Clinical Trials

Showing trials with last updates posted in 2025.

NCT04990167 | TERMINATED | PHASE2
11 Participants

Tiotropium vs. Inhaled Corticosteroids in Children With Nonatopic Asthma Pilot Study (TioNAAP)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2022-01-01
Completion: 2025-10-31
Conditions
Asthma in Children
Interventions
DRUG
No Results Yet
NCT04982575 | COMPLETED | PHASE2
92 Participants

Research Study to Look at How Well Cagrilintide Together With Semaglutide Works in People With Type 2 Diabetes

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2021-08-02
Completion: 2022-07-07
Conditions
Diabetes Mellitus, Type 2
Interventions
DRUG
NCT04975776 | ACTIVE_NOT_RECRUITING | NA
104 Participants

Sleep Restriction Therapy for Insomnia in Primary Health Care

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2022-02-01
Completion: 2027-08-30
Conditions
Insomnia
Interventions
BEHAVIORAL
No Results Yet
NCT04965766 | RECRUITING | PHASE2
139 Participants

Patritumab Deruxtecan (U3-1402) in Unresectable Locally Advanced or Metastatic Breast Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2021-05-11
Completion: 2027-04-11
Conditions
Advanced Breast Cancer Metastatic Breast Cancer
Interventions
DRUG
No Results Yet
NCT04960072 | RECRUITING | EARLY_PHASE1
50 Participants

A Study of GC101 TIL in r/r Gastrointestinal Tumors (10hospital)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2021-06-30
Completion: 2025-12-30
Conditions
Gastrointestinal Tumor
Interventions
BIOLOGICAL
No Results Yet
NCT04952766 | COMPLETED | PHASE4
196 Participants

Study Evaluating SARS-CoV-2 (COVID-19) Humoral Response After BNT162b2 Vaccine in Immunocompromised Adults Compared to Healthy Adults

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2021-03-26
Completion: 2022-02-06
Conditions
Kidney Transplant Myeloma Cancer Hematologic Malignancy Multiple Sclerosis Hypergammaglobulinemia Malignant Tumor Hiv Diabetes Type 2
Interventions
BIOLOGICAL
No Results Yet
NCT04948333 | ACTIVE_NOT_RECRUITING | PHASE3
199 Participants

Asciminib Treatment Optimization in ≥ 3rd Line CML-CP

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2021-10-13
Completion: 2024-03-12
Conditions
Chronic Myelogenous Leukemia
Interventions
DRUG
NCT04937647 | RECRUITING
1650 Participants

Evaluation of Neoplasia With Artificial Intelligence in Gastrointestinal Endoscopy

Study Type: OBSERVATIONAL
Last Updated: 2025-12-23
Start Date: 2021-06-16
Completion: 2026-06-03
Conditions
Gastrointestinal Neoplasms
Interventions
OTHER
No Results Yet
NCT04936035 | COMPLETED | PHASE2
394 Participants

A Study to Evaluate Efficacy and Safety of ALN-AGT01 in Patients With Mild To-Moderate Hypertension

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2021-07-07
Completion: 2023-04-04
Conditions
Hypertension
Interventions
DRUG
NCT04933721 | ENROLLING_BY_INVITATION | PHASE3
139 Participants

Open-label Berotralstat Access to HAE Patients Previously Enrolled in Berotralstat Studies

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2021-07-23
Completion: 2031-08-31
Conditions
Hereditary Angioedema HAE
Interventions
DRUG
No Results Yet
NCT04930822 | COMPLETED | NA
37 Participants

Evaluation of Bioness Integrated Therapy System (BITS) Touch Screen Technology to Improve Field Awareness

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2021-01-08
Completion: 2024-06-12
Conditions
Stroke Neurologic Disorder Traumatic Brain Injury Acquired Brain Injury
Interventions
OTHER DEVICE
NCT04925752 | ACTIVE_NOT_RECRUITING | PHASE3
3292 Participants

Study of Lenacapavir for HIV Pre-Exposure Prophylaxis in People Who Are at Risk for HIV Infection

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2021-06-28
Completion: 2024-08-21
Conditions
Pre-Exposure Prophylaxis of HIV Infection
Interventions
DRUG
NCT04914455 | COMPLETED
40 Participants

Transhepatic Echography for Fluid Responsiveness After Cardiovascular Surgery

Study Type: OBSERVATIONAL
Last Updated: 2025-12-23
Start Date: 2020-12-08
Completion: 2021-06-04
Conditions
Inferior Vena Cava Abnormality Fluid Responsiveness Fluid Overload Venous Congestion Cardiovascular Surgery
Interventions
DIAGNOSTIC_TEST
No Results Yet
NCT04911036 | RECRUITING
240 Participants

Study of the Effect of the Time of Diagnosis (Antenatal vs. Postnatal) on the Post-traumatic Reactions of Parents of Children Undergoing Oesophageal Atresia Surgery "

