Clinical Trials Updated in 2025

NCT06235229 | RECRUITING | PHASE1/PHASE2

110 Participants

A Study of GC012F in Patients With Relapsed/Refractory Multiple Myeloma

Study Type: INTERVENTIONAL

Last Updated: 2025-12-19

Start Date: 2023-12-26

Completion: 2026-03-02

Conditions

Multiple Myeloma

Interventions

BIOLOGICAL

No Results Yet

NCT06232655 | RECRUITING | PHASE2

20 Participants

Cladribine Venetoclax in Monocytic AML

Study Type: INTERVENTIONAL

Last Updated: 2025-12-19

Start Date: 2024-02-08

Completion: 2026-10-31

Conditions

Acute Myeloid Leukemia

Interventions

DRUG

No Results Yet

NCT06231472 | COMPLETED | NA

110 Participants

Effect of Preoperative Fluid Therapy on Post-induction Hypotension

Study Type: INTERVENTIONAL

Last Updated: 2025-12-19

Start Date: 2022-05-01

Completion: 2023-11-01

Conditions

Hypovolemia

Interventions

OTHER

No Results Yet

NCT06228703 | COMPLETED | NA

26 Participants

The Effects of Different Flow Settings on Lung Impedance

Study Type: INTERVENTIONAL

Last Updated: 2025-12-19

Start Date: 2024-05-19

Completion: 2024-10-15

Conditions

Healthy

Interventions

DEVICE

Results Available

NCT06226844 | RECRUITING | NA

54 Participants

Can the BeatMove Device Help Patients With Obliterative Arterial Disease of the Lower Limbs?

Study Type: INTERVENTIONAL

Last Updated: 2025-12-19

Start Date: 2024-06-14

Completion: 2027-11-01

Conditions

Atheromatous Lower Limb Ischemia Artery Disease

Interventions

DEVICE

No Results Yet

NCT06225271 | ACTIVE_NOT_RECRUITING | NA

934 Participants

Effects of the Combined Intervention of Exercise, Fruit, and Vitamin Supplementation on Frailty in Older Adults

Study Type: INTERVENTIONAL

Last Updated: 2025-12-19

Start Date: 2024-03-08

Completion: 2025-04-15

Conditions

Frailty

Interventions

BEHAVIORAL

No Results Yet

NCT06208150 | RECRUITING | PHASE3

795 Participants

A Study Comparing Talquetamab Plus Pomalidomide, Talquetamab Plus Teclistamab, and Elotuzumab, Pomalidomide, and Dexamethasone or Pomalidomide, Bortezomib, and Dexamethasone in Participants With Relapsed or Refractory Myeloma Who Have Received an Anti-CD38 Antibody and Lenalidomide

Study Type: INTERVENTIONAL

Last Updated: 2025-12-19

Start Date: 2024-01-22

Completion: 2026-04-23

Conditions

Multiple Myeloma

Interventions

DRUG

No Results Yet

NCT06202066 | SUSPENDED | PHASE2

60 Participants

Temozolomide and Survivin Long Peptide Vaccine (SurVaxM) for the Treatment of Patients With Progressing Metastatic Neuroendocrine Carcinomas

Study Type: INTERVENTIONAL

Last Updated: 2025-12-19

Start Date: 2026-02-15

Completion: 2027-10-15

Conditions

Digestive System Neuroendocrine Neoplasm Lung Neuroendocrine Neoplasm Malignant Solid Neoplasm Pancreatic Neuroendocrine Neoplasm

Interventions

PROCEDURE BIOLOGICAL DRUG

No Results Yet

NCT06186856 | RECRUITING

13000 Participants

Epidemiological Data on Mast Cell Pathologies in France

Study Type: OBSERVATIONAL

Last Updated: 2025-12-19

Start Date: 2024-01-01

Completion: 2038-12-31

Conditions

Mast Cell Disorder

No Results Yet

NCT06168942 | SUSPENDED | NA

1500 Participants

A Pivotal Investigational Device Exemption Study on Laminar Left Atrial Appendage Elimination

Study Type: INTERVENTIONAL

Last Updated: 2025-12-19

Start Date: 2024-02-19

Completion: 2028-12-01

Conditions

Non-valvular Atrial Fibrillation Stroke Systemic Embolism

Interventions

DEVICE

No Results Yet

NCT06160791 | RECRUITING | PHASE2

36 Participants

Ruxolitinib With De-Intensified HLH-94 for the Treatment of Hemophagocytic Lymphohistiocytosis (HLH)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-19

