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Clinical Trials

Showing trials with last updates posted in 2025.

NCT05080465 | COMPLETED | PHASE3
700 Participants

Long Term Follow up Mesenchymal Stem Cell Therapy for Patients Virus-related Liver Cirrhosis

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2018-12-02
Completion: 2024-10-07
Conditions
Liver Cirrhosis
Interventions
BIOLOGICAL
No Results Yet
NCT05075824 | ACTIVE_NOT_RECRUITING | PHASE2
90 Participants

A Study Evaluating the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Crovalimab as Adjunct Treatment in Prevention of Vaso-Occlusive Episodes (VOE) in Sickle Cell Disease (SCD)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-03-09
Completion: 2025-06-11
Conditions
Sickle Cell Disease
Interventions
DRUG
No Results Yet
NCT05074277 | COMPLETED | NA
20 Participants

Skeletal Response to Simulated Night Shift

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-02-08
Completion: 2025-12-18
Conditions
Osteoporosis Circadian Rhythm Sleep Disorder, Shift Work Type
Interventions
BEHAVIORAL
No Results Yet
NCT05069038 | ACTIVE_NOT_RECRUITING | PHASE2
51 Participants

Clinical Trial Assessing the Safety of Neoadjuvant Palbociclib in Combination With Endocrine Therapy

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-03-02
Completion: 2026-09-30
Conditions
Breast Cancer
Interventions
DRUG
No Results Yet
NCT05067569 | COMPLETED | NA
270 Participants

App-delivered Sleep ThERapy for Older Individuals With Insomnia

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-10-01
Completion: 2025-01-31
Conditions
Insomnia
Interventions
BEHAVIORAL
No Results Yet
NCT05066997 | ACTIVE_NOT_RECRUITING | PHASE2/PHASE3
552 Participants

A Pivotal Safety and Efficacy Study of OCS-01 Eye Drops in Participants With Diabetic Macular Edema (DIAMOND 1)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2021-10-19
Completion: 2026-04-30
Conditions
Diabetic Macular Edema
Interventions
DRUG
No Results Yet
NCT05066711 | ENROLLING_BY_INVITATION
75 Participants

NuVasive® ACP System Study

Study Type: OBSERVATIONAL
Last Updated: 2025-12-22
Start Date: 2022-05-22
Completion: 2026-09-30
Conditions
Cervical Spondylosis Cervical Radiculopathy Cervical Myelopathy Cervical Disc Disease Cervical Stenosis Cervical Disc Herniation Cervical Spine Disease
No Results Yet
NCT05063565 | ACTIVE_NOT_RECRUITING | PHASE2
100 Participants

TheraSphere With Durvalumab and Tremelimumab for HCC

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2023-11-03
Completion: 2027-06-30
Conditions
Hepatocellular Carcinoma
Interventions
DEVICE DRUG
No Results Yet
NCT05060016 | ACTIVE_NOT_RECRUITING | PHASE2
222 Participants

A Phase 2 Study of Tarlatamab in Patients With Small Cell Lung Cancer (SCLC)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2021-12-01
Completion: 2026-12-30
Conditions
Relapsed/Refractory Small Cell Lung Cancer
Interventions
DRUG
No Results Yet
NCT05039151 | COMPLETED
26 Participants

Interstitial Fluid Composition in Patients With Septic Versus Non-septic Shock: an Exploratory Pilot Study

Study Type: OBSERVATIONAL
Last Updated: 2025-12-22
Start Date: 2021-01-25
Completion: 2025-07-19
Conditions
Interstitial Liquid Septic Shock
Interventions
BIOLOGICAL
No Results Yet
NCT05035836 | RECRUITING | PHASE2
20 Participants

A Phase 2 Single-Arm Open-Label Pilot Trial Evaluating Zanidatamab (ZW25) in Patients With Early Stage HER2/Neu Positive (HER2+) Breast Cancer (BC)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2021-11-16
Completion: 2028-12-29
Conditions
Breast Cancer HER2-positive
Interventions
DRUG
No Results Yet
NCT05014204 | COMPLETED | NA
20 Participants

Safety and Feasibility of Novel Therapy for Duodenal Mucosal Regeneration for Type II Diabetes

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2021-10-29
Completion: 2024-05-29
Conditions
Diabetes Diabetes Type 2 Diabetes Mellitus, Type 2 Glucose Metabolism Disorders Metabolic Disease Endocrine System Diseases Diabetes Mellitus
Interventions
DEVICE
Results Available
NCT04996628 | RECRUITING | NA
150 Participants

