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Clinical Trials

NCT06807424 | RECRUITING | PHASE3
750 Participants

A Study to Evaluate the Efficacy and Safety of Icotrokinra (JNJ-77242113) in Biologic-experienced Participants With Active Psoriatic Arthritis

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2025-01-09
Completion: 2027-02-10
Conditions
Arthritis, Psoriatic
Interventions
DRUG
No Results Yet
NCT06794996 | RECRUITING | PHASE2
45 Participants

Inaxaplin in Participants With Proteinuric APOL1 Mediated Kidney Disease With or Without Comorbidities

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2025-02-04
Completion: 2026-12-30
Conditions
Proteinuric Kidney Disease
Interventions
DRUG
No Results Yet
NCT06792695 | RECRUITING | PHASE2
120 Participants

A Study of Novel Study Interventions and Combinations in Participants With Colorectal Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2025-03-12
Completion: 2027-05-31
Conditions
Metastatic Colorectal Cancer
Interventions
DRUG
No Results Yet
NCT06792552 | RECRUITING | PHASE1
414 Participants

A Phase I Study of SIM0505 in Participants With Advanced Solid Tumors

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2025-02-26
Completion: 2028-02-29
Conditions
Advanced Solid Tumors
Interventions
DRUG
No Results Yet
NCT06790693 | RECRUITING | PHASE3
450 Participants

A Study Evaluating the Efficacy and Safety of Inavolisib Plus CDK4/6 Inhibitor and Letrozole vs Placebo + CDK4/6i and Letrozole in Participants With Endocrine-Sensitive PIK3CA-Mutated, Hormone Receptor-Positive, HER2-Negative Advanced Breast Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2025-04-09
Completion: 2032-05-30
Conditions
Breast Cancer
Interventions
DRUG
No Results Yet
NCT06788990 | RECRUITING | PHASE2/PHASE3
650 Participants

FORTIFI-HN01: A Study of Ficerafusp Alfa (BCA101) or Placebo in Combination With Pembrolizumab in First-Line PD-L1-pos, R or M HNSCC

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2025-01-28
Completion: 2028-04-30
Conditions
Metastatic Head and Neck Squamous Cell Carcinoma Recurrent Head and Neck Squamous Cell Carcinoma
Interventions
DRUG
No Results Yet
NCT06788522 | NOT_YET_RECRUITING | PHASE4
40120 Participants

The Effects of Orexin Antagonism on Fear Extinction in PTSD

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2026-01-01
Completion: 2032-03-01
Conditions
Insomnia PTSD
Interventions
DRUG
No Results Yet
NCT06786572 | RECRUITING | NA
48 Participants

Interoceptive Training Enhanced Mindfulness

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2025-09-10
Completion: 2027-03-31
Conditions
Anxiety Sensitivity
Interventions
OTHER BEHAVIORAL
No Results Yet
NCT06786494 | COMPLETED | NA
20 Participants

Tart Cherry Juice for Sleep in Older Adults With Insomnia: A Pilot Study of Feasibility and Comprehensive Mechanisms

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2025-01-15
Completion: 2025-08-13
Conditions
Sleep Problems Insomnia
Interventions
OTHER
No Results Yet
NCT06785012 | RECRUITING | PHASE2
124 Participants

A Study to Explore the Efficacy of JNJ-89495120 in the Treatment of Major Depressive Disorder

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2024-12-26
Completion: 2026-06-26
Conditions
Depressive Disorder, Major
Interventions
DRUG
No Results Yet
NCT06780111 | RECRUITING | PHASE1/PHASE2
228 Participants

Substudy 06E: Umbrella Study of Combination Therapies in Esophageal Cancer (MK-3475-06E/KEYMAKER-U06)

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2025-07-30
Completion: 2032-01-04
Conditions
Esophageal Squamous Cell Carcinoma
Interventions
BIOLOGICAL DRUG
No Results Yet
NCT06779851 | RECRUITING | PHASE1
100 Participants

A Study to Evaluate Safety and Tolerability of BPT567 in Patients With Advanced Solid Tumors

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2024-10-15
Completion: 2027-12-31
Conditions
Advanced Solid Tumors
Interventions
DRUG
No Results Yet
NCT06777368 | RECRUITING
225 Participants

REdo tranScatheter Aortic Valve Replacement for Transcatheter aOrtic Valve failuRE

Study Type: OBSERVATIONAL
Last Updated: 2025-11-10
Start Date: 2025-02-06
Completion: 2029-03-31
Conditions
Aortic Stenosis
Interventions
DEVICE
No Results Yet
NCT06773962 | RECRUITING | PHASE2
62 Participants

A Phase 2a Multicenter Clinical Trial of TB006 in Participants With Parkinson's Disease

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2025-03-20
Completion: 2025-12-29
Conditions
Parkinson's Disease (PD)
Interventions
DRUG
No Results Yet
NCT06771115 | COMPLETED | PHASE2
176 Participants

