Basilar Artery Occlusion Chinese Endovascular Registry in Patients With Large-Core Infarct

NCT ID: NCT07345702

Last Updated: 2026-01-20

Basic Information

• Recruitment Status: NOT_YET_RECRUITING
• Total Enrollment: 518 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2026-01-31
• Study Completion Date: 2026-10-31

Brief Summary

This multicenter retrospective registry study evaluates the safety and effectiveness of endovascular therapy versus medical therapy for acute large-core basilar artery occlusion. It also investigates clinical, imaging, and laboratory factors associated with functional outcomes and mortality. Patients are grouped according to the treatment received in routine clinical practice.

Conditions

Basilar Artery Occlusion; Ischemic Stroke; Large Core Infarct

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: RETROSPECTIVE

Study Groups

Endovascular Therapy

Endovascular Therapy

Intervention Type: PROCEDURE

Endovascular therapy performed as part of routine clinical care for acute basilar artery occlusion, including mechanical thrombectomy with stent retriever and/or aspiration. Rescue angioplasty and/or intracranial stenting may be used at the operator's discretion. Peri-procedural management and concomitant medical therapy follow local standard practice.

Best Medical Treatment Alone

No interventions assigned to this group

Interventions

Endovascular Therapy

Endovascular therapy performed as part of routine clinical care for acute basilar artery occlusion, including mechanical thrombectomy with stent retriever and/or aspiration. Rescue angioplasty and/or intracranial stenting may be used at the operator's discretion. Peri-procedural management and concomitant medical therapy follow local standard practice.

Intervention Type: PROCEDURE

Eligibility Criteria

Inclusion Criteria

1. Age ≥18 years, men or women.

2. Occlusion (TIMI 0-1) of the basilar artery or intracranial segments of both vertebral arteries (V4) as evidenced by CTA/MRA/DSA.

3. Time from symptom onset (or last known well) to treatment (endovascular therapy or medical therapy) ≤7 days.

4. Patients with large core infarction in the posterior circulation, defined as a posterior circulation Acute Stroke Prognosis Early CT score (pc-ASPECTS) score of 0-5 on CT angiography source images or MR with diffusion-weighted imaging or non-contrast CT.

Exclusion Criteria

1. Subjects with occlusions in both anterior and posterior circulation.

2. CT or MR evidence of hemorrhage (the presence of microbleeds on MRI is allowed).

3. Missing key clinical information (e.g., unavailable baseline NIHSS, unclear symptom onset/last known well time, or missing major treatment information including whether EVT was performed).

4. Baseline NIHSS score <6.

5. Woman of childbearing potential who is known to be pregnant or lactating or who has a positive pregnancy test on admission.

6. Missing follow-up outcomes at 90 days.

7. Any other condition judged by investigators to substantially affect analysis or interpretation.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Xuanwu Hospital, Beijing

OTHER

Sponsor Role: lead

Responsible Party

Chuanhui Li

Associate Professor, Xuanwu Hospital, Captimal Medical University

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Xuanwu Hospital

Beijing, Beijing Municipality, China

Countries

China

Central Contacts

Chuanhui Li

Role: CONTACT

lichuanhui@xwh.ccmu.edu.cn

15210439828

Facility Contacts

Chuanhui Li

Role: primary

lichuanhui@xwh.ccmu.edu.cn

15210439828

Other Identifiers

BAOCHE-LC

Identifier Type: -

Identifier Source: org_study_id