Pancreatic Quantitative Sensory Testing (P-QST) to Predict Treatment Response for Pain in Chronic Pancreatitis

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-01-04
Completion: 2026-06-30
Conditions
Chronic Pancreatitis Chronic Pain
Interventions
DIAGNOSTIC_TEST
No Results Yet
NCT04994132 | ACTIVE_NOT_RECRUITING | PHASE3
118 Participants

A Study to Compare Early Use of Vinorelbine and Maintenance Therapy for Patients With High Risk Rhabdomyosarcoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2021-09-14
Completion: 2027-09-30
Conditions
Alveolar Rhabdomyosarcoma Botryoid-Type Embryonal Rhabdomyosarcoma Embryonal Rhabdomyosarcoma Metastatic Embryonal Rhabdomyosarcoma Metastatic Rhabdomyosarcoma Solid Alveolar Rhabdomyosarcoma Spindle Cell Rhabdomyosarcoma Spindle Cell/Sclerosing Rhabdomyosarcoma
Interventions
PROCEDURE DRUG BIOLOGICAL RADIATION
No Results Yet
NCT04975347 | COMPLETED | PHASE1
47 Participants

Opioid Antagonism in Individuals Ascertained Through the Partners HealthCare Biobank

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-06-03
Completion: 2025-08-08
Conditions
Reproductive Disorders
Interventions
DRUG
No Results Yet
NCT04975334 | COMPLETED | PHASE1
23 Participants

Opioid Antagonism in Hypogonadotropic Hypogonadism

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2025-06-18
Completion: 2025-09-26
Conditions
Hypogonadotropic Hypogonadism Low Testosterone
Interventions
DRUG
No Results Yet
NCT04965298 | RECRUITING | PHASE3
298 Participants

Treating People With Idiopathic Pulmonary Fibrosis With the Addition of Lansoprazole

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2021-06-16
Completion: 2026-02-28
Conditions
Idiopathic Pulmonary Fibrosis
Interventions
DRUG OTHER
No Results Yet
NCT04959279 | SUSPENDED | NA
26 Participants

ED-TREAT (Early Detection and Treatment to Reduce Events With Agitation Tool) Compared to Usual Care

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2026-03-01
Completion: 2026-08-01
Conditions
Psychomotor Agitation Behavioral Disorder
Interventions
OTHER
No Results Yet
NCT04953286 | COMPLETED | NA
55 Participants

Ocular Surface Metabolo-lipidomics in Lateral Amyotrophic Sclerosis

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2021-09-17
Completion: 2023-09-30
Conditions
Amyotrophic Lateral Sclerosis
Interventions
OTHER
No Results Yet
NCT04940299 | ACTIVE_NOT_RECRUITING | PHASE2
35 Participants

Tocilizumab, Ipilimumab, and Nivolumab for the Treatment of Advanced Melanoma, Non-Small Cell Lung Cancer, or Urothelial Carcinoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2021-09-23
Completion: 2027-12-31
Conditions
Clinical Stage III Cutaneous Melanoma AJCC v8 Clinical Stage IV Cutaneous Melanoma AJCC v8 Locally Advanced Bladder Carcinoma Locally Advanced Bladder Urothelial Carcinoma Locally Advanced Lung Non-Small Cell Carcinoma Locally Advanced Renal Pelvis Carcinoma Locally Advanced Renal Pelvis Urothelial Carcinoma Locally Advanced Ureter Urothelial Carcinoma Locally Advanced Urethral Urothelial Carcinoma Malignant Solid Neoplasm Metastatic Bladder Carcinoma Metastatic Bladder Urothelial Carcinoma Metastatic Lung Non-Small Cell Carcinoma Metastatic Melanoma Metastatic Renal Pelvis Urothelial Carcinoma Metastatic Ureter Urothelial Carcinoma Metastatic Urethral Carcinoma Metastatic Urethral Urothelial Carcinoma Pathologic Stage III Cutaneous Melanoma AJCC v8 Pathologic Stage IIIA Cutaneous Melanoma AJCC v8 Pathologic Stage IIIB Cutaneous Melanoma AJCC v8 Pathologic Stage IIIC Cutaneous Melanoma AJCC v8 Pathologic Stage IIID Cutaneous Melanoma AJCC v8 Pathologic Stage IV Cutaneous Melanoma AJCC v8 Stage III Bladder Cancer AJCC v8 Stage III Lung Cancer AJCC v8 Stage III Renal Pelvis Cancer AJCC v8 Stage III Ureter Cancer AJCC v8 Stage III Urethral Cancer AJCC v8 Stage IIIA Bladder Cancer AJCC v8 Stage IIIA Lung Cancer AJCC v8 Stage IIIB Bladder Cancer AJCC v8 Stage IIIB Lung Cancer AJCC v8 Stage IIIC Lung Cancer AJCC v8 Stage IV Bladder Cancer AJCC v8 Stage IV Lung Cancer AJCC v6 Stage IV Renal Pelvis Cancer AJCC v8 Stage IV Ureter Cancer AJCC v8 Stage IV Urethral Cancer AJCC v8 Stage IVA Lung Cancer AJCC v8 Stage IVB Lung Cancer AJCC v8 Unresectable Melanoma
Interventions
BIOLOGICAL
No Results Yet
NCT04939597 | ACTIVE_NOT_RECRUITING | PHASE3
192 Participants

