Clinical Trials
1000
Participants
An Intervention to Increase Genetic Testing in Families Who May Share a Gene Mutation Related to Cancer Risk and An Intervention to Help Patients and Their Primary Care Providers Stay Up-to-date About Uncertain Genetic Test Results
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-12
Start Date:
2022-12-01
Completion:
2026-05-31
Conditions
BRCA1 Mutation
POLD1 Gene Mutation
CDKN2A Mutation
BRCA2 Mutation
POLE Gene Mutation
APC Gene Mutation
ATM Gene Mutation
MLH1 Gene Mutation
BARD1 Gene Mutation
MSH2 Gene Mutation
BRIP1 Gene Mutation
MSH6 Gene Mutation
CHEK2 Gene Mutation
PMS2 Gene Mutation
PALB2 Gene Mutation
EPCAM Gene Mutation
RAD51C Gene Mutation
BMPR1A Gene Mutation
RAD51D Gene Mutation
SMAD4
PTEN Gene Mutation
GREM1
Interventions
BEHAVIORAL
No Results Yet
346
Participants
A Study to Evaluate Patient Preference for Home Administration of Fixed-Dose Combination of Pertuzumab and Trastuzumab for Subcutaneous Administration in Participants With Early or Locally Advanced/Inflammatory HER2-Positive Breast Cancer
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-12
Start Date:
2022-07-05
Completion:
2024-11-20
Conditions
Early Breast Cancer
Locally Advanced Breast Cancer
Inflammatory Breast Cancer
Interventions
DRUG
PROCEDURE
RADIATION
No Results Yet
4000
Participants
Natural History Protocol for Movement Disorders
Study Type:
OBSERVATIONAL
Last Updated:
2025-11-12
Start Date:
2022-10-17
Completion:
2030-12-31
Conditions
Movement Disorder
Tremor
Parkinson's Disease
No Results Yet
70
Participants
Care Planning Framework in Advanced Cancer (ABC123)
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-12
Start Date:
2022-02-15
Completion:
2025-12-22
Conditions
Advanced Cancer
Interventions
BEHAVIORAL
No Results Yet
12
Participants
Natural Killer (NK) Cells in Combination With Interleukin-2 (IL-2) and Transforming Growth Factor Beta (TGFbeta) Receptor I Inhibitor Vactosertib in Cancer
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-12
Start Date:
2022-09-09
Completion:
2025-12-31
Conditions
Colorectal Cancer
Hematologic Malignancy
Rectum Cancer
Acute Myeloid Leukemia
Myelodysplastic Syndromes
Acute Lymphoblastic Leukemia
Chronic Myeloid Leukemia
Chronic Lymphocytic Leukemia
Hodgkin Lymphoma
Non Hodgkin Lymphoma
Myeloproliferative Syndrome
Plasma Cell Myeloma
Gastric Cancer
Esophageal Cancer
Esophagus Cancer
Gastric Cancer, Metastatic
Unresectable Esophageal Cancer
Metastatic Esophageal Cancer
Interventions
DRUG
No Results Yet
100
Participants
Neurofeedback for Borderline Personality Disorder
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-12
Start Date:
2022-09-02
Completion:
2026-04-30
Conditions
Borderline Personality Disorder
Interventions
DEVICE
No Results Yet
754
Participants
Study of RMC-6236 in Patients With Advanced Solid Tumors Harboring Specific Mutations in RAS
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-12
Start Date:
2022-05-31
Completion:
2027-05-31
Conditions
Non-small Cell Lung Cancer (NSCLC)
Colorectal Cancer (CRC)
Pancreatic Ductal Adenocarcinoma (PDAC)
Advanced Solid Tumors
Interventions
DRUG
No Results Yet
82
Participants
Intergenerational Transmission of Low-calorie Sweeteners Via Breast Milk
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-12
Start Date:
2022-02-28
Completion:
2022-12-02
Conditions
Breastfeeding
Interventions
OTHER
700
Participants
Met Non Small Cell Cancer Registry (MOMENT)
Study Type:
OBSERVATIONAL
Last Updated:
2025-11-12
Start Date:
2022-10-04
Completion:
2028-04-28
Conditions
Cancer
No Results Yet
156
Participants
A Study to Learn About the Study Medicine Called PF-07799933 in People With Advanced Solid Tumors With BRAF Alterations.
