Clinical Trials Updated in 2025

NCT05457257 | COMPLETED | PHASE4

43 Participants

Clinical Study to Assess the Efficacy and Safety of Olaparib in Chinese Patients With Metastatic Castration-Resistant Prostate Cancer Who Have Failed Prior Treatment With a New Hormonal Agent and Have BRCA1/2 Mutations

Study Type: INTERVENTIONAL

Last Updated: 2025-12-19

Start Date: 2022-07-29

Completion: 2024-10-22

Conditions

Metastatic Castration-resistant Prostate Cancer

Interventions

DRUG

Results Available

NCT05453500 | RECRUITING | PHASE2

30 Participants

Chemotherapy (DA-EPOCH+/-R) and Targeted Therapy (Tafasitamab) for the Treatment of Newly-Diagnosed Philadelphia Chromosome Negative B Acute Lymphoblastic Leukemia

Study Type: INTERVENTIONAL

Last Updated: 2025-12-19

Start Date: 2023-03-27

Completion: 2026-03-01

Conditions

B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative

Interventions

DRUG BIOLOGICAL PROCEDURE

No Results Yet

NCT05438043 | RECRUITING | PHASE3

500 Participants

A Study of Daratumumab

Study Type: INTERVENTIONAL

Last Updated: 2025-12-19

Start Date: 2022-12-15

Completion: 2026-01-30

Conditions

Multiple Myeloma

Interventions

DRUG

No Results Yet

NCT05432817 | ACTIVE_NOT_RECRUITING | NA

120 Participants

PTSD Treatment for Incarcerated Men and Women: WPP

Study Type: INTERVENTIONAL

Last Updated: 2025-12-19

Start Date: 2024-01-04

Completion: 2026-01-31

Conditions

PTSD

Interventions

BEHAVIORAL

No Results Yet

NCT05429853 | TERMINATED | NA

17 Participants

TOLER-ENT Study: A Study to Investigate the Tolerance of the High Energy, High Protein Formula Sondalis® HP 2 kcal

Study Type: INTERVENTIONAL

Last Updated: 2025-12-19

Start Date: 2022-07-08

Completion: 2024-05-28

Conditions

Malnutrition

Interventions

DIETARY_SUPPLEMENT

No Results Yet

NCT05428436 | COMPLETED | PHASE1

24 Participants

A Study in Healthy People to Compare 2 Different Formulations of BI 1015550 Taken With or Without Food

Study Type: INTERVENTIONAL

Last Updated: 2025-12-19

Start Date: 2022-08-15

Completion: 2022-09-30

Conditions

Healthy

Interventions

DRUG

Results Available

NCT05421858 | RECRUITING | PHASE3

450 Participants

A Phase 3 Efficacy and Safety Study of Fosmanogepix for the Treatment of Adult Participants With Candidemia and/or Invasive Candidiasis.

Study Type: INTERVENTIONAL

Last Updated: 2025-12-19

Start Date: 2024-12-11

Completion: 2028-01-30

Conditions

Candidemia Candidiasis, Invasive

Interventions

DRUG

No Results Yet

NCT05407025 | ACTIVE_NOT_RECRUITING

191 Participants

Targeting Inflammation for Endometrial Cancer Prevention

Study Type: OBSERVATIONAL

Last Updated: 2025-12-19

Start Date: 2021-12-01

Completion: 2026-12-31

Conditions

Endometrial Carcinoma

Interventions

PROCEDURE OTHER

No Results Yet

NCT05388669 | ACTIVE_NOT_RECRUITING | PHASE3

418 Participants

A Study of Lazertinib With Subcutaneous Amivantamab Compared With Intravenous Amivantamab in Participants With Epidermal Growth Factor Receptor (EGFR)-Mutated Advanced or Metastatic Non-small Cell Lung Cancer

Study Type: INTERVENTIONAL

Last Updated: 2025-12-19

Start Date: 2022-08-05

Completion: 2024-01-03

Conditions

Advanced or Metastatic Non-small Cell Lung Cancer

Interventions

DRUG

No Results Yet

NCT05379595 | RECRUITING | PHASE1/PHASE2

225 Participants

A Study of Amivantamab Monotherapy and in Addition to Standard-of-Care Chemotherapy in Participants With Advanced or Metastatic Colorectal Cancer

Study Type: INTERVENTIONAL

Last Updated: 2025-12-19

Start Date: 2022-07-29

Completion: 2027-04-27

Conditions

Advanced or Metastatic Colorectal Cancer

Interventions

BIOLOGICAL

No Results Yet

NCT05377476 | COMPLETED | NA

48 Participants

Effects of Motor Imagery and Action Observation in People With Multiple Sclerosis

