Clinical Trials

Showing trials with last updates posted in 2025.

NCT05614063 | ACTIVE_NOT_RECRUITING | PHASE3
360 Participants

A Randomized Study of XEN1101 Versus Placebo in Focal-Onset Seizures

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2022-11-18
Completion: 2025-12-31
Conditions
Focal Onset Seizures
Interventions
DRUG
No Results Yet
NCT05590377 | TERMINATED | PHASE1/PHASE2
15 Participants

A Study of Modakafusp Alfa Together With Daratumumab Adults With Relapsed or Refractory Multiple Myeloma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2023-01-23
Completion: 2024-05-22
Conditions
Multiple Myeloma
Interventions
DRUG
NCT05582187 | COMPLETED | PHASE1
28 Participants

A Clinical Trial of the Study Medicine (Called Fosmanogepix) in Participants With Varying Degrees of Hepatic Function.

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2022-10-31
Completion: 2025-10-16
Conditions
Hepatic Impairment
Interventions
DRUG
No Results Yet
NCT05575700 | COMPLETED | PHASE4
2904 Participants

Safety of Ibuprofen After Major Orthopaedic Surgeries

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2023-04-17
Completion: 2025-08-19
Conditions
Safety Issues Analgesia Analgesic Adverse Reaction Postoperative Pain Postoperative Complications Knee Arthropathy Pain, Acute Hip Arthropathy
Interventions
DRUG
No Results Yet
NCT05572905 | COMPLETED | NA
60 Participants

Effect of Acute Bout of Exercise on Levels of PAHSA

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2021-05-01
Completion: 2025-12-12
Conditions
Insulin Sensitivity
Interventions
OTHER
No Results Yet
NCT05572515 | ACTIVE_NOT_RECRUITING | PHASE3
614 Participants

A Study Comparing Teclistamab Monotherapy Versus Pomalidomide, Bortezomib, Dexamethasone (PVd) or Carfilzomib, Dexamethasone (Kd) in Participants With Relapsed or Refractory Multiple Myeloma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2023-03-29
Completion: 2026-02-13
Conditions
Relapsed or Refractory Multiple Myeloma
Interventions
DRUG
No Results Yet
NCT05568459 | ACTIVE_NOT_RECRUITING
11 Participants

A Trial That Evaluates Disease Characteristics in Hemophilia B Adult Male Participants Receiving Prophylaxis With Standard of Care Factor IX Protein (FIX) Replacement Therapy

Study Type: OBSERVATIONAL
Last Updated: 2025-12-19
Start Date: 2024-01-17
Completion: 2026-01-21
Conditions
Hemophilia B
Interventions
OTHER
No Results Yet
NCT05565560 | ACTIVE_NOT_RECRUITING | PHASE3
17 Participants

A Study to Assess the Efficacy and Safety of Apremilast in Japanese Pediatric Participants With Moderate to Severe Plaque Psoriasis

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2023-01-25
Completion: 2025-11-20
Conditions
Plaque Psoriasis
Interventions
DRUG
No Results Yet
NCT05557201 | RECRUITING
700 Participants

Cohort of Patients Presenting Unexplained Recurrent Miscarriages and Identification of Early Miscarriage Recidivism Factors

Study Type: OBSERVATIONAL
Last Updated: 2025-12-19
Start Date: 2022-10-24
Completion: 2027-10-31
Conditions
Miscarriage Early Pregnancy Loss
No Results Yet
NCT05556616 | TERMINATED | PHASE1
15 Participants

A Study of Modakafusp Alfa in Adult Participants With Multiple Myeloma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2023-01-12
Completion: 2024-06-04
Conditions
Multiple Myeloma
Interventions
DRUG
NCT05552222 | RECRUITING | PHASE3
1590 Participants

A Study of Teclistamab in Combination With Daratumumab and Lenalidomide (Tec-DR) and Talquetamab in Combination With Daratumumab and Lenalidomide (Tal-DR) in Participants With Newly Diagnosed Multiple Myeloma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2022-10-25
Completion: 2031-04-30
Conditions
Multiple Myeloma
Interventions
DRUG
No Results Yet
NCT05517434 | RECRUITING | PHASE2/PHASE3
148 Participants

Autologous BMA vs Saline and LAM + LP-PRP vs Saline Evaluations in Knee OA

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2025-01-01
Completion: 2026-06-30
Conditions
Osteoarthritis, Knee
Interventions
BIOLOGICAL OTHER
No Results Yet
NCT05499013 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2
69 Participants

Study to Assess SLN124 in Patients With Polycythemia Vera

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2023-01-26
Completion: 2026-09-30
Conditions
Polycythemia Vera
Interventions
DRUG
No Results Yet
NCT05498428 | RECRUITING | PHASE2
520 Participants

