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Clinical Trials

Showing trials with last updates posted in 2025.

NCT06388733 | RECRUITING | PHASE3
450 Participants

A Study Comparing Niraparib With Temozolomide in Adult Participants With Newly-diagnosed, MGMT Unmethylated Glioblastoma

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2024-06-19
Completion: 2027-12-31
Conditions
Glioblastoma GBM Brain Neoplasms, Adult, Malignant Brain Tumor
Interventions
DRUG
No Results Yet
NCT06375044 | RECRUITING | PHASE1
130 Participants

Study of SIM0500 Alone in Participants With Relapsed or Refractory Multiple Myeloma

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2024-05-24
Completion: 2026-06-30
Conditions
Relapsed or Refractory Multiple Myeloma
Interventions
DRUG
No Results Yet
NCT06369467 | RECRUITING | PHASE1
6 Participants

Short-Term Linvoseltamab Treatment on Top of Chronic Dupilumab Treatment for Adults With Severe Immunoglobulin E (IgE)-Mediated Food Allergy

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2024-05-17
Completion: 2028-03-28
Conditions
Food Allergy
Interventions
DRUG
No Results Yet
NCT06356129 | RECRUITING | PHASE3
850 Participants

Study to Compare the Effectiveness and Safety of Golcadomide Plus R-CHOP vs Placebo Plus R-CHOP in Participants With Previously Untreated High-risk Large B-cell Lymphoma

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2024-06-19
Completion: 2028-08-14
Conditions
Large B-cell Lymphoma
Interventions
DRUG
No Results Yet
NCT06348875 | NOT_YET_RECRUITING
50 Participants

Clinical Evaluation of Radiation Reduction for Optimized Safety

Study Type: OBSERVATIONAL
Last Updated: 2025-11-13
Start Date: 2026-02-15
Completion: 2026-06-15
Conditions
Coronary Artery Disease Myocardial Infarction Coronary Disease Coronary Stenosis Angina Pectoris Chest Pain
No Results Yet
NCT06343402 | RECRUITING | PHASE1
250 Participants

Open-label Study of BBO-8520 in Adult Subjects With KRASG12C Non-small Cell Lung Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2024-05-22
Completion: 2027-08-31
Conditions
Non-small Cell Lung Cancer Metastatic Non-Small Cell Lung Cancer NSCLC KRAS G12C Metastatic Lung Cancer Advanced Lung Carcinoma
Interventions
DRUG
No Results Yet
NCT06337318 | RECRUITING | PHASE3
600 Participants

Comparing Rituximab and Mosunetuzumab Drug Treatments for People With Low Tumor Burden Follicular Lymphoma

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2024-10-23
Completion: 2032-03-31
Conditions
Classic Follicular Lymphoma Follicular Lymphoma With Unusual Cytological Features
Interventions
PROCEDURE BIOLOGICAL
No Results Yet
NCT06328127 | RECRUITING | NA
400 Participants

Positive Psychology Intervention for Hematopoietic Stem Cell Transplantation Survivors

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2024-12-17
Completion: 2029-05-31
Conditions
Hematopoietic Stem Cell Transplant
Interventions
BEHAVIORAL
No Results Yet
NCT06319027 | RECRUITING | PHASE2
100 Participants

Identifying Findings on Brain Scans That Could Help Make Better Predictions About Brain Cancer Progression, The GABLE Trial

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2024-04-11
Completion: 2027-05-31
Conditions
Glioblastoma, IDH-Wildtype
Interventions
PROCEDURE OTHER DRUG
No Results Yet
NCT06315595 | RECRUITING
1000 Participants

Improvements in Dynamic Contrast-Enhanced MR Angiography and Perfusion and Non-Contrast MRI

Study Type: OBSERVATIONAL
Last Updated: 2025-11-13
Start Date: 2015-09-30
Completion: 2030-09-30
Conditions
Prostate Neoplasm
Interventions
OTHER
No Results Yet
NCT06311721 | RECRUITING | PHASE3
927 Participants

A Study to Compare ABP 234 and Keytruda® (Pembrolizumab) in Participants With Advanced or Metastatic Non-squamous Non-Small Cell Lung Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2024-09-09
Completion: 2028-02-14
Conditions
Advanced or Metastatic Non-squamous Non-Small Cell Lung Cancer
Interventions
DRUG
No Results Yet
NCT06308978 | RECRUITING | PHASE1
244 Participants

A Phase 1 Study of FT819 in B-cell Mediated Autoimmune Disease

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2024-03-28
Completion: 2027-09-30
Conditions
Antineutrophilic Cytoplasmic Antibody (ANCA)- Associated Vasculitis (AAV) Idiopathic Inflammatory Myositis (IIM) Systemic Sclerosis (SSc) Systemic Lupus Erythematosus (SLE)
Interventions
DRUG
No Results Yet
NCT06295471 | RECRUITING | NA
23 Participants

A Comparative Clinical Study to Assess Pain Score and Wound Healing Following Fractional Ablation With a DFG Laser and CO2 Laser