Study Type: OBSERVATIONAL
Last Updated: 2025-12-23
Start Date: 2021-05-06
Completion: 2027-05-31
Conditions
Atresia, Esophageal
Interventions
OTHER
No Results Yet
NCT04902443 | RECRUITING | PHASE1
58 Participants

Pomalidomide and Nivolumab in People With Virus-Associated Malignancies With or Without HIV

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2021-12-10
Completion: 2026-12-01
Conditions
Viral Associated Malignancies Kaposi Sarcoma EBV/KSHV-associated Lymphomas
Interventions
DRUG
No Results Yet
NCT04895839 | RECRUITING | NA
2130 Participants

Predictors of Mental Health in Men With Prostate Cancer Undergoing a Patient Empowerment Program

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2021-09-29
Completion: 2027-09-29
Conditions
Prostate Cancer
Interventions
BEHAVIORAL
No Results Yet
NCT04894253 | TERMINATED
7 Participants

Immune Response to SARS-CoV-2 Vaccination in Systemic Lupus

Study Type: OBSERVATIONAL
Last Updated: 2025-12-23
Start Date: 2021-06-07
Completion: 2021-06-07
Conditions
Systemic Lupus
Interventions
BIOLOGICAL
No Results Yet
NCT04889118 | COMPLETED | PHASE3
131 Participants

Safety and Efficacy Study of Pembrolizumab (MK-3475) Combined With Lenvatinib (MK-7902/E7080) as First-line Intervention in Adults With Advanced Melanoma (MK-7902-003/E7080-G000-312/LEAP-003)-China Extension Study

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2020-07-14
Completion: 2023-01-18
Conditions
Malignant Melanoma
Interventions
BIOLOGICAL DRUG
NCT04887428 | RECRUITING
460 Participants

Occupational Insertion and Educational Level of Adult Patients With Pediatric Early Inflammatory Bowel Disease (IBD)

Study Type: OBSERVATIONAL
Last Updated: 2025-12-23
Start Date: 2019-11-28
Completion: 2026-01-31
Conditions
Crohn Disease Ulcerative Colitis
No Results Yet
NCT04881240 | RECRUITING | PHASE1
60 Participants

Study of CD19-directed Allogeneic Memory T-cell Therapy for Relapsed/Refractory CD19+ Leukemia

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2024-02-14
Completion: 2027-07-01
Conditions
Acute Lymphoblastic Leukemia, in Relapse Acute Lymphoblastic Leukemia, Refractory Pediatric ALL
Interventions
BIOLOGICAL DRUG DEVICE PROCEDURE
No Results Yet
NCT04863222 | RECRUITING | PHASE4
646 Participants

Clinical and Radiographic Success of MTA vs Biodentine

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2021-11-12
Completion: 2026-08-01
Conditions
Indirect Pulp Cap Pulpotomy
Interventions
DEVICE BIOLOGICAL
No Results Yet
NCT04862663 | RECRUITING | PHASE3
895 Participants

Capivasertib + CDK4/6i + Fulvestrant for Advanced/Metastatic HR+/HER2- Breast Cancer (CAPItello-292)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2021-05-10
Completion: 2027-11-01
Conditions
Locally Advanced (Inoperable) or Metastatic Breast Cancer
Interventions
DRUG
No Results Yet
NCT04845620 | COMPLETED | PHASE3
652 Participants

Trial of PDE4 Inhibition With Roflumilast for the Management of Atopic Dermatitis (Integument-PED)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2021-04-07
Completion: 2023-06-01
Conditions
Atopic Dermatitis Eczema
Interventions
DRUG
NCT04844684 | RECRUITING
30 Participants

Evaluation of Cortisol and Bile Acids Metabolism in Obese Patients

Study Type: OBSERVATIONAL
Last Updated: 2025-12-23
Start Date: 2023-03-30
Completion: 2026-12-30
Conditions
Obesity
Interventions
OTHER
No Results Yet
NCT04832282 | ACTIVE_NOT_RECRUITING | NA
100 Participants

Napoleon Measurement of Gastrojejunal Anastomosis

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2021-06-14
Completion: 2025-06-30
Conditions
Gastric Bypass Weight Regain
Interventions
DEVICE OTHER
No Results Yet
NCT04826744 | RECRUITING
550 Participants

Frequency of Palpebral Involvement in Adult With Atopic Dermatitis

Study Type: OBSERVATIONAL
Last Updated: 2025-12-23
Start Date: 2021-09-01
Completion: 2026-06-30
Conditions
Atopic Dermatitis
Interventions
OTHER
No Results Yet
NCT04817254 | ACTIVE_NOT_RECRUITING | PHASE2
47 Participants

