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Clinical Trials

Showing trials with last updates posted in 2025.

NCT05632809 | RECRUITING | PHASE2
39 Participants

REStoring lymphoCytes Using NKTR-255* After chemoradiothErapy in Solid Tumors (RESCUE)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2023-01-10
Completion: 2027-12-31
Conditions
Lung Cancer
Interventions
DRUG
No Results Yet
NCT05626114 | RECRUITING | PHASE2
60 Participants

A Study to Optimize Subretinal Surgical Delivery and to Evaluate Safety and Activity of Opregen in Participants With Geographic Atrophy Secondary to Age-Related Macular Degeneration (GAlette); Adaptive Optics (AO) Retinal Imaging Substudy in Association With Study GR44251

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2023-03-23
Completion: 2031-03-01
Conditions
Geographic Atrophy
Interventions
BIOLOGICAL
No Results Yet
NCT05619367 | AVAILABLE

A Compassionate Use (CU) Program of Odronextamab

Study Type: EXPANDED_ACCESS
Last Updated: 2025-12-23
Conditions
Relapsed or Refractory (R/R) Follicular Lymphoma (FL) Diffuse Large B-Cell Lymphoma (DLBCL) B-Cell Non-Hodgkin Lymphoma (NHL) High-Grade B-Cell Lymphoma (HGBCL)
Interventions
DRUG
No Results Yet
NCT05618028 | RECRUITING | PHASE1
150 Participants

Study to Evaluate Adverse Events and Change in Disease Activity in Adult Participants With B-Cell Malignancies Receiving Oral ABBV-525 Tablets

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2023-04-04
Completion: 2029-07-31
Conditions
Diffuse Large B-Cell Lymphoma Chronic Lymphocytic Leukemia B Cell Malignancies Non-Hodgkin's Lymphoma
Interventions
DRUG
No Results Yet
NCT05598970 | COMPLETED | NA
3585 Participants

Family and Childhood Development: The Next Generation ('Kizazi Kijacho')

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2022-09-26
Completion: 2024-06-05
Conditions
Parenting Early Child Development
Interventions
OTHER
No Results Yet
NCT05598008 | COMPLETED
85 Participants

Effects of Glucagon-like-Peptide-1 Analogues on Sexuality

Study Type: OBSERVATIONAL
Last Updated: 2025-12-23
Start Date: 2022-11-25
Completion: 2025-10-24
Conditions
Sexual Desire
No Results Yet
NCT05595681 | TERMINATED | PHASE1
21 Participants

Effect of Mesenchymal Stem Cells on Healing of Foot Ulcers in Diabetes Patients.

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2022-12-15
Completion: 2025-11-28
Conditions
Diabetic Foot Ulcer Mesenchymal Stromal Cells
Interventions
DRUG
No Results Yet
NCT05588128 | RECRUITING
350 Participants

Prospective Monitoring of Subjects With Biochemically Recurrent Prostate Cancer Using 18FDCFPyL

Study Type: OBSERVATIONAL
Last Updated: 2025-12-23
Start Date: 2023-03-21
Completion: 2026-12-31
Conditions
Prostate Cancer Biochemically Recurrent
Interventions
DRUG
No Results Yet
NCT05576051 | COMPLETED
9159 Participants

To Estimate the Efficacy of Treatment With TNFi as Monotherapy or Combination Therapy With MTX and Compare and Contrast Efficacy With Tofacitinib as Monotherapy and Combination Therapy in a Real World Setting.

Study Type: OBSERVATIONAL
Last Updated: 2025-12-23
Start Date: 2015-06-04
Completion: 2015-10-07
Conditions
Rheumatoid Arthritis
Interventions
OTHER
Results Available
NCT05570006 | COMPLETED | PHASE2
30 Participants

Study of ABBV-668 Oral Capsules to Assess Adverse Events and Change in Disease Activity in Adult Participants With Moderate to Severe Ulcerative Colitis

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2023-03-16
Completion: 2024-12-23
Conditions
Ulcerative Colitis
Interventions
DRUG
Results Available
NCT05568095 | ACTIVE_NOT_RECRUITING | PHASE3
1040 Participants

A Clinical Trial of a New Combination Treatment, Domvanalimab and Zimberelimab, Plus Chemotherapy, for People With an Upper Gastrointestinal Tract Cancer That Cannot be Removed With Surgery That Has Spread to Other Parts of the Body

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2022-11-21
Completion: 2026-06-30
Conditions
Advanced Upper Gastrointestinal Tract Adenocarcinoma
Interventions
DRUG
No Results Yet
NCT05555589 | RECRUITING | PHASE3
70 Participants