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2024-10-16
Completion: 2026-03-31
Conditions
Healthy
Interventions
DEVICE
No Results Yet
NCT06295367 | RECRUITING | NA
760 Participants

Cost Communication and Financial Navigation in Cancer Patients (COSTCOM)

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2024-02-29
Completion: 2027-12-01
Conditions
Malignant Solid Neoplasm
Interventions
OTHER
No Results Yet
NCT06267560 | ACTIVE_NOT_RECRUITING | PHASE3
422 Participants

Lp(a) Lowering Study of Pelacarsen (TQJ230) in US Black/African American and Hispanic Participants With Elevated Lp(a) and Established ASCVD

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2024-04-24
Completion: 2026-03-31
Conditions
Elevated Lp(a) and Established Atherosclerotic Cardiovascular Disease
Interventions
DRUG
No Results Yet
NCT06263738 | RECRUITING | NA
162 Participants

Cold and Heat Investigation to Lower Levels of Depression

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2024-05-14
Completion: 2027-04-01
Conditions
Depression Mood Disorders Healthy (Controls)
Interventions
PROCEDURE
No Results Yet
NCT06259916 | RECRUITING | NA
99 Participants

Distinguishing Alcohol Intoxication, Cannabis Intoxication and Co-intoxication Using Electroencephalography (EEG)

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2024-01-05
Completion: 2026-05-30
Conditions
Cannabis Use Alcohol Use, Unspecified
Interventions
OTHER
No Results Yet
NCT06252649 | RECRUITING | PHASE3
450 Participants

Study of Sotorasib, Panitumumab and FOLFIRI Versus FOLFIRI With or Without Bevacizumab-awwb in Treatment-naïve Participants With Metastatic Colorectal Cancer With KRAS p.G12C Mutation

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2024-07-17
Completion: 2028-01-31
Conditions
Metastatic Colorectal Cancer
Interventions
DRUG
No Results Yet
NCT06235697 | RECRUITING | PHASE3
710 Participants

Androgen Suppression Combined With Nodal Irradiation and Dose Escalated Prostate Treatment

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2024-04-25
Completion: 2032-10-31
Conditions
Prostate Cancer
Interventions
RADIATION DRUG
No Results Yet
NCT06233110 | RECRUITING | PHASE1
30 Participants

Ruxolitinib Plus Fostamatinib for Steroid Refractory cGvHD

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2025-12-31
Completion: 2029-01-01
Conditions
Chronic Graft Versus Host Disease
Interventions
DRUG
No Results Yet
NCT06230224 | RECRUITING | PHASE3
216 Participants

A Trial to Learn How Effective and Safe Odronextamab is Compared to Standard of Care for Adult Participants With Previously Treated Aggressive B-cell Non-Hodgkin Lymphoma

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2024-02-15
Completion: 2027-05-14
Conditions
B-Cell Non-Hodgkin Lymphoma (B-NHL)
Interventions
DRUG
No Results Yet
NCT06217081 | WITHHELD

[Trial of device that is not approved or cleared by the U.S. FDA]

Last Updated: 2025-11-13
No Results Yet
NCT06207864 | RECRUITING | NA
1001 Participants

Engagement of American Indians of Southwestern Tribal Nations in Cancer Genome Sequencing

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2022-03-22
Completion: 2028-12-31
Conditions
Malignant Neoplasm
Interventions
PROCEDURE OTHER
No Results Yet
NCT06205589 | NOT_YET_RECRUITING | PHASE2
1500 Participants

Therapeutic ID93 + GLA-SE Vaccination in Participants With Rifampicin-Susceptible Pulmonary TB

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2026-02-15
Completion: 2028-10-31
Conditions
Tuberculosis, Pulmonary
Interventions
BIOLOGICAL
No Results Yet
NCT06205485 | RECRUITING | PHASE3
250 Participants

Neoadjuvant Chemotherapy, Excision And Observation vs Chemoradiotherapy For Rectal Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2024-06-26
Completion: 2030-01-30
Conditions
Rectal Cancer
Interventions
DRUG RADIATION
No Results Yet
NCT06192641 | COMPLETED | PHASE2
24 Participants

Melatonin Use in Patients With Climacterious Symptoms in the Perimenopause

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2023-10-20
Completion: 2024-11-30
Conditions
Perimenopausal Disorder
Interventions
DRUG
No Results Yet
NCT06176690 | RECRUITING | PHASE1
90 Participants

Constitutive IL7R (C7R) Modified Banked Allogeneic CD30.CAR EBVSTS for CD30-Positive Lymphomas

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2025-10-27
Completion: 2028-07-27
Conditions
CD30-Positive Diffuse Large B-Cell Lymphoma Anaplastic Large Cell Lymphoma, T Cell and Null Cell Type Anaplastic Large Cell Lymphoma, ALK-Positive Peripheral T-cell Lymphoma Anaplastic Large Cell Lymphoma, ALK-negative Non-Hodgkin Lymphoma Hodgkin Lymphoma
Interventions
BIOLOGICAL
No Results Yet
NCT06174805 | RECRUITING | NA
67 Participants