Start Date: 2024-10-01

Completion: 2027-12-31

Conditions

Hemophagocytic Lymphohistiocytoses

Interventions

DRUG PROCEDURE

No Results Yet

NCT06152003 | NOT_YET_RECRUITING | NA

60 Participants

Intervention Development for Syndemics Among PWH in SA

Study Type: INTERVENTIONAL

Last Updated: 2025-12-19

Start Date: 2026-03-01

Completion: 2027-12-31

Conditions

HIV Infections

Interventions

BEHAVIORAL

No Results Yet

NCT06145282 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2

6 Participants

Non-myeloablative Haploidentical HCT Study for Patients With Sickle Cell Disease, Including Compromised Organ Function

Study Type: INTERVENTIONAL

Last Updated: 2025-12-19

Start Date: 2023-12-28

Completion: 2025-10-27

Conditions

Sickle Cell Disease

Interventions

DRUG

No Results Yet

NCT06125860 | RECRUITING | NA

6750 Participants

BEP Targeting Strategies in Ethiopia

Study Type: INTERVENTIONAL

Last Updated: 2025-12-19

Start Date: 2023-08-07

Completion: 2026-07-31

Conditions

Small for Gestational Age at Delivery Gestational Weight Gain Stillbirth Preterm Birth Birth Weight Maternal Anemia in Pregnancy, Before Birth Neonatal Death Perinatal Death

Interventions

DIETARY_SUPPLEMENT

No Results Yet

NCT06111937 | COMPLETED | NA

148 Participants

Time Interval After Gastric Emptying and Quality of Bowel Cleansing

Study Type: INTERVENTIONAL

Last Updated: 2025-12-19

Start Date: 2023-11-01

Completion: 2024-06-30

Conditions

Colonoscopy

Interventions

OTHER

No Results Yet

NCT06111586 | RECRUITING | PHASE2

192 Participants

FrexalimAB in Preservation of Endogenous insULIN Secretion Compared to Placebo in adUlts and Adolescents on Top of inSulin Therapy (FABULINUS)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-19

Start Date: 2023-12-11

Completion: 2027-04-28

Conditions

Type 1 Diabetes Mellitus

Interventions

DRUG

No Results Yet

NCT06110754 | COMPLETED | NA

45 Participants

Development and Adaptation of I-STRONG for SCD

Study Type: INTERVENTIONAL

Last Updated: 2025-12-19

Start Date: 2023-06-08

Completion: 2024-06-14

Conditions

Sickle Cell Disease

Interventions

BEHAVIORAL

Results Available

NCT06108232 | RECRUITING | PHASE2

36 Participants

Phase 2 Trial of Obinutuzumab and CC-99282 for Patients With Previously Untreated High Tumor Burden Follicular Lymphoma

Study Type: INTERVENTIONAL

Last Updated: 2025-12-19

Start Date: 2024-03-15

Completion: 2027-12-31

Conditions

Follicular Lymphoma Tumor

Interventions

DRUG

No Results Yet

NCT06104124 | ACTIVE_NOT_RECRUITING | PHASE3

651 Participants

A Study to Evaluate the Efficacy and Safety of Dazodalibep in Participants With Sjögren's Syndrome (SS) With Moderate-to-severe Systemic Disease Activity

Study Type: INTERVENTIONAL

Last Updated: 2025-12-19

Start Date: 2024-01-24

Completion: 2026-06-24

Conditions

Sjogren's Syndrome

Interventions

DRUG

No Results Yet

NCT06099236 | RECRUITING

1070 Participants

A Prospective, Non-interventional, Observational Study of Presentation, Treatment Patterns and Outcomes in Atypical Hemolytic Uremic Syndrome Patients

Study Type: OBSERVATIONAL

Last Updated: 2025-12-19

Start Date: 2024-01-15

Completion: 2027-12-31

Conditions

Atypical Hemolytic Uremic Syndrome(aHUS)