Assessment of the Safety and Efficacy of 0.1% RGN-259 Ophthalmic Solution for the Treatment of NK: SEER-2

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2023-04-11
Completion: 2026-04-30
Conditions
Neurotrophic Keratopathy
Interventions
DRUG
No Results Yet
NCT05546515 | COMPLETED | PHASE2
20 Participants

Suvorexant for Opioid/Stimulant Co-use

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2022-12-01
Completion: 2024-11-30
Conditions
Opioid Use Disorder Stimulant Use Disorder
Interventions
DRUG
Results Available
NCT05514054 | RECRUITING | PHASE3
8000 Participants

A Study of Imlunestrant Versus Standard Endocrine Therapy in Participants With Early Breast Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2022-10-04
Completion: 2027-10-31
Conditions
Breast Neoplasms
Interventions
DRUG
No Results Yet
NCT05509777 | RECRUITING | PHASE3
90 Participants

A Study of Mirikizumab (LY3074828) in Pediatric Participants With Crohn's Disease

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2024-03-13
Completion: 2027-12-31
Conditions
Crohn's Disease
Interventions
DRUG
No Results Yet
NCT05506423 | ENROLLING_BY_INVITATION
300 Participants

Study of the CycloPen Micro-Interventional System and Long-Term Clinical Outcomes

Study Type: OBSERVATIONAL
Last Updated: 2025-12-23
Start Date: 2022-08-17
Completion: 2026-08-31
Conditions
Open Angle Glaucoma
Interventions
DEVICE
No Results Yet
NCT05505630 | COMPLETED | EARLY_PHASE1
20 Participants

The Effects of Sedatives on Tobacco Use Disorder Version 2

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2023-01-31
Completion: 2025-12-10
Conditions
Tobacco Smoking
Interventions
DRUG
No Results Yet
NCT05494723 | NOT_YET_RECRUITING | PHASE1
6 Participants

Safety and Efficacy of YB-1113 in Treatment of POI

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2026-12-09
Completion: 2028-01-09
Conditions
POI
Interventions
DRUG
No Results Yet
NCT05483933 | COMPLETED | PHASE1
86 Participants

Phase 1b Study of SL-172154 Administered With Combination Agent(s) in Subjects With Ovarian Cancers

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2022-08-18
Completion: 2025-02-07
Conditions
Platinum-resistant Ovarian Cancer Fallopian Tube Cancer Epithelial Ovarian Cancer Ovarian Cancer Platinum-Resistant Fallopian Tube Carcinoma Platinum-Resistant Primary Peritoneal Carcinoma Primary Peritoneal Carcinoma
Interventions
DRUG
Results Available
NCT05470023 | RECRUITING | NA
275 Participants

Imaging-based Assessment of Oral Biofilm and Gingival Health

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2022-09-01
Completion: 2028-12-31
Conditions
Plaque, Dental Gingivitis
Interventions
OTHER
No Results Yet
NCT05469373 | RECRUITING
86 Participants

ESIS in Pediatric DRE

Study Type: OBSERVATIONAL
Last Updated: 2025-12-23
Start Date: 2022-02-17
Completion: 2026-06-30
Conditions
Epilepsy
No Results Yet
NCT05463120 | ENROLLING_BY_INVITATION
566 Participants

Minipuberty of Infancy and the Timing of Pubertal Development in Adolescence: a Follow-up of the Infant Feeding and Early Development (IFED) Cohort

Study Type: OBSERVATIONAL
Last Updated: 2025-12-23
Start Date: 2022-10-10
Completion: 2026-03-01
Conditions
Puberty
No Results Yet
NCT05445323 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2
8 Participants

Gene Therapy for Cardiomyopathy Associated With Friedreich's Ataxia

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2022-08-24
Completion: 2029-09-30
Conditions
Friedreich Ataxia Cardiomyopathy, Secondary
Interventions
GENETIC
No Results Yet
NCT05418049 | ACTIVE_NOT_RECRUITING | PHASE2
45 Participants

Evaluating the Neurophysiologic and Clinical Effects of Single Dose Drug Challenge

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2022-09-08
Completion: 2025-10-28
Conditions
Fragile X Syndrome
Interventions
DRUG
No Results Yet
NCT05417789 | ACTIVE_NOT_RECRUITING | PHASE3
128 Participants

Study of Emactuzumab for Tenosynovial Giant Cell Tumor (TGCT)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2024-10-09
Completion: 2026-04-30
Conditions
TGCT
Interventions
DRUG
No Results Yet
NCT05414903 | RECRUITING | NA
90 Participants