AXIOS™ Gastroenterostomy for Gastric Outlet Obstruction IDE

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2025-02-11
Completion: 2027-02-28
Conditions
Gastric Outlet Obstruction
Interventions
DEVICE
No Results Yet
NCT06170788 | RECRUITING | PHASE3
614 Participants

Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab Versus Pembrolizumab Alone in Metastatic Non-small Cell Lung Cancer (NSCLC) With Programmed Cell Death Ligand 1 (PD-L1) Tumor Proportion Score (TPS) ≥ 50% (MK-2870-007)

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2023-12-15
Completion: 2028-01-25
Conditions
Non-small Cell Lung Cancer (NSCLC)
Interventions
BIOLOGICAL DRUG
No Results Yet
NCT06169540 | RECRUITING
90 Participants

Salivary Extracellular Vesicle Associated lncRNAs in Heart Failure (SEAL-HF)

Study Type: OBSERVATIONAL
Last Updated: 2025-11-13
Start Date: 2023-04-19
Completion: 2026-12-31
Conditions
CHF ADHF Control
No Results Yet
NCT06151574 | RECRUITING | PHASE3
416 Participants

Beamion LUNG-2: A Study to Test Whether Zongertinib (BI 1810631) Helps People With Advanced Non-small Cell Lung Cancer With HER2 Mutations Compared With Standard Treatment

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2024-02-09
Completion: 2026-11-01
Conditions
Lung Cancer, Non-squamous, Non-small Cell
Interventions
DRUG
No Results Yet
NCT06147037 | RECRUITING | PHASE1
70 Participants

A Phase 1, Dose-escalation Study of [225Ac]-FPI-2068 in Adult Patients With Advanced Solid Tumours

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2024-07-31
Completion: 2028-05-12
Conditions
Advanced Solid Tumor Metastatic Colorectal Carcinoma Head and Neck Squamous Cell Carcinoma Non-small Cell Lung Cancer Pancreatic Ductal Adenocarcinoma Gastric Cancer Renal Cell Carcinoma
Interventions
DRUG
No Results Yet
NCT06115811 | NOT_YET_RECRUITING | NA
20 Participants

Radiation Treatment Plan Evaluation Learning Tool Pilot Project

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2026-01-15
Completion: 2026-11-01
Conditions
Radiation Oncology
Interventions
BEHAVIORAL
No Results Yet
NCT06113237 | RECRUITING
50 Participants

Pregnancy Surveillance Program of Patients Exposed to Epidiolex/Epidyolex During Pregnancy

Study Type: OBSERVATIONAL
Last Updated: 2025-11-13
Start Date: 2025-08-05
Completion: 2033-08-31
Conditions
Maternal Complications Pregnancy Complication Birth Outcomes, Adverse Pregnancy
Interventions
DRUG
No Results Yet
NCT06112613 | RECRUITING | NA
410 Participants

Mobile Health for Adherence in Breast Cancer Patients

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2024-01-26
Completion: 2027-07-31
Conditions
Anatomic Stage IV Breast Cancer AJCC v8 Breast Carcinoma HER2-Negative Breast Carcinoma Hormone Receptor-Positive Breast Carcinoma
Interventions
OTHER PROCEDURE BEHAVIORAL
No Results Yet
NCT06096844 | RECRUITING | PHASE3
304 Participants

Chemotherapy Combined With Immunotherapy Versus Immunotherapy Alone for Older Adults With Stage IIIB-IV Lung Cancer, The ACHIEVE Trial

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2024-07-19
Completion: 2026-06-01
Conditions
Advanced Lung Non-Small Cell Carcinoma Stage IIIB Lung Cancer AJCC v8 Stage IIIC Lung Cancer AJCC v8 Stage IV Lung Cancer AJCC v8
Interventions
DRUG PROCEDURE BIOLOGICAL OTHER
No Results Yet
NCT06094088 | RECRUITING | NA
120 Participants

Researching Heat and Yoga for Mood Enhancement

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2025-07-01
Completion: 2026-09-01
Conditions
Depression
Interventions
BEHAVIORAL
No Results Yet
NCT06090097 | RECRUITING | NA
60 Participants

Knee Biofeedback Rehabilitation Through Game Therapy

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2024-09-04
Completion: 2025-11-30
Conditions
Knee Osteoarthritis
Interventions
DEVICE OTHER
No Results Yet
NCT06085625 | RECRUITING | PHASE2
224 Participants

A Randomized Control Trial for Patient Reported Outcomes and Safety in Outpatient Thyroid Lobectomy

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2024-11-26
Completion: 2027-11-01
Conditions
Thyroid Lobectomy
Interventions
BEHAVIORAL
No Results Yet
NCT06079372 | ACTIVE_NOT_RECRUITING | PHASE3
43 Participants

Phase 3 Study of ALXN1850 in Pediatric Participants With HPP Previously Treated With Asfotase Alfa

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2024-04-02
Completion: 2025-07-23
Conditions
Hypophosphatasia
Interventions
DRUG
No Results Yet
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