Clinical Trials

Showing trials with last updates posted in 2025.

NCT05834881 | RECRUITING | NA
80 Participants

Reducing Drug Use in Justice-Involved Emerging Adults

Study Type: INTERVENTIONAL
Last Updated: 2025-12-16
Start Date: 2023-05-26
Completion: 2026-01-31
Conditions
Substance-Related Disorders
Interventions
BEHAVIORAL
No Results Yet
NCT05820997 | TERMINATED | PHASE4
2 Participants

Paravertebral Block vs no Block in Open Pancreaticoduodenectomy

Study Type: INTERVENTIONAL
Last Updated: 2025-12-16
Start Date: 2023-04-24
Completion: 2024-12-04
Conditions
Pancreaticoduodenectomy
Interventions
DRUG
NCT05799287 | ACTIVE_NOT_RECRUITING | PHASE3
318 Participants

A Study of Telitacicept for IgA Nephropathy (TELIGAN)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-16
Start Date: 2023-04-28
Completion: 2026-06-30
Conditions
Primary IgA Nephropathy
Interventions
BIOLOGICAL DRUG
No Results Yet
NCT05793996 | RECRUITING | PHASE4
100 Participants

The Prevalence of Iron Deficiency and the Effectiveness of Ferinject® in Patients With HFpEF (ID-HFpEF)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-16
Start Date: 2023-04-28
Completion: 2026-12-31
Conditions
Chronic Heart Failure Iron Deficiency, Latent
Interventions
DRUG OTHER
No Results Yet
NCT05793853 | RECRUITING
106 Participants

Hypoparathyroidism Natural History Study

Study Type: OBSERVATIONAL
Last Updated: 2025-12-16
Start Date: 2022-08-25
Completion: 2026-12-31
Conditions
Hypoparathyroidism
No Results Yet
NCT05760898 | RECRUITING | NA
25 Participants

Improving Hypertension Control in Rheumatoid Arthritis

Study Type: INTERVENTIONAL
Last Updated: 2025-12-16
Start Date: 2025-12-17
Completion: 2025-12-31
Conditions
Hypertension Rheumatoid Arthritis
Interventions
BEHAVIORAL
No Results Yet
NCT05745363 | COMPLETED | PHASE1/PHASE2
33 Participants

Clinical Study of AL2846 Capsule in the Treatment of Differentiated Thyroid Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-16
Start Date: 2023-02-24
Completion: 2025-11-13
Conditions
Differentiated Thyroid Cancer
Interventions
DRUG
No Results Yet
NCT05710185 | TERMINATED | PHASE4
3 Participants

Deucravacitinib for the Treatment of Palmoplantar Pustulosis

Study Type: INTERVENTIONAL
Last Updated: 2025-12-16
Start Date: 2023-07-01
Completion: 2024-12-01
Conditions
Palmoplantar Pustulosis
Interventions
DRUG
NCT05705024 | RECRUITING | PHASE2
38 Participants

Efficacy of Locally Delivered Allogeneic Mesenchymal Stromal Cells

Study Type: INTERVENTIONAL
Last Updated: 2025-12-16
Start Date: 2023-09-29
Completion: 2026-09-28
Conditions
Corneal Ulcer
Interventions
BIOLOGICAL OTHER
No Results Yet
NCT05700747 | COMPLETED | NA
5 Participants

Health Through Activity: A Pilot Study of a Rehabilitation Intervention for People Living With Multiple Myeloma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-16
Start Date: 2023-02-01
Completion: 2025-03-28
Conditions
Multiple Myeloma
Interventions
BEHAVIORAL
NCT05700721 | RECRUITING | PHASE2
120 Participants

Phase II Trial of the PARP Inhibitor Niraparib and PD-1 Inhibitor Dostarlimab in Patients With Advanced Cancers With Active Progressing Brain Metastases (STARLET)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-16
Start Date: 2023-06-02
Completion: 2026-02-05
Conditions
Brain Metastases
Interventions
DRUG
No Results Yet
NCT05694364 | COMPLETED | PHASE1
3 Participants

Dose Escalation/Dose Expansion Study of PRGN-3007 UltraCAR-T Cells in Patients With Advanced Hematologic and Solid Tumor Malignancies

Study Type: INTERVENTIONAL
Last Updated: 2025-12-16
Start Date: 2023-01-25
Completion: 2024-04-18
Conditions
Chronic Lymphocytic Leukemia Mantle Cell Lymphoma Acute Lymphoblastic Leukemia Diffuse Large B Cell Lymphoma Triple Negative Breast Cancer Malignancies
Interventions
DRUG BIOLOGICAL
No Results Yet
NCT05686798 | RECRUITING | PHASE1
18 Participants

Adenovirus Mediated Suicide Gene Therapy With Radiotherapy in Progressive Astrocytoma.

