Role of Circulating MicroRNAs in Differentiating Psychological Disorders Among Women With Chronic Toxoplasmosis
NCT ID: NCT07346833
Last Updated: 2026-01-16
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
55 participants
OBSERVATIONAL
2025-11-20
2026-04-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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T. gondii Seropositive Group
Women with diagnosed psychiatric disorders (Schizophrenia, MDD, or Bipolar Disorder) who test positive for anti-Toxoplasma IgG antibodies, indicating chronic infection.
Circulating miRNA Expression and T. gondii Serology
Serology: ELISA testing to detect anti-Toxoplasma IgG (confirming chronic infection) and IgM (excluding acute infection).
Genetic Analysis: Quantitative Reverse-transcriptase PCR (qRT-PCR) to measure the expression levels of a predetermined panel of plasma miRNAs.
Psychiatric Evaluation: Clinical diagnosis according to DSM-5 criteria.
T. gondii Seronegative Group
Women with the same diagnosed psychiatric disorders who test negative for anti-Toxoplasma IgG antibodies
Circulating miRNA Expression and T. gondii Serology
Serology: ELISA testing to detect anti-Toxoplasma IgG (confirming chronic infection) and IgM (excluding acute infection).
Genetic Analysis: Quantitative Reverse-transcriptase PCR (qRT-PCR) to measure the expression levels of a predetermined panel of plasma miRNAs.
Psychiatric Evaluation: Clinical diagnosis according to DSM-5 criteria.
Interventions
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Circulating miRNA Expression and T. gondii Serology
Serology: ELISA testing to detect anti-Toxoplasma IgG (confirming chronic infection) and IgM (excluding acute infection).
Genetic Analysis: Quantitative Reverse-transcriptase PCR (qRT-PCR) to measure the expression levels of a predetermined panel of plasma miRNAs.
Psychiatric Evaluation: Clinical diagnosis according to DSM-5 criteria.
Eligibility Criteria
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Inclusion Criteria
* Seronegative for T. gondii IgM (to ensure infection is not in the acute phase).
* Signed informed consent.
Exclusion Criteria
Seropositive for T. gondii IgM (indicating acute infection).
Refusal to participate.
18 Years
50 Years
FEMALE
No
Sponsors
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Benha University
OTHER
Responsible Party
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Heba M. Aboelela
Assistant Professor of Medical Parasitology, Faculty of Medicine, Benha University, Egypt
Principal Investigators
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Basma Salem, MD
Role: PRINCIPAL_INVESTIGATOR
Assistant Professor Clinical and Chemical Pathology. Faculty of Medicine, Benha University, Egypt
Dina Abd El hadi, MD
Role: PRINCIPAL_INVESTIGATOR
Assistant Professor Medical Parasitology. Faculty of Medicine, Benha University, Egypt
Locations
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Benha faculty of Medicine
Banhā, El Qalyoubia, Egypt
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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RC 10.10.2025
Identifier Type: -
Identifier Source: org_study_id
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