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-12
Start Date:
2022-07-05
Completion:
2027-03-28
Conditions
Melanoma
Non-Small-Cell Lung Cancer
Thyroid Cancer
Glioma
Interventions
DRUG
BIOLOGICAL
No Results Yet
4500
Participants
A Study Called FINE-REAL to Learn More About the Use of the Drug Finerenone in a Routine Medical Care Setting
Study Type:
OBSERVATIONAL
Last Updated:
2025-11-12
Start Date:
2022-06-13
Completion:
2026-09-30
Conditions
Chronic Kidney Disease
Type 2 Diabetes Mellitus
Interventions
DRUG
No Results Yet
12
Participants
Efficacy and Safety Study of Ravulizumab IV in Pediatric Participants With NMOSD
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-12
Start Date:
2022-06-23
Completion:
2026-03-31
Conditions
Neuromyelitis Optica Spectrum Disorder
Interventions
DRUG
No Results Yet
90
Participants
Bone Marrow Derived Stem Cells Mobilization for Treatment of Abnormal Endometrium
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-12
Start Date:
2023-11-01
Completion:
2026-12-31
Conditions
Asherman Syndrome
Atrophic Endometrium
Recurrent Implantation Failure
Interventions
DRUG
No Results Yet
8
Participants
CPI-613 (Devimistat) in Combination With Chemoradiation in Patients With Pancreatic Adenocarcinoma
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-12
Start Date:
2022-10-31
Completion:
2025-07-08
Conditions
Pancreas Adenocarcinoma
Interventions
DRUG
RADIATION
No Results Yet
373
Participants
A Study Evaluating the Efficacy and Safety of Giredestrant Plus Everolimus Compared With the Physician's Choice of Endocrine Therapy Plus Everolimus in Participants With Estrogen Receptor-Positive, HER2-Negative, Locally Advanced or Metastatic Breast Cancer (evERA Breast Cancer)
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-12
Start Date:
2022-08-03
Completion:
2025-07-16
Conditions
Estrogen Receptor (ER)-Positive, HER2-negative, Locally Advanced or Metastatic Breast Cancer
Interventions
DRUG
No Results Yet
28
Participants
A Study to Evaluate the Effect of Spinal Cord Stimulation (SCS) on Painful Diabetic Peripheral Neuropathy (pDPN)
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-12
Start Date:
2022-09-22
Completion:
2026-04-30
Conditions
Chronic Pain
Interventions
DEVICE
No Results Yet
197
Participants
Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation (DIAN-TU)
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-12
Start Date:
2021-12-22
Completion:
2028-04-30
Conditions
Alzheimers Disease
Dementia
Alzheimers Disease, Familial
Interventions
DRUG
No Results Yet
80
Participants
Diffusion MRI of the Abdomen
Study Type:
OBSERVATIONAL
Last Updated:
2025-11-12
Start Date:
2023-11-22
Completion:
2026-06-30
Conditions
Abdominal Imaging
Interventions
DEVICE
No Results Yet
160
Participants
Rural Hospital-Level Care at Home for Acutely Ill Adults
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-12
Start Date:
2022-02-16
Completion:
2023-12-17
Conditions
Infections
Heart Failure
Chronic Obstructive Pulmonary Disease
Asthma
Gout Flare
Chronic Kidney Diseases
Hypertensive Urgency
Atrial Fibrillation Rapid
Anticoagulation
Diabetes and Its Complications
End of Life/Desires Only Medical Management
Interventions
OTHER
No Results Yet
360
Participants
Testing the Addition of Herceptin Hylecta or Phesgo to the Usual Chemotherapy for HER2 Positive Endometrial Serous Carcinoma or Carcinosarcoma
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-12
Start Date:
2022-11-16
Completion:
2027-10-31
Conditions
Endometrial Carcinoma
Endometrial Clear Cell Adenocarcinoma
Endometrial Dedifferentiated Carcinoma
Endometrial Endometrioid Adenocarcinoma
Endometrial Mixed Cell Adenocarcinoma
Endometrial Serous Adenocarcinoma
Endometrial Undifferentiated Carcinoma
Uterine Corpus Carcinosarcoma
Interventions
PROCEDURE
DRUG
RADIATION
OTHER
No Results Yet
100
Participants
Study of Pembrolizumab (MK-3475) Versus Chemotherapy in Chinese Participants With Stage IV Colorectal Cancer (MK-3475-C66)
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-12
Start Date:
2022-04-02
Completion:
2028-09-19
Conditions
Colorectal Neoplasms