Phase 2a Placebo-Controlled Study of VTX3232 Alone or in Combination With Semaglutide in Obesity

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2025-01-07
Completion: 2025-09-10
Conditions
Obesity
Interventions
DRUG
No Results Yet
NCT06767319 | COMPLETED
79 Participants

Prospective, Multi-center, Non-interventional, Open Label, Randomized (Depth of Focus Testing Sequences), Clinical Study

Study Type: OBSERVATIONAL
Last Updated: 2025-11-10
Start Date: 2024-12-18
Completion: 2025-03-11
Conditions
Depth of Focus
Interventions
OTHER
No Results Yet
NCT06756932 | RECRUITING | PHASE1
120 Participants

BGB-21447 (Bcl-2 Inhibitor) Combinations for Adults With Hormone-Receptor Positive (HR+)/Human Epidermal Growth Factor Receptor 2 Negative (HER2-) Metastatic Breast Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2025-02-04
Completion: 2027-07-30
Conditions
Hormone-receptor-positive Breast Cancer HER2-negative Breast Cancer Metastatic Breast Cancer
Interventions
DRUG
No Results Yet
NCT06750094 | RECRUITING | PHASE3
700 Participants

A Study of Amivantamab and FOLFIRI Versus Cetuximab/Bevacizumab and FOLFIRI in Participants With KRAS/NRAS and BRAF Wild-type Colorectal Cancer Who Have Previously Received Chemotherapy

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2024-12-12
Completion: 2027-12-15
Conditions
Colorectal Neoplasms
Interventions
BIOLOGICAL DRUG
No Results Yet
NCT06749496 | COMPLETED | NA
134 Participants

Evaluation of Delefilcon A and Senofilcon A Daily Disposable Toric Soft Contact Lenses Over One Week of Wear

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2025-01-07
Completion: 2025-03-20
Conditions
Astigmatism
Interventions
DEVICE
No Results Yet
NCT06747117 | RECRUITING
300 Participants

A Study of Patients With Lower Extremity Acute Limb Ischemia to Remove Thrombus With the Indigo™ Aspiration System (STRIDE II)

Study Type: OBSERVATIONAL
Last Updated: 2025-11-10
Start Date: 2025-05-18
Completion: 2028-06-30
Conditions
Lower Extremity Acute Limb Ischemia LE ALI
Interventions
DEVICE
No Results Yet
NCT06745024 | RECRUITING | PHASE3
280 Participants

Comparing Radiation Therapy to Usual Care for Patients With High-Risk Bone Asymptomatic Metastases, PREEMPT Trial

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2025-04-14
Completion: 2029-02-01
Conditions
Metastatic Malignant Neoplasm in the Bone Metastatic Malignant Solid Neoplasm
Interventions
OTHER PROCEDURE RADIATION
No Results Yet
NCT06742996 | RECRUITING | PHASE3
300 Participants

A Study to Investigate the Efficacy and Safety of Sonrotoclax Plus Zanubrutinib Compared With Placebo Plus Zanubrutinib in Adults With Relapsed/Refractory Mantle Cell Lymphoma

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2025-03-05
Completion: 2029-03-31
Conditions
Mantle Cell Lymphoma B Cell Lymphoma
Interventions
DRUG
No Results Yet
NCT06742853 | COMPLETED | PHASE1
81 Participants

A Study to Investigate the Pharmacokinetics, Safety, Tolerability, and Efficacy of AZD0780 With Ezetimibe Combinations in Healthy Adults With Elevated LDL-C.

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2024-12-20
Completion: 2025-10-29
Conditions
Dyslipidemia
Interventions
DRUG
No Results Yet
NCT06741969 | RECRUITING | PHASE3
600 Participants

Nipocalimab in Moderate to Severe Sjogren's Disease

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2024-12-04
Completion: 2028-01-01
Conditions
Sjogrens Syndrome
Interventions
DRUG
No Results Yet
NCT06739811 | RECRUITING | NA
40 Participants

Clinical Evaluation of the Medtronic Implantable Insulin Pump System (MIIPS 2020) in Adult Subjects With Type 1 Diabetes (CIP347)

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2025-03-26
Completion: 2026-06-30
Conditions
Type I Diabetes
Interventions
DEVICE
No Results Yet
NCT06736990 | RECRUITING | PHASE2
150 Participants

A Phase 2 Study of CAL101 in Patients With Idiopathic Pulmonary Fibrosis

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2025-06-20
Completion: 2027-08-31
Conditions
Idiopathic Pulmonary Fibrosis
Interventions
DRUG
No Results Yet
NCT06735950 | NOT_YET_RECRUITING | NA
200 Participants

The Volunteering-in-Place Program for Apathetic Assisted Living Residents With ADRD

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2026-01-31
Completion: 2027-12-31
Conditions
Apathy in Dementia
Interventions
BEHAVIORAL
No Results Yet
NCT06735833 | RECRUITING | NA
50 Participants

