Critical Illness After Hematopoietic Cell Transplantation

NCT ID: NCT07328724

Last Updated: 2026-01-09

Basic Information

• Recruitment Status: NOT_YET_RECRUITING
• Total Enrollment: 4000 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2026-01-01
• Study Completion Date: 2036-12-31

Brief Summary

This is a prospective, multicenter observational trial for patients who develop critical illness after hematopoietic cell transplantation. Patients who are admitted to the intensive care unit after undergoing hematopoietic cell transplantation at the participating medical centers will be enrolled in this study. The clinical characteristics, laboratory profiles, managements, and clinical outcomes will be prospectively collected.

Conditions

Critical Illness; Ventilated Patients; Hematopoetic Stem Cell Transplantation; Transplant Complication

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Study Groups

Critically ill patients after hematopoietic cell transplantation

Patients who are admitted to the intensive care unit after undergoing hematopoietic cell transplantation

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• Patients who underwent hematopoietic cell transplantation at any of the participating medical centers.
• Patients who are admitted to ICU for the management of critical illness following hematopoietic cell transplantation.

Exclusion Criteria

• Admitted to ICU for a reason other than critical illness (e.g., routine postoperative monitoring) and discharged within 2 days of ICU admission.
• Unavailable in-ICU clinical outcomes or absent key baseline characteristics.
• Any other conditions that, in the opinion of the investigator, can interfere with the interpretation of data.

• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Hematology Hospital of Chinese Academy of Medical Sciences (Hematology Research Center of Chinese Academy of Medical Sciences)

UNKNOWN

Sponsor Role: collaborator

Xinqiao hospital of the third military medical university

UNKNOWN

Sponsor Role: collaborator

First Affiliated Hospital of Zhejiang University

OTHER

Sponsor Role: collaborator

First Affiliated Hospital of Harbin Medical University

OTHER

Sponsor Role: collaborator

Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

OTHER

Sponsor Role: collaborator

Peking University People's Hospital

OTHER

Sponsor Role: lead

Responsible Party

Xiao Hui Zhang

MD

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Peking University People's Hospital

Beijing, , China

Xinqiao hospital of the third military medical university

Chongqing, , China

First Affiliated Hospital of Zhejiang University

Hangzhou, , China

First Affiliated Hospital of Harbin Medical University

Harbin, , China

Hematology Hospital of Chinese Academy of Medical Sciences

Tianjin, , China

Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

Wuhan, , China

Countries

China

Central Contacts

Xiao Hui Zhang, MD

Role: CONTACT

zhangxh@bjmu.edu.cn

861088324577

Peng Zhao, MD

Role: CONTACT

ZhaoP@pku.edu.cn

861088324577

Facility Contacts

Zhi Xue Li, MD

Role: primary

lzx2010301121@stu.pku.edu.cn

861088324577

Xi Zhang, MD

Role: primary

zhangxxi@sina.com

861088324577

Yi Luo, MD

Role: primary

luoyijr@zju.edu.cn

861088324577

Sheng Jing Fan, MD

Role: primary

fansjhmu@163.com

861088324577

Er Lie Jiang

Role: primary

jiangerlