A Prospective Study of Cardiovascular Risk of Patients Admitted for Acute Exacerbation of COPD

NCT ID: NCT07344285

Last Updated: 2026-01-21

Basic Information

• Recruitment Status: NOT_YET_RECRUITING
• Clinical Phase: NA
• Total Enrollment: 150 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2026-01-15
• Study Completion Date: 2029-02-28

Brief Summary

This is a prospective study to assess the burden of existing or hidden cardiovascular (CV) and renal disease in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) in a Hong Kong public hospital setting. By implementing a chronic obstructive pulmonary disease (COPD) discharge care bundle with integrated CV/renal screening, the study aims to quantify undiscovered disease prevalence, evaluate risk factors for future exacerbations, and compare re-admission rates against historical controls, ultimately informing integrated cardiopulmonary management strategies.

Detailed Description

Chronic obstructive pulmonary disease (COPD) is a major global health concern, characterized by persistent respiratory symptoms and airflow limitation, and it frequently coexists with cardiovascular disease (CVD), which significantly contributes to morbidity and mortality in this population.

This is a prospective study to assess the burden of existing or hidden cardiovascular (CV) and renal disease in patients with acute exacerbation of COPD (AECOPD) in a Hong Kong public hospital setting. By implementing a COPD discharge care bundle with integrated CV/renal screening, the study aims to quantify undiscovered disease prevalence, evaluate risk factors for future exacerbations, and compare re-admission rates against historical controls, ultimately informing integrated cardiopulmonary management strategies.

The objectives and hypotheses are as follows:

Objectives and Hypotheses Primary Objective To describe the prevalence of undiscovered cardiovascular and renal disease burden among patients hospitalized for AECOPD in a Hong Kong public clinical setting.

• Hypothesis: A significant proportion of AECOPD patients will have previously undiagnosed CV or renal diseases identified through proactive screening, highlighting the need for routine assessments.

Secondary Objectives

1. To describe the pattern of AECOPD risk factors among COPD patients.

2. To describe the hospital re-admission rate after care optimization. • Hypotheses: Patients with identified CV diseases will exhibit higher-risk profiles (e.g., elevated BMI, severe symptoms, frequent prior exacerbations), and the implementation of the care bundle will reduce re-admission rates compared to historical standard care.

Exploratory Objectives

1. To describe the hospital re-admission rate after care optimization according to the cause of hospitalization (e.g., COPD exacerbation vs. CV/renal-related causes).

2. To describe the change in COPD treatment before and after care optimization. • Hypotheses: Re-admissions will be lower for CV/renal causes post-optimization, and a notable percentage of patients will require medication adjustments, such as escalation of inhaler or cardio-kidney-metabolic medications.

The COPD discharge care bundle includes:

1. COPD treatment optimization (per Global Obstructive Lung Disease [GOLD] 14 recommendations).

2. CV and renal disease check-up (NT-proBNP, Hba1c, troponin, eGFR, uACR, blood pressure and ECG).

3. Early follow-up at weeks 4-8.

4. Inhaler technique review and education. Patients with newly screened/diagnosed CV or renal diseases will be managed per routine clinical practice according to the relevant international guidelines, with referrals to cardiologists as needed.

Conditions

COPD

Study Design

• Allocation Method: NON_RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Implementation of the COPD discharge care bundle

Prospective recruitment with implementation of the COPD discharge care bundle

Group Type: EXPERIMENTAL

Intervention Group

Intervention Type: PROCEDURE

Implementation of a COPD discharge care bundle for multidisciplinary support, providing optimal care for patients following acute exacerbations during hospital discharge.

Historic controls

Historical records of prior acute exacerbation of COPD episodes and management under standard care from the database

Group Type: OTHER

Usual Care

Intervention Type: PROCEDURE

Patient undergoing usual care from historic controls

Interventions

Intervention Group

Implementation of a COPD discharge care bundle for multidisciplinary support, providing optimal care for patients following acute exacerbations during hospital discharge.

Intervention Type: PROCEDURE

Usual Care

Patient undergoing usual care from historic controls

Intervention Type: PROCEDURE

Eligibility Criteria

Inclusion Criteria

• Age ≥40 years
• Patients hospitalized due to COPD exacerbation.
• Patients diagnosed with COPD, a confirmed COPD diagnosis with a specific FEV1/FVC ratio (<0.70)
• Able to provide informed consent

Exclusion Criteria

• Pregnant subjects
• Inability to give informed consent
• Cancer patient who are on active chemotherapy or on palliative care

• Minimum Eligible Age: 40 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Chinese University of Hong Kong

OTHER

Sponsor Role: lead

Responsible Party

Fanny W.S. Ko

Honorary clinical professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

David SC Hui, MD

Role: STUDY_DIRECTOR

Chinese University of Hong Kong

Central Contacts

Fanny WS Ko, MD

Role: CONTACT

fannyko@cuhk.edu.hk

85235053133

David SC Hui, MD

Role: CONTACT

dschui@cuhk.edu.hk

85235053128

Other Identifiers

CUHK_Resp_2026_Ko_01

Identifier Type: -

Identifier Source: org_study_id