A Study of Amivantamab in Participants With Advanced or Metastatic Solid Tumors Including Epidermal Growth Factor Receptor (EGFR)-Mutated Non-Small Cell Lung Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2022-11-11
Completion: 2027-08-17
Conditions
Carcinoma, Non-small-Cell Lung
Interventions
DRUG
No Results Yet
NCT05493982 | ENROLLING_BY_INVITATION | NA
10800 Participants

Evaluation of the Be Vape Free Curriculum of the Tobacco Prevention Toolkit

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2022-10-19
Completion: 2026-06-01
Conditions
E-cigarette Use
Interventions
BEHAVIORAL
No Results Yet
NCT05490238 | RECRUITING | NA
708 Participants

DIStal Versus COnventional Radial Access for COMPLEX Large-bore Percutaneous Coronary Intervention

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2023-08-31
Completion: 2026-06-01
Conditions
Vascular Access Site Occlusion
Interventions
PROCEDURE
No Results Yet
NCT05488314 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2
57 Participants

A Study of Amivantamab and Capmatinib Combination Therapy in Unresectable Metastatic Non-small Cell Lung Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2022-12-13
Completion: 2026-06-09
Conditions
Carcinoma, Non-Small-Cell Lung
Interventions
DRUG
No Results Yet
NCT05479006 | RECRUITING | NA
30 Participants

Determine the Effect of Targeted High-definition Transcranial Direct Current Stimulation (tDCS) on Reducing Post-stroke Upper Limb Motor Impairments

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2022-09-30
Completion: 2026-06-30
Conditions
Stroke
Interventions
DEVICE
No Results Yet
NCT05477004 | ENROLLING_BY_INVITATION
100 Participants

Observational Study of Ketamine Infusions for the Treatment of Chronic Pain

Study Type: OBSERVATIONAL
Last Updated: 2025-12-19
Start Date: 2022-06-01
Completion: 2026-12-31
Conditions
Chronic Pain
Interventions
DRUG
No Results Yet
NCT05475002 | COMPLETED | NA
92 Participants

A Care Empowerment Program Using Virtual Reality for Family Caregivers of People With Dementia

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2022-08-01
Completion: 2023-07-01
Conditions
Dementia Family Caregiver
Interventions
OTHER
No Results Yet
NCT05465343 | COMPLETED | PHASE2
24 Participants

Furmonertinib in EGFR-Mutant NSCLC With Brain Metastases (iFORCE)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2022-07-11
Completion: 2025-12-12
Conditions
Furmonertinib EGFR-mutation NSCLC Brain Metastases
Interventions
DRUG
No Results Yet
NCT05457257 | COMPLETED | PHASE4
43 Participants

Clinical Study to Assess the Efficacy and Safety of Olaparib in Chinese Patients With Metastatic Castration-Resistant Prostate Cancer Who Have Failed Prior Treatment With a New Hormonal Agent and Have BRCA1/2 Mutations

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2022-07-29
Completion: 2024-10-22
Conditions
Metastatic Castration-resistant Prostate Cancer
Interventions
DRUG
NCT05453500 | RECRUITING | PHASE2
30 Participants

Chemotherapy (DA-EPOCH+/-R) and Targeted Therapy (Tafasitamab) for the Treatment of Newly-Diagnosed Philadelphia Chromosome Negative B Acute Lymphoblastic Leukemia

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2023-03-27
Completion: 2026-03-01
Conditions
B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative
Interventions
DRUG BIOLOGICAL PROCEDURE
No Results Yet
NCT05438043 | RECRUITING | PHASE3
500 Participants

A Study of Daratumumab

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2022-12-15
Completion: 2026-01-30
Conditions
Multiple Myeloma
Interventions
DRUG
No Results Yet
NCT05432817 | ACTIVE_NOT_RECRUITING | NA
120 Participants

PTSD Treatment for Incarcerated Men and Women: WPP

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2024-01-04
Completion: 2026-01-31
Conditions
PTSD
Interventions
BEHAVIORAL
No Results Yet
NCT05429853 | TERMINATED | NA
17 Participants

TOLER-ENT Study: A Study to Investigate the Tolerance of the High Energy, High Protein Formula Sondalis® HP 2 kcal

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2022-07-08
Completion: 2024-05-28
Conditions
Malnutrition
Interventions
DIETARY_SUPPLEMENT
No Results Yet
NCT05428436 | COMPLETED | PHASE1
24 Participants

A Study in Healthy People to Compare 2 Different Formulations of BI 1015550 Taken With or Without Food

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2022-08-15
Completion: 2022-09-30
Conditions
Healthy
Interventions
DRUG
NCT05421858 | RECRUITING | PHASE3
450 Participants

A Phase 3 Efficacy and Safety Study of Fosmanogepix for the Treatment of Adult Participants With Candidemia and/or Invasive Candidiasis.

