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Normal Donor Blood Draws for Platelet Studies and Biomarker Evaluation (ND-PLT)

NCT ID: NCT05628974

Last Updated: 2025-12-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

400 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-05-01

Study Completion Date

2031-06-30

Brief Summary

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This is a single-center study at the Cleveland Clinic Main Campus designed to study biomarkers in healthy individuals to identify novel mechanisms of platelet activation and how platelets drive vascular inflammation and thrombosis in diseases.

Detailed Description

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Our past studies have discovered novel platelet activation pathways that may be targets of therapeutic development. We have also defined an important role for a shift in platelet phenotype in vascular disease. Our studies use both in vivo animal models and validation using human platelets from isolated blood. Platelets from healthy individuals may be compared to patients with vascular diseases in the IRB approved protocol "Vascular Lab Resource" (IRB #19-1451) study which is actively recruiting patients at the Cleveland Clinic Main Campus and studies patients with vascular diseases.

Conditions

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Healthy

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Adults aged 18 to 65 years old
* Healthy Male \& Female voluntary participants

Exclusion Criteria

* Individuals who have taken anticoagulant or antiplatelet medications in past 10 days
* Individuals with hematopoetic diseases
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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National Heart, Lung, and Blood Institute (NHLBI)

NIH

Sponsor Role collaborator

The Cleveland Clinic

OTHER

Sponsor Role lead

Responsible Party

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Scott Cameron, MD, PhD

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Scott Cameron, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

The Cleveland Clinic

Locations

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Cleveland Clinic

Cleveland, Ohio, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Scott Cameron, MD, PhD

Role: CONTACT

[email protected]
216-444-1680

Facility Contacts

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Scott Cameron, MD, PhD

Role: primary

[email protected]
216-444-1680

References

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Laakso L. Migrants in hospital. Aust N Z J Obstet Gynaecol. 1973 Nov;13(4):231. doi: 10.1111/j.1479-828x.1973.tb02318.x. No abstract available.

Reference Type BACKGROUND
PMID: 4532543 (View on PubMed)

[Hospital policy]. Rev Clin Inst Matern Lisb. 1965 Jul-Dec;16(62):59-70. No abstract available. Portuguese.

Reference Type BACKGROUND
PMID: 5898983 (View on PubMed)

Lonnerdal B, Keen CL, Glazier CE, Anderson J. A longitudinal study of rhesus monkey (Macaca mulatta) milk composition: trace elements, minerals, protein, carbohydrate, and fat. Pediatr Res. 1984 Sep;18(9):911-4. doi: 10.1203/00006450-198409000-00023.

Reference Type BACKGROUND
PMID: 6483513 (View on PubMed)

Faraday N, Goldschmidt-Clermont PJ, Bray PF. Gender differences in platelet GPIIb-IIIa activation. Thromb Haemost. 1997 Apr;77(4):748-54.

Reference Type BACKGROUND
PMID: 9134654 (View on PubMed)

Other Identifiers

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5R01HL158801-04

Identifier Type: NIH

Identifier Source: secondary_id

View Link

20-413

Identifier Type: -

Identifier Source: org_study_id