Reading Outcomes in Children With Vestibular Loss

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2022-06-06
Completion: 2026-06-30
Conditions
Vestibular Disorder Hearing Loss, Sensorineural
Interventions
BEHAVIORAL
No Results Yet
NCT05399498 | COMPLETED | PHASE2
9 Participants

Psilocybin in Co-occuring Major Depressive Disorder and Borderline Personality Disorder

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2023-11-01
Completion: 2025-12-01
Conditions
Borderline Personality Disorder Major Depressive Disorder
Interventions
DRUG
No Results Yet
NCT05371210 | COMPLETED | NA
105 Participants

An End-to-end System for Assessment and Intervention of Frailty

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2021-03-15
Completion: 2022-06-16
Conditions
Frailty
Interventions
OTHER
No Results Yet
NCT05367102 | COMPLETED | NA
1022 Participants

Supporting Healthy Relationships Program for FRAMEWorks (SHR FRAMEWorks)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2021-04-01
Completion: 2025-06-10
Conditions
Parenting Family Relations Relationship, Family
Interventions
BEHAVIORAL
No Results Yet
NCT05337982 | RECRUITING | NA
49 Participants

Eccentric Muscle Training, Stimulation, and Biomarkers in SCI

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2022-05-17
Completion: 2026-12-31
Conditions
Spinal Cord Injuries Healthy
Interventions
OTHER
No Results Yet
NCT05333263 | COMPLETED | NA
12 Participants

A Study to Validate Treadmill Parameters

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2022-06-17
Completion: 2024-12-17
Conditions
Healthy
Interventions
DEVICE
Results Available
NCT05323630 | COMPLETED | NA
10 Participants

Evaluation of the Use of the Renuvion APR System in the Labia

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2023-04-19
Completion: 2024-04-23
Conditions
Labia Enlarged Labium; Hypertrophy
Interventions
DEVICE
Results Available
NCT05321459 | RECRUITING
100 Participants

Predictive Outcome in Comatose Patients

Study Type: OBSERVATIONAL
Last Updated: 2025-12-23
Start Date: 2023-11-15
Completion: 2028-03-01
Conditions
Coma Heart Arrest Cardiopulmonary Resuscitation
Interventions
OTHER
No Results Yet
NCT05316584 | ACTIVE_NOT_RECRUITING | NA
123 Participants

A Novel Remote Patient and Medication Monitoring Solution to Improve Adherence and PerSiStence With IBD Therapy

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2022-09-06
Completion: 2025-12-31
Conditions
Inflammatory Bowel Diseases Crohn Disease Ulcerative Colitis
Interventions
BEHAVIORAL
No Results Yet
NCT05311007 | COMPLETED
175 Participants

Intrahospital Transport in Patients With High-flow Nasal Oxygenation: Prospective Observational Study

Study Type: OBSERVATIONAL
Last Updated: 2025-12-23
Start Date: 2022-05-28
Completion: 2024-05-04
Conditions
Critical Illness
Interventions
OTHER
No Results Yet
NCT05310981 | COMPLETED | NA
100 Participants

A Cannabis E-intervention for Young Cannabis Users With Early Psychosis (iCC)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2022-07-06
Completion: 2024-07-31
Conditions
Cannabis Use Disorder
Interventions
BEHAVIORAL
No Results Yet
NCT05306132 | RECRUITING | PHASE1
150 Participants

Study to Assess the Safety, Tolerability, Pharmacokinetics and Preliminary Anti-tumor Activity of ASKC202 With or Without ASK120067

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2022-08-08
Completion: 2026-12-31
Conditions
Advanced Solid Tumor
Interventions
DRUG
No Results Yet
NCT05305365 | ACTIVE_NOT_RECRUITING | PHASE2
21 Participants

Study Assessing QBS72S For Treating Brain Metastases

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2022-08-16
Completion: 2025-06-20
Conditions
Brain Metastases Breast Cancer Lung Cancer Leptomeningeal Disease LMD
Interventions
DRUG
No Results Yet
NCT05297890 | ACTIVE_NOT_RECRUITING | PHASE2
70 Participants

A Study of Lorlatinib in Subjects With ROS1-Positive Non-Small Cell Lung Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2022-05-27
Completion: 2023-12-26
Conditions
Advanced or Metastatic ROS1-Positive Non-Small Cell Lung Cancer
Interventions
DRUG
No Results Yet
NCT05295433 | RECRUITING | PHASE1/PHASE2
56 Participants

An Extension Study to Evaluate the Long-Term Safety and Clinical Activity of mRNA-3705 in Participants Previously Enrolled in Other Clinical Studies of mRNA-3705

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2022-03-08
Completion: 2034-04-02
Conditions
Methylmalonic Acidemia
Interventions
DRUG
No Results Yet
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