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Clinical Trials

Showing trials with last updates posted in 2025.

NCT03245892 | COMPLETED | PHASE1
27 Participants

A Study of Carboplatin and Paclitaxel Chemotherapy With Nivolumab With or Without Ipilimumab in Patients With Ovarian Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2017-08-04
Completion: 2025-12-04
Conditions
High Grade Serous Ovarian Fallopian Tube Primary Peritoneal Cancer
Interventions
DRUG PROCEDURE
No Results Yet
NCT03224000 | ACTIVE_NOT_RECRUITING | PHASE2
90 Participants

Trial of Magnetic Resonance Imaging Guided Radiotherapy Dose Adaptation in Human Papilloma Virus Positive Oropharyngeal Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2018-01-17
Completion: 2026-12-31
Conditions
Malignant Neoplasms of Lip Oral Cavity and Pharynx Oropharyngeal Cancer
Interventions
PROCEDURE BEHAVIORAL RADIATION
No Results Yet
NCT03215706 | COMPLETED | PHASE3
719 Participants

A Study of Nivolumab and Ipilimumab Combined With Chemotherapy Compared to Chemotherapy Alone in First Line NSCLC

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2017-08-24
Completion: 2019-08-16
Conditions
Non-Small Cell Lung Cancer
Interventions
BIOLOGICAL DRUG
Results Available
NCT03152773 | SUSPENDED | NA
22 Participants

Heart Catheterization Using Magnetic Resonance Imaging (MRI) Fluoroscopy and Passive Guidewires

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2017-08-02
Completion: 2027-12-01
Conditions
Pulmonary Artery Hypertension Congenital Heart Disease Structural Heart Disease
Interventions
PROCEDURE
No Results Yet
NCT03092856 | ACTIVE_NOT_RECRUITING | PHASE2
62 Participants

Axitinib With or Without Anti-OX40 Antibody PF-04518600 in Treating Patients With Metastatic Kidney Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2017-07-19
Completion: 2026-06-30
Conditions
Clear Cell Renal Cell Carcinoma Metastatic Renal Cell Cancer Recurrent Renal Cell Carcinoma Stage IV Renal Cell Cancer
Interventions
OTHER BIOLOGICAL DRUG
No Results Yet
NCT03077451 | COMPLETED | PHASE2
36 Participants

Nelfinavir Mesylate in Treating Patients With Kaposi Sarcoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2017-03-13
Completion: 2022-05-23
Conditions
Recurrent Kaposi Sarcoma Skin Kaposi Sarcoma
Interventions
OTHER DRUG
Results Available
NCT03065881 | COMPLETED | NA
664 Participants

RETeval All Comers Trial (REACT)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2017-02-13
Completion: 2021-12-21
Conditions
Retinal Disease, Electroretinogram
Interventions
DEVICE
No Results Yet
NCT03013998 | RECRUITING | PHASE1/PHASE2
3000 Participants

Study of Biomarker-Based Treatment of Acute Myeloid Leukemia

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2016-11-30
Completion: 2028-12-31
Conditions
Previously Untreated Relapsed Refractory Acute Myeloid Leukemia
Interventions
DRUG BIOLOGICAL OTHER
No Results Yet
NCT02996721 | COMPLETED | PHASE4
634 Participants

A Trial Evaluating Vitamin D Normalization on Major Adverse Cardiovascular-Related Events Among Myocardial Infarction Patients

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2017-04-03
Completion: 2025-03-30
Conditions
Death Myocardial Infarction Cerebral Vascular Accident Heart Failure Hospitalization
Interventions
BIOLOGICAL
No Results Yet
NCT02987257 | COMPLETED | PHASE3
2 Participants

NATIENS: Optimal Management and Mechanisms of SJS/TEN

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2023-03-21
Completion: 2025-10-31
Conditions
Stevens-Johnson Syndrome Toxic Epidermal Necrolyses
Interventions
DRUG
No Results Yet
NCT02965521 | COMPLETED | NA
50 Participants

Survivor Choices for Eating and Drinking - Colorectal Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2017-04-10
Completion: 2018-09-02
Conditions
Colon Cancer Rectal Cancer ColoRectal Cancer
Interventions
BEHAVIORAL
No Results Yet
NCT02960022 | RECRUITING | PHASE2
900 Participants

A Study for Subjects With Prostate Cancer Who Previously Participated in an Enzalutamide Clinical Study

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2016-12-22
Completion: 2029-07-31
Conditions
Prostate Cancer
Interventions
DRUG
No Results Yet
NCT02959021 | COMPLETED | NA
375 Participants

Partnership Optimizes Weight Management in Primary Care

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2017-01-31
Completion: 2021-04-15
Conditions
Obesity
Interventions
BEHAVIORAL
No Results Yet
NCT02955940 | ACTIVE_NOT_RECRUITING | PHASE2
10 Participants

An Open-Label Study to Enable Continued Treatment Access for Subjects Previously Enrolled in Studies of Ruxolitinib

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2016-11-30
Completion: 2027-09-30
Conditions
Pancreatic Cancer Colorectal Cancer (CRC) Breast Cancer Lung Cancer
Interventions
DRUG
No Results Yet
NCT02954094 | ACTIVE_NOT_RECRUITING
10000 Participants