Study Type: INTERVENTIONAL

Last Updated: 2025-12-19

Start Date: 2022-06-01

Completion: 2024-04-01

Conditions

Multiple Sclerosis

Interventions

OTHER

No Results Yet

NCT05365581 | RECRUITING | PHASE1

398 Participants

A Study of ASP2138 Given by Itself or Given With Other Cancer Treatments in Adults With Stomach Cancer, Gastroesophageal Junction Cancer, or Pancreatic Cancer

Study Type: INTERVENTIONAL

Last Updated: 2025-12-19

Start Date: 2022-06-07

Completion: 2026-11-30

Conditions

Gastric Adenocarcinoma Gastroesophageal Junction (GEJ) Adenocarcinoma Pancreatic Adenocarcinoma

Interventions

DRUG

No Results Yet

NCT05357482 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2

40 Participants

Addition of JSP191 (C-kit Antibody) to Nonmyeloablative Hematopoietic Cell Transplantation for Sickle Cell Disease and Beta-Thalassemia

Study Type: INTERVENTIONAL

Last Updated: 2025-12-19

Start Date: 2022-05-12

Completion: 2026-01-31

Conditions

Sickle Cell Anemia Beta Thalassemia

Interventions

RADIATION DRUG BIOLOGICAL

No Results Yet

NCT05345158 | RECRUITING | NA

25 Participants

R-RPLND as First-line Treatment for Clinical Stage IIA/B Testicular Seminoma

Study Type: INTERVENTIONAL

Last Updated: 2025-12-19

Start Date: 2022-02-23

Completion: 2030-11-30

Conditions

Lymphadenopathy Retroperitoneal Stage II Testicular Seminoma

Interventions

PROCEDURE

No Results Yet

NCT05330325 | ACTIVE_NOT_RECRUITING | PHASE3

399 Participants

A Research Study to Compare Somapacitan Once a Week With Norditropin® Once a Day in Children Who Need Help to Grow

Study Type: INTERVENTIONAL

Last Updated: 2025-12-19

Start Date: 2022-08-10

Completion: 2024-08-05

Conditions

SGA, Turner Syndrome, Noonan Syndrome, ISS

Interventions

DRUG

No Results Yet

NCT05327114 | RECRUITING | PHASE2/PHASE3

201 Participants

Efficacy and Safety Study of Nipocalimab for Adults With Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-19

Start Date: 2022-09-23

Completion: 2027-05-14

Conditions

Polyradiculoneuropathy, Chronic Inflammatory Demyelinating

Interventions

DRUG

No Results Yet

NCT05316155 | RECRUITING | PHASE1/PHASE2

262 Participants

Study of Erdafitinib Intravesical Delivery System for Localized Bladder Cancer

Study Type: INTERVENTIONAL

Last Updated: 2025-12-19

Start Date: 2022-04-11

Completion: 2028-03-30

Conditions

Urinary Bladder Neoplasms Receptors, Fibroblast Growth Factor

Interventions

DRUG

No Results Yet

NCT05299658 | ACTIVE_NOT_RECRUITING | PHASE2

40 Participants

An Open-Label Extension for the Phase 2 Study in Early Symptomatic Amyotrophic Lateral Sclerosis Patients on Stable Background Therapy to Assess Bioenergetic Catalysis With CNM-Au8 to Slow Disease Progression in ALS

Study Type: INTERVENTIONAL

Last Updated: 2025-12-19

Start Date: 2021-11-13

Completion: 2026-06-30

Conditions

Amyotrophic Lateral Sclerosis

Interventions

DRUG

No Results Yet

NCT05287594 | COMPLETED | NA

55 Participants

Feasibility of a Train-the-Trainer Delivered Exercise Intervention in Firefighters

Study Type: INTERVENTIONAL

Last Updated: 2025-12-19

Start Date: 2023-04-01

Completion: 2025-09-26

Conditions

Firefighter High Intensity Interval Training

Interventions

BEHAVIORAL

No Results Yet

NCT05277051 | RECRUITING | PHASE1

158 Participants

First-Time-in-Human Study of GSK4381562 in Participants With Advanced Solid Tumors

Study Type: INTERVENTIONAL

Last Updated: 2025-12-19

Start Date: 2022-03-22

Completion: 2027-08-31

Conditions

Neoplasms

Interventions

DRUG

No Results Yet

NCT05276973 | ACTIVE_NOT_RECRUITING | PHASE1

25 Participants

Testing the Addition of Ipatasertib to the Usual Chemotherapy Treatment (Paclitaxel and Carboplatin) for Stage III or IV Epithelial Ovarian Cancer