MMA Embolization for Refractory Chronic Migraine

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2025-04-23
Completion: 2028-12-25
Conditions
Migraine
Interventions
DEVICE
No Results Yet
NCT06733363 | RECRUITING | PHASE2
344 Participants

A Cruciferous Vegetable Eating Program for the Reduction of Cancer Recurrence and Progression in Patients With Non-muscle Invasive Bladder Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2026-01-15
Completion: 2029-02-28
Conditions
Non-Muscle Invasive Bladder Carcinoma Recurrent Bladder Carcinoma Recurrent Non-Muscle Invasive Bladder Carcinoma Stage 0a Bladder Cancer AJCC v8 Stage 1 Bladder Cancer AJCC v8
Interventions
BEHAVIORAL
No Results Yet
NCT06727422 | NOT_YET_RECRUITING | PHASE2
225 Participants

Efficacy of Rifaximin With NAC in IBS-D

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2025-12-15
Completion: 2026-04-01
Conditions
IBS (Irritable Bowel Syndrome) IBS-D (Diarrhea-predominant)
Interventions
DRUG
No Results Yet
NCT06712745 | RECRUITING | EARLY_PHASE1
30 Participants

Feasibility Study of Personalized Ultra-fractionated Stereotactic Ablative Radiotherapy (PULSAR) for Cancers of the Central Lung

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2025-09-19
Completion: 2028-12-31
Conditions
Cancer, Lung Metastasis
Interventions
RADIATION
No Results Yet
NCT06709014 | RECRUITING | PHASE3
760 Participants

A Double-blind Dual Study Assessing Safety and Efficacy of Buntanetap in Participants With Early AD

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2025-02-04
Completion: 2027-12-31
Conditions
Early Alzheimers Disease
Interventions
DRUG
No Results Yet
NCT06702917 | RECRUITING
50 Participants

GSI Cardiac on Revolution Apex - US

Study Type: OBSERVATIONAL
Last Updated: 2025-11-10
Start Date: 2025-09-10
Completion: 2026-03-31
Conditions
Coronary Computed Tomographic Angiography Myocardial Infarction (MI) Cardiac Catheterization
Interventions
DEVICE OTHER
No Results Yet
NCT06701006 | RECRUITING | NA
100 Participants

Integrated Suicide Supports and Safety Planning for Youth

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2025-08-19
Completion: 2026-04-30
Conditions
Suicidal Ideation Suicidal Behavior
Interventions
OTHER
No Results Yet
NCT06693778 | RECRUITING
3000 Participants

Utilizing Electronic Clinical Decision Support to Enhance mTBI Care at the Primary Care Point of Entry

Study Type: OBSERVATIONAL
Last Updated: 2025-11-10
Start Date: 2023-04-01
Completion: 2026-03-31
Conditions
Brain Concussion Mild Traumatic Brain Injury
Interventions
OTHER
No Results Yet
NCT06690996 | ACTIVE_NOT_RECRUITING | PHASE1
118 Participants

A Study of LY4005130 in Healthy Participants

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2024-11-08
Completion: 2026-04-30
Conditions
Healthy
Interventions
DRUG
No Results Yet
NCT06681220 | NOT_YET_RECRUITING | PHASE1/PHASE2
166 Participants

Biomarker Directed Trial of Temozolomide and Stenoparib in Relapsed SCLC

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2025-11-17
Completion: 2029-12-31
Conditions
Relapsed Small Cell Lung Cancer Recurrent Small Cell Lung Cancer
Interventions
COMBINATION_PRODUCT DRUG
No Results Yet
NCT06675136 | RECRUITING | PHASE1
30 Participants

Nab-Paclitaxel PIPAC in Combination With Paclitaxel and Ramucirumab for the Treatment of Stomach Cancer With Peritoneal Metastases

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2025-10-29
Completion: 2029-01-14
Conditions
Clinical Stage IVB Gastric Cancer AJCC v8 Metastatic Gastric Adenocarcinoma Metastatic Malignant Neoplasm in the Peritoneum
Interventions
PROCEDURE OTHER DRUG BIOLOGICAL
No Results Yet
NCT06671613 | RECRUITING | NA
66 Participants

Evaluating a Fasting-mimicking Diet in Combination With Immunotherapy in Patients With Non-small Cell Lung Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2025-10-27
Completion: 2029-12-31
Conditions
Stage IV NSCLC NSCLC Immunotherapy Fasting Mimicking Diet
Interventions
DIETARY_SUPPLEMENT COMBINATION_PRODUCT
No Results Yet
NCT06667908 | RECRUITING | PHASE2
130 Participants

A Study of JNJ-90301900 in Combination With Chemoradiation Followed by Consolidation Immunotherapy for Non-Small Cell Lung Cancer (NSCLC)

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2024-12-06
Completion: 2028-12-31
Conditions
Carcinoma, Non-Small-Cell Lung
Interventions
DRUG BIOLOGICAL RADIATION
No Results Yet
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