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Clinical Trials

NCT06003881 | APPROVED_FOR_MARKETING

Compassionate Use of Pozelimab in Patients With CD55-Deficient Protein-Losing Enteropathy

Study Type: EXPANDED_ACCESS
Last Updated: 2025-11-10
Conditions
CD55-Deficient Protein-Losing Enteropathy
Interventions
DRUG
No Results Yet
NCT06001788 | RECRUITING | PHASE1
171 Participants

Safety and Tolerability of Ziftomenib Combinations in Patients With Relapsed/Refractory Acute Myeloid Leukemia

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2024-02-22
Completion: 2026-08-31
Conditions
AML AML With Mutated NPM1 Hematologic Malignancy KMT2Ar NPM1 Mutation MLL Rearrangement Leukemia Acute Myeloid Leukemia Leukemia, Myeloid Leukemia, Myeloid, Acute Acute Leukemia Neoplasms by Histologic Type
Interventions
DRUG BIOLOGICAL
No Results Yet
NCT05992909 | RECRUITING
20 Participants

Prophylactic Lymphovenous Bypass Procedure Following Inguinal Lymphadenectomy: A Prospective Observational Study

Study Type: OBSERVATIONAL
Last Updated: 2025-11-10
Start Date: 2023-08-02
Completion: 2027-08-01
Conditions
Lymphadenectomy
Interventions
PROCEDURE
No Results Yet
NCT05989815 | COMPLETED | NA
30 Participants

Effect of Whole-body Photobiomodulation on Muscular Performance Enhancement.

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2023-07-10
Completion: 2023-11-10
Conditions
Sports Performance Injury Prevention Muscle Damage Musculoskeletal Pain
Interventions
OTHER DEVICE
Results Available
NCT05988385 | RECRUITING | NA
200 Participants

The Effects of Successful OSA Treatment on Memory and AD Biomarkers in Older Adults Study

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2024-04-22
Completion: 2027-06-30
Conditions
Obstructive Sleep Apnea Cognitive Decline
Interventions
DEVICE
No Results Yet
NCT05987449 | RECRUITING | PHASE1/PHASE2
60 Participants

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of NXT007 in Persons With Severe or Moderate Hemophilia A

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2023-09-21
Completion: 2030-06-16
Conditions
Hemophilia A
Interventions
DRUG
No Results Yet
NCT05987332 | RECRUITING | PHASE2/PHASE3
420 Participants

IDE196 (Darovasertib) in Combination With Crizotinib as First-line Therapy in Metastatic Uveal Melanoma

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2023-10-31
Completion: 2027-01-15
Conditions
Metastatic Uveal Melanoma
Interventions
DRUG
No Results Yet
NCT05986240 | RECRUITING | PHASE1
38 Participants

Danvatirsen Monotherapy Followed by Combination With Venetoclax in Relapsed/Refractory MDS & AML

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2024-05-08
Completion: 2027-06-30
Conditions
AML/MDS Acute Myeloid Leukemia Myelodysplastic Syndromes
Interventions
DRUG COMBINATION_PRODUCT
No Results Yet
NCT05986097 | COMPLETED | PHASE1/PHASE2
119 Participants

The Breakfast Study

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2023-08-02
Completion: 2025-10-09
Conditions
Type 2 Diabetes
Interventions
BEHAVIORAL
No Results Yet
NCT05980949 | RECRUITING | PHASE3
800 Participants

Open-Label Extension Study to Assess the Long-Term Safety and Tolerability of KarXT and KarXT + KarX-EC in Subjects With Psychosis Associated With Alzheimer's Disease (ADEPT-3)

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2023-07-11
Completion: 2027-09-07
Conditions
Psychosis Associated With Alzheimer's Disease
Interventions
DRUG
No Results Yet
NCT05978128 | RECRUITING | NA
800 Participants

Utilizing Advocates and Supporters to Increase Lung Cancer Screening Rates in Eligible Participants

