Clinical Trials Updated in 2025

NCT05788302 | RECRUITING | NA

50 Participants

Mechanisms Underlying Efficacy of Prolonged Exposure

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2023-04-01

Completion: 2027-03-01

Conditions

Post Traumatic Stress Disorder

Interventions

BEHAVIORAL

No Results Yet

NCT05775159 | RECRUITING | PHASE2

294 Participants

Study of Novel Immunomodulators as Monotherapy and in Combination With Anticancer Agents in Participants With Advanced Hepatobiliary Cancer

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2023-04-24

Completion: 2026-10-27

Conditions

Hepatocellular Carcinoma Biliary Tract Cancer

Interventions

DRUG

No Results Yet

NCT05767658 | RECRUITING | NA

3000 Participants

Support Via Online Social Networks to Promote Safe Infant Care Practices

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2024-03-01

Completion: 2026-07-01

Conditions

Breastfeeding Infant Death Sudden Infant Death Syndrome Without Mention of Autopsy

Interventions

BEHAVIORAL

No Results Yet

NCT05733520 | RECRUITING | NA

160 Participants

I-CARE 2: Mobile Telehealth to Reduce Alzheimer'S-related Symptoms

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2023-05-30

Completion: 2027-07-30

Conditions

Caregiver Burden Alzheimer Disease

Interventions

BEHAVIORAL

No Results Yet

NCT05726487 | ACTIVE_NOT_RECRUITING | NA

224 Participants

Physical Activity Intervention for Black Women With Asthma

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2023-05-04

Completion: 2026-07-30

Conditions

Asthma

Interventions

BEHAVIORAL OTHER

No Results Yet

NCT05723562 | ACTIVE_NOT_RECRUITING | PHASE2

154 Participants

A Study of Dostarlimab in Untreated dMMR/MSI-H Locally Advanced Rectal Cancer

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2023-04-03

Completion: 2026-11-02

Conditions

Neoplasms, Rectal

Interventions

BIOLOGICAL

No Results Yet

NCT05721755 | RECRUITING | PHASE3

290 Participants

Combining Radiation Therapy With Immunotherapy for the Treatment of Metastatic Squamous Cell Carcinoma of the Head and Neck

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2023-06-08

Completion: 2029-03-31

Conditions

Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 Metastatic Head and Neck Squamous Cell Carcinoma Metastatic Hypopharyngeal Squamous Cell Carcinoma Metastatic Laryngeal Squamous Cell Carcinoma Metastatic Oral Cavity Squamous Cell Carcinoma Metastatic Oropharyngeal Squamous Cell Carcinoma Stage IV Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8 Stage IV Hypopharyngeal Carcinoma AJCC v8 Stage IV Laryngeal Cancer AJCC v8 Stage IV Lip and Oral Cavity Cancer AJCC v8 Stage IV Oropharyngeal (p16-Negative) Carcinoma AJCC v8

Interventions

DRUG PROCEDURE BIOLOGICAL OTHER RADIATION

No Results Yet

NCT05721222 | TERMINATED | PHASE1/PHASE2

42 Participants

Trial of PRO1160 (GEN1160) in Relapsed or Refractory Non-Hodgkin Lymphoma (NHL) (PRO1160-001)

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2023-03-15

Completion: 2025-11-05

Conditions

Renal Cell Carcinoma Nasopharyngeal Carcinoma Non Hodgkin Lymphoma

Interventions

BIOLOGICAL

No Results Yet

NCT05719558 | RECRUITING | PHASE1

210 Participants

A Study of ASP1002 in Adults for Treatment of Solid Tumors

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2023-03-13

Completion: 2028-04-30

Conditions

Advanced Solid Tumors

Interventions

DRUG

No Results Yet

NCT05714085 | RECRUITING | PHASE2/PHASE3

342 Participants

Efficacy, Safety, and Pharmacokinetics of Vericiguat in Pediatric Participants With Heart Failure Due to Left Ventricular Systolic Dysfunction (MK-1242-036)

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2023-05-31

Completion: 2032-04-15

Conditions

Heart Failure Left Ventricular Systolic Dysfunction

Interventions

DRUG

No Results Yet

NCT05710328 | RECRUITING | PHASE2

235 Participants

Testing the Role of FDG-PET/CT to Predict Response to Therapy Prior to Surgery for HER2-positive Breast Cancer, The DIRECT Trial

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2023-05-10

Completion: 2027-05-31

Conditions

Anatomic Stage II Breast Cancer AJCC v8 Anatomic Stage III Breast Cancer AJCC v8 HER2-Positive Breast Carcinoma Invasive Breast Carcinoma

