Dexamethasone, Dexmedetomidine and Their Combination on Post op. GIT Function Measured by I-FFED Score Post Laparoscopic Cholecystectomy
NCT ID: NCT07329933
Last Updated: 2026-01-09
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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NOT_YET_RECRUITING
NA
160 participants
INTERVENTIONAL
2025-12-15
2026-06-01
Brief Summary
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What medical problems do participants have when taking Dexamethasone and Dexmedetomidine? Researchers will compare Dexamethasone and Dexmedetomidine and Their Combination to a placebo (a look-alike substance that contains no drug) to see the effect on Post op. GIT Function Measured by I-FFED Score Post Laparoscopic Cholecystectomy Participants will receive Dexamethasone 8 mg IV + Saline IV (total volume 10 ml) over 10 minutes administered after induction of anesthesia.
Participants will receive Dexmedetomidine 0.5 mcg /kg IV + Saline IV (total volume 10 ml) over 10 minutes administered after induction of anesthesia.
Participants will receive Dexamethasone 8 mg IV + Dexmedetomidine 0.5 mcg/kg IV+ Saline IV (total volume 10 ml) over 10 minutes administered after induction of anesthesia.
Participants will receive Saline IV (total volume 10 ml) over 10 minutes administered after induction of anesthesia
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
SUPPORTIVE_CARE
QUADRUPLE
Study Groups
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Group D (Dexamethasone)
Dexamethasone
Participants will receive Dexamethasone 8 mg IV + Saline IV (total volume 10 ml) over 10 minutes administered after induction of anesthesia.
Group X (Dexmedetomidine)
Dexmedetomidine
Participants will receive Dexmedetomidine 0.5 mcg /kg IV + Saline IV (total volume 10 ml) over 10 minutes administered after induction of anesthesia.
Group DX (Combination)
Dexamethasone and dexmedetomidine
Participants will receive Dexamethasone 8 mg IV + Dexmedetomidine 0.5 mcg/kg IV+ Saline IV (total volume 10 ml) over 10 minutes administered after induction of anesthesia
Group P (Placebo)
Placebo
Participants will receive Saline IV (total volume 10 ml) over 10 minutes administered after induction of anesthesia
Interventions
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Dexamethasone and dexmedetomidine
Participants will receive Dexamethasone 8 mg IV + Dexmedetomidine 0.5 mcg/kg IV+ Saline IV (total volume 10 ml) over 10 minutes administered after induction of anesthesia
Placebo
Participants will receive Saline IV (total volume 10 ml) over 10 minutes administered after induction of anesthesia
Dexamethasone
Participants will receive Dexamethasone 8 mg IV + Saline IV (total volume 10 ml) over 10 minutes administered after induction of anesthesia.
Dexmedetomidine
Participants will receive Dexmedetomidine 0.5 mcg /kg IV + Saline IV (total volume 10 ml) over 10 minutes administered after induction of anesthesia.
Eligibility Criteria
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Inclusion Criteria
4\. Ability to provide written informed consent
Exclusion Criteria
2\. Pre-existing gastrointestinal motility disorders (e.g., gastroparesis, inflammatory bowel disease).
3\. Chronic use of opioids, steroids, or antiemetics. 4. History of severe cardiac disease (e.g., high-grade AV block, severe bradycardia).
5\. Uncontrolled diabetes mellitus (HbA1c \> 8.0%). 6. Emergency surgery or conversion to open surgery. 7. Pregnancy or breastfeeding. 8. Morbid obesity (BMI \>40). 9. Severe hepatic or renal dysfunction.
18 Years
65 Years
ALL
No
Sponsors
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Benha University
OTHER
Responsible Party
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Taghreed Elshahat Sakr
lecturer of anesthesia and icu
Locations
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Benha University Hospital
Banhā, , Egypt
Countries
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Facility Contacts
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Other Identifiers
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RC.3.11.2025
Identifier Type: -
Identifier Source: org_study_id
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