Impact of a Multicomponent Exercise Program on Cognitive and Functional Outcomes in Patients With Mild Cognitive Impairment

NCT ID: NCT07334392

Last Updated: 2026-01-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

45 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-12-01

Study Completion Date

2026-11-30

Brief Summary

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The goal of this randomised clinical trial is to investigate the effectiveness of an innovative therapeutic exercise program emphasizing in dual-task exercises in people with amnestic Mild Cognitive Impairment. The main questions it aims to answer are:

Does the innovative therapeutic exercise program improve gait and balance? Does the innovative therapeutic exercise program improve cognition?

Researchers will compare the innovative therapeutic exercise program emphasizing in dual-task exercises to a therapeutic exercise program without emphasizing in dual-task exercises and to a control group (given instruction about the benefits of exercise).

Participants will:

* Perform the exercise program twice a week for three months.
* Will be assessed before and after the intervention.
* Will record The Borg Scale of Perceived Exertion every second week to monitor and assess the progression of exercise intensity.

Detailed Description

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Conditions

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Mild Cognitive Impairment Walking Balance Cognition

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Randomized Control Trial with Two Experimental Groups and one Control Group
Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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Innovative therapeutic exercise program emphasizing in dual tasking

Participants will perform aerobic exercises, strengthening exercises and balance exercises combined with cognitive exercises at the same time for 60- 90 minutes/ twice a week/ three months.

Group Type EXPERIMENTAL

Innovative therapeutic exercise program

Intervention Type OTHER

Aerobic, strengthening and balance exercises combined with cognitive training -name: Experimental group 1 (EXP1)

Therapeutic exercise program

Participants will perform aerobic exercises, strengthening exercises and balance exercises for 60- 90 minutes/ twice a week/ three months.

Group Type ACTIVE_COMPARATOR

Therapeutic exercise program

Intervention Type OTHER

Aerobic, strengthening and balance exercises without cognitive training- name: Experimental group 2 (EXP2)

Control group

The control group will be provided with educational material in the form of a flyer outlining the health benefits of exercise and general lifestyle recommendations.

Group Type ACTIVE_COMPARATOR

Flyer

Intervention Type OTHER

The control group will receive only educational material in the form of a flyer, outlining the importance and potential benefits of physical activity, along with general lifestyle recommendations, without participating in the structured exercise intervention- name: Control group (CG)

Interventions

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Innovative therapeutic exercise program

Aerobic, strengthening and balance exercises combined with cognitive training -name: Experimental group 1 (EXP1)

Intervention Type OTHER

Therapeutic exercise program

Aerobic, strengthening and balance exercises without cognitive training- name: Experimental group 2 (EXP2)

Intervention Type OTHER

Flyer

The control group will receive only educational material in the form of a flyer, outlining the importance and potential benefits of physical activity, along with general lifestyle recommendations, without participating in the structured exercise intervention- name: Control group (CG)

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* individuals \> 50 years old
* people with confirmed cognitive impairment, as evidenced by values within normal limits on the Montreal Cognitive Assessment test (MOCA ) \>20
* stable medication in the last month
* independent walking

Exclusion Criteria

* people with dementia
* people suffering from chronic mental illness (e.g. schizophrenia, bipolar disorder)
* people suffering from a neurological disorder or injuries (e.g. multiple sclerosis, Parkinson's, traumatic brain injury)
* people with clinical depression (as determined by the Neuropsychiatric Inventory (NPI) assessment and medical diagnosis)
* people who have had recent surgery
* people with insufficient knowledge of the Greek language
Minimum Eligible Age

50 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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General University Hospital of Patras

OTHER

Sponsor Role collaborator

Andreas Mentzelopoulos Foundation

UNKNOWN

Sponsor Role collaborator

University of Patras

OTHER

Sponsor Role lead

Responsible Party

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Eftychia Nastou

PhD candidate

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Department of Physiotherapy, University of Patras

Pátrai, , Greece

Site Status RECRUITING

Countries

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Greece

Central Contacts

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Eftychia A Nastou

Role: CONTACT

+30 6948694966

Sofia Lampropoulou

Role: CONTACT

Facility Contacts

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Sofia Lampropoulou

Role: primary

Evdokia Biliis

Role: backup

Other Identifiers

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17335/01-06-2025

Identifier Type: -

Identifier Source: org_study_id

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