Treatment for Psychogenic Nonepileptic Seizures and Post-traumatic Stress Disorder Using Prolonged Exposure Therapy (PE) or Psychoeducation for PNES

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

44 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-11-16

Study Completion Date

2025-05-30

Brief Summary

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An outpatient randomized controlled clinical trial conducted at the Northeast Regional Epilepsy Group's PNES Program, involving mental health clinicians certified in PE and trained in administering PsychoEd.

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Detailed Description

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A randomized parallel group trial was utilized to compare two therapeutic interventions for PNES, PE or PsychoEd, both delivered remotely via teletherapy. Each psychotherapeutic modality provided 12, 90-minute sessions. Seizure frequency was the primary outcome measure. Secondary outcome measures were depression (Beck Depression Inventory) and post-traumatic stress symptomatology (Post-Traumatic Disorder Diagnostic Scale and PTSD Checklist). Data was collected prospectively, including baseline measures before initiating treatment, upon treatment completion, and at follow-up intervals of 3, 6, and 12-months post-treatment.

Conditions

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Psychogenic Nonepileptic Seizures (PNESs) Post Traumatic Stress Disorder PTSD

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Prolonged exposure

Group Type ACTIVE_COMPARATOR

imaginal and in vivo exposure

Intervention Type BEHAVIORAL

Prolonged exposure is a form of cognitive behavioral treatment that uses exposure to avoided memories and reminders

Psychoeducational Intervention for PNES

This psychoeducational treatment was based on a similar intervention reported in 2004

Group Type ACTIVE_COMPARATOR

psychoeducation for psychogenic nonepileptic seizures

Intervention Type BEHAVIORAL

A combination of psychoeducation about PNES and skills for emotional regulation and relaxation.

Interventions

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imaginal and in vivo exposure

Prolonged exposure is a form of cognitive behavioral treatment that uses exposure to avoided memories and reminders

Intervention Type BEHAVIORAL

psychoeducation for psychogenic nonepileptic seizures

A combination of psychoeducation about PNES and skills for emotional regulation and relaxation.

Intervention Type BEHAVIORAL

Other Intervention Names

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PsychoEd for PNES

Eligibility Criteria

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Inclusion Criteria

English-speaking adults (18 years and older) Confirmed diagnosis of PNES through video-EEG monitoring Confirmed diagnosis of current PTSD At least one psychogenic non-epileptic seizure in the month prior to beginning treatment.

Exclusion Criteria

Concurrent mixed epilepsy and PNES or video EEG findings that cannot clearly distinguish epilepsy and PNES Active suicidality Active psychotic symptoms Active substance or alcohol use or dependence that could interfere with participation in therapy Application for disability

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Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No