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Clinical Trials

Showing trials with last updates posted in 2025.

NCT04914455 | COMPLETED
40 Participants

Transhepatic Echography for Fluid Responsiveness After Cardiovascular Surgery

Study Type: OBSERVATIONAL
Last Updated: 2025-12-23
Start Date: 2020-12-08
Completion: 2021-06-04
Conditions
Inferior Vena Cava Abnormality Fluid Responsiveness Fluid Overload Venous Congestion Cardiovascular Surgery
Interventions
DIAGNOSTIC_TEST
No Results Yet
NCT04911036 | RECRUITING
240 Participants

Study of the Effect of the Time of Diagnosis (Antenatal vs. Postnatal) on the Post-traumatic Reactions of Parents of Children Undergoing Oesophageal Atresia Surgery "

Study Type: OBSERVATIONAL
Last Updated: 2025-12-23
Start Date: 2021-05-06
Completion: 2027-05-31
Conditions
Atresia, Esophageal
Interventions
OTHER
No Results Yet
NCT04902443 | RECRUITING | PHASE1
58 Participants

Pomalidomide and Nivolumab in People With Virus-Associated Malignancies With or Without HIV

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2021-12-10
Completion: 2026-12-01
Conditions
Viral Associated Malignancies Kaposi Sarcoma EBV/KSHV-associated Lymphomas
Interventions
DRUG
No Results Yet
NCT04895839 | RECRUITING | NA
2130 Participants

Predictors of Mental Health in Men With Prostate Cancer Undergoing a Patient Empowerment Program

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2021-09-29
Completion: 2027-09-29
Conditions
Prostate Cancer
Interventions
BEHAVIORAL
No Results Yet
NCT04894253 | TERMINATED
7 Participants

Immune Response to SARS-CoV-2 Vaccination in Systemic Lupus

Study Type: OBSERVATIONAL
Last Updated: 2025-12-23
Start Date: 2021-06-07
Completion: 2021-06-07
Conditions
Systemic Lupus
Interventions
BIOLOGICAL
No Results Yet
NCT04889118 | COMPLETED | PHASE3
131 Participants

Safety and Efficacy Study of Pembrolizumab (MK-3475) Combined With Lenvatinib (MK-7902/E7080) as First-line Intervention in Adults With Advanced Melanoma (MK-7902-003/E7080-G000-312/LEAP-003)-China Extension Study

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2020-07-14
Completion: 2023-01-18
Conditions
Malignant Melanoma
Interventions
BIOLOGICAL DRUG
Results Available
NCT04887428 | RECRUITING
460 Participants

Occupational Insertion and Educational Level of Adult Patients With Pediatric Early Inflammatory Bowel Disease (IBD)

Study Type: OBSERVATIONAL
Last Updated: 2025-12-23
Start Date: 2019-11-28
Completion: 2026-01-31
Conditions
Crohn Disease Ulcerative Colitis
No Results Yet
NCT04881240 | RECRUITING | PHASE1
60 Participants

Study of CD19-directed Allogeneic Memory T-cell Therapy for Relapsed/Refractory CD19+ Leukemia

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2024-02-14
Completion: 2027-07-01
Conditions
Acute Lymphoblastic Leukemia, in Relapse Acute Lymphoblastic Leukemia, Refractory Pediatric ALL
Interventions
BIOLOGICAL DRUG DEVICE PROCEDURE
No Results Yet
NCT04863222 | RECRUITING | PHASE4
646 Participants

Clinical and Radiographic Success of MTA vs Biodentine

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2021-11-12
Completion: 2026-08-01
Conditions
Indirect Pulp Cap Pulpotomy
Interventions
DEVICE BIOLOGICAL
No Results Yet
NCT04862663 | RECRUITING | PHASE3
895 Participants

Capivasertib + CDK4/6i + Fulvestrant for Advanced/Metastatic HR+/HER2- Breast Cancer (CAPItello-292)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2021-05-10
Completion: 2027-11-01
Conditions
Locally Advanced (Inoperable) or Metastatic Breast Cancer
Interventions
DRUG
No Results Yet
NCT04845620 | COMPLETED | PHASE3
652 Participants