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2023-07-28
Completion: 2028-09-30
Conditions
Breast Carcinoma Lung Carcinoma
Interventions
BEHAVIORAL OTHER
No Results Yet
NCT05972109 | ACTIVE_NOT_RECRUITING | NA
700 Participants

Metabolic Health Improvement Program: Effects of a Workplace Sugary Beverages Sales Ban and Motivational Counseling

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2023-08-01
Completion: 2025-10-01
Conditions
Obesity, Abdominal Insulin Sensitivity
Interventions
OTHER BEHAVIORAL
No Results Yet
NCT05963074 | RECRUITING | PHASE2
320 Participants

A Study to Customize Ibrutinib Treatment Regimens for Participants With Previously Untreated Chronic Lymphocytic Leukemia

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2024-05-30
Completion: 2025-11-15
Conditions
Leukemia, Lymphocytic, Chronic, B-Cell Small Lymphocytic Lymphoma
Interventions
DRUG
No Results Yet
NCT05957276 | ACTIVE_NOT_RECRUITING
892 Participants

Global Patient Registry of Inherited Retinal Diseases

Study Type: OBSERVATIONAL
Last Updated: 2025-11-10
Start Date: 2023-08-31
Completion: 2026-07-03
Conditions
Inherited Retinal Diseases
Interventions
OTHER
No Results Yet
NCT05948566 | RECRUITING | PHASE2
300 Participants

Strategy for Improving Stroke Treatment Response

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2024-03-18
Completion: 2027-07-31
Conditions
Ischemic Stroke
Interventions
BIOLOGICAL
No Results Yet
NCT05947838 | RECRUITING | NA
48 Participants

A Prospective Feasibility Study Using ctDNA to Tailor Neoadjuvant Chemotherapy for Patients With Colorectal or Appendiceal Adenocarcinoma

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2023-12-04
Completion: 2026-04-30
Conditions
Appendiceal Adenocarcinoma Colorectal
Interventions
PROCEDURE
No Results Yet
NCT05946213 | RECRUITING | PHASE3
1209 Participants

Testing Shorter Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With High Risk Prostate Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2023-12-14
Completion: 2036-03-31
Conditions
Prostate Adenocarcinoma Stage III Prostate Cancer AJCC v8 Stage IVA Prostate Cancer AJCC v8
Interventions
PROCEDURE RADIATION OTHER
No Results Yet
NCT05937776 | RECRUITING
20 Participants

Developing a New Metabolic Imaging Approach (aMRI) for Evaluating Neurological Disease in Patients With Gliomas

Study Type: OBSERVATIONAL
Last Updated: 2025-11-10
Start Date: 2023-12-11
Completion: 2025-12-31
Conditions
Glioma
Interventions
OTHER PROCEDURE
No Results Yet
NCT05929937 | RECRUITING | PHASE4
904 Participants

No Opioids vs. Minimal Opioids Following Inguinal Hernia Repair

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2023-07-10
Completion: 2027-06-30
Conditions
Postoperative Pain Inguinal Hernia
Interventions
DRUG OTHER
No Results Yet
NCT05927532 | COMPLETED | NA
40 Participants

Argyle Safety Fistula Cannula With Anti-reflux Valve Clinical Study

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2024-03-10
Completion: 2024-12-15
Conditions
End Stage Renal Failure on Dialysis
Interventions
DEVICE
No Results Yet
NCT05923073 | RECRUITING | PHASE3
120 Participants

A Study of Guselkumab in Pediatric Participants With Moderately to Severely Active Crohn's Disease

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2024-03-13
Completion: 2027-10-27
Conditions
Crohn's Disease
Interventions
DRUG
No Results Yet
NCT05913908 | RECRUITING | NA
15 Participants

EFS of the DUO System for Tricuspid Regurgitation

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2024-08-13
Completion: 2025-12-31
Conditions
Tricuspid Regurgitation Tricuspid Valve Insufficiency Tricuspid Valve Disease Heart Valve Diseases
Interventions
DEVICE
No Results Yet
NCT05912517 | RECRUITING | PHASE3
120 Participants

