Clinical Trials

NCT04634552 | RECRUITING | PHASE2
510 Participants

A Study of Talquetamab in Participants With Relapsed or Refractory Multiple Myeloma

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2021-02-01
Completion: 2026-03-31
Conditions
Hematological Malignancies
Interventions
DRUG
No Results Yet
NCT04619420 | ACTIVE_NOT_RECRUITING | PHASE2
523 Participants

A Study of JNJ-63733657 in Participants With Early Alzheimer's Disease

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2021-01-06
Completion: 2026-02-27
Conditions
Alzheimer Disease Cognitive Dysfunction Dementia
Interventions
DRUG
No Results Yet
NCT04609566 | ACTIVE_NOT_RECRUITING | PHASE2
161 Participants

Brentuximab Vedotin With Pembrolizumab in Metastatic Solid Tumors

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2021-01-26
Completion: 2026-12-31
Conditions
Melanoma Non-small Cell Lung Cancer Squamous Cell Carcinoma of the Head and Neck
Interventions
DRUG
No Results Yet
NCT04606381 | ACTIVE_NOT_RECRUITING | PHASE1
158 Participants

A Study of Amivantamab Subcutaneous (SC) Administration for the Treatment of Advanced Solid Malignancies

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2020-11-10
Completion: 2024-07-11
Conditions
Advanced Solid Malignancies
Interventions
DRUG
No Results Yet
NCT04590326 | RECRUITING | PHASE1/PHASE2
612 Participants

A Study to Find Out How Safe REGN5668 is and How Well it Works In Adult Women When Given With Either Cemiplimab, or Cemiplimab + Fianlimab, or Ubamatamab

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2020-12-08
Completion: 2027-03-25
Conditions
Ovarian Cancer Fallopian Tube Cancer Primary Peritoneal Cancer Endometrial Cancer
Interventions
DRUG
No Results Yet
NCT04586426 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2
228 Participants

A Study of the Combination of Talquetamab and Teclistamab in Participants With Relapsed or Refractory Multiple Myeloma

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2020-12-15
Completion: 2025-03-18
Conditions
Multiple Myeloma
Interventions
DRUG
No Results Yet
NCT04585958 | SUSPENDED | PHASE1
55 Participants

Testing the Combination of DS-8201a and Olaparib in HER2-Expressing Cancers With Expansion in Patients With Platinum Resistant Ovarian Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2021-05-21
Completion: 2026-12-31
Conditions
Metastatic Malignant Solid Neoplasm Platinum-Resistant Ovarian High Grade Serous Adenocarcinoma Unresectable Malignant Solid Neoplasm
Interventions
PROCEDURE DRUG BIOLOGICAL
No Results Yet
NCT04585685 | RECRUITING | NA
12 Participants

Healthy Recovery After Trauma Study

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2020-09-10
Completion: 2026-11-30
Conditions
Stress Disorders, Post-Traumatic Shame Guilt Sexual Assault and Rape
Interventions
BEHAVIORAL
No Results Yet
NCT04583891 | COMPLETED | NA
313 Participants

Mobile Apps to Reduce Distress in Breast Cancer Survivors Using an Adaptive Design

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2021-09-27
Completion: 2024-01-16
Conditions
Depression, Anxiety Engagement, Patient
Interventions
BEHAVIORAL
NCT04577833 | ACTIVE_NOT_RECRUITING | PHASE1
136 Participants

A Study of Comparative Formulations of Niraparib and Abiraterone Acetate (AA) in Men With Prostate Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2020-11-13
Completion: 2021-10-15
Conditions
Prostatic Neoplasms
Interventions
DRUG
No Results Yet
NCT04569240 | COMPLETED | NA
40 Participants

Accuracy of the Dexcom G6 Continuous Glucose Monitoring System Following Cardiac Surgery

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2021-05-01
Completion: 2024-01-20
Conditions
Surgery--Complications
Interventions
DEVICE
NCT04560972 | ACTIVE_NOT_RECRUITING | PHASE1
3 Participants

LB-100, Carboplatin, Etoposide, and Atezolizumab for the Treatment of Untreated Extensive-Stage Small Cell Lung Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2021-05-28
Completion: 2026-03-09
Conditions
Extensive Stage Lung Small Cell Carcinoma
Interventions
DRUG
No Results Yet
NCT04557098 | ACTIVE_NOT_RECRUITING | PHASE2
194 Participants