Trial of PDE4 Inhibition With Roflumilast for the Management of Atopic Dermatitis (Integument-PED)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2021-04-07
Completion: 2023-06-01
Conditions
Atopic Dermatitis Eczema
Interventions
DRUG
Results Available
NCT04844684 | RECRUITING
30 Participants

Evaluation of Cortisol and Bile Acids Metabolism in Obese Patients

Study Type: OBSERVATIONAL
Last Updated: 2025-12-23
Start Date: 2023-03-30
Completion: 2026-12-30
Conditions
Obesity
Interventions
OTHER
No Results Yet
NCT04832282 | ACTIVE_NOT_RECRUITING | NA
100 Participants

Napoleon Measurement of Gastrojejunal Anastomosis

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2021-06-14
Completion: 2025-06-30
Conditions
Gastric Bypass Weight Regain
Interventions
DEVICE OTHER
No Results Yet
NCT04826744 | RECRUITING
550 Participants

Frequency of Palpebral Involvement in Adult With Atopic Dermatitis

Study Type: OBSERVATIONAL
Last Updated: 2025-12-23
Start Date: 2021-09-01
Completion: 2026-06-30
Conditions
Atopic Dermatitis
Interventions
OTHER
No Results Yet
NCT04817254 | ACTIVE_NOT_RECRUITING | PHASE2
47 Participants

Association of Peripheral Blood Immunologic Response to Therapeutic Response to Adjuvant Treatment With Immune Checkpoint Inhibition (ICI) in Patients With Newly Diagnosed Glioblastoma or Gliosarcoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2021-12-08
Completion: 2026-11-30
Conditions
Glioblastoma Gliosarcoma Malignant Glioma
Interventions
DRUG
No Results Yet
NCT04804930 | RECRUITING
200 Participants

Trichoscopy and Systemic Scleroderma

Study Type: OBSERVATIONAL
Last Updated: 2025-12-23
Start Date: 2021-11-08
Completion: 2026-05-31
Conditions
Scleroderma, Systemic
Interventions
PROCEDURE
No Results Yet
NCT04804605 | COMPLETED | PHASE3
1220 Participants

Open Label Extension Trial of PDE4 Inhibition With Roflumilast for the Management of Atopic Dermatitis

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2021-02-25
Completion: 2024-05-28
Conditions
Atopic Dermatitis Eczema
Interventions
DRUG
Results Available
NCT04784234 | TERMINATED | NA
12 Participants

Vision Preservation and Restoration Following a 6 Month Trial of GlaucoCetin

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2021-02-01
Completion: 2022-10-27
Conditions
Primary Open Angle Glaucoma
Interventions
DIETARY_SUPPLEMENT OTHER
No Results Yet
NCT04783181 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2
8 Participants

A Study of Gene Therapy for Classic Congenital Adrenal Hyperplasia (CAH)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2021-07-01
Completion: 2029-02-28
Conditions
Congenital Adrenal Hyperplasia
Interventions
BIOLOGICAL
No Results Yet
NCT04777994 | RECRUITING | PHASE1
248 Participants

Study With ABBV-CLS-484 in Participants With Locally Advanced or Metastatic Tumors

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2021-03-09
Completion: 2026-10-31
Conditions
Advanced Solid Tumor Cancer
Interventions
DRUG
No Results Yet
NCT04776252 | ACTIVE_NOT_RECRUITING | PHASE3
2000 Participants

Open-label, Follow-up of Doravirine/Islatravir (DOR/ISL 100 mg/0.75mg) for Participants With Human Immunodeficiency Virus-1 (HIV-1) Infection (MK-8591A-033)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2021-09-15
Completion: 2029-05-29
Conditions
HIV-1 Infection
Interventions
DRUG
No Results Yet
NCT04760769 | COMPLETED | PHASE3
992 Participants

Open-label Trial in Parkinson's Disease (PD)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2021-02-24
Completion: 2025-12-01
Conditions
Parkinson Disease
Interventions
DRUG
No Results Yet
NCT04746313 | COMPLETED
71 Participants