No Results Yet

NCT06088784 | COMPLETED | PHASE1

76 Participants

A Study Assessing the Safety of Oral ATH-399A in Healthy Adult Participants

Study Type: INTERVENTIONAL

Last Updated: 2025-12-19

Start Date: 2023-09-19

Completion: 2024-04-24

Conditions

Healthy Volunteers

Interventions

DRUG

Results Available

NCT06087835 | ACTIVE_NOT_RECRUITING | PHASE3

1835 Participants

Study to Investigate Efficacy, Safety, and Tolerability of Zibotentan/Dapagliflozin Compared to Dapagliflozin in Participants With Chronic Kidney Disease and High Proteinuria (ZENITH High Proteinuria)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-19

Start Date: 2023-11-07

Completion: 2027-01-22

Conditions

Chronic Kidney Disease With High Proteinuria

Interventions

DRUG

No Results Yet

NCT06085742 | RECRUITING | PHASE2

25 Participants

BRE-08 Phase II Study of CMC Regimen for Early Stage Breast Cancer

Study Type: INTERVENTIONAL

Last Updated: 2025-12-19

Start Date: 2023-11-22

Completion: 2034-09-30

Conditions

Breast Cancer

Interventions

DRUG

No Results Yet

NCT06085274 | RECRUITING | NA

100 Participants

Sentinel lympH Node Biopsy With Indocyanine Green in Breast Cancer After NEoadjuvant Chemotherapy (SHINE)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-19

Start Date: 2025-09-03

Completion: 2026-04-30

Conditions

Breast Cancer

Interventions

PROCEDURE

No Results Yet

NCT06084403 | COMPLETED | NA

90 Participants

Ultrasound-Guided Adductor Canal Block for Total Knee Arthroplasty Surgery

Study Type: INTERVENTIONAL

Last Updated: 2025-12-19

Start Date: 2023-12-20

Completion: 2024-03-20

Conditions

Knee Disease Knee Deformity Knee Pain Chronic Knee Arthropathy Knee Osteoarthritis

Interventions

DRUG

No Results Yet

NCT06077773 | TERMINATED | PHASE2

113 Participants

Phase 2, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Effects of EP262 in Subjects With Chronic Spontaneous Urticaria

Study Type: INTERVENTIONAL

Last Updated: 2025-12-19

Start Date: 2023-09-25

Completion: 2024-12-18

Conditions

Chronic Spontaneous Urticaria

Interventions

DRUG

Results Available

NCT06074328 | COMPLETED | NA

30 Participants

Blended Reality Immersion for Geriatric Head Trauma: The BRIGHT Study

Study Type: INTERVENTIONAL

Last Updated: 2025-12-19

Start Date: 2023-11-29

Completion: 2025-08-15

Conditions

Traumatic Brain Injury

Interventions

DEVICE

No Results Yet

NCT06070233 | RECRUITING | NA

22 Participants

Radiosurgery Treatment for Spasticity Associated With Stroke, SCI & Cerebral Palsy

Study Type: INTERVENTIONAL

Last Updated: 2025-12-19

Start Date: 2023-10-12

Completion: 2026-12-31

Conditions

Spasticity as Sequela of Stroke Spastic Cerebral Palsy Spasticity, Muscle

Interventions

RADIATION OTHER

No Results Yet

NCT06067828 | ACTIVE_NOT_RECRUITING | PHASE3

171 Participants

A Study to Evaluate the Effect of Budesonide, Glycopyrronium, Formoterol Fumarate (BGF) Metered Dose Inhaler (MDI), Budesonide and Formoterol Fumarate (BFF) MDI and Placebo MDI on Exercise Parameters in Participants With Chronic Obstructive Pulmonary Disease (COPD).

Study Type: INTERVENTIONAL

Last Updated: 2025-12-19

Start Date: 2023-10-24

Completion: 2026-01-30

Conditions

Chronic Obstructive Pulmonary Disease

Interventions

DRUG

No Results Yet

NCT06065371 | RECRUITING | PHASE1

20 Participants

Sacituzumab Govitecan in Combination With Capecitabine for Advanced Gastrointestinal Cancers After Progression on Standard Therapy

Study Type: INTERVENTIONAL

Last Updated: 2025-12-19

Start Date: 2024-11-20

Completion: 2026-12-31

Conditions

Gastrointestinal Cancer

Interventions

DRUG

No Results Yet

NCT06050733 | RECRUITING

16 Participants

The Gut Microbiome and Immunotherapy Response in Solid Cancers

Study Type: OBSERVATIONAL

Last Updated: 2025-12-19

Start Date: 2023-06-30

Completion: 2026-12-30

Conditions

Cancer

No Results Yet

NCT06049654 | RECRUITING | NA

104 Participants

Comparison of Allegra vs Sapien Transcatheter Aortic Valves in Valve-In-Valve Indication