A Longitudinal Observational Study of the Natural History and Management of Patients With HCC

Study Type: OBSERVATIONAL
Last Updated: 2025-12-17
Start Date: 2016-12-31
Completion: 2026-02-28
Conditions
Hepatocellular Cancer
No Results Yet
NCT02931175 | COMPLETED | PHASE2
28 Participants

ACTH as A Re-emerging theRapy for Uveitis (The ACTHAR Study)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2017-11-10
Completion: 2020-04-03
Conditions
Uveitis
Interventions
DRUG
No Results Yet
NCT02915198 | RECRUITING | PHASE4
7410 Participants

Investigation of Metformin in Pre-Diabetes on Atherosclerotic Cardiovascular OuTcomes

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2023-04-03
Completion: 2029-09-28
Conditions
Prediabetic State Atherosclerosis Metformin
Interventions
DRUG
No Results Yet
NCT02910700 | ACTIVE_NOT_RECRUITING | PHASE2
52 Participants

Nivolumab With Trametinib and Dabrafenib, or Encorafenib and Binimetinib in Treating Patients With BRAF Mutated Metastatic or Unresectable Stage III-IV Melanoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2016-12-09
Completion: 2027-12-08
Conditions
Metastatic Malignant Neoplasm in the Brain Metastatic Melanoma Stage III Cutaneous Melanoma AJCC v7 Stage IIIA Cutaneous Melanoma AJCC v7 Stage IIIB Cutaneous Melanoma AJCC v7 Stage IIIC Cutaneous Melanoma AJCC v7 Stage IV Cutaneous Melanoma AJCC v6 and v7 Unresectable Melanoma
Interventions
DRUG OTHER BIOLOGICAL
No Results Yet
NCT02902757 | COMPLETED | NA
7 Participants

FDG PET/CT in Monitoring Very Early Therapy Response in Patients With Glioblastoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2015-08-25
Completion: 2025-01-29
Conditions
Glioblastoma
Interventions
PROCEDURE RADIATION
No Results Yet
NCT02861573 | RECRUITING | PHASE1/PHASE2
1200 Participants

Study of Pembrolizumab (MK-3475) Combination Therapies in Metastatic Castration-Resistant Prostate Cancer (MK-3475-365/KEYNOTE-365)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2016-11-17
Completion: 2027-10-22
Conditions
Metastatic Castration-Resistant Prostate Cancer
Interventions
BIOLOGICAL DRUG OTHER
No Results Yet
NCT02846571 | RECRUITING | PHASE1/PHASE2
2 Participants

Pancreatic Islet Transplantation Into the Anterior Chamber of the Eye

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2019-12-05
Completion: 2026-12-31
Conditions
Diabetes
Interventions
BIOLOGICAL
No Results Yet
NCT02817880 | COMPLETED | NA
36 Participants

Comparison of the Analgesic Effect Between the Motor Cortex Stimulation and the Trans-spinal Stimulation in the Algoneurodystrophy.

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2016-07-25
Completion: 2021-06-11
Conditions
Algoneurodystrophy
Interventions
DEVICE
No Results Yet
NCT02738606 | TERMINATED | PHASE2
28 Participants

Liver Surgery and Chemotherapy in Treating Patients With Colorectal Cancer With Liver Metastases That Can Be Removed by Surgery and Lung Metastases That Cannot Be Removed by Surgery

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2016-05-25
Completion: 2025-12-05
Conditions
Metastatic Colorectal Carcinoma Metastatic Malignant Neoplasm in the Liver Metastatic Malignant Neoplasm in the Lung Recurrent Colorectal Carcinoma Resectable Colorectal Carcinoma Stage IV Colorectal Cancer AJCC v7 Stage IVA Colorectal Cancer AJCC v7 Stage IVB Colorectal Cancer AJCC v7
Interventions
PROCEDURE DRUG OTHER
No Results Yet
NCT02736669 | COMPLETED | NA
223 Participants

CARE Trial: Comparing Different Levels of Calorie Reduction for Weight Loss

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2015-10-31
Completion: 2021-04-30
Conditions
Overweight Obesity
Interventions
BEHAVIORAL
No Results Yet
NCT02716246 | RECRUITING | PHASE2/PHASE3
36 Participants

Phase I/II/III Gene Transfer Clinical Trial of scAAV9.U1a.hSGSH

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2016-04-25
Completion: 2027-07-31
Conditions
MPS IIIA Sanfilippo Syndrome Sanfilippo A Mucopolysaccharidosis III
Interventions
BIOLOGICAL DRUG
No Results Yet
NCT02707029 | RECRUITING
10000 Participants

Clinical and Scientific Assessment of Pain and Painful Disorders

Study Type: OBSERVATIONAL
Last Updated: 2025-12-17
Start Date: 2016-07-22
Completion: 2026-02-09
Conditions
Normal Physiology Pain
No Results Yet
NCT02694783 | COMPLETED | EARLY_PHASE1
60 Participants