Prevalence of Hyperprolactinemia in Systemic Scleroderma

Study Type: OBSERVATIONAL
Last Updated: 2025-12-23
Start Date: 2021-03-01
Completion: 2021-05-12
Conditions
Sclerosis, Systemic Scleroderma Hyperprolactinemia
Interventions
BIOLOGICAL
No Results Yet
NCT04729322 | ACTIVE_NOT_RECRUITING | PHASE2
15 Participants

Fecal Microbiota Transplant and Re-introduction of Anti-PD-1 Therapy (Pembrolizumab or Nivolumab) for the Treatment of Metastatic Colorectal Cancer in Anti-PD-1 Non-responders

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2021-02-22
Completion: 2027-12-31
Conditions
Metastatic Colorectal Adenocarcinoma Metastatic Small Intestinal Adenocarcinoma Stage IV Colorectal Cancer AJCC v8 Stage IV Small Intestinal Adenocarcinoma AJCC v8 Stage IVA Colorectal Cancer AJCC v8 Stage IVB Colorectal Cancer AJCC v8 Stage IVC Colorectal Cancer AJCC v8
Interventions
PROCEDURE DRUG BIOLOGICAL OTHER
No Results Yet
NCT04727489 | RECRUITING
3800 Participants

Study of the Genetic Factors Involved in Autism and Related Disorders

Study Type: OBSERVATIONAL
Last Updated: 2025-12-23
Start Date: 2021-03-30
Completion: 2036-03-31
Conditions
Autism Spectrum Disorder
Interventions
GENETIC
No Results Yet
NCT04711824 | RECRUITING | PHASE1/PHASE2
41 Participants

Study of Stereotactic Radiosurgery With Olaparib Followed by Durvalumab and Physician's Choice Systemic Therapy in Subjects With Breast Cancer Brain Metastases

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2022-03-09
Completion: 2026-02-28
Conditions
Breast Cancer Brain Metastases, Adult
Interventions
DRUG RADIATION
No Results Yet
NCT04704115 | RECRUITING
62 Participants

The Therapy of Large Endometrioma

Study Type: OBSERVATIONAL
Last Updated: 2025-12-23
Start Date: 2021-01-21
Completion: 2026-12-31
Conditions
Endometrioma Endometriosis Ovary
No Results Yet
NCT04679285 | COMPLETED
9 Participants

Minimal Residual Disease Evaluation on Cryopreserved Ovarian Fragments in Younger Patients Treated for Acute Myeloid Leukemia

Study Type: OBSERVATIONAL
Last Updated: 2025-12-23
Start Date: 2021-04-26
Completion: 2022-09-04
Conditions
Acute Myeloid Leukemia
No Results Yet
NCT04674813 | ACTIVE_NOT_RECRUITING | PHASE1
180 Participants

A Study of CC-95266 in Participants With Relapsed and/or Refractory Multiple Myeloma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2021-02-24
Completion: 2026-01-08
Conditions
Multiple Myeloma
Interventions
DRUG
No Results Yet
NCT04673669 | COMPLETED | NA
46 Participants

Measurement of the Strength of the Posterior Tibial Muscle by Hand-held Dynamometer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2021-03-23
Completion: 2022-03-11
Conditions
Valgus Foot Deformity
Interventions
DIAGNOSTIC_TEST
No Results Yet
NCT04657120 | COMPLETED | NA
698 Participants

Safety and Efficiency of the YEARS Algorithm Versus Computed Tomography Pulmonary Angiography Alone for Suspected Pulmonary Embolism in Patients With Malignancy

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2019-06-01
Completion: 2025-08-23
Conditions
Pulmonary Embolism Embolism Embolism and Thrombosis Vascular Diseases Cardiovascular Diseases Lung Diseases Respiratory Tract Diseases Cancer Diagnosis
Interventions
PROCEDURE
No Results Yet
NCT04655365 | ACTIVE_NOT_RECRUITING | PHASE2
50 Participants

Detecting Metastases by PyL PET/CT in Subjects Starting Enzalutamide for Untreated Castration Resistant Prostate Cancer.