Interventions
BIOLOGICAL
DRUG
No Results Yet
300
Participants
Tissue Procurement and Natural History Study of Neuroendocrine Neoplasms (NENs) Including Adrenocortical Carcinoma (ACC)
Study Type:
OBSERVATIONAL
Last Updated:
2025-11-12
Start Date:
2022-04-25
Completion:
2032-12-31
Conditions
Neuroendocrine Tumors
Carcinoma, Neuroendocrine
No Results Yet
108
Participants
Control Network Neuromodulation to Enhance Cognitive Training in Complex Traumatic Brain Injury
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-12
Start Date:
2022-01-21
Completion:
2026-04-01
Conditions
Traumatic Brain Injury
Interventions
DEVICE
OTHER
No Results Yet
60
Participants
A Study to Evaluate the Safety and Tolerability of ALN-APP in Patients With EOAD
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-12
Start Date:
2022-02-04
Completion:
2029-03-28
Conditions
Early-Onset Alzheimer Disease
Interventions
DRUG
No Results Yet
20
Participants
Psilocybin-assisted Therapy for Phantom Limb Pain
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-12
Start Date:
2022-10-03
Completion:
2024-03-07
Conditions
Phantom Limb Pain
Interventions
DRUG
No Results Yet
30
Participants
Cutaneous Hydration Assessment in SCD
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-12
Start Date:
2022-01-21
Completion:
2026-12-31
Conditions
Sickle Cell Disease
Interventions
DEVICE
No Results Yet
99
Participants
Study of Efficacy and Safety of Ofatumumab in Relapsing Multiple Sclerosis (RMS) Patients in China
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-12
Start Date:
2022-07-22
Completion:
2025-02-13
Conditions
Relapsing Multiple Sclerosis
Interventions
BIOLOGICAL
146
Participants
PHE885 CAR-T Therapy in Adult Participants With Relapsed and Refractory Multiple Myeloma
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-12
Start Date:
2022-03-03
Completion:
2025-05-21
Conditions
Multiple Myeloma
Interventions
BIOLOGICAL
No Results Yet
242
Participants
A Study Evaluating Efficacy and Safety of Mosunetuzumab in Combination With Polatuzumab Vedotin Compared to Rituximab in Combination With Gemcitabine Plus Oxaliplatin in Participants With Relapsed or Refractory Aggressive B-Cell Non-Hodgkin's Lymphoma
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-12
Start Date:
2022-04-25
Completion:
2025-02-17
Conditions
Non-Hodgkin Lymphoma
Interventions
DRUG
No Results Yet
80
Participants
Dietary Intake and Dietary Behaviors in Adults With Sickle Cell Disease
Study Type:
OBSERVATIONAL
Last Updated:
2025-11-12
Start Date:
2022-05-26
Completion:
2026-12-31
Conditions
Sickle Cell Disease
No Results Yet
500
Participants
Implementation of Whole Genome Sequencing as Screening in a Diverse Cohort of Healthy Infants
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-12
Start Date:
2022-12-21
Completion:
2025-06-30
Conditions
Genetic Predisposition to Disease
Hereditary Diseases
Interventions
GENETIC
No Results Yet
640
Participants
Efficacy and Safety Study of Rimegepant for the Preventative Treatment of Migraine in Pediatric Subjects
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-12
Start Date:
2022-02-28
Completion:
2031-11-29
Conditions
Migraine
Interventions
DRUG
No Results Yet
8
Participants
Highest Dose of Uproleselan in Combination With Fludarabine and Cytarabine for Patients With Acute Myeloid Leukemia, Myelodysplastic Syndrome, or Mixed Phenotype Acute Leukemia Relapsed or Refractory That Expresses E-selectin Ligand on the Cell Membrane
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-12
Start Date:
2023-10-10
Completion:
2025-03-31
Conditions
Acute Myeloid Leukemia Post Cytotoxic Therapy
Myelodysplastic Syndrome Post Cytotoxic Therapy
Myeloid Leukemia Associated With Down Syndrome
Recurrent Acute Myeloid Leukemia
Recurrent Mixed Phenotype Acute Leukemia
Recurrent Myelodysplastic Syndrome
Refractory Acute Myeloid Leukemia
Refractory Mixed Phenotype Acute Leukemia
Refractory Myelodysplastic Syndrome
Interventions
DRUG
No Results Yet
8
Participants
Long - Term Follow Up of Sickle Cell Disease and Beta-thalassemia Subjects Previously Exposed to BIVV003 or ST-400.
