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Clinical Trials

Showing trials with last updates posted in 2025.

NCT05371210 | COMPLETED | NA
105 Participants

An End-to-end System for Assessment and Intervention of Frailty

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2021-03-15
Completion: 2022-06-16
Conditions
Frailty
Interventions
OTHER
No Results Yet
NCT05367102 | COMPLETED | NA
1022 Participants

Supporting Healthy Relationships Program for FRAMEWorks (SHR FRAMEWorks)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2021-04-01
Completion: 2025-06-10
Conditions
Parenting Family Relations Relationship, Family
Interventions
BEHAVIORAL
No Results Yet
NCT05337982 | RECRUITING | NA
49 Participants

Eccentric Muscle Training, Stimulation, and Biomarkers in SCI

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2022-05-17
Completion: 2026-12-31
Conditions
Spinal Cord Injuries Healthy
Interventions
OTHER
No Results Yet
NCT05333263 | COMPLETED | NA
12 Participants

A Study to Validate Treadmill Parameters

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2022-06-17
Completion: 2024-12-17
Conditions
Healthy
Interventions
DEVICE
Results Available
NCT05323630 | COMPLETED | NA
10 Participants

Evaluation of the Use of the Renuvion APR System in the Labia

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2023-04-19
Completion: 2024-04-23
Conditions
Labia Enlarged Labium; Hypertrophy
Interventions
DEVICE
Results Available
NCT05321459 | RECRUITING
100 Participants

Predictive Outcome in Comatose Patients

Study Type: OBSERVATIONAL
Last Updated: 2025-12-23
Start Date: 2023-11-15
Completion: 2028-03-01
Conditions
Coma Heart Arrest Cardiopulmonary Resuscitation
Interventions
OTHER
No Results Yet
NCT05316584 | ACTIVE_NOT_RECRUITING | NA
123 Participants

A Novel Remote Patient and Medication Monitoring Solution to Improve Adherence and PerSiStence With IBD Therapy

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2022-09-06
Completion: 2025-12-31
Conditions
Inflammatory Bowel Diseases Crohn Disease Ulcerative Colitis
Interventions
BEHAVIORAL
No Results Yet
NCT05311007 | COMPLETED
175 Participants

Intrahospital Transport in Patients With High-flow Nasal Oxygenation: Prospective Observational Study

Study Type: OBSERVATIONAL
Last Updated: 2025-12-23
Start Date: 2022-05-28
Completion: 2024-05-04
Conditions
Critical Illness
Interventions
OTHER
No Results Yet
NCT05310981 | COMPLETED | NA
100 Participants

A Cannabis E-intervention for Young Cannabis Users With Early Psychosis (iCC)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2022-07-06
Completion: 2024-07-31
Conditions
Cannabis Use Disorder
Interventions
BEHAVIORAL
No Results Yet
NCT05306132 | RECRUITING | PHASE1
150 Participants

Study to Assess the Safety, Tolerability, Pharmacokinetics and Preliminary Anti-tumor Activity of ASKC202 With or Without ASK120067

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2022-08-08
Completion: 2026-12-31
Conditions
Advanced Solid Tumor
Interventions
DRUG
No Results Yet
NCT05305365 | ACTIVE_NOT_RECRUITING | PHASE2
21 Participants

Study Assessing QBS72S For Treating Brain Metastases

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2022-08-16
Completion: 2025-06-20
Conditions
Brain Metastases Breast Cancer Lung Cancer Leptomeningeal Disease LMD
Interventions
DRUG
No Results Yet
NCT05297890 | ACTIVE_NOT_RECRUITING | PHASE2
70 Participants

A Study of Lorlatinib in Subjects With ROS1-Positive Non-Small Cell Lung Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2022-05-27
Completion: 2023-12-26
Conditions
Advanced or Metastatic ROS1-Positive Non-Small Cell Lung Cancer
Interventions
DRUG
No Results Yet
NCT05295433 | RECRUITING | PHASE1/PHASE2
56 Participants

An Extension Study to Evaluate the Long-Term Safety and Clinical Activity of mRNA-3705 in Participants Previously Enrolled in Other Clinical Studies of mRNA-3705

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2022-03-08
Completion: 2034-04-02
Conditions
Methylmalonic Acidemia
Interventions
DRUG
No Results Yet
NCT05290246 | ACTIVE_NOT_RECRUITING | NA
115 Participants

TRE in Type 2 Diabetes (See Food Study 3)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2022-05-27
Completion: 2025-12-12
Conditions
Type2Diabetes
Interventions
BEHAVIORAL
No Results Yet
NCT05274243 | COMPLETED | PHASE2
32 Participants