Study Type: INTERVENTIONAL

Last Updated: 2025-12-19

Start Date: 2022-09-08

Completion: 2025-01-30

Conditions

Fallopian Tube Endometrioid Adenocarcinoma Fallopian Tube High Grade Serous Adenocarcinoma Ovarian Endometrioid Adenocarcinoma Ovarian High Grade Serous Adenocarcinoma Primary Peritoneal Endometrioid Adenocarcinoma Primary Peritoneal High Grade Serous Adenocarcinoma Stage III Fallopian Tube Cancer AJCC v8 Stage III Ovarian Cancer AJCC v8 Stage III Primary Peritoneal Cancer AJCC v8 Stage IV Fallopian Tube Cancer AJCC v8 Stage IV Ovarian Cancer AJCC v8 Stage IV Primary Peritoneal Cancer AJCC v8 Unresectable Fallopian Tube Endometrioid Adenocarcinoma Unresectable Fallopian Tube High Grade Serous Adenocarcinoma Unresectable Ovarian Endometrioid Adenocarcinoma Unresectable Ovarian High Grade Serous Adenocarcinoma Unresectable Primary Peritoneal Endometrioid Adenocarcinoma Unresectable Primary Peritoneal High Grade Serous Adenocarcinoma

Interventions

PROCEDURE DRUG

Results Available

NCT05270213 | RECRUITING | PHASE1

164 Participants

Evaluation of RBS2418 in Subjects With Advanced, Metastatic Solid Tumors

Study Type: INTERVENTIONAL

Last Updated: 2025-12-19

Start Date: 2022-07-11

Completion: 2027-04-30

Conditions

Advanced Cancer

Interventions

DRUG

No Results Yet

NCT05259839 | ACTIVE_NOT_RECRUITING | PHASE1

283 Participants

A Study to Assess Adverse Events and Change in Disease Activity of Intravenously (IV) Infused Etentamig (ABBV-383) in Combination With Anti-Cancer Regimens for the Treatment of Adult Participants With Relapsed/Refractory Multiple Myeloma

Study Type: INTERVENTIONAL

Last Updated: 2025-12-19

Start Date: 2022-10-20

Completion: 2033-09-30

Conditions

Relapsed/Refractory Multiple Myeloma

Interventions

DRUG

No Results Yet

NCT05257824 | COMPLETED | PHASE4

528 Participants

Optimal Duration of Dual Antiplatelet Therapy After Stent-assisted Coiling

Study Type: INTERVENTIONAL

Last Updated: 2025-12-19

Start Date: 2022-06-23

Completion: 2025-12-02

Conditions

Aneurysm Cerebral Endovascular Procedures

Interventions

DRUG

No Results Yet

NCT05250973 | ACTIVE_NOT_RECRUITING | PHASE2

151 Participants

A Study of Daratumumab-Based Therapies in Participants With Amyloid Light Chain (AL) Amyloidosis

Study Type: INTERVENTIONAL

Last Updated: 2025-12-19

Start Date: 2022-03-01

Completion: 2025-05-30

Conditions

Amyloidosis

Interventions

DRUG

No Results Yet

NCT05249101 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2

70 Participants

A Study of Ivaltinostat Plus Capecitabine or Capecitabine in Metastatic Pancreatic Adenocarcinoma

Study Type: INTERVENTIONAL

Last Updated: 2025-12-19

Start Date: 2022-08-15

Completion: 2026-06-30

Conditions

Metastatic Pancreatic Adenocarcinoma

Interventions

DRUG

No Results Yet

NCT05242471 | ACTIVE_NOT_RECRUITING | PHASE2

703 Participants

A Study of Combination Therapy With Guselkumab and Golimumab in Participants With Moderately to Severely Active Crohn's Disease

Study Type: INTERVENTIONAL

Last Updated: 2025-12-19

Start Date: 2022-07-22

Completion: 2025-05-23

Conditions

Crohn's Disease

Interventions

BIOLOGICAL DRUG

No Results Yet

NCT05235425 | COMPLETED | NA

304 Participants

The Lifestyle Education About Prediabetes (Leap) Study

Study Type: INTERVENTIONAL

Last Updated: 2025-12-19

Start Date: 2022-03-20

Completion: 2025-11-14

Conditions

PreDiabetes

Interventions

BEHAVIORAL

No Results Yet

NCT05231785 | RECRUITING | PHASE1

60 Participants

A Study to Evaluate the Safety and Tolerability of ALN-APP in Patients With EOAD

Study Type: INTERVENTIONAL

Last Updated: 2025-12-19

Start Date: 2022-02-04

Completion: 2029-03-28

Conditions

Early-Onset Alzheimer Disease

Interventions

DRUG

No Results Yet

NCT05221931 | RECRUITING | NA

1350 Participants

Drug-Coated Balloon in Patients With High Bleeding Risk

Study Type: INTERVENTIONAL

Last Updated: 2025-12-19

Start Date: 2022-07-29

Completion: 2027-11-30

Conditions

Coronary Artery Disease

Interventions

PROCEDURE

No Results Yet

Study Type: INTERVENTIONAL

Last Updated: 2025-12-19

Start Date: 2021-11-02

Completion: 2024-11-20

Conditions

Chronic Heart Failure With Reduced Ejection Fraction

Interventions

DRUG

Results Available