A Study of Nipocalimab in Pregnancies at Risk for Severe Hemolytic Disease of the Fetus and Newborn (HDFN)

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2023-12-20
Completion: 2027-08-05
Conditions
Hemolytic Disease of the Fetus and Newborn
Interventions
DRUG
No Results Yet
NCT05911997 | RECRUITING | PHASE1
60 Participants

MTC Versus FMT in for RCDI

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2024-01-08
Completion: 2026-07-25
Conditions
Clostridiodies Difficile Infections
Interventions
DRUG
No Results Yet
NCT05908734 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2
71 Participants

A Study of Combination Therapy With Amivantamab and Cetrelimab in Participants With Metastatic Non-small Cell Lung Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2023-05-18
Completion: 2026-01-30
Conditions
Carcinoma, Non-Small-Cell Lung
Interventions
DRUG
No Results Yet
NCT05904080 | RECRUITING | PHASE2
50 Participants

Testing Nivolumab and Ipilimumab Immunotherapy With or Without the Targeted Drug Cabozantinib in Recurrent, Metastatic, or Incurable Nasopharyngeal Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2024-02-19
Completion: 2028-06-16
Conditions
Metastatic Nasopharyngeal Carcinoma Recurrent Nasopharyngeal Carcinoma Stage IV Nasopharyngeal Carcinoma AJCC v8
Interventions
PROCEDURE DRUG BIOLOGICAL
No Results Yet
NCT05902169 | ACTIVE_NOT_RECRUITING | PHASE3
560 Participants

Sonocloud-9 in Association With Carboplatin Versus Standard-of-Care Chemotherapies (CCNU or TMZ) in Recurrent GBM

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2024-01-29
Completion: 2028-01-28
Conditions
Glioblastoma Recurrent Glioblastoma GBM
Interventions
DEVICE DRUG
No Results Yet
NCT05899049 | ACTIVE_NOT_RECRUITING | PHASE3
249 Participants

A Study of Pembrolizumab (MK-3475) in Combination With Belzutifan (MK-6482) and Lenvatinib (MK-7902), or Pembrolizumab/Quavonlimab (MK-1308A) in Combination With Lenvatinib, vs Pembrolizumab and Lenvatinib, for Treatment of Advanced Clear Cell Renal Cell Carcinoma (MK-6482-012)-China Extension Study

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2022-07-27
Completion: 2027-06-07
Conditions
Carcinoma, Renal Cell
Interventions
BIOLOGICAL DRUG
No Results Yet
NCT05898620 | RECRUITING | PHASE3
33 Participants

A Novel, Regulated Gene Therapy (NGN-401) Study for Females With Rett Syndrome

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2023-06-13
Completion: 2029-12-31
Conditions
Rett Syndrome
Interventions
GENETIC
No Results Yet
NCT05896839 | RECRUITING | PHASE1/PHASE2
16 Participants

Immunotherapy in Combination With Prednisone and Sirolimus for Kidney Transplant Recipients With Unresectable or Metastatic Skin Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2024-07-24
Completion: 2027-01-31
Conditions
Clinical Stage III Cutaneous Melanoma AJCC v8 Clinical Stage III Cutaneous Merkel Cell Carcinoma AJCC v8 Clinical Stage IV Cutaneous Melanoma AJCC v8 Clinical Stage IV Cutaneous Merkel Cell Carcinoma AJCC v8 Metastatic Basal Cell Carcinoma Metastatic Carcinoma in the Skin Metastatic Melanoma Metastatic Merkel Cell Carcinoma Metastatic Skin Squamous Cell Carcinoma Unresectable Basal Cell Carcinoma Unresectable Melanoma Unresectable Merkel Cell Carcinoma Unresectable Skin Squamous Cell Carcinoma
Interventions
PROCEDURE BIOLOGICAL DRUG
No Results Yet
NCT05893797 | COMPLETED | NA
36 Participants