Association of Peripheral Blood Immunologic Response to Therapeutic Response to Adjuvant Treatment With Immune Checkpoint Inhibition (ICI) in Patients With Newly Diagnosed Glioblastoma or Gliosarcoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2021-12-08
Completion: 2026-11-30
Conditions
Glioblastoma Gliosarcoma Malignant Glioma
Interventions
DRUG
No Results Yet
NCT04804930 | RECRUITING
200 Participants

Trichoscopy and Systemic Scleroderma

Study Type: OBSERVATIONAL
Last Updated: 2025-12-23
Start Date: 2021-11-08
Completion: 2026-05-31
Conditions
Scleroderma, Systemic
Interventions
PROCEDURE
No Results Yet
NCT04804605 | COMPLETED | PHASE3
1220 Participants

Open Label Extension Trial of PDE4 Inhibition With Roflumilast for the Management of Atopic Dermatitis

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2021-02-25
Completion: 2024-05-28
Conditions
Atopic Dermatitis Eczema
Interventions
DRUG
NCT04784234 | TERMINATED | NA
12 Participants

Vision Preservation and Restoration Following a 6 Month Trial of GlaucoCetin

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2021-02-01
Completion: 2022-10-27
Conditions
Primary Open Angle Glaucoma
Interventions
DIETARY_SUPPLEMENT OTHER
No Results Yet
NCT04783181 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2
8 Participants

A Study of Gene Therapy for Classic Congenital Adrenal Hyperplasia (CAH)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2021-07-01
Completion: 2029-02-28
Conditions
Congenital Adrenal Hyperplasia
Interventions
BIOLOGICAL
No Results Yet
NCT04777994 | RECRUITING | PHASE1
248 Participants

Study With ABBV-CLS-484 in Participants With Locally Advanced or Metastatic Tumors

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2021-03-09
Completion: 2026-10-31
Conditions
Advanced Solid Tumor Cancer
Interventions
DRUG
No Results Yet
NCT04776252 | ACTIVE_NOT_RECRUITING | PHASE3
2000 Participants

Open-label, Follow-up of Doravirine/Islatravir (DOR/ISL 100 mg/0.75mg) for Participants With Human Immunodeficiency Virus-1 (HIV-1) Infection (MK-8591A-033)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2021-09-15
Completion: 2029-05-29
Conditions
HIV-1 Infection
Interventions
DRUG
No Results Yet
NCT04760769 | COMPLETED | PHASE3
992 Participants

Open-label Trial in Parkinson's Disease (PD)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2021-02-24
Completion: 2025-12-01
Conditions
Parkinson Disease
Interventions
DRUG
No Results Yet
NCT04746313 | COMPLETED
71 Participants

Prevalence of Hyperprolactinemia in Systemic Scleroderma

Study Type: OBSERVATIONAL
Last Updated: 2025-12-23
Start Date: 2021-03-01
Completion: 2021-05-12
Conditions
Sclerosis, Systemic Scleroderma Hyperprolactinemia
Interventions
BIOLOGICAL
No Results Yet
NCT04729322 | ACTIVE_NOT_RECRUITING | PHASE2
15 Participants

Fecal Microbiota Transplant and Re-introduction of Anti-PD-1 Therapy (Pembrolizumab or Nivolumab) for the Treatment of Metastatic Colorectal Cancer in Anti-PD-1 Non-responders

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2021-02-22
Completion: 2027-12-31
Conditions
Metastatic Colorectal Adenocarcinoma Metastatic Small Intestinal Adenocarcinoma Stage IV Colorectal Cancer AJCC v8 Stage IV Small Intestinal Adenocarcinoma AJCC v8 Stage IVA Colorectal Cancer AJCC v8 Stage IVB Colorectal Cancer AJCC v8 Stage IVC Colorectal Cancer AJCC v8
Interventions
PROCEDURE DRUG BIOLOGICAL OTHER
No Results Yet
NCT04727489 | RECRUITING
3800 Participants

Study of the Genetic Factors Involved in Autism and Related Disorders

Study Type: OBSERVATIONAL
Last Updated: 2025-12-23
Start Date: 2021-03-30
Completion: 2036-03-31
Conditions
Autism Spectrum Disorder
Interventions
GENETIC
No Results Yet
NCT04711824 | RECRUITING | PHASE1/PHASE2
41 Participants

Study of Stereotactic Radiosurgery With Olaparib Followed by Durvalumab and Physician's Choice Systemic Therapy in Subjects With Breast Cancer Brain Metastases

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2022-03-09
Completion: 2026-02-28
Conditions
Breast Cancer Brain Metastases, Adult
Interventions
DRUG RADIATION
No Results Yet
NCT04704115 | RECRUITING
62 Participants

The Therapy of Large Endometrioma

Study Type: OBSERVATIONAL
Last Updated: 2025-12-23
Start Date: 2021-01-21
Completion: 2026-12-31
Conditions
Endometrioma Endometriosis Ovary
No Results Yet
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