Study Type:
OBSERVATIONAL
Last Updated:
2025-11-12
Start Date:
2021-12-21
Completion:
2038-07-14
Conditions
Blood and Lymphatic Diseases
Interventions
DRUG
No Results Yet
280
Participants
Clinical Trial Evaluating the Safety, Tolerability and Preliminary Efficacy of BNT116 Alone and in Combinations in Patients With Advanced Non-small Cell Lung Cancer
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-12
Start Date:
2022-06-17
Completion:
2030-02-28
Conditions
Non-Small Cell Lung Cancer
Interventions
BIOLOGICAL
DRUG
No Results Yet
492
Participants
Trial of Preemptive Pharmacogenetics in Underserved Patients
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-12
Start Date:
2022-08-01
Completion:
2025-09-08
Conditions
Use of Prescription Medications
Pharmacogenetic Testing
Interventions
DIAGNOSTIC_TEST
No Results Yet
190
Participants
A Study to Evaluate How Safe Pozelimab + Cemdisiran Combination Therapy is and How Well it Works in Adult Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH) Who Have Not Recently Received or Have Not Received Complement Inhibitor Treatment
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-12
Start Date:
2022-08-01
Completion:
2027-01-28
Conditions
Paroxysmal Nocturnal Hemoglobinuria
Interventions
DRUG
No Results Yet
120
Participants
A Study of NKT2152, a HIF2α Inhibitor, in Patients With Advanced Clear Cell Renal Cell Carcinoma
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-12
Start Date:
2021-10-26
Completion:
2025-08-22
Conditions
ccRCC
Clear Cell Renal Cell Carcinoma
Kidney Cancer
Kidney Neoplasms
Renal Cancer
Renal Neoplasms
Recurrent Renal Cell Carcinoma
Metastatic Renal Cell Carcinoma
Refractory Renal Cell Carcinoma
Advanced Renal Cell Carcinoma
Hypoxia
Renal Cell Carcinoma
Hypoxia Inducible Factor (HIF)
HIF2α Inhibitor
Hypoxia Inducible Factor 2 Alpha (HIF-2 Alpha)
Hypoxia Inducible Factor 2α (HIF-2α)
Clear Cell
Interventions
DRUG
No Results Yet
201
Participants
Breaking Implicit Bias Habits: An Individuation Pilot Study In Rheumatology
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-12
Start Date:
2022-06-17
Completion:
2024-09-27
Conditions
Systemic Lupus Erythematosus
Rheumatoid Arthritis
Inflammatory Arthritis
Osteoarthritis
Interventions
BEHAVIORAL
OTHER
6
Participants
Limb Health and Socket Pressure in Response to Powered Ankle Protheses
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-12
Start Date:
2021-11-15
Completion:
2023-07-19
Conditions
Pressure Ulcer, Ankle
Prosthesis User
Prosthesis Durability
Mobility Limitation
Skin Wound
Amputation; Traumatic, Foot
Amputation
Limb Deficiencies
Interventions
DEVICE
Showing 40 trials per page · Total 557382 trials