A Study to See if Memantine Protects the Brain During Radiation Therapy Treatment for a Brain Tumor

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-05-10
Completion: 2026-06-30
Conditions
Central Nervous System Carcinoma
Interventions
PROCEDURE DRUG OTHER
No Results Yet
NCT04936178 | COMPLETED | PHASE1
258 Participants

A Study of NB003 in Patients With Advanced Malignancies

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2021-08-06
Completion: 2025-08-01
Conditions
Advanced Solid Tumor
Interventions
DRUG
No Results Yet
NCT04920604 | COMPLETED | NA
172 Participants

Anesthetic and Perioperative Risk Assessment Before Programmed Surgery: Anesthetic Teleconsultation Versus Face-to-face Anesthesia Consultation.

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2021-05-20
Completion: 2022-04-21
Conditions
Telemedicine Anesthesia Consultation, Remote
Interventions
OTHER
No Results Yet
NCT04916522 | ACTIVE_NOT_RECRUITING | PHASE2
150 Participants

The COlchicine HypERtENsion Trial

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2021-08-10
Completion: 2026-01-31
Conditions
Hypertension
Interventions
DRUG
No Results Yet
NCT04886804 | RECRUITING | PHASE1
554 Participants

Beamion LUNG-1: A Study to Test Different Doses of Zongertinib in People With Different Types of Advanced Cancer (Solid Tumours With Changes in the HER2 Gene)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2021-07-02
Completion: 2026-12-30
Conditions
Neoplasm Metastasis Non-Small Cell Lung Cancer
Interventions
DRUG
No Results Yet
NCT04879277 | COMPLETED | NA
40 Participants

Study of Low-grade Systemic Inflammation in Adult Patients With Phenylketonuria

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2021-05-26
Completion: 2021-08-25
Conditions
Phenylketonuria
Interventions
BIOLOGICAL
No Results Yet
NCT04870944 | RECRUITING | PHASE1/PHASE2
63 Participants

CBL0137 for the Treatment of Relapsed or Refractory Solid Tumors, Including CNS Tumors and Lymphoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-01-28
Completion: 2026-12-31
Conditions
Diffuse Midline Glioma, H3 K27-Altered Metastatic Malignant Neoplasm in the Central Nervous System Recurrent Diffuse Intrinsic Pontine Glioma Recurrent Diffuse Midline Glioma, H3 K27-Altered Recurrent Lymphoma Recurrent Malignant Solid Neoplasm Recurrent Primary Malignant Central Nervous System Neoplasm Refractory Lymphoma Refractory Malignant Solid Neoplasm Refractory Primary Malignant Central Nervous System Neoplasm
Interventions
PROCEDURE DRUG
No Results Yet
NCT04855370 | WITHDRAWN | NA
0 Participants

Non-Invasive Measurement of Cardiac Output and Stroke Volume in PE

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2025-07-15
Completion: 2026-01-31
Conditions
Pulmonary Embolism Pulmonary Embolus/Emboli Pulmonary Disease Pulmonary Embolism and Thrombosis Pulmonary Embolism Subacute Massive Pulmonary Embolism Acute Massive
Interventions
DEVICE
No Results Yet
NCT04854278 | RECRUITING
400 Participants

Introduction of an Operating Room Black Box to Identify, Analyse and Prevent Errors in the Vascular Hybrid Room

Study Type: OBSERVATIONAL
Last Updated: 2025-12-22
Start Date: 2019-02-19
Completion: 2027-12-31
Conditions
Patient Safety Endovascular Procedures Quality Improvement
Interventions
OTHER
No Results Yet
NCT04853251 | RECRUITING | PHASE4
188 Participants

A Study Assessing Corneal Endothelial Cells in Participants With Neovascular Age-related Macular Degeneration (nAMD) Treated With the Port Delivery System With Ranibizumab (PDS)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2021-12-14
Completion: 2028-03-31
Conditions
Neovascular Age-related Macular Degeneration
Interventions
DEVICE DRUG
No Results Yet
NCT04847089 | COMPLETED | NA
16 Participants