2-HOBA Phase 2 Clinical Trial in Rheumatoid Arthritis

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2022-08-09
Completion: 2025-05-28
Conditions
Rheumatoid Arthritis
Interventions
DRUG OTHER
No Results Yet
NCT05259501 | COMPLETED | NA
15 Participants

Remote Methadone Ingestion Surveillance Trial (RMIST)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2025-01-15
Completion: 2025-03-13
Conditions
Opioid Use Disorder
Interventions
OTHER
No Results Yet
NCT05245669 | COMPLETED | PHASE1
207 Participants

Study to Compare the Pharmacokinetics, Pharmacodynamics, Safety, Tolerability, and Immunogenicity of Biosimilar Denosumab With Prolia® in Healthy Adult Male Volunteers

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2022-01-10
Completion: 2024-05-22
Conditions
Healthy Male Subjects
Interventions
BIOLOGICAL
Results Available
NCT05239143 | ACTIVE_NOT_RECRUITING | PHASE1
180 Participants

P-MUC1C-ALLO1 Allogeneic CAR-T Cells in the Treatment of Subjects With Advanced or Metastatic Solid Tumors

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2022-02-15
Completion: 2026-04-30
Conditions
Breast Cancer Ovarian Cancer Non Small Cell Lung Cancer Colorectal Cancer Pancreatic Cancer Renal Cell Carcinoma Nasopharyngeal Cancer Head and Neck Squamous Cell Carcinoma Gastric Cancer
Interventions
BIOLOGICAL DRUG
No Results Yet
NCT05217849 | ACTIVE_NOT_RECRUITING | NA
80 Participants

Multi-domain Online Therapeutic Investigation Of Neurocognition (MOTION)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2022-02-15
Completion: 2025-12-31
Conditions
Mild Cognitive Impairment Subjective Memory Decline
Interventions
BEHAVIORAL
No Results Yet
NCT05211895 | RECRUITING | PHASE3
860 Participants

A Global Study to Assess the Effects of Durvalumab + Domvanalimab Following Concurrent Chemoradiation in Participants With Stage III Unresectable NSCLC

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2022-02-18
Completion: 2028-07-12
Conditions
Non-Small Cell Lung Cancer
Interventions
DRUG OTHER
No Results Yet
NCT05197049 | ACTIVE_NOT_RECRUITING | PHASE3
350 Participants

A Study of Guselkumab Subcutaneous Therapy in Participants With Moderately to Severely Active Crohn's Disease

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2022-01-19
Completion: 2023-07-04
Conditions
Crohn Disease
Interventions
DRUG
Results Available
NCT05192434 | ACTIVE_NOT_RECRUITING | NA
219 Participants

Trauma Intervention to Optimize PrEP Among Women Who Inject Drugs

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2022-06-17
Completion: 2026-12-31
Conditions
HIV Infections Opioid Use Trauma, Psychological
Interventions
BEHAVIORAL
No Results Yet
NCT05182879 | RECRUITING
740 Participants

Evaluation of Frail Elderly in Ambulatory Primary Care

Study Type: OBSERVATIONAL
Last Updated: 2025-12-23
Start Date: 2019-02-12
Completion: 2026-01-31
Conditions
Frailty
Interventions
DIAGNOSTIC_TEST
No Results Yet
NCT05160701 | ACTIVE_NOT_RECRUITING | NA
300 Participants

Bringing Health Home

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2022-05-09
Completion: 2025-08-15
Conditions
Mental Disorders, Severe
Interventions
OTHER
No Results Yet
NCT05150210 | ACTIVE_NOT_RECRUITING | NA
32 Participants

SP Thoracic IDE Study

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2022-07-20
Completion: 2023-06-16
Conditions
Primary Lung Cancer Benign Lung Disease Thymoma Myasthenia Gravis
Interventions
DEVICE
Results Available
NCT05147792 | RECRUITING | NA
1600 Participants

The CONFORM Pivotal Trial

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2022-05-26
Completion: 2028-06-30
Conditions
Atrial Fibrillation Stroke
Interventions
DEVICE
No Results Yet
NCT05137743 | ACTIVE_NOT_RECRUITING | NA
80 Participants

Pilot Test of Apnea and Insomnia Relief for Veterans With Gulf War Illness

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2022-02-15
Completion: 2025-12-31
Conditions
Gulf War Illness
Interventions
BEHAVIORAL
No Results Yet
NCT05133245 | ENROLLING_BY_INVITATION
50 Participants