Study Type: INTERVENTIONAL
Last Updated: 2025-12-16
Start Date: 2022-11-29
Completion: 2027-01-31
Conditions
Malignant Glioma of Brain Astrocytoma Malignant Astrocytoma Brain Tumor Glioma Brain Cancer Glioblastoma Glioblastoma Multiforme GBM
Interventions
BIOLOGICAL
No Results Yet
NCT05673759 | TERMINATED
148 Participants

Event-Related Potential (ERP) Components in Clinical Diagnosis

Study Type: OBSERVATIONAL
Last Updated: 2025-12-16
Start Date: 2023-03-06
Completion: 2025-05-01
Conditions
Alzheimer Disease Dementia, Mild Mild Cognitive Impairment
Interventions
DEVICE BEHAVIORAL
No Results Yet
NCT05660850 | COMPLETED | PHASE2
49 Participants

A Study To Evaluate The Efficacy, Safety, Pharmacokinetics, And Pharmacodynamic Effects Of GDC-6599 In Patients With Chronic Cough

Study Type: INTERVENTIONAL
Last Updated: 2025-12-16
Start Date: 2023-03-22
Completion: 2024-10-20
Conditions
Chronic Refractory Cough (CRC) With Non-atopic Asthma CRC With Atopic Asthma Unexplained Chronic Cough CRC With Chronic Obstructive Pulmonary Disease CRC With Chronic Obstructive Pulmonary Disease With Chronic Bronchitis
Interventions
DRUG OTHER DIAGNOSTIC_TEST
NCT05652868 | TERMINATED | PHASE1
227 Participants

Clinical Study of Antibody-Drug Conjugate MYTX-011 in Subjects With Non-Small Cell Lung Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-16
Start Date: 2023-03-23
Completion: 2025-10-31
Conditions
NSCLC NSCLC Stage IV NSCLC Stage IIIB Non-Small Cell Lung Cancer Advanced Non-Small Cell Squamous Lung Cancer Advanced Non-Small Cell Lung Cancer Advanced Non-Small Cell Non-Squamous Lung Cancer
Interventions
DRUG
No Results Yet
NCT05651594 | RECRUITING | PHASE2
40 Participants

Propranolol in Combination With Pembrolizumab and Standard Chemotherapy for the Treatment of Unresectable Locally Advanced or Metastatic Esophageal or Gastroesophageal Junction Adenocarcinoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-16
Start Date: 2023-03-07
Completion: 2029-03-30
Conditions
Clinical Stage II Esophageal Adenocarcinoma AJCC v8 Clinical Stage III Esophageal Adenocarcinoma AJCC v8 Clinical Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8 Clinical Stage IV Esophageal Adenocarcinoma AJCC v8 Clinical Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8 Locally Advanced Esophageal Adenocarcinoma Locally Advanced Gastroesophageal Junction Adenocarcinoma Metastatic Esophageal Adenocarcinoma Metastatic Gastroesophageal Junction Adenocarcinoma Unresectable Esophageal Adenocarcinoma Unresectable Gastroesophageal Junction Adenocarcinoma
Interventions
PROCEDURE DRUG BIOLOGICAL OTHER
No Results Yet
NCT05651438 | COMPLETED
86 Participants

Pain, Fatigue and Sleep Quality of E-Athletes

Study Type: OBSERVATIONAL
Last Updated: 2025-12-16
Start Date: 2023-08-01
Completion: 2023-11-01
Conditions
E-Athletes
Interventions
OTHER
No Results Yet
NCT05650411 | NOT_YET_RECRUITING | NA
828 Participants

Ultrathin-strut Biodegradable Polymer Sirolimus-eluting Stents With P2Y12 Inhibitor-based Single Antiplatelet Therapy vs. Conventional DAPT for Unprotected Left Main Coronary Artery Disease (ULTIMATE-LM)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-16
Start Date: 2026-03-01
Completion: 2027-05-01
Conditions
Left Main Coronary Artery Stenosis
Interventions
DEVICE DRUG
No Results Yet
NCT05645107 | RECRUITING | PHASE3
386 Participants

