

Predictive Outcome in Comatose Patients

Study Type: OBSERVATIONAL

Last Updated: 2025-12-23

Start Date: 2023-11-15

Completion: 2028-03-01

Conditions

Coma Heart Arrest Cardiopulmonary Resuscitation

Interventions

OTHER

No Results Yet

NCT05316584 | ACTIVE_NOT_RECRUITING | NA

123 Participants

A Novel Remote Patient and Medication Monitoring Solution to Improve Adherence and PerSiStence With IBD Therapy

Study Type: INTERVENTIONAL

Last Updated: 2025-12-23

Start Date: 2022-09-06

Completion: 2025-12-31

Conditions

Inflammatory Bowel Diseases Crohn Disease Ulcerative Colitis

Interventions

BEHAVIORAL

No Results Yet

NCT05311007 | COMPLETED

175 Participants

Intrahospital Transport in Patients With High-flow Nasal Oxygenation: Prospective Observational Study

Study Type: OBSERVATIONAL

Last Updated: 2025-12-23

Start Date: 2022-05-28

Completion: 2024-05-04

Conditions

Critical Illness

Interventions

OTHER

No Results Yet

NCT05310981 | COMPLETED | NA

100 Participants

A Cannabis E-intervention for Young Cannabis Users With Early Psychosis (iCC)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-23

Start Date: 2022-07-06

Completion: 2024-07-31

Conditions

Cannabis Use Disorder

Interventions

BEHAVIORAL

No Results Yet

NCT05306132 | RECRUITING | PHASE1

150 Participants

Study to Assess the Safety, Tolerability, Pharmacokinetics and Preliminary Anti-tumor Activity of ASKC202 With or Without ASK120067

Study Type: INTERVENTIONAL

Last Updated: 2025-12-23

Start Date: 2022-08-08

Completion: 2026-12-31

Conditions

Advanced Solid Tumor

Interventions

DRUG

No Results Yet

NCT05305365 | ACTIVE_NOT_RECRUITING | PHASE2

21 Participants

Study Assessing QBS72S For Treating Brain Metastases

Study Type: INTERVENTIONAL

Last Updated: 2025-12-23

Start Date: 2022-08-16

Completion: 2025-06-20

Conditions

Brain Metastases Breast Cancer Lung Cancer Leptomeningeal Disease LMD

Interventions

DRUG

No Results Yet

NCT05297890 | ACTIVE_NOT_RECRUITING | PHASE2

70 Participants

A Study of Lorlatinib in Subjects With ROS1-Positive Non-Small Cell Lung Cancer

Study Type: INTERVENTIONAL

Last Updated: 2025-12-23

Start Date: 2022-05-27

Completion: 2023-12-26

Conditions

Advanced or Metastatic ROS1-Positive Non-Small Cell Lung Cancer

Interventions

DRUG

No Results Yet

NCT05295433 | RECRUITING | PHASE1/PHASE2

56 Participants

An Extension Study to Evaluate the Long-Term Safety and Clinical Activity of mRNA-3705 in Participants Previously Enrolled in Other Clinical Studies of mRNA-3705

Study Type: INTERVENTIONAL

Last Updated: 2025-12-23

Start Date: 2022-03-08

Completion: 2034-04-02

Conditions

Methylmalonic Acidemia

Interventions

DRUG

No Results Yet

NCT05290246 | ACTIVE_NOT_RECRUITING | NA

115 Participants

TRE in Type 2 Diabetes (See Food Study 3)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-23

Start Date: 2022-05-27

Completion: 2025-12-12

Conditions

Type2Diabetes

Interventions

BEHAVIORAL

No Results Yet

NCT05274243 | COMPLETED | PHASE2

32 Participants

2-HOBA Phase 2 Clinical Trial in Rheumatoid Arthritis

Study Type: INTERVENTIONAL

Last Updated: 2025-12-23

Start Date: 2022-08-09

Completion: 2025-05-28

Conditions

Rheumatoid Arthritis

Interventions

DRUG OTHER

No Results Yet

NCT05259501 | COMPLETED | NA

15 Participants

Remote Methadone Ingestion Surveillance Trial (RMIST)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-23

Start Date: 2025-01-15

Completion: 2025-03-13

Conditions

Opioid Use Disorder

Interventions

OTHER

No Results Yet

NCT05245669 | COMPLETED | PHASE1

207 Participants

Study to Compare the Pharmacokinetics, Pharmacodynamics, Safety, Tolerability, and Immunogenicity of Biosimilar Denosumab With Prolia® in Healthy Adult Male Volunteers

Study Type: INTERVENTIONAL

Last Updated: 2025-12-23

Start Date: 2022-01-10

Completion: 2024-05-22

Conditions

Healthy Male Subjects

Interventions

BIOLOGICAL

Results Available

NCT05239143 | ACTIVE_NOT_RECRUITING | PHASE1

180 Participants

P-MUC1C-ALLO1 Allogeneic CAR-T Cells in the Treatment of Subjects With Advanced or Metastatic Solid Tumors

Study Type: INTERVENTIONAL

Last Updated: 2025-12-23

Start Date: 2022-02-15

Completion: 2026-04-30

Conditions

Breast Cancer Ovarian Cancer Non Small Cell Lung Cancer Colorectal Cancer Pancreatic Cancer Renal Cell Carcinoma Nasopharyngeal Cancer Head and Neck Squamous Cell Carcinoma Gastric Cancer

Interventions

BIOLOGICAL DRUG

No Results Yet