Motor Imagery BCI Rehabilitation After Stroke

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-04-14
Completion: 2025-07-01
Conditions
Stroke Hemiparesis
Interventions
DEVICE
No Results Yet
NCT04833556 | COMPLETED
649 Participants

Perioperative Outcomes of Postpartum Hemorrhage in Patients Undergoing Cesarean Delivery

Study Type: OBSERVATIONAL
Last Updated: 2025-12-22
Start Date: 2021-04-22
Completion: 2024-12-31
Conditions
Cesarean Section Complications Postpartum Hemorrhage Anesthesia Complication Blood Transfusion Complication Uterine Atony With Hemorrhage
No Results Yet
NCT04832763 | ACTIVE_NOT_RECRUITING | NA
32 Participants

Medical and Psychosocial Issues in Adolescents and Young Adults With Colorectal Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2019-09-27
Completion: 2026-12-31
Conditions
Stage I Colorectal Cancer AJCC v8 Stage II Colorectal Cancer AJCC v8 Stage IIA Colorectal Cancer AJCC v8 Stage IIB Colorectal Cancer AJCC v8 Stage IIC Colorectal Cancer AJCC v8 Stage III Colorectal Cancer AJCC v8 Stage IIIA Colorectal Cancer AJCC v8 Stage IIIB Colorectal Cancer AJCC v8 Stage IIIC Colorectal Cancer AJCC v8 Stage IV Colorectal Cancer AJCC v8 Stage IVA Colorectal Cancer AJCC v8 Stage IVB Colorectal Cancer AJCC v8 Stage IVC Colorectal Cancer AJCC v8
Interventions
PROCEDURE OTHER
No Results Yet
NCT04824794 | TERMINATED | PHASE1/PHASE2
130 Participants

GEN3014 Trial in Relapsed or Refractory Hematologic Malignancies

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2021-03-09
Completion: 2025-06-30
Conditions
Relapsed or Refractory Multiple Myeloma (RRMM) Diffuse Large B Cell Lymphoma (DLBCL) Acute Myeloid Leukemia (AML)
Interventions
BIOLOGICAL DRUG
No Results Yet
NCT04800341 | COMPLETED
233 Participants

Long-term Follow-up in Patients Included in the European Sleep Apnea Data Base (ESADA)

Study Type: OBSERVATIONAL
Last Updated: 2025-12-22
Start Date: 2021-05-12
Completion: 2022-06-06
Conditions
Sleep Apnea
Interventions
OTHER
No Results Yet
NCT04799288 | RECRUITING | PHASE1/PHASE2
24 Participants

Teriflunomide in HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2021-09-24
Completion: 2027-12-31
Conditions
HAM/TSP
Interventions
DRUG
No Results Yet
NCT04770571 | ENROLLING_BY_INVITATION
150 Participants

Posterior Cervical Fixation Study

Study Type: OBSERVATIONAL
Last Updated: 2025-12-22
Start Date: 2022-05-10
Completion: 2026-09-30
Conditions
Degenerative Disc Disease Craniocervical Injuries Cervical Radiculopathy Cervical Disc Disease Cervical Fusion Cervical Spine Disease Cervical Myelopathy Cervical Instabilities Spine Thoracic Injury
Interventions
DEVICE
No Results Yet
NCT04768777 | NOT_YET_RECRUITING | NA
30 Participants

Behavioral Intervention for Physical Activity and Sexual Dysfunction in Multiple Sclerosis

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2026-12-01
Completion: 2026-12-01
Conditions
Multiple Sclerosis, Relapsing-Remitting Sexual Dysfunction
Interventions
BEHAVIORAL
No Results Yet
NCT04752696 | COMPLETED | PHASE2
41 Participants

Onvansertib in Combination With Nanoliposomal Irinotecan, Leucovorin, and Fluorouracil for Second-Line Treatment of Participants With Metastatic Pancreatic Ductal Adenocarcinoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2021-05-25
Completion: 2024-12-24
Conditions
Pancreatic Ductal Adenocarcinoma
Interventions
DRUG
No Results Yet
NCT04751578 | ACTIVE_NOT_RECRUITING | NA
15 Participants

Abdominal Aortic Aneurysm Sac Healing and Prevention of Endoleaks - Netherlands

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2021-07-13
Completion: 2022-04-13
Conditions
Abdominal Aortic Aneurysm
Interventions
DEVICE
No Results Yet
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