A Study to Evaluate Efficacy, Safety, and PK of XEMBIFY®+Standard Medical Treatment (SMT) Compared to Placebo+SMT to Prevent Infections in Participants With HGG and Recurrent or Severe Infections Associated With B-cell Chronic Lymphocytic Leukemia, Multiple Myeloma, and Non-Hodgkin Lymphoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-16
Start Date: 2022-12-26
Completion: 2026-05-31
Conditions
Hypogammaglobulinemia Bacterial Infections B-cell Chronic Lymphocytic Leukemia Multiple Myleoma Non-Hodgkin Lymphoma
Interventions
DRUG
No Results Yet
NCT05637099 | ACTIVE_NOT_RECRUITING
266 Participants

The Value of Repeated BIOMarker Measurements During an SBT to Predict EXtubation Failure in ICU Patients

Study Type: OBSERVATIONAL
Last Updated: 2025-12-16
Start Date: 2022-08-01
Completion: 2025-05-07
Conditions
Weaning Failure Mechanical Ventilation Spontaneous Breathing Trial Extubation Failure
No Results Yet
NCT05628974 | RECRUITING
400 Participants

Normal Donor Blood Draws for Platelet Studies and Biomarker Evaluation (ND-PLT)

Study Type: OBSERVATIONAL
Last Updated: 2025-12-16
Start Date: 2020-05-01
Completion: 2030-12-31
Conditions
Healthy
No Results Yet
NCT05617599 | RECRUITING
508 Participants

SUPRAFLEX CRUZ PMCF Study ( rEpic05 )

Study Type: OBSERVATIONAL
Last Updated: 2025-12-16
Start Date: 2023-05-10
Completion: 2026-12-01
Conditions
Coronary Artery Disease (CAD) Ischemic Heart Disease
Interventions
DEVICE
No Results Yet
NCT05596539 | RECRUITING
130 Participants

Prospective, Longitudinal, Observational Registry of Adult Patients With Hypophosphatasia (REG-HYPO)

Study Type: OBSERVATIONAL
Last Updated: 2025-12-16
Start Date: 2023-03-22
Completion: 2026-03-31
Conditions
Hypophosphatasia
Interventions
OTHER
No Results Yet
NCT05592223 | COMPLETED | PHASE1
20 Participants

Phase I Open Label BCG Clinical Trial Assessing TB Drugs and Vaccines

Study Type: INTERVENTIONAL
Last Updated: 2025-12-16
Start Date: 2022-12-06
Completion: 2023-08-23
Conditions
Tuberculosis
Interventions
DRUG
NCT05556772 | ACTIVE_NOT_RECRUITING | NA
619 Participants

Optimizing Screening for Cervical Cancer Among Women Living With HIV in the Dominican Republic

Study Type: INTERVENTIONAL
Last Updated: 2025-12-16
Start Date: 2022-11-14
Completion: 2025-10-31
Conditions
Malignant Female Reproductive System Neoplasm
Interventions
PROCEDURE OTHER
No Results Yet
NCT05547984 | RECRUITING | NA
100 Participants

Ceramic Modular Dual Mobility in Primary Total Hip Arthroplasty (THA)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-16
Start Date: 2022-11-21
Completion: 2027-09-30
Conditions
Coxarthrosis; Primary
Interventions
DEVICE
No Results Yet
NCT05522972 | RECRUITING | NA
180 Participants

Establishing New Treatment Approaches for Amblyopia: Perceptual Learning and Video Games

Study Type: INTERVENTIONAL
Last Updated: 2025-12-16
Start Date: 2022-09-13
Completion: 2029-08-31
Conditions
Amblyopia
Interventions
BEHAVIORAL
No Results Yet
NCT05503550 | NO_LONGER_AVAILABLE

Pre-Approval Access Single Patient Request for Talquetamab in Relapsed or Refractory Multiple Myeloma

Study Type: EXPANDED_ACCESS
Last Updated: 2025-12-16
Conditions
Relapsed or Refractory Multiple Myeloma
Interventions
DRUG
No Results Yet
NCT05473780 | ACTIVE_NOT_RECRUITING
161 Participants

Oxygen Therapy Remote Monitoring in COPD Patients.