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2024-12-11
Completion: 2028-01-30
Conditions
Candidemia Candidiasis, Invasive
Interventions
DRUG
No Results Yet
NCT05407025 | ACTIVE_NOT_RECRUITING
191 Participants

Targeting Inflammation for Endometrial Cancer Prevention

Study Type: OBSERVATIONAL
Last Updated: 2025-12-19
Start Date: 2021-12-01
Completion: 2026-12-31
Conditions
Endometrial Carcinoma
Interventions
PROCEDURE OTHER
No Results Yet
NCT05388669 | ACTIVE_NOT_RECRUITING | PHASE3
418 Participants

A Study of Lazertinib With Subcutaneous Amivantamab Compared With Intravenous Amivantamab in Participants With Epidermal Growth Factor Receptor (EGFR)-Mutated Advanced or Metastatic Non-small Cell Lung Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2022-08-05
Completion: 2024-01-03
Conditions
Advanced or Metastatic Non-small Cell Lung Cancer
Interventions
DRUG
No Results Yet
NCT05379595 | RECRUITING | PHASE1/PHASE2
225 Participants

A Study of Amivantamab Monotherapy and in Addition to Standard-of-Care Chemotherapy in Participants With Advanced or Metastatic Colorectal Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2022-07-29
Completion: 2027-04-27
Conditions
Advanced or Metastatic Colorectal Cancer
Interventions
BIOLOGICAL
No Results Yet
NCT05377476 | COMPLETED | NA
48 Participants

Effects of Motor Imagery and Action Observation in People With Multiple Sclerosis

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2022-06-01
Completion: 2024-04-01
Conditions
Multiple Sclerosis
Interventions
OTHER
No Results Yet
NCT05365581 | RECRUITING | PHASE1
398 Participants

A Study of ASP2138 Given by Itself or Given With Other Cancer Treatments in Adults With Stomach Cancer, Gastroesophageal Junction Cancer, or Pancreatic Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2022-06-07
Completion: 2026-11-30
Conditions
Gastric Adenocarcinoma Gastroesophageal Junction (GEJ) Adenocarcinoma Pancreatic Adenocarcinoma
Interventions
DRUG
No Results Yet
NCT05357482 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2
40 Participants

Addition of JSP191 (C-kit Antibody) to Nonmyeloablative Hematopoietic Cell Transplantation for Sickle Cell Disease and Beta-Thalassemia

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2022-05-12
Completion: 2026-01-31
Conditions
Sickle Cell Anemia Beta Thalassemia
Interventions
RADIATION DRUG BIOLOGICAL
No Results Yet
NCT05345158 | RECRUITING | NA
25 Participants

R-RPLND as First-line Treatment for Clinical Stage IIA/B Testicular Seminoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2022-02-23
Completion: 2030-11-30
Conditions
Lymphadenopathy Retroperitoneal Stage II Testicular Seminoma
Interventions
PROCEDURE
No Results Yet
NCT05330325 | ACTIVE_NOT_RECRUITING | PHASE3
399 Participants

A Research Study to Compare Somapacitan Once a Week With Norditropin® Once a Day in Children Who Need Help to Grow

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2022-08-10
Completion: 2024-08-05
Conditions
SGA, Turner Syndrome, Noonan Syndrome, ISS
Interventions
DRUG
No Results Yet
NCT05327114 | RECRUITING | PHASE2/PHASE3
201 Participants

Efficacy and Safety Study of Nipocalimab for Adults With Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2022-09-23
Completion: 2027-05-14
Conditions
Polyradiculoneuropathy, Chronic Inflammatory Demyelinating
Interventions
DRUG
No Results Yet
NCT05316155 | RECRUITING | PHASE1/PHASE2
262 Participants

Study of Erdafitinib Intravesical Delivery System for Localized Bladder Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2022-04-11
Completion: 2028-03-30
Conditions
Urinary Bladder Neoplasms Receptors, Fibroblast Growth Factor
Interventions
DRUG
No Results Yet
NCT05299658 | ACTIVE_NOT_RECRUITING | PHASE2
40 Participants

An Open-Label Extension for the Phase 2 Study in Early Symptomatic Amyotrophic Lateral Sclerosis Patients on Stable Background Therapy to Assess Bioenergetic Catalysis With CNM-Au8 to Slow Disease Progression in ALS

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2021-11-13
Completion: 2026-06-30
Conditions
Amyotrophic Lateral Sclerosis
Interventions
DRUG
No Results Yet
NCT05287594 | COMPLETED | NA
55 Participants

Feasibility of a Train-the-Trainer Delivered Exercise Intervention in Firefighters

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2023-04-01
Completion: 2025-09-26
Conditions
Firefighter High Intensity Interval Training
Interventions
BEHAVIORAL
No Results Yet
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