Clinical Trials Updated in 2025

NCT07026942 | NOT_YET_RECRUITING | PHASE1/PHASE2

42 Participants

Phase I/II Clinical Trial of Universal Donor CD33 CAR Natural Killer Cells for AML

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2026-04-01

Completion: 2032-07-01

Conditions

Relapsed/Refractory AML

Interventions

BIOLOGICAL

No Results Yet

NCT07025538 | NOT_YET_RECRUITING | PHASE1

42 Participants

Biomarker-Guided Ruxolitinib for the Prevention of Chronic Graft Versus Host Disease After Allogeneic Hematopoietic Cell Transplantation

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2025-12-09

Completion: 2028-04-05

Conditions

Hematopoietic and Lymphatic System Neoplasm

Interventions

OTHER PROCEDURE DRUG

No Results Yet

NCT07025330 | RECRUITING | PHASE2

5 Participants

A Study of Efgartigimod in Patients With IgG4-Related Disease

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2025-11-12

Completion: 2028-03-01

Conditions

IgG4-related Disease

Interventions

DRUG

No Results Yet

NCT07023289 | RECRUITING | PHASE2

140 Participants

A Study to Assess Adverse Events and Change in Disease Activity in Adult Participants Receiving Intravenously Infused Telisotuzumab Adizutecan Alone or With Standard of Care in Participants With Post Adjuvant Circulating Tumor DNA Positive Colorectal Cancer and No Radiographic Evidence of Disease

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2025-08-07

Completion: 2029-11-30

Conditions

Colorectal Cancer

Interventions

DRUG

No Results Yet

NCT07013474 | RECRUITING | PHASE3

300 Participants

A Study to Learn About the Study Medicine Ibuzatrelvir in Adults With COVID-19 Who Are Severely Immunocompromised

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2025-07-14

Completion: 2026-12-06

Conditions

COVID-19 Infection

Interventions

DRUG

No Results Yet

NCT07012395 | RECRUITING | PHASE2

645 Participants

A Study of Long-acting Antibodies Alone and in Combinations for Moderate to Severe Ulcerative Colitis

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2025-05-27

Completion: 2026-06-30

Conditions

Ulcerative Colitis Inflammatory Bowel Diseases Colitis Colitis, Ulcerative

Interventions

DRUG OTHER

No Results Yet

NCT07012031 | NOT_YET_RECRUITING | PHASE1/PHASE2

37 Participants

Sotorasib in Combination With Trastuzumab Deruxtecan for the Treatment of Locally Advanced and Metastatic Non-small Cell Lung Cancer With a KRAS G12C Mutation

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2025-12-01

Completion: 2027-06-14

Conditions

Locally Advanced Lung Non-Small Cell Carcinoma Metastatic Lung Non-Small Cell Carcinoma Stage III Lung Cancer AJCC v8 Stage IV Lung Cancer AJCC v8

Interventions

PROCEDURE DRUG BIOLOGICAL

No Results Yet

NCT07009886 | RECRUITING | NA

155 Participants

Development of an Educational Patient Decision Aid (Treatments in Advanced Cancer - Decision Aid, TA-DA) to Promote Shared Decision Making for Third-line or Beyond Palliative Systemic Therapy

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2025-07-10

Completion: 2028-07-31

Conditions

Advanced Cancer

Interventions

OTHER

No Results Yet

NCT07008963 | RECRUITING

50 Participants

Interview of Patients With HR+/HER2- Metastatic Breast Cancer Who Received Capivasertib + Fulvestrant

Study Type: OBSERVATIONAL

Last Updated: 2025-11-12

Start Date: 2025-07-31

Completion: 2025-12-31

Conditions

Metastatic Breast Cancer

Interventions

OTHER

No Results Yet

NCT06996639 | RECRUITING | NA

400 Participants

Breaking Fasts Ahead of Cardiac Caths

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2025-10-13

Completion: 2026-06-30

Conditions

Stable Angina (SA) Unstable Angina (UA) NSTEMI - Non-ST Segment Elevation MI

Interventions

BEHAVIORAL

No Results Yet

NCT06995651 | RECRUITING | PHASE1

15 Participants

Dorzagliatin in Pancreatic Insufficient Cystic Fibrosis

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2025-12-31

Completion: 2027-07-31

Conditions

Pancreatic Insufficiency Cystic Fibrosis-related Diabetes

Interventions

DRUG

No Results Yet

NCT06991556 | RECRUITING | PHASE2

150 Participants

An Open-label Study of JSB462 (Luxdegalutamide) in Combination With Abiraterone in Adult Male Patients With Metastatic Hormone-sensitive Prostate Cancer (mHSPC)

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2025-07-07

Completion: 2032-04-19

Conditions

Metastatic Hormone-sensitive Prostate Cancer

Interventions

DRUG

No Results Yet

NCT06989437 | RECRUITING | PHASE2/PHASE3

982 Participants

A Study to Learn About the Medicine Ponsegromab in Adults With Cancer of the Pancreas Which Has Spread and Caused Significant Body Weight Loss and Fatigue