A Study of Teclistamab in Participants With Relapsed or Refractory Multiple Myeloma

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2020-09-17
Completion: 2025-11-30
Conditions
Hematological Malignancies
Interventions
DRUG
No Results Yet
NCT04557059 | ACTIVE_NOT_RECRUITING | PHASE3
694 Participants

A Study of Adding Apalutamide to Radiotherapy and LHRH Agonist in High-Risk Patients With Hormone-Sensitive Prostate Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2020-11-12
Completion: 2029-08-27
Conditions
Prostatic Neoplasms
Interventions
RADIATION DRUG
No Results Yet
NCT04553770 | RECRUITING | PHASE2
88 Participants

Trastuzumab Deruxtecan Alone or in Combination With Anastrozole for the Treatment of Early Stage HER2 Low, Hormone Receptor Positive Breast Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2020-10-09
Completion: 2026-12-31
Conditions
Early-stage Breast Cancer Hormone Receptor Positive Breast Carcinoma Invasive Breast Cancer Stage II Breast Cancer Stage IIA Breast Cancer Stage IIB Breast Cancer Stage III Breast Cancer
Interventions
DRUG PROCEDURE BIOLOGICAL
No Results Yet
NCT04551222 | ACTIVE_NOT_RECRUITING | PHASE2/PHASE3
99 Participants

The Re-Prosper HF Study

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2021-06-09
Completion: 2025-12-31
Conditions
Heart Failure
Interventions
DRUG
No Results Yet
NCT04551092 | TERMINATED | NA
11 Participants

Neurofeedback-EEG-VR System for Non-opioid Pain Therapy

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2021-01-07
Completion: 2022-03-31
Conditions
Pain Management
Interventions
DEVICE
NCT04545866 | ACTIVE_NOT_RECRUITING | PHASE3
642 Participants

The Budesonide in Babies (BiB) Trial

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2021-04-01
Completion: 2024-09-05
Conditions
Bronchopulmonary Dysplasia (BPD) Respiratory Distress Syndrome Prematurity; Extreme Neonatal
Interventions
DRUG
NCT04545424 | RECRUITING | PHASE2
340 Participants

Trial of Therapeutic Hypothermia in Patients With ARDS

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2021-06-29
Completion: 2026-08-31
Conditions
Respiratory Distress Syndrome, Adult
Interventions
DEVICE DRUG
No Results Yet
NCT04513717 | ACTIVE_NOT_RECRUITING | PHASE3
2753 Participants

Two Studies for Patients With High Risk Prostate Cancer Testing Less Intense Treatment for Patients With a Low Gene Risk Score and Testing a More Intense Treatment for Patients With a High Gene Risk Score, The PREDICT-RT Trial

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2021-01-21
Completion: 2033-12-31
Conditions
Prostate Adenocarcinoma Stage III Prostate Cancer AJCC v8 Stage IVA Prostate Cancer AJCC v8
Interventions
DRUG PROCEDURE OTHER RADIATION
No Results Yet
NCT04505267 | ACTIVE_NOT_RECRUITING | PHASE1
34 Participants

NBTXR3 and Radiation Therapy for the Treatment of Inoperable Recurrent Non-small Cell Lung Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2021-02-10
Completion: 2026-03-31
Conditions
Recurrent Lung Non-Small Cell Carcinoma Stage I Lung Cancer AJCC v8 Stage IA1 Lung Cancer AJCC v8 Stage IA2 Lung Cancer AJCC v8 Stage IA3 Lung Cancer AJCC v8 Stage IB Lung Cancer AJCC v8 Stage II Lung Cancer AJCC v8 Stage IIA Lung Cancer AJCC v8 Stage IIB Lung Cancer AJCC v8 Stage III Lung Cancer AJCC v8 Stage IIIA Lung Cancer AJCC v8 Stage IIIB Lung Cancer AJCC v8 Stage IIIC Lung Cancer AJCC v8 Unresectable Lung Non-Small Cell Carcinoma
Interventions
OTHER RADIATION
No Results Yet
NCT04504916 | TERMINATED | PHASE2
102 Participants

A Study of Zilovertamab Vedotin (MK-2140/VLS-101) in Participants With Solid Tumors (MK-2140-002)