Study Type: INTERVENTIONAL

Last Updated: 2025-12-19

Start Date: 2024-02-01

Completion: 2026-11-01

Conditions

Aortic Valve Stenosis Structural Valve Deterioration

Interventions

DEVICE

No Results Yet

NCT06049212 | ACTIVE_NOT_RECRUITING | PHASE1

30 Participants

Sacituzumab Tirumotecan (MK-2870) as Monotherapy and in Combination With Pembrolizumab in Participants With Advanced Solid Tumors (MK-2870-008)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-19

Start Date: 2023-10-26

Completion: 2026-06-30

Conditions

Non-small Cell Lung Cancer Solid Tumors Programmed Cell Death-1 (PD1, PD-1) Programmed Cell Death 1 Ligand 1(PDL1, PD-L1) Programmed Cell Death 1 Ligand 2 (PDL2, PD-L2)

Interventions

BIOLOGICAL DRUG

No Results Yet

NCT06049017 | ACTIVE_NOT_RECRUITING | PHASE2

252 Participants

A Study of JNJ-77242113 in Participants With Moderately to Severely Active Ulcerative Colitis

Study Type: INTERVENTIONAL

Last Updated: 2025-12-19

Start Date: 2023-10-09

Completion: 2024-09-26

Conditions

Colitis, Ulcerative

Interventions

DRUG

No Results Yet

NCT06043713 | RECRUITING | PHASE1

24 Participants

Autologous CD8+ and CD4+ Transgenic T Cells Expressing High Affinity KRASG12V Mutation-Specific T Cell Receptors (FH-A11KRASG12V-TCR) in Treating Patients With Metastatic Solid Tumor Cancers With KRAS G12V Mutations

Study Type: INTERVENTIONAL

Last Updated: 2025-12-19

Start Date: 2023-12-15

Completion: 2028-01-01

Conditions

Metastatic Malignant Solid Neoplasm

Interventions

DRUG PROCEDURE BIOLOGICAL

No Results Yet

NCT06040099 | RECRUITING | PHASE2

60 Participants

A US Study to Evaluate Transarterial Radioembolization (TARE) in Combination With Durvalumab and Bevacizumab Therapy in People With Unresectable Hepatocellular Carcinoma Amenable to TARE

Study Type: INTERVENTIONAL

Last Updated: 2025-12-19

Start Date: 2024-02-13

Completion: 2026-10-23

Conditions

Hepatocellular Carcinoma (HCC)

Interventions

DRUG PROCEDURE

No Results Yet

NCT06034457 | COMPLETED

180 Participants

Testing the Effectiveness of WW Clinic GLP1

Study Type: OBSERVATIONAL

Last Updated: 2025-12-19

Start Date: 2024-01-18

Completion: 2024-10-17

Conditions

Weight Loss Obesity

Results Available

NCT06024265 | COMPLETED | EARLY_PHASE1

10 Participants

The Safety and Tolerability Study With ER2001 Intravenous Injection in Adults With Early Manifest Huntington's Disease

Study Type: INTERVENTIONAL

Last Updated: 2025-12-19

Start Date: 2023-04-04

Completion: 2025-01-31

Conditions

Huntington Disease

Interventions

DRUG

No Results Yet

NCT06021626 | RECRUITING | PHASE1

72 Participants

A Study of CRD3874-SI in People With Solid Tumors

Study Type: INTERVENTIONAL

Last Updated: 2025-12-19

Start Date: 2023-08-25

Completion: 2029-08-31

Conditions

Sarcoma Merkel Cell Carcinoma

Interventions

DRUG

No Results Yet

NCT06017557 | RECRUITING | NA

151 Participants

Predicting Outcome of Cytoreduction in Advanced Ovarian Cancer

Study Type: INTERVENTIONAL

Last Updated: 2025-12-19

Start Date: 2023-01-02

Completion: 2025-12-15

Conditions

Ovarian Cancer Stage III Ovarian Cancer Stage IV

Interventions

DIAGNOSTIC_TEST

No Results Yet