Adoptive Cellular Immunotherapy for Progressive Multifocal Leukoencephalopathy With Ex Vivo Generated Polyomavirus-Specific T-Cells

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2016-03-28
Completion: 2019-12-13
Conditions
Progressive Multifocal Leukoencephalopathy
Interventions
BIOLOGICAL
No Results Yet
NCT02630615 | RECRUITING
80 Participants

Circulating Tumor Cells (CTC) in Lung Cancer

Study Type: OBSERVATIONAL
Last Updated: 2025-12-17
Start Date: 2017-10-19
Completion: 2026-10-31
Conditions
Lung Neoplasms
Interventions
OTHER
No Results Yet
NCT02600156 | COMPLETED | NA
7 Participants

Focal Laser Ablation of Low to Intermediate Prostate Cancer Tumors

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2015-09-01
Completion: 2025-08-20
Conditions
Prostate Cancer Prostate Adenocarcinoma Stage I Prostate Cancer AJCC v8 Stage II Prostate Cancer AJCC v8 Localized Prostate Carcinoma
Interventions
PROCEDURE
No Results Yet
NCT02591420 | COMPLETED | PHASE1
24 Participants

Safety and Virologic Effect of a Human Monoclonal Antibody (VRC01) Administered Intravenously to Adults During Early Acute HIV Infection

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2016-04-30
Completion: 2021-03-15
Conditions
HIV Infections
Interventions
BIOLOGICAL DRUG
Results Available
NCT02466607 | COMPLETED | NA
18 Participants

Study of Stimulus Parameters in Flicker Electroretinogram (ERG)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2015-03-31
Completion: 2015-07-31
Conditions
Retinopathy
Interventions
DEVICE OTHER
No Results Yet
NCT02461888 | COMPLETED | PHASE2
112 Participants

Phase II Randomised Trial of Cyclophosphamide & Dexamethasone in Combination With Ixazomib in Relapsed or Refractory Multiple Myeloma.

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2015-12-31
Completion: 2022-04-30
Conditions
Multiple Myeloma
Interventions
DRUG
No Results Yet
NCT02440672 | ACTIVE_NOT_RECRUITING
170 Participants

JOURNEY™ II CR Total Knee System

Study Type: OBSERVATIONAL
Last Updated: 2025-12-17
Start Date: 2015-09-30
Completion: 2028-06-30
Conditions
Osteoarthritis, Knee
Interventions
DEVICE
No Results Yet
NCT02422641 | RECRUITING | PHASE2
16 Participants

Prospective Evaluation Of High-Dose Systemic Methotrexate In Patients With Breast Cancer And Leptomeningeal Metastasis

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2015-05-31
Completion: 2026-05-31
Conditions
Metastatic Breast Cancer Leptomeningeal Disease
Interventions
DRUG
No Results Yet
NCT02363595 | RECRUITING
500 Participants

Genomic Predictors of Papillary Microcarcinoma Disease Progression

Study Type: OBSERVATIONAL
Last Updated: 2025-12-17
Start Date: 2014-12-31
Completion: 2026-12-31
Conditions
Papillary Microcarcinoma
No Results Yet
NCT02292004 | ACTIVE_NOT_RECRUITING | NA
20 Participants

Bridge-Enhanced ACL Repair-Safety Study (BEAR Trial)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2015-01-31
Completion: 2018-03-19
Conditions
Anterior Cruciate Ligament Injury Anterior Cruciate Ligament Tear
Interventions
DEVICE PROCEDURE
No Results Yet
NCT02271919 | ACTIVE_NOT_RECRUITING | PHASE4
631 Participants

Varenicline and Combined NRT for Smoking Cessation

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2015-05-14
Completion: 2025-06-30
Conditions
Cigarette Smoker Tobacco Use Disorder
Interventions
DRUG OTHER
No Results Yet
NCT02247843 | COMPLETED | PHASE1/PHASE2
4 Participants

Stem Cell Gene Therapy for Sickle Cell Disease

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2014-12-31
Completion: 2025-09-24
Conditions
Sickle Cell Disease
Interventions
BIOLOGICAL
No Results Yet
NCT02092155 | ENROLLING_BY_INVITATION
95 Participants

Biomarker Levels During Indwelling Pleural cAtheter Sample Testing

Study Type: OBSERVATIONAL
Last Updated: 2025-12-17
Start Date: 2014-01-31
Completion: 2026-12-31
Conditions
Malignant Pleural Effusions
No Results Yet
NCT02079662 | ACTIVE_NOT_RECRUITING | NA
110 Participants

The Role of Lifestyle Factors in Breast Cancer-Related Outcomes

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2013-06-13
Completion: 2030-12-31
Conditions
Stage II Breast Cancer AJCC v6 and v7 Stage IIA Breast Cancer AJCC v6 and v7 Stage IIB Breast Cancer AJCC v6 and v7 Stage III Breast Cancer AJCC v7 Stage IIIA Breast Cancer AJCC v7 Stage IIIB Breast Cancer AJCC v7 Stage IIIC Breast Cancer AJCC v7
Interventions
OTHER BEHAVIORAL
No Results Yet
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