Clinical Trials Updated in 2025

NCT04606095 | RECRUITING | NA

150 Participants

Explosive Synchronization of Brain Network Activity in Chronic Pain

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2020-11-13

Completion: 2026-02-20

Conditions

Fibromyalgia Healthy Volunteers

Interventions

DIAGNOSTIC_TEST DEVICE

No Results Yet

NCT04561518 | RECRUITING

1500 Participants

ConTTRibute: A Global Observational Study of Patients With Transthyretin (TTR)-Mediated Amyloidosis (ATTR Amyloidosis)

Study Type: OBSERVATIONAL

Last Updated: 2025-11-12

Start Date: 2020-11-23

Completion: 2030-09-01

Conditions

Transthyretin-Mediated Amyloidosis ATTR Amyloidosis

No Results Yet

NCT04551430 | ACTIVE_NOT_RECRUITING | PHASE2

105 Participants

Cabozantinib Combined With PD-1 and CTLA-4 Inhibition in Metastatic Soft Tissue Sarcoma

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2021-01-05

Completion: 2027-02-01

Conditions

Metastatic Soft-tissue Sarcoma

Interventions

DRUG

No Results Yet

NCT04551170 | ACTIVE_NOT_RECRUITING | PHASE2

34 Participants

Theophylline Treatment for Pseudohypoparathyroidism - Children 2-12 Years Old

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2020-07-13

Completion: 2026-12-31

Conditions

Pseudohypoparathyroidism Albright Hereditary Osteodystrophy Pseudohypoparathyroidism Type 1a

Interventions

DRUG

No Results Yet

NCT04543591 | ACTIVE_NOT_RECRUITING | PHASE3

148 Participants

Ravulizumab in Thrombotic Microangiopathy After Hematopoietic Stem Cell Transplant

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2020-12-10

Completion: 2025-09-19

Conditions

Thrombotic Microangiopathy

Interventions

BIOLOGICAL OTHER

No Results Yet

NCT04527549 | TERMINATED | PHASE2

5 Participants

Testing Dabrafenib and Trametinib With or Without Hydroxychloroquine in Stage IIIC or IV BRAF V600E/K Melanoma

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2021-06-01

Completion: 2024-01-08

Conditions

Clinical Stage IV Cutaneous Melanoma AJCC v8 Locally Advanced Melanoma Pathologic Stage IIIC Cutaneous Melanoma AJCC v8 Pathologic Stage IV Cutaneous Melanoma AJCC v8 Unresectable Melanoma

Interventions

DRUG

Results Available

NCT04518228 | COMPLETED

205 Participants

Pharmacokinetic Properties of Antiretroviral and Anti-Tuberculosis Drugs During Pregnancy and Postpartum

Study Type: OBSERVATIONAL

Last Updated: 2025-11-12

Start Date: 2021-09-01

Completion: 2025-04-24

Conditions

HIV Infections Tuberculosis

Interventions

DRUG

No Results Yet

NCT04514861 | ACTIVE_NOT_RECRUITING | NA

53 Participants

Monitoring Local Tissue Oxygen Changes Using the Wireless Lumee Oxygen Platform in Correlation to TcPO2

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2020-12-18

Completion: 2027-03-30

Conditions

Peripheral Artery Disease

Interventions

DEVICE

No Results Yet

NCT04477512 | COMPLETED | PHASE1

18 Participants

Cabozantinib and Abiraterone With Checkpoint Inhibitor Immunotherapy in Metastatic Hormone Sensitive Prostate Cancer (CABIOS Trial)

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2021-02-19

Completion: 2021-09-09

Conditions

Metastatic Hormone Refractory Prostate Cancer

Interventions

DRUG PROCEDURE

No Results Yet

NCT04465214 | COMPLETED

49 Participants

Mobile Sensor Technologies to Assess General Symptomology of People With Cancer

Study Type: OBSERVATIONAL

Last Updated: 2025-11-12

Start Date: 2020-11-23

Completion: 2024-04-10

Conditions

Neoplasms Solid Tumors Prostate Cancer Lung Cancer Colon Cancer

No Results Yet

NCT04440228 | COMPLETED | NA

90 Participants

TeamSTEPPS in School Mental Health

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2022-05-23

Completion: 2024-04-30

Conditions

Child Behavior Problem Multidisciplinary Communication Interprofessional Relations

Interventions

BEHAVIORAL

Results Available

NCT04415515 | TERMINATED | NA

592023 Participants

Standard Care Coordination Expansion Pilot

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2015-10-31

Completion: 2023-12-31

Conditions

Superutilizers, Health Care Utilization

Interventions

BEHAVIORAL

No Results Yet

NCT04384172 | COMPLETED | NA

9 Participants

Effect of Peripheral Neuromodulation on Vaginal Blood Flow

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2020-11-11

Completion: 2022-03-15

Conditions

Female Sexual Dysfunction Spinal Cord Injuries

Interventions

DEVICE

Results Available

NCT04375072 | COMPLETED | NA

208 Participants

Home-based tDCS and Mindfulness-based Meditation for Self-management of Clinical Pain and Symptoms