Interventions

DRUG PROCEDURE OTHER

No Results Yet

NCT05704478 | ACTIVE_NOT_RECRUITING | PHASE4

30 Participants

Impact of Vericiguat on Hemodynamics of Heart Failure

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2024-01-01

Completion: 2026-03-31

Conditions

Heart Failure

Interventions

DRUG

No Results Yet

NCT05664789 | RECRUITING | PHASE2/PHASE3

144 Participants

Targeting the Neurobiology of RRB in Autism Using N-acetylcysteine: Trial

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2023-04-26

Completion: 2026-01-31

Conditions

Autism Spectrum Disorder

Interventions

DRUG

No Results Yet

NCT05661461 | RECRUITING | PHASE1

28 Participants

Dose-escalation Study to Assess Safety and Pharmacokinetics of Nab-Sirolimus in Patients With Locally Advanced or Metastatic Solid Tumors and Moderate Liver Impairment

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2022-11-23

Completion: 2026-06-01

Conditions

Tumor, Solid Tumor Advanced Solid Tumor

Interventions

DRUG

No Results Yet

NCT05650749 | RECRUITING | PHASE1

45 Participants

GPC2 CAR T Cells for Relapsed or Refractory Neuroblastoma and Metastatic Retinoblastoma

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2023-05-23

Completion: 2028-01-30

Conditions

Refractory Neuroblastoma Relapsed Neuroblastoma High-risk Neuroblastoma Retinoblastoma Metastatic Retinoblastoma

Interventions

BIOLOGICAL

No Results Yet

NCT05650632 | RECRUITING | PHASE1

180 Participants

A Study to Assess Adverse Events of Intravenously (IV) Infused ABBV-383 in Adult Participants With Relapsed or Refractory Multiple Myeloma

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2023-03-21

Completion: 2029-08-31

Conditions

Multiple Myeloma

Interventions

DRUG

No Results Yet

NCT05641844 | RECRUITING | NA

110 Participants

A Double Blind, Randomized Controlled Study, Evaluating the Safety and Efficacy of RD2 Ver.02 For the Management of Anal Fistulas

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2024-01-20

Completion: 2027-12-31

Conditions

Anal Fistula

Interventions

DEVICE OTHER

No Results Yet

NCT05640843 | RECRUITING | NA

150 Participants

A Study Comparing a Plant-Based Diet With Supplements and Placebo in People With Monoclonal Gammopathy of Undetermined Significance (MGUS) or Smoldering Multiple Myeloma (SMM)

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2022-11-29

Completion: 2026-11-30

Conditions

Monoclonal Gammopathy of Undetermined Significance Smoldering Multiple Myeloma

Interventions

OTHER DIETARY_SUPPLEMENT

No Results Yet

NCT05630183 | ACTIVE_NOT_RECRUITING | PHASE2

81 Participants

A Study of Botensilimab in Participants With Metastatic Pancreatic Cancer

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2023-03-27

Completion: 2025-12-05

Conditions

Metastatic Pancreatic Ductal Adenocarcinoma

Interventions

DRUG

No Results Yet

NCT05607095 | RECRUITING | PHASE1

20 Participants

A Study of LN-144 or LN-145 in People With Advanced Uveal Melanoma, Undifferentiated Pleomorphic Sarcoma, or Dedifferentiated Liposarcoma

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2022-11-01

Completion: 2026-05-01

Conditions

Uveal Melanoma Melanoma Metastatic Uveal Melanoma Metastatic Melanoma

Interventions

BIOLOGICAL

No Results Yet

NCT05582187 | COMPLETED | PHASE1

28 Participants

A Clinical Trial of the Study Medicine (Called Fosmanogepix) in Participants With Varying Degrees of Hepatic Function.

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2022-10-31

Completion: 2025-10-16

Conditions

Hepatic Impairment

Interventions

DRUG

No Results Yet

NCT05562895 | COMPLETED

155 Participants

A Multicenter Study to Evaluate the Cios Spin and the Ion Endoluminal System for Pulmonary Nodule Biopsy

Study Type: OBSERVATIONAL

Last Updated: 2025-11-13

Start Date: 2022-12-31

Completion: 2023-12-31

Conditions

Lung Cancer

Interventions

DEVICE

No Results Yet

NCT05554146 | COMPLETED | NA

35 Participants

Pain Inflammation and Cannabis in HIV

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2022-10-28

Completion: 2024-05-03

Conditions

HIV Infections Neuropathic Pain Cannabis

Interventions

OTHER

Results Available

NCT05552976 | RECRUITING | PHASE3

525 Participants

A Study to Evaluate Mezigdomide in Combination With Carfilzomib and Dexamethasone (MeziKD) Versus Carfilzomib and Dexamethasone (Kd) in Participants With Relapsed or Refractory Multiple Myeloma (SUCCESSOR-2)

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2023-01-10

Completion: 2026-02-04

Conditions

Relapsed or Refractory Multiple Myeloma

Interventions

DRUG

No Results Yet

NCT05552469 | RECRUITING | PHASE1

105 Participants

Dose Optimization and Expansion Study of DFV890 in Adult Patients With Myeloid Diseases

