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Clinical Trials

Showing trials with last updates posted in 2025.

NCT06305754 | RECRUITING | PHASE3
520 Participants

Sacituzumab Tirumotecan (MK-2870) Versus Pemetrexed and Carboplatin Combination Therapy in Participants With Epidermal Growth Factor (EGFR)-Mutated, Advanced Nonsquamous Non-small Cell Lung Cancer (NSCLC) Who Have Progressed on Prior EGFR Tyrosine Kinase Inhibitors (MK-2870-009)

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2024-06-11
Completion: 2028-09-12
Conditions
Non-small Cell Lung Cancer (NSCLC)
Interventions
BIOLOGICAL DRUG
No Results Yet
NCT06305676 | RECRUITING
400 Participants

Biomarker Approach to Screening for the Early Detection of HPV-related Oropharyngeal Cancer (BASH OPC)

Study Type: OBSERVATIONAL
Last Updated: 2025-11-14
Start Date: 2024-01-22
Completion: 2029-01-31
Conditions
Oropharyngeal Cancer HPV-Related Carcinoma
Interventions
DIAGNOSTIC_TEST
No Results Yet
NCT06305247 | RECRUITING | PHASE1/PHASE2
220 Participants

A Study to Assess IPN01194 When Administered Alone in Adults With Advanced Solid Tumours

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2024-04-03
Completion: 2028-03-20
Conditions
Melanoma Head and Neck Squamous Cell Carcinoma Pancreatic Ductal Adenocarcinoma Colorectal Cancer Solid Tumor
Interventions
DRUG
No Results Yet
NCT06303180 | RECRUITING
1000 Participants

NIDCD Otolaryngology Clinical Protocol Biospecimen Bank

Study Type: OBSERVATIONAL
Last Updated: 2025-11-14
Start Date: 2024-03-04
Completion: 2033-12-30
Conditions
Hearing Loss Head and Neck Neoplasms Hearing Disorders Laryngeal Disease
No Results Yet
NCT06285643 | RECRUITING | PHASE2
87 Participants

A Study of AAV2-GDNF in Adults With Moderate Parkinson's Disease (REGENERATE-PD)

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2024-06-11
Completion: 2027-11-30
Conditions
Parkinson Disease
Interventions
DRUG PROCEDURE
No Results Yet
NCT06282809 | RECRUITING | NA
50 Participants

The HistoSonics Edison™ System for Treatment of Pancreatic Adenocarcinoma Using Histotripsy

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2024-12-10
Completion: 2026-02-28
Conditions
Pancreas Cancer Adenocarcinoma of the Pancreas Pancreatic Cancer Tumor of Pancreas
Interventions
DEVICE
No Results Yet
NCT06261905 | COMPLETED | PHASE1
5 Participants

Vitamin D in OUD: Exploration of Alterations on the Dopamine D2/D3 Receptor System

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2024-03-13
Completion: 2025-02-18
Conditions
Opioid Use Disorder
Interventions
DRUG DIETARY_SUPPLEMENT OTHER PROCEDURE
No Results Yet
NCT06255782 | RECRUITING | PHASE1/PHASE2
8 Participants

An Open-label Study to Investigate ECUR-506 in Male Babies Less Than 9 Months of Age With Neonatal Onset OTC Deficiency

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2024-04-08
Completion: 2026-09-30
Conditions
Ornithine Transcarbamylase Deficiency Ornithine Transcarbamylase Deficiency Disease Ornithine Carbamoyltransferase Deficiency (Disorder) Urea Cycle Disorders, Inborn
Interventions
GENETIC
No Results Yet
NCT06255496 | COMPLETED
296 Participants

QStat Cartridge in Obstetric Patients

Study Type: OBSERVATIONAL
Last Updated: 2025-11-14
Start Date: 2024-05-09
Completion: 2025-08-15
Conditions
Blood Loss Massive Post Partum Hemorrhage
Interventions
DIAGNOSTIC_TEST
No Results Yet
NCT06252038 | RECRUITING | NA
160 Participants