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2020-08-13

Completion: 2025-01-30

Conditions

Osteo Arthritis Knee

Interventions

DEVICE

Results Available

NCT04353492 | COMPLETED | PHASE3

562 Participants

An Open-label Study Evaluating Ofatumumab Treatment Effectiveness and PROs in Subjects With RMS Transitioning From Fumarate-based RMS Approved Therapies or Fingolimod to Ofatumumab

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2020-07-14

Completion: 2024-10-09

Conditions

Relapsing Multiple Sclerosis

Interventions

BIOLOGICAL

Results Available

NCT04349059 | RECRUITING | NA

46 Participants

The Impact of Dietary Pattern on Erectile Function

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2023-10-30

Completion: 2026-12-31

Conditions

Erectile Dysfunction

Interventions

OTHER

No Results Yet

NCT04325828 | ACTIVE_NOT_RECRUITING | PHASE2

31 Participants

A Study of Apalutamide Combined With GnRH Agonist in Participants With Androgen Receptor Positive Salivary Gland Carcinoma

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2020-04-07

Completion: 2021-06-09

Conditions

Salivary Gland Neoplasms

Interventions

DRUG

Results Available

NCT04305431 | RECRUITING | NA

55 Participants

Dietary Behavior Intervention in African Americans at Risk for Cardiovascular Disease

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2021-02-25

Completion: 2026-12-19

Conditions

Diet Cooking

Interventions

BEHAVIORAL

No Results Yet

NCT04272086 | COMPLETED | PHASE4

140 Participants

Utility of Liposomal Bupivacaine Transversus Abdominal Plane Block for Open Myomectomy

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2020-11-09

Completion: 2025-10-28

Conditions

Fibroid Uterus

Interventions

DRUG

No Results Yet

NCT04240821 | ENROLLING_BY_INVITATION | PHASE2

34 Participants

Theophylline for Treatment of Pseudohypoparathyroidism

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2020-05-22

Completion: 2026-12-31

Conditions

Pseudohypoparathyroidism Pseudohypoparathyroidism Type 1a Albright Hereditary Osteodystrophy

Interventions

DRUG

No Results Yet

NCT04228367 | RECRUITING | NA

104 Participants

JuggerStitch Post Market Clinical Follow-up Study

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2020-09-25

Completion: 2026-03-31

Conditions

Meniscus Tear, Tibial Meniscus Lesion

Interventions

DEVICE

No Results Yet

NCT04221438 | TERMINATED | PHASE2

3 Participants

Testing Treatment With Encorafenib and Binimetinib Before Surgery for Melanoma With Lymph Node Involvement

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2021-09-22

Completion: 2024-06-10

Conditions

Melanoma of Unknown Primary Metastatic Malignant Neoplasm in Lymph Node Pathologic Stage IIIB Cutaneous Melanoma AJCC v8 Pathologic Stage IIIC Cutaneous Melanoma AJCC v8 Pathologic Stage IIID Cutaneous Melanoma AJCC v8 Recurrent Cutaneous Melanoma

Interventions

DRUG PROCEDURE OTHER

Results Available

NCT04216290 | ACTIVE_NOT_RECRUITING | PHASE2

95 Participants

A Study of Chemotherapy and Radiation Therapy Compared to Chemotherapy and Radiation Therapy Plus MEDI4736 (Durvalumab) Immunotherapy for Bladder Cancer Which Has Spread to the Lymph Nodes, INSPIRE Trial

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2021-03-17

Completion: 2026-06-30

Conditions

Bladder Urothelial Carcinoma Stage III Bladder Cancer AJCC v8

Interventions

PROCEDURE DRUG BIOLOGICAL OTHER RADIATION

No Results Yet

NCT04214067 | ACTIVE_NOT_RECRUITING | PHASE3

168 Participants

Testing the Addition of the Immunotherapy Drug, Pembrolizumab, to the Usual Radiation Treatment for Newly Diagnosed Early Stage High Intermediate Risk Endometrial Cancer

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2020-04-09

Completion: 2025-12-30

Conditions

Endometrial Endometrioid Adenocarcinoma Stage I Uterine Corpus Carcinoma or Carcinosarcoma AJCC v8 Stage II Uterine Corpus Carcinoma or Carcinosarcoma AJCC v8

Interventions

PROCEDURE RADIATION BIOLOGICAL OTHER

No Results Yet

NCT04204616 | ACTIVE_NOT_RECRUITING | PHASE3

500 Participants

A Long-term Study of Nemolizumab (CD14152) in Participants With Prurigo Nodularis (PN)