PHACE - Prospective Genetic Investigation

Study Type: OBSERVATIONAL
Last Updated: 2025-12-23
Start Date: 2021-11-01
Completion: 2026-11-01
Conditions
PHACE Syndrome
Interventions
OTHER
No Results Yet
NCT05105152 | RECRUITING | PHASE1
18 Participants

PLAT-08: A Study Of SC-DARIC33 CAR T Cells In Pediatric And Young Adults With Relapsed Or Refractory CD33+ AML

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2021-11-29
Completion: 2028-02-28
Conditions
Acute Myeloid Leukemia Acute Myeloid Leukemia Refractory Acute Myeloid Leukemia, in Relapse
Interventions
BIOLOGICAL
No Results Yet
NCT05103943 | ACTIVE_NOT_RECRUITING | NA
50 Participants

Amyloidosis TTR Flow Reserve Evaluation

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2022-02-24
Completion: 2026-12-11
Conditions
Amyloid Cardiomyopathy
Interventions
OTHER
No Results Yet
NCT05091684 | TERMINATED | PHASE2
1 Participants

Administration of Fibrinogen Concentrate for Refractory Bleeding

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2022-02-10
Completion: 2023-05-25
Conditions
Hematological Patients Bleeding Platelet Refractoriness
Interventions
DRUG
No Results Yet
NCT05066503 | RECRUITING | NA
60 Participants

Nutritional Therapy for Delirium in Elderly Hospitalized Subjects

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2020-11-16
Completion: 2026-08-31
Conditions
Subacute Delirium
Interventions
DIETARY_SUPPLEMENT
No Results Yet
NCT05048797 | ACTIVE_NOT_RECRUITING | PHASE3
454 Participants

A Study to Investigate the Efficacy and Safety of Trastuzumab Deruxtecan as the First Treatment Option for Unresectable, Locally Advanced/Metastatic Non-Small Cell Lung Cancer With HER2 Mutations

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2021-10-28
Completion: 2026-03-30
Conditions
Locally Advanced or Metastatic Non-Small Cell Lung Cancer
Interventions
DRUG
No Results Yet
NCT05029895 | COMPLETED
167 Participants

A Study to Evaluate Adverse Events and Change in Disease State of Oral Upadacitinib in Adolescent Participants Ages 12 to <18 Years Old Diagnosed With Atopic Dermatitis (AD)

Study Type: OBSERVATIONAL
Last Updated: 2025-12-23
Start Date: 2021-09-29
Completion: 2025-09-17
Conditions
Atopic Dermatitis
No Results Yet
NCT05026632 | RECRUITING | PHASE1/PHASE2
30 Participants

NPI-002 Intravitreal Implant for the Delay of Cataract Progression

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2022-01-27
Completion: 2026-04-30
Conditions
Cataract
Interventions
DRUG
No Results Yet
NCT05005429 | COMPLETED | PHASE2
47 Participants

Study of the Efficacy and Safety of the Bintrafusp Alfa in Previously Treated Advanced Malignant Pleural Mesothelioma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2021-09-20
Completion: 2024-02-01
Conditions
Mesothelioma; Lung
Interventions
DRUG
Results Available
NCT05003986 | RECRUITING | PHASE2
67 Participants

Study of Sparsentan Treatment in Pediatrics With Proteinuric Glomerular Diseases

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2021-08-12
Completion: 2027-03-12
Conditions
Focal Segmental Glomerulosclerosis Minimal Change Disease Immunoglobulin A Nephropathy IgA Vasculitis Alport Syndrome
Interventions
DRUG
No Results Yet
NCT04998864 | COMPLETED
53 Participants

Assessment of Safety and Feasibility of ExAblate Blood-Brain Barrier (BBB) Disruption in GBM Patients

Study Type: OBSERVATIONAL
Last Updated: 2025-12-23
Start Date: 2021-08-25
Completion: 2023-07-27
Conditions
Glioma, Malignant Glioblastoma
Interventions
DEVICE
No Results Yet
NCT04997902 | COMPLETED | PHASE1/PHASE2
45 Participants

Combination Trial of Tipifarnib and Alpelisib in Adult Recurrent/ Metastatic Head and Neck Squamous Cell Carcinoma (R/M HNSCC)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2021-12-07
Completion: 2025-07-30
Conditions
HNSCC
Interventions
DRUG
No Results Yet
NCT04990401 | COMPLETED | NA
65 Participants

Behavioral Activation Teletherapy to Increase Physical Activity

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2021-08-31
Completion: 2025-05-30
Conditions
Depression Depressive Disorder Depressive Symptoms Depressive Episode
Interventions
BEHAVIORAL
No Results Yet
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