A Study of LY8888AX in Participants Using a Connected Insulin Management Platform

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2023-10-05
Completion: 2024-09-16
Conditions
Type 1 Diabetes Type 2 Diabetes Type 2 Diabetes Treated With Insulin
Interventions
DRUG DEVICE
Results Available
NCT05884398 | ACTIVE_NOT_RECRUITING | PHASE3
420 Participants

A Study of an Intermittent ADT Approach With Apalutamide Monotherapy in Participants With mCSPC

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2023-08-31
Completion: 2026-10-12
Conditions
Metastatic Castrate-sensitive Prostate Cancer
Interventions
DRUG
No Results Yet
NCT05877300 | RECRUITING | PHASE1
10 Participants

Safety and Feasibility Study of the CELLSPAN Esophageal Implant (CEI) in Patients Requiring Short Segment Esophageal Replacement

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2023-07-13
Completion: 2026-07-31
Conditions
Esophageal Diseases
Interventions
COMBINATION_PRODUCT
No Results Yet
NCT05876923 | RECRUITING | NA
70 Participants

The Effects of Exercise on Immune Phenotype of Indolent Non-Hodgkin Lymphoma and Chronic Lymphocytic Leukemia Patients

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2023-06-12
Completion: 2028-03-13
Conditions
Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Indolent Non-hodgkin Lymphoma
Interventions
PROCEDURE OTHER
No Results Yet
NCT05868330 | RECRUITING | PHASE4
56 Participants

Comparison of Interscalene Catheter to Single Injection Interscalene Blocks for Total Shoulder Arthroplasties

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2024-08-19
Completion: 2026-10-31
Conditions
Post Operative Pain Anesthesia Nerve Block Shoulder Osteoarthritis
Interventions
PROCEDURE
No Results Yet
NCT05860413 | COMPLETED | NA
57 Participants

Intermittent Fasting for the Treatment of Type 2 Diabetes Mellitus

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2023-01-24
Completion: 2025-05-20
Conditions
Type 2 Diabetes
Interventions
BEHAVIORAL
No Results Yet
NCT05848089 | COMPLETED | NA
41 Participants

Real-time Intervention for Suicide Risk Reduction

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2023-09-25
Completion: 2024-09-16
Conditions
Suicidal Ideation Suicide Attempt
Interventions
BEHAVIORAL
No Results Yet
NCT05843643 | RECRUITING | PHASE3
1000 Participants

Program to Assess Adverse Events and Change in Disease Activity of Oral Upadacitinib in Adult Participants With Moderate to Severe Systemic Lupus Erythematosus

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2023-07-19
Completion: 2026-12-31
Conditions
Systemic Lupus Erythematosus
Interventions
DRUG
No Results Yet
NCT05843253 | RECRUITING | PHASE2
120 Participants

Study of Ribociclib and Everolimus in HGG and DIPG or Ribociclib and Temozolomide in DHG, H3G34-mutant

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2024-08-22
Completion: 2029-08-31
Conditions
High Grade Glioma Diffuse Intrinsic Pontine Glioma Anaplastic Astrocytoma Glioblastoma Glioblastoma Multiforme Diffuse Midline Glioma, H3 K27M-Mutant Metastatic Brain Tumor WHO Grade III Glioma WHO Grade IV Glioma Diffuse Hemispheric Glioma, H3 G34-Mutant
Interventions
DRUG
No Results Yet
NCT05841030 | ACTIVE_NOT_RECRUITING
544 Participants

A Study in Participants With Major Depressive Disorder (MDD) With Anhedonia and Inadequate Response to Current Antidepressant Therapy Including a Selective Serotonin Reuptake Inhibitor (SSRI) or Serotonin Norepinephrine Reuptake Inhibitor (SNRI)

Study Type: OBSERVATIONAL
Last Updated: 2025-11-10
Start Date: 2023-04-28
Completion: 2025-11-21
Conditions
Depressive Disorder, Major
Interventions
OTHER
No Results Yet
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