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2021-01-11

Completion: 2026-10-26

Conditions

Prurigo Nodularis

Interventions

DRUG

No Results Yet

NCT04198870 | ACTIVE_NOT_RECRUITING | NA

500 Participants

MitraClip REPAIR MR Study

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2020-07-21

Completion: 2027-12-31

Conditions

Mitral Valve Regurgitation

Interventions

DEVICE PROCEDURE

No Results Yet

NCT04196530 | COMPLETED | PHASE1

40 Participants

BDB001-102: Open Label Dose Escalation of BDB001 in Combination w Atezolizumab

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2019-11-21

Completion: 2024-07-31

Conditions

Tumor, Solid

Interventions

DRUG

No Results Yet

NCT04196374 | COMPLETED | NA

48 Participants

Return of Genomic Results and Aggregate Penetrance in Population-Based Cohorts

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2021-06-09

Completion: 2025-05-30

Conditions

Seemingly Healthy Genetic Predisposition to Disease

Interventions

GENETIC

No Results Yet

NCT04166409 | RECRUITING | PHASE3

170 Participants

A Study of the Drugs Selumetinib vs. Carboplatin and Vincristine in Patients With Low-Grade Glioma

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2020-01-31

Completion: 2030-12-31

Conditions

Low Grade Astrocytoma Low Grade Glioma Metastatic Low Grade Astrocytoma Metastatic Low Grade Glioma WHO Grade 1 Glioma WHO Grade 2 Glioma

Interventions

PROCEDURE DRUG OTHER

No Results Yet

NCT04150614 | RECRUITING | PHASE4

90 Participants

BMT-08: A Comparative Effectiveness Study of Transdermal Granisetron to Ondansetron

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2020-05-14

Completion: 2026-07-31

Conditions

Nausea With Vomiting Chemotherapy-Induced

Interventions

DRUG

No Results Yet

NCT04145141 | RECRUITING

500 Participants

National Translational Science Network of Precision-based Immunotherapy for Primary Liver Cancer

Study Type: OBSERVATIONAL

Last Updated: 2025-11-12

Start Date: 2021-07-28

Completion: 2025-12-31

Conditions

Hepatocellular Carcinoma Liver Cancer Cholangiocarcinoma

No Results Yet

NCT04122976 | ACTIVE_NOT_RECRUITING

805 Participants

A Study in Which Non-metastatic Castration-resistant Prostate Cancer (nmCRPC) Patients for Whom a Decision to Treat With Darolutamide Has Been Made Before Enrollment Are Observed and Certain Outcomes Are Described

Study Type: OBSERVATIONAL

Last Updated: 2025-11-12

Start Date: 2020-01-30

Completion: 2026-07-07

Conditions

Prostate Cancer

Interventions

DRUG

No Results Yet

NCT04122196 | COMPLETED | PHASE2/PHASE3

118 Participants

Perioperative Pregabalin in Ureteroscopy

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2020-06-01

Completion: 2023-07-01

Conditions

Kidney Stone Pain, Postoperative Addiction Opioid Use

Interventions

DRUG

Results Available

NCT04115306 | RECRUITING | PHASE1/PHASE2

61 Participants

Phase 1/1b/2 Study of Oral PMD-026 in Patients With Metastatic Breast Cancer

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2019-11-14

Completion: 2026-09-30

Conditions

Metastatic Breast Cancer

Interventions

DRUG

No Results Yet

NCT04102371 | ACTIVE_NOT_RECRUITING | PHASE3

8800 Participants

Pragmatic Pediatric Trial of Balanced Versus Normal Saline Fluid in Sepsis

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2020-08-25

Completion: 2026-01-31

Conditions

Shock Septic

Interventions

DRUG

No Results Yet

NCT04083976 | ACTIVE_NOT_RECRUITING | PHASE2

316 Participants

A Study of Erdafitinib in Participants With Advanced Solid Tumors and Fibroblast Growth Factor Receptor (FGFR) Gene Alterations

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2019-11-20

Completion: 2023-12-04

Conditions

Advanced Solid Tumor

Interventions

DRUG

Results Available

NCT04074512 | AVAILABLE

Copper Histidinate Treatment for Menkes Disease

Study Type: EXPANDED_ACCESS

Last Updated: 2025-11-12

Conditions

Menkes Disease

Interventions

DRUG

No Results Yet

NCT04064060 | RECRUITING | PHASE3

665 Participants

A Study to Evaluate Long-term Safety in Participants Who Have Participated in Other Luspatercept (ACE-536) Clinical Trials

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2019-08-12

Completion: 2028-05-12

Conditions

Myelodysplastic Syndromes (MDS) Beta-thalassemia Myeloproliferative Neoplasm(MPN)-Associated Myelofibrosis

Interventions

DRUG

No Results Yet

NCT04033445 | ACTIVE_NOT_RECRUITING | PHASE2/PHASE3

1064 Participants

A Study of Guselkumab in Participants With Moderately to Severely Active Ulcerative Colitis

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2019-09-26

Completion: 2023-09-19

Conditions

Ulcerative Colitis

Interventions

DRUG

Results Available

NCT04026386 | RECRUITING | NA

75 Participants

A Center Based Early Intervention Program For Preschoolers With Developmental Disorders

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2019-10-19

Completion: 2034-12-30

Conditions

Development Disorder, Child Developmental Disability Development Delay Autism Spectrum Disorder

Interventions

BEHAVIORAL

No Results Yet