Diuretic Effect of Aminophylline and Furosemide in Adult Patients Undergoing Cardiac Surgical Procedures

NCT ID: NCT07348510

Last Updated: 2026-01-21

Basic Information

• Recruitment Status: RECRUITING
• Clinical Phase: NA
• Total Enrollment: 106 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2026-01-17
• Study Completion Date: 2026-07-26

Brief Summary

This work aims to investigate the diuretic effect of Aminophylline in comparison to Furosemide in adult patients undergoing cardiac surgical procedures.

Detailed Description

Acute Kidney injury (AKI) is a serious and common complication after either adult or pediatric cardiac surgery.

The results of a recent meta-analysis suggested that loop diuretics (furosemide) may reduce postoperative creatinine clearance, whereas aldosterone agonists (spironolactone) increase the incidence of cardiac surgery-associated acute kidney injury (CSA-AKI). Diuretics are not recommended for the prevention of AKI, but loop diuretics may be used for the management of volume overload Aminophylline in cardiac surgery can reduce the frequency of AKI and could be used in the prevention of AKI as a safe and efficient modality in high-risk patients.

Conditions

Diuretic Effect; Aminophylline; Furosemide; Cardiac Surgical Procedures

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: DOUBLE

Study Groups

Aminophylline group (control group)

Patients will receive Aminophylline.

Group Type: ACTIVE_COMPARATOR

Aminophylline

Intervention Type: DRUG

Patients will receive Aminophylline.

Furosemide group

Patients will receive furosemide.

Group Type: EXPERIMENTAL

Furosemide

Intervention Type: DRUG

Patients will receive furosemide.

Interventions

Aminophylline

Patients will receive Aminophylline.

Intervention Type: DRUG

Furosemide

Patients will receive furosemide.

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

• Age from 18-65 years.
• Both sexes.
• All adult patients presenting for elective cardiac surgical procedures performed on cardiopulmonary bypass (Coronary artery bypass surgery, Cardiac valve repair and/or replacement, Repair of large septal defects, Repair and/or palliation of congenital heart defects, Transplantation, surgery of thoracic aneurysms.).
• Body mass index (BMI) ranged between 20 and 40 kg/m2.

Exclusion Criteria

• Sensitivity or contraindication to Aminophylline or furosemide
• Stage-5 chronic kidney disease (CKD) [Glomerular filtration rate (GFR) of less than 15 mL/min].
• The presence of both factors (GFR less than 60 mL/min and albumin greater than 30 mg per gram of creatinine) along with abnormalities of kidney structure or function for greater than three months signifies chronic kidney disease.
• Recipients of dialysis before surgery.
• Recipients of solid-organ transplantation before surgery.
• Emergency cardiac surgical procedures (e.g. left main coronary artery bypass graft, stuck valves, etc).
• Patient refusal.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 65 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Cairo University

OTHER

Sponsor Role: lead

Responsible Party

Ahmed Mohamed Hassan

Assistant Lecturer of Anesthesia, surgical ICU and Pain management, Cairo University, Cairo, Egypt

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Cairo University

Cairo, , Egypt

Site Status: RECRUITING

Countries

Egypt

Central Contacts

Ahmed M Hassan, MSc

Role: CONTACT

ahm33hassan@gmail.com

00201033752020

Facility Contacts

Ahmed M Hassan, MSc

Role: primary

ahm33hassan@gmail.com

00201033752020

Other Identifiers

MD-258-2024

Identifier Type: -

Identifier Source: org_study_id