Rural Alliance for Diabetes Prevention

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2024-09-24
Completion: 2028-05-31
Conditions
PreDiabetes
Interventions
BEHAVIORAL
No Results Yet
NCT06239272 | RECRUITING | PHASE1/PHASE2
139 Participants

NRSTS2021, A Risk Adapted Study Evaluating Maintenance Pazopanib, Limited Margin, Dose-Escalated Radiation Therapy and Selinexor in Non-Rhabdomyosarcoma Soft Tissue Sarcoma (NRSTS)

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2024-03-27
Completion: 2034-06-30
Conditions
Adipocytic Neoplasm Liposarcoma Atypical Fibroxanthoma Angiomatoid Fibrous Histiocytoma Myoepithelioma Fibrosarcoma NOS Myxofibrosarcoma Angiosarcoma Osteosarcoma, Extraskeletal
Interventions
PROCEDURE RADIATION DRUG
No Results Yet
NCT06233461 | RECRUITING | PHASE2
268 Participants

A Study on the Safety of TAK-279 and Whether it Can Reduce Inflammation in the Bowel of Participants With Moderately to Severely Active Crohn's Disease

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2024-03-05
Completion: 2026-09-18
Conditions
Crohn's Disease
Interventions
DRUG
No Results Yet
NCT06216483 | RECRUITING | NA
60 Participants

Using EMR Data and AI to Develop a Passive Digital Marker to Predict Postoperative Delirium

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2024-07-23
Completion: 2025-12-31
Conditions
Delirium in Old Age
Interventions
OTHER
No Results Yet
NCT06215716 | RECRUITING | PHASE3
1650 Participants

A Study Evaluating Efruxifermin in Subjects With Non-Cirrhotic Nonalcoholic Steatohepatitis (NASH)/Metabolic Dysfunction-Associated Steatohepatitis (MASH) and Fibrosis

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2023-12-01
Completion: 2032-11-30
Conditions
NASH With Fibrosis MASH With Fibrosis
Interventions
DRUG
No Results Yet
NCT06199726 | RECRUITING
25 Participants

REFLECT: Reproductive Education and Fertility Links for Cancer Treatment

Study Type: OBSERVATIONAL
Last Updated: 2025-11-14
Start Date: 2023-12-11
Completion: 2025-12-05
Conditions
Reproductive Behavior
Interventions
BEHAVIORAL
No Results Yet
NCT06179472 | ACTIVE_NOT_RECRUITING | NA
20 Participants

Infant Survival and Long-term Outcome Following Fetoscopic Endoluminal Tracheal Occlusion in Severe Left and Right Congenital Diaphragmatic Hernia, A Phase III Trial

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2024-04-14
Completion: 2031-01-01
Conditions
Congenital Diaphragmatic Hernia
Interventions
DEVICE
No Results Yet
NCT06179446 | COMPLETED | PHASE1
157 Participants

A Study to Learn How Safe, Tolerable and Capable of Producing an Immune Response is, a Modified RNA Vaccine Against Pandemic Influenza

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2023-12-13
Completion: 2025-09-23
Conditions
Grippe Influenza Vaccines
Interventions
BIOLOGICAL
No Results Yet
NCT06177067 | RECRUITING | PHASE1
24 Participants

Study of Revumenib, Azacitidine, and Venetoclax in Pediatric and Young Adult Patients With Refractory or Relapsed Acute Myeloid Leukemia

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2024-04-19
Completion: 2026-07-31
Conditions
Refractory Acute Myeloid Leukemia Relapsed Acute Myeloid Leukemia Acute Leukemia of Ambiguous Lineage
Interventions
DRUG
No Results Yet
NCT06157151 | RECRUITING | PHASE2
46 Participants