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2025-10-03

Completion: 2028-01-30

Conditions

Cachexia Metastatic Pancreatic Ductal Adenocarcinoma

Interventions

DRUG

No Results Yet

NCT06987318 | NOT_YET_RECRUITING | PHASE1

40 Participants

A Study to Evaluate the Safety and Antiviral Activity of Two Human Monoclonal Antibodies (VRC07-523LS and PGT121.414.LS) During Analytic Treatment Interruption in Participants Living With HIV Who Initiated ART During Acute/Early HIV-1 Infection

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2026-02-15

Completion: 2027-08-29

Conditions

HIV-1-infection

Interventions

BIOLOGICAL

No Results Yet

NCT06979453 | RECRUITING | PHASE3

366 Participants

A Study to Evaluate the Efficacy, Safety, and Drug Levels of Deucravacitinib (BMS-986165) in Adolescent Participants With Moderate to Severe Plaque Psoriasis

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2025-11-15

Completion: 2029-10-12

Conditions

Plaque Psoriasis

Interventions

DRUG OTHER

No Results Yet

NCT06977503 | NOT_YET_RECRUITING | NA

40 Participants

Alpha-Stim AID® Together With Life Coaching for the Support of Burnout Symptoms in Healthcare Workers

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2025-12-01

Completion: 2026-12-15

Conditions

Psychiatric Disorder

Interventions

PROCEDURE OTHER BEHAVIORAL

No Results Yet

NCT06976476 | RECRUITING | PHASE2

100 Participants

Study of IgPro20 to Prevent Infection in People With Multiple Myeloma and Hypogammaglobulinemia

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2025-05-08

Completion: 2029-05-08

Conditions

Multiple Myeloma Hypogammaglobulinemia Hypogammaglobulinemia, Acquired

Interventions

DRUG

No Results Yet

NCT06976216 | RECRUITING | PHASE3

586 Participants

A Study to Evaluate the Efficacy and Safety of KarXT + KarX-EC for Cognitive Impairment in Alzheimer's Disease

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2025-07-14

Completion: 2028-09-11

Conditions

Alzheimer's Disease

Interventions

DRUG OTHER

No Results Yet

NCT06976203 | RECRUITING | PHASE3

586 Participants

A Study to Evaluate the Efficacy and Safety of KarXT + KarX-EC for Cognitive Impairment in Alzheimer's Disease (MINDSET 2)

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2025-07-21

Completion: 2028-09-11

Conditions

Alzheimer's Disease

Interventions

DRUG OTHER

No Results Yet

NCT06975046 | NOT_YET_RECRUITING | NA

365 Participants

Aerodynamic Measurements in the Pediatric Population

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2025-12-31

Completion: 2030-12-31

Conditions

Normal Voice

Interventions

DEVICE

No Results Yet

NCT06973564 | RECRUITING | PHASE1/PHASE2

294 Participants

JAB-23E73 in Adult Participants With Advanced Solid Tumors With KRAS Alteration

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2025-05-29

Completion: 2027-11-30

Conditions

Advanced Solid Tumors

Interventions

DRUG

No Results Yet

NCT06972381 | RECRUITING | NA

68 Participants

Piloting a Patient Navigator Program for Weight Loss

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2025-09-15

Completion: 2027-02-15

Conditions

Obesity Overweight

Interventions

BEHAVIORAL

No Results Yet

NCT06966479 | RECRUITING | PHASE2

436 Participants

A Long-Term Safety and Efficacy Study of Verekitug (UPB-101) in Adult Participants With Severe Asthma (VALOUR)

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2025-05-21

Completion: 2027-09-30

Conditions

Severe Asthma

Interventions

DRUG

No Results Yet

NCT06965413 | ACTIVE_NOT_RECRUITING | PHASE2

285 Participants

A Study to Assess Efficacy, Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of RO7204239 in Combination With Tirzepatide in Participants With Obesity or Overweight With At Least One Weight-related Comorbidity

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2025-05-05

Completion: 2026-08-21

Conditions

Obesity Overweight Overweight With One Weight Related Comorbidity

Interventions

DRUG

No Results Yet

NCT06963827 | RECRUITING | PHASE3

347 Participants

A Study of Mezagitamab in Adults With Primary IgA Nephropathy Kidney Condition

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2025-07-15

Completion: 2028-09-07

Conditions

Kidney Disease

Interventions

DRUG

No Results Yet

NCT06961357 | RECRUITING | PHASE1/PHASE2

36 Participants

Clinical Trial of CD40L-augmented TIL for Patients With Advanced Melanoma

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2025-12-01

Completion: 2029-05-31

Conditions

Melanoma

Interventions

DRUG

No Results Yet

NCT06954792 | ENROLLING_BY_INVITATION

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2026-07-19

Completion: 2029-06-02

Conditions

Locally Advanced Adrenal Cortical Carcinoma Metastatic Adrenal Cortical Carcinoma Recurrent Adrenal Cortical Carcinoma Stage III Adrenal Cortical Carcinoma AJCC v8 Stage IV Adrenal Cortical Carcinoma AJCC v8 Unresectable Adrenal Cortical Carcinoma

Interventions

PROCEDURE DRUG BIOLOGICAL

No Results Yet