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2020-10-07
Completion: 2023-06-12
Conditions
Triple-negative Breast Cancer Non-squamous Non-small-cell Lung Cancer NSCLC Estrogen-receptor-positive Breast Cancer Progesterone-receptor-positive Breast Cancer Estrogen-receptor-negative Breast Cancer ER-negative Breast Cancer Progesterone-receptor Negative Breast Cancer PR-negative Breast Cancer HER2-negative Breast Cancer ER-positive Breast Cancer PR-positive Breast Cancer Platinum-resistant Ovarian Cancer Gastric Cancer Pancreatic Cancer
Interventions
DRUG
NCT04499248 | RECRUITING | PHASE1/PHASE2
96 Participants

AGN-193408 SR in the Treatment of Open-angle Glaucoma or Ocular Hypertension

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2020-11-16
Completion: 2029-02-28
Conditions
Open-angle Glaucoma Ocular Hypertension
Interventions
DRUG OTHER
No Results Yet
NCT04497844 | ACTIVE_NOT_RECRUITING | PHASE3
696 Participants
NCT04485546 | COMPLETED | PHASE4
37 Participants

Study to Evaluate OXERVATEยฎ in Patients With Stage 1 Neurotrophic Keratitis

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2020-09-09
Completion: 2021-09-30
Conditions
Neurotrophic Keratitis
Interventions
DRUG
NCT04484142 | ACTIVE_NOT_RECRUITING | PHASE2
137 Participants

Study of DS-1062a in Advanced or Metastatic Non-small Cell Lung Cancer With Actionable Genomic Alterations (TROPION-Lung05)

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2021-03-30
Completion: 2023-03-10
Conditions
Non-small Cell Lung Cancer
Interventions
DRUG
NCT04479072 | RECRUITING | PHASE4
180 Participants

Aspirin and Preeclampsia

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2021-02-15
Completion: 2026-03-01
Conditions
Preeclampsia Postpartum
Interventions
DRUG
No Results Yet
NCT04472338 | RECRUITING
450 Participants

Prostate Cancer Screening for People at Genetic Risk for Aggressive Disease, PATROL Study

Study Type: OBSERVATIONAL
Last Updated: 2025-11-10
Start Date: 2020-05-21
Completion: 2030-08-31
Conditions
Prostate Carcinoma
Interventions
PROCEDURE OTHER
No Results Yet
NCT04463719 | COMPLETED | NA
107 Participants

AIM2: Adequate Selection of Patients for Thyroid Biopsy: Evaluation of a Shared Decision Making Conversation Aid

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2022-02-20
Completion: 2024-09-30
Conditions
Thyroid Nodules Thyroid Cancer
Interventions
BEHAVIORAL
NCT04434092 | ACTIVE_NOT_RECRUITING | PHASE3
210 Participants

A Study Evaluating the Efficacy and Safety of Crovalimab Versus Eculizumab in Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH) Not Previously Treated With Complement Inhibitors

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2020-10-08
Completion: 2022-11-16
Conditions
Paroxysmal Nocturnal Hemoglobinuria
Interventions
DRUG
NCT04429061 | COMPLETED | NA
2153 Participants

Reaching 90 90 90 in Adolescents in Zambia: Using All Our SKILLZ

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2020-02-01
Completion: 2022-12-31
Conditions
HIV Infections Pregnancy Related STI Mental Health Wellness 1
Interventions
BEHAVIORAL
NCT04381897 | NOT_YET_RECRUITING | PHASE2
10 Participants

Use of N-Acetylcysteine in the Treatment of Repetitive and Self-Injurious Behaviors in Cornelia de Lange Syndrome

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2026-03-01
Completion: 2027-05-01
Conditions
Cornelia de Lange Syndrome
Interventions
DRUG OTHER
No Results Yet
NCT04374877 | COMPLETED | PHASE1
145 Participants

Study of CHS-388 (Formerly Known as SRF388) in Patients With Advanced Solid Tumors

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2020-04-22
Completion: 2025-05-28
Conditions
Advanced Solid Tumor Clear Cell Renal Cell Carcinoma Hepatocellular Carcinoma Non-small Cell Lung Cancer
Interventions
DRUG
No Results Yet
NCT04374786 | TERMINATED | NA
7 Participants