PRGN-2009 in Combination With Pembrolizumab Versus Pembrolizumab in Patients With Recurrent or Metastatic Cervical Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2025-03-21
Completion: 2028-01-30
Conditions
Cervical Cancer HPV-Related Carcinoma HPV-Related Malignancy Recurrent Cervical Carcinoma Metastatic Cervical Cancer
Interventions
BIOLOGICAL DRUG
No Results Yet
NCT06156410 | RECRUITING | PHASE1
30 Participants

Cabozantinib With Ifosfamide in Relapsed/Refractory Sarcomas

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2023-10-24
Completion: 2027-11-30
Conditions
Ewing Sarcoma Osteosarcoma Sarcomas
Interventions
DRUG
No Results Yet
NCT06144619 | RECRUITING
500 Participants

Non-Invasive Biomarkers in Prostate Cancer Disease Management

Study Type: OBSERVATIONAL
Last Updated: 2025-11-14
Start Date: 2023-11-21
Completion: 2029-01-31
Conditions
Prostate Cancer
Interventions
GENETIC
No Results Yet
NCT06144606 | RECRUITING | PHASE2
60 Participants

Study of KTE-X19 in Minimal Residual Disease (MRD) Positive B-Cell Acute Lymphoblastic Leukemia (B-ALL)

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2023-12-26
Completion: 2028-11-15
Conditions
B-Cell Lymphoblastic Leukemia Acute Lymphoblastic Leukemia
Interventions
DRUG
No Results Yet
NCT06139107 | RECRUITING | PHASE1
15 Participants

RADIANT: Pre-op Radiation With Abemaciclib and Letrozole

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2024-08-22
Completion: 2026-09-30
Conditions
Breast Cancer
Interventions
DRUG
No Results Yet
NCT06136559 | RECRUITING | PHASE3
1200 Participants

A Study of Nemtabrutinib (MK-1026) Versus Comparator (Investigator's Choice of Ibrutinib or Acalabrutinib) in First Line (1L) Chronic Lymphocytic Leukemia (CLL)/ Small Lymphocytic Lymphoma (SLL) (MK-1026-011/BELLWAVE-011)

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2023-12-13
Completion: 2032-09-07
Conditions
Chronic Lymphocytic Leukemia Small Lymphocytic Lymphoma
Interventions
DRUG
No Results Yet
NCT06132945 | ACTIVE_NOT_RECRUITING | PHASE1
2 Participants

A Study of Cabozantinib and Nivolumab With Radiation Therapy for People With Renal Cell Carcinoma That Has Spread to the Brain

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2023-11-10
Completion: 2027-11-30
Conditions
Metastatic Renal Cell Carcinoma Brain Metastases
Interventions
DRUG DEVICE RADIATION
No Results Yet
NCT06129487 | COMPLETED | NA
1053 Participants

Evaluations of Alcohol Warning Labels

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2024-01-19
Completion: 2024-03-06
Conditions
Oral Cancer Esophageal Cancer Larynx Cancer Alcohol Drinking
Interventions
BEHAVIORAL
Results Available
NCT06120504 | ACTIVE_NOT_RECRUITING | PHASE1
22 Participants

A Safety Study of PF-08046045/SGN-35T in Adults With Advanced Cancers

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2024-02-29
Completion: 2026-01-21
Conditions
Lymphoma, T-Cell, Cutaneous Hodgkin Disease Lymphoma, T-Cell, Peripheral Lymphoma, Large-Cell, Anaplastic Lymphoma, Large B-Cell, Diffuse Lymphoma, Non-Hodgkin
Interventions
DRUG
No Results Yet
NCT06117007 | COMPLETED | NA
42 Participants

Effects of Betalains on Cardiovascular Health and Quality of Life

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2023-10-30
Completion: 2024-12-19
Conditions
Vascular Stiffness Vasodilation Sleep Quality of Life
Interventions
DIETARY_SUPPLEMENT OTHER
No Results Yet
NCT06112275 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2
4 Participants

A Clinical Study to Evaluate the Safety and Efficacy of ETX101, an AAV9-Delivered Gene Therapy in Children With SCN1A-positive Dravet Syndrome (Australia Only)