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2023-05-08

Completion: 2027-01-29

Conditions

Myeloid Diseases

Interventions

DRUG

No Results Yet

NCT05545501 | RECRUITING | NA

35 Participants

Ketone Ester and Salt (KEAS) in Young Adults

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2023-03-24

Completion: 2026-09-30

Conditions

Salt; Excess Hypertension

Interventions

DIETARY_SUPPLEMENT

No Results Yet

NCT05541718 | COMPLETED | NA

164 Participants

New Options for Treating Knee Osteoarthritis Pain

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2023-01-13

Completion: 2024-08-13

Conditions

Knee Osteoarthritis

Interventions

BEHAVIORAL

No Results Yet

NCT05541406 | TERMINATED | NA

228 Participants

Efficacy of a Multi-level School Intervention for LGBTQ Youth

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2022-09-14

Completion: 2025-07-01

Conditions

Depression Anxiety Post Traumatic Stress Disorder Coping Behavior Sexual Minority Stress Suicidality Substance Use Bullying Harassment

Interventions

BEHAVIORAL

No Results Yet

NCT05538663 | RECRUITING | PHASE3

870 Participants

Intravesical BCG vs GEMDOCE in NMIBC

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2023-02-07

Completion: 2029-11-01

Conditions

Non-muscle-invasive Bladder Cancer

Interventions

DRUG

No Results Yet

NCT05535855 | RECRUITING | PHASE1

29 Participants

UCD19 CAR T Therapy in Adults With B-ALL and MRD Positivity in CR1

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2024-01-24

Completion: 2027-06-30

Conditions

Acute Lymphoid Leukemia Acute Lymphoblastic Leukemia

Interventions

DRUG

No Results Yet

NCT05531565 | RECRUITING | PHASE2/PHASE3

474 Participants

A 2-Part Study to Learn Whether Litifilimab (BIIB059) Injections Can Improve Symptoms of Adult Participants Who Have Active Cutaneous Lupus Erythematosus

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2022-09-13

Completion: 2026-10-20

Conditions

Subacute Cutaneous Lupus Erythematosus Chronic Cutaneous Lupus Erythematosus

Interventions

DRUG

No Results Yet

NCT05515341 | RECRUITING

50000 Participants

A DirEct to PatieNt Study in Chronic Pain

Study Type: OBSERVATIONAL

Last Updated: 2025-11-13

Start Date: 2023-01-10

Completion: 2029-12-31

Conditions

Chronic Pain

Interventions

DEVICE

No Results Yet

NCT05502939 | ACTIVE_NOT_RECRUITING | NA

114 Participants

Music Training and Child Development Study

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2022-09-11

Completion: 2027-10-01

Conditions

Music

Interventions

BEHAVIORAL

No Results Yet

NCT05494398 | ENROLLING_BY_INVITATION | PHASE2/PHASE3

48 Participants

Targeting the Neurobiology of RRB in Autism Using N-acetylcysteine: Open Label

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2024-03-12

Completion: 2027-09-30

Conditions

Autism Spectrum Disorder

Interventions

DRUG

No Results Yet

NCT05478213 | RECRUITING | NA

10 Participants

Ventricular Tachycardia Mechanisms

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2022-10-25

Completion: 2025-12-31

Conditions

Ventricular Tachycardia

Interventions

DEVICE

No Results Yet

NCT05455671 | COMPLETED

48 Participants

Real-Time Assessment of Lung Structure and Function in Children and Young Adults With CF Using Electrical Impedance Tomography

Study Type: OBSERVATIONAL

Last Updated: 2025-11-13

Start Date: 2022-08-01

Completion: 2024-08-20

Conditions

Cystic Fibrosis Healthy

No Results Yet

NCT05451914 | COMPLETED | NA

458 Participants

Effects of My Diabetes Care on Patient Outcomes

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2023-07-06

Completion: 2025-07-14

Conditions

Diabetes Mellitus, Type 2

Interventions

OTHER

No Results Yet

NCT05451004 | RECRUITING | PHASE3

510 Participants

SPECT-CT Guided ELEctive Contralateral Neck Treatment for Patients With Lateralized Oropharyngeal Cancer

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2023-02-10

Completion: 2030-08-30

Conditions

Oropharyngeal Cancer

Interventions

OTHER RADIATION

No Results Yet

NCT05420844 | COMPLETED | NA

20 Participants

Pilot Study to Evaluate a Voice Journaling Application in Adolescents With Cystic Fibrosis

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2022-07-29

Completion: 2024-04-16

Conditions

Cystic Fibrosis

Interventions

OTHER

No Results Yet

NCT05419076 | RECRUITING | PHASE2

62 Participants

A Study of Stereotactic Radiosurgery (SRS) for People With Lung Cancer That Has Spread to the Brain

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2022-06-10

Completion: 2026-06-10

Conditions

Lung Cancer Lung Cancer Metastatic Brain Metastases Brain Metastases, Adult Small-cell Lung Cancer Small Cell Lung Carcinoma

Interventions

RADIATION PROCEDURE

No Results Yet