Effects of Mobile App in House Staff Health and Well-being During COVID-19 Pandemic

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2020-05-15
Completion: 2020-07-15
Conditions
Perceived Stress Anxiety Sleep Disturbance Burnout PTSD
Interventions
DEVICE
No Results Yet
NCT04372108 | RECRUITING
1056 Participants

A Study to Assess the Long-Term Safety of Ustekinumab Versus Other Biologics in Patients With Crohn's Disease and Ulcerative Colitis

Study Type: OBSERVATIONAL
Last Updated: 2025-11-10
Start Date: 2021-06-24
Completion: 2029-08-31
Conditions
Crohn Disease Colitis, Ulcerative
Interventions
DRUG
No Results Yet
NCT04371315 | RECRUITING
400 Participants

Risk Factors, Clinical Characteristics and Outcomes of Acute Infection With Coronavirus 2019 (COVID-19) In Children

Study Type: OBSERVATIONAL
Last Updated: 2025-11-10
Start Date: 2020-04-27
Completion: 2025-12-01
Conditions
Corona Virus Infection Pediatric Cancer Adult Children Cancer
No Results Yet
NCT04355832 | WITHDRAWN | EARLY_PHASE1
0 Participants

Glucagon-like Peptide-1 in Type 1 Diabetes

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2020-06-24
Completion: 2025-09-24
Conditions
Type1 Diabetes Mellitus
Interventions
DRUG
No Results Yet
NCT04333537 | RECRUITING | PHASE2/PHASE3
686 Participants

Comparing Sentinel Lymph Node (SLN) Biopsy With Standard Neck Dissection for Patients With Early-Stage Oral Cavity Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2020-09-23
Completion: 2031-04-27
Conditions
Buccal Mucosa Squamous Cell Carcinoma Floor of Mouth Squamous Cell Carcinoma Gingival Squamous Cell Carcinoma Hard Palate Squamous Cell Carcinoma Lip Squamous Cell Carcinoma Lower Alveolar Ridge Squamous Cell Carcinoma Oral Cavity Squamous Cell Carcinoma Retromolar Trigone Squamous Cell Carcinoma Stage I Lip and Oral Cavity Cancer AJCC v8 Stage II Lip and Oral Cavity Cancer AJCC v8 Tongue Squamous Cell Carcinoma Upper Alveolar Ridge Squamous Cell Carcinoma
Interventions
PROCEDURE OTHER DRUG
No Results Yet
NCT04329494 | RECRUITING | PHASE1
49 Participants

PIPAC for the Treatment of Peritoneal Carcinomatosis in Patients With Ovarian, Uterine, Appendiceal, Colorectal, or Gastric Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2020-08-21
Completion: 2028-01-05
Conditions
Clinical Stage IV Gastric Cancer AJCC v8 Clinical Stage IVA Gastric Cancer AJCC v8 Clinical Stage IVB Gastric Cancer AJCC v8 Malignant Uterine Neoplasm Metastatic Appendix Carcinoma Metastatic Colorectal Carcinoma Metastatic Gastric Carcinoma Metastatic Malignant Neoplasm in the Peritoneum Metastatic Malignant Solid Neoplasm Metastatic Ovarian Carcinoma Pathologic Stage IV Gastric Cancer AJCC v8 Peritoneal Carcinomatosis Postneoadjuvant Therapy Stage IV Gastric Cancer AJCC v8 Stage IV Appendix Carcinoma AJCC v8 Stage IV Colorectal Cancer AJCC v8 Stage IV Ovarian Cancer AJCC v8 Stage IV Uterine Corpus Cancer AJCC v8 Stage IVA Appendix Carcinoma AJCC v8 Stage IVA Colorectal Cancer AJCC v8 Stage IVA Ovarian Cancer AJCC v8 Stage IVA Uterine Corpus Cancer AJCC v8 Stage IVB Appendix Carcinoma AJCC v8 Stage IVB Colorectal Cancer AJCC v8 Stage IVB Ovarian Cancer AJCC v8 Stage IVB Uterine Corpus Cancer AJCC v8 Stage IVC Appendix Carcinoma AJCC v8 Stage IVC Colorectal Cancer AJCC v8
Interventions
PROCEDURE DRUG DEVICE OTHER
No Results Yet
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