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2024-02-28
Completion: 2030-09-30
Conditions
Dravet Syndrome
Interventions
DRUG
No Results Yet
NCT06109467 | RECRUITING | PHASE2
36 Participants

Neratinib In Combination With Chemotherapy/Trastuzumab/Pembrolizumab In HER2 Gastroesophageal Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2024-01-12
Completion: 2028-04-30
Conditions
GastroEsophageal Cancer Gastric Cancer
Interventions
DRUG
No Results Yet
NCT06108232 | RECRUITING | PHASE2
36 Participants

Phase 2 Trial of Obinutuzumab and CC-99282 for Patients With Previously Untreated High Tumor Burden Follicular Lymphoma

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2024-03-15
Completion: 2025-12-31
Conditions
Follicular Lymphoma Tumor
Interventions
DRUG
No Results Yet
NCT06097728 | RECRUITING | PHASE3
825 Participants

MEDI5752 in Combination With Carboplatin Plus Pemetrexed in Unresectable Pleural Mesothelioma

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2023-11-09
Completion: 2027-11-19
Conditions
Unresectable Pleural Mesothelioma
Interventions
DRUG
No Results Yet
NCT06090643 | ACTIVE_NOT_RECRUITING | NA
9745 Participants

Implementation Research to Increase Colorectal Cancer Screening Rates Among Low Income and Ethnic Minority Groups

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2019-11-01
Completion: 2026-11-01
Conditions
Colorectal Carcinoma
Interventions
OTHER BEHAVIORAL
No Results Yet
NCT06089746 | RECRUITING | NA
20 Participants

Lumbosacral Spinal Stenosis - Non-Invasive Postural Therapy for Older Adult Veterans

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2024-11-15
Completion: 2026-07-31
Conditions
Lumbar Spinal Stenosis
Interventions
OTHER
No Results Yet
NCT06088498 | RECRUITING | PHASE2
3600 Participants

App for Reducing Cravings to Smoke

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2024-06-11
Completion: 2027-05-01
Conditions
Smoking
Interventions
BEHAVIORAL
No Results Yet
NCT06081283 | TERMINATED | PHASE4
5 Participants

Antiseizure Medication in Seizure Networks at Early Acute Brain Injury

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2023-11-20
Completion: 2024-12-22
Conditions
Brain Injuries, Acute Brain Injuries, Traumatic Brain Ischemia Brain Hypoxia Hypoxia-Ischemia, Brain Heart Arrest Stroke Intracranial Hemorrhages Coma Persistent Vegetative State
Interventions
DRUG
Results Available
NCT06079190 | ACTIVE_NOT_RECRUITING | PHASE2
367 Participants

Efficacy and Safety of GSK4527226 [AL101] in Participants With Early Alzheimer's Disease

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2023-10-20
Completion: 2026-09-30
Conditions
Alzheimer's Disease
Interventions
DRUG OTHER
No Results Yet
NCT06077760 | RECRUITING | PHASE3
868 Participants

A Study of Intismeran Autogene (V940) Plus Pembrolizumab (MK-3475) Versus Placebo Plus Pembrolizumab in Participants With Non-small Cell Lung Cancer (V940-002)

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2023-12-06
Completion: 2030-06-25
Conditions
Non-small Cell Lung Cancer
Interventions
BIOLOGICAL OTHER
No Results Yet
NCT06077162 | ACTIVE_NOT_RECRUITING | NA
67 Participants

Diabetes Nutrition Education and Healthy Food Resource for AIANs With T2D

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2023-09-01
Completion: 2026-01-01
Conditions
Type 2 Diabetes
Interventions
OTHER
No Results Yet
NCT06072781 | RECRUITING | PHASE3
270 Participants

A Study of Avutometinib (VS-6766) + Defactinib (VS-6063) in Recurrent Low-Grade Serous Ovarian Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2024-03-18
Completion: 2028-10-15
Conditions
Low Grade Serous Ovarian Cancer
Interventions
DRUG
No Results Yet
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