Study Type: OBSERVATIONAL
Last Updated: 2025-12-16
Start Date: 2023-01-27
Completion: 2025-12-15
Conditions
Chronic Obstructive Pulmonary Disease
No Results Yet
NCT05460533 | ACTIVE_NOT_RECRUITING | PHASE2
30 Participants

A Second Infusion (Early Reinfusion) of Tisagenlecleucel in Children and Young Adults With B-Cell Acute Lymphoblastic Leukemia(B-ALL)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-16
Start Date: 2022-07-12
Completion: 2026-07-31
Conditions
B-cell Acute Lymphoblastic Leukemia
Interventions
BIOLOGICAL
No Results Yet
NCT05458648 | COMPLETED
37 Participants

Single Center Pilot Study Using the ECGenius System to Collect Electrogram Data to Test an Ablation Impact Algorithm

Study Type: OBSERVATIONAL
Last Updated: 2025-12-16
Start Date: 2022-07-28
Completion: 2023-10-30
Conditions
Persistent Atrial Fibrillation Cardiac Arrhythmia
Interventions
PROCEDURE
NCT05456880 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2
15 Participants

BEACON: A Study Evaluating the Safety and Efficacy of BEAM-101 in Patients With Severe Sickle Cell Disease

Study Type: INTERVENTIONAL
Last Updated: 2025-12-16
Start Date: 2022-08-30
Completion: 2028-02-29
Conditions
Sickle Cell Disease
Interventions
BIOLOGICAL
No Results Yet
NCT05443594 | COMPLETED | NA
669 Participants

A Prospective Single Arm Open Label Study of the FARAPULSE Pulsed Field Ablation System in Subjects With Persistent Atrial Fibrillation

Study Type: INTERVENTIONAL
Last Updated: 2025-12-16
Start Date: 2023-02-28
Completion: 2025-02-11
Conditions
Persistent Atrial Fibrillation
Interventions
DEVICE
NCT05436418 | RECRUITING | PHASE1/PHASE2
260 Participants

The Lowest Effective Dose of Post-Transplantation Cyclophosphamide in Combination With Sirolimus and Mycophenolate Mofetil as Graft-Versus-Host Disease Prophylaxis After Reduced Intensity Conditioning and Peripheral Blood Stem Cell Transplantation

Study Type: INTERVENTIONAL
Last Updated: 2025-12-16
Start Date: 2022-11-18
Completion: 2027-06-25
Conditions
Peripheral Blood Stem Cell Transplantation Hematopoietic Stem Cell Transplantation
Interventions
DRUG RADIATION PROCEDURE
No Results Yet
NCT05419362 | COMPLETED | PHASE2
42 Participants

GEN-001 in Combination With Avelumab for Patients With PD-L1 Positive Gastric Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-16
Start Date: 2022-04-07
Completion: 2024-08-26
Conditions
Gastric Cancer Gastroesophageal Junction Adenocarcinoma
Interventions
DRUG
No Results Yet
NCT05418972 | ACTIVE_NOT_RECRUITING | PHASE2
20 Participants

A Phase 2 Clinical Trial of Neoadjuvant Relatlimab and Nivolumab in High Risk, Clinical Stage II Cutaneous Melanoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-16
Start Date: 2023-08-14
Completion: 2026-01-31
Conditions
Stage II Melanoma
Interventions
DRUG
No Results Yet
NCT05399537 | RECRUITING | PHASE3
40 Participants

Safety Evaluation of Prismocitrate 18 in Patients Receiving CRRT

Study Type: INTERVENTIONAL
Last Updated: 2025-12-16
Start Date: 2024-07-12
Completion: 2026-12-31
Conditions
Regional Citrate Anticoagulation (RCA) Continuous Renal Replacement Therapy (CRRT) Acute Kidney Injury (AKI)
Interventions
DRUG DEVICE
No Results Yet
NCT05391126 | RECRUITING | NA
178 Participants

GENOCARE: A Prospective, Randomized Clinical Trial of Genotype-Guided Dosing Versus Usual Care

Study Type: INTERVENTIONAL
Last Updated: 2025-12-16
Start Date: 2022-09-28
Completion: 2027-05-31
Conditions
Colorectal Cancer Pancreatic Cancer
Interventions
DRUG
No Results Yet
NCT05389332 | RECRUITING | NA
114 Participants

A Mobile Health Intervention Among Hispanics

Study Type: INTERVENTIONAL
Last Updated: 2025-12-16
Start Date: 2025-04-20
Completion: 2026-10-31
Conditions
Cancer of Skin
Interventions
BEHAVIORAL
No Results Yet
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