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2022-03-22
Completion: 2025-11-01
Conditions
Prostate Cancer
Interventions
DRUG
No Results Yet
NCT04653246 | ACTIVE_NOT_RECRUITING | PHASE2
52 Participants

Isatuximab, Lenalidomide, Bortezomib, and Dexamethasone in NDMM

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2021-07-13
Completion: 2025-12-15
Conditions
Multiple Myeloma Newly Diagnosed Multiple Myeloma (NDMM) Autologous Stem Cell Transplant
Interventions
DRUG
No Results Yet
NCT04649554 | TERMINATED | NA
2 Participants

Study of MRgFUS Exablate Treatment Following the Neuropathic Pain

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2020-10-08
Completion: 2021-12-31
Conditions
Neuropathic Pain
Interventions
DEVICE
No Results Yet
NCT04645251 | RECRUITING
500 Participants

Polycystic Liver Disease Registry (UK)

Study Type: OBSERVATIONAL
Last Updated: 2025-12-23
Start Date: 2021-01-21
Completion: 2030-12-01
Conditions
Polycystic Liver Disease
No Results Yet
NCT04639050 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2
241 Participants

Brainshuttle AD: A Multiple Ascending Dose Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO7126209 Following Intravenous Infusion in Participants With Prodromal or Mild to Moderate Alzheimer's Disease

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2021-03-15
Completion: 2030-06-30
Conditions
Alzheimers Disease
Interventions
DRUG
No Results Yet
NCT04634201 | RECRUITING | NA
116 Participants

Effect of Probiotics on the Periodontal Status of Orthodontic Patients

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2022-03-23
Completion: 2026-03-31
Conditions
Periodontal Health Gingivitis
Interventions
DIETARY_SUPPLEMENT
No Results Yet
NCT04618471 | ACTIVE_NOT_RECRUITING | NA
177 Participants

Paresthesia-Free Fast-Acting Subperception (FAST) Study

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2021-02-10
Completion: 2022-12-14
Conditions
Chronic Pain
Interventions
DEVICE
Results Available
NCT04616664 | COMPLETED
158 Participants

Diagnostic Accuracy of the "LLIFT", a Novel Non-invasive Biomarker for the Diagnosis of Non Alcoholic Fatty Liver (NAFL) and SteatoHepatitis (NASH) in a Population With High Risk of Metabolic Syndrome"

Study Type: OBSERVATIONAL
Last Updated: 2025-12-23
Start Date: 2021-02-16
Completion: 2024-01-17
Conditions
Obesity NASH - Nonalcoholic Steatohepatitis
No Results Yet
NCT04616183 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2
46 Participants

LY3214996 and Cetuximab Alone or in Combination With Abemaciclib for the Treatment of Unresectable or Metastatic Colorectal Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2020-12-02
Completion: 2028-12-31
Conditions
Metastatic Colon Adenocarcinoma Metastatic Colorectal Carcinoma Metastatic Rectal Adenocarcinoma Recurrent Colorectal Carcinoma Stage III Colon Cancer AJCC v8 Stage III Colorectal Cancer AJCC v8 Stage III Rectal Cancer AJCC v8 Stage IIIA Colon Cancer AJCC v8 Stage IIIA Colorectal Cancer AJCC v8 Stage IIIA Rectal Cancer AJCC v8 Stage IIIB Colon Cancer AJCC v8 Stage IIIB Colorectal Cancer AJCC v8 Stage IIIB Rectal Cancer AJCC v8 Stage IIIC Colon Cancer AJCC v8 Stage IIIC Colorectal Cancer AJCC v8 Stage IIIC Rectal Cancer AJCC v8 Stage IV Colon Cancer AJCC v8 Stage IV Colorectal Cancer AJCC v8 Stage IV Rectal Cancer AJCC v8 Stage IVA Colon Cancer AJCC v8 Stage IVA Colorectal Cancer AJCC v8 Stage IVA Rectal Cancer AJCC v8 Stage IVB Colon Cancer AJCC v8 Stage IVB Colorectal Cancer AJCC v8 Stage IVB Rectal Cancer AJCC v8 Stage IVC Colon Cancer AJCC v8 Stage IVC Colorectal Cancer AJCC v8 Stage IVC Rectal Cancer AJCC v8 Unresectable Colon Adenocarcinoma Unresectable Colorectal Carcinoma Unresectable Rectal Adenocarcinoma
Interventions
DRUG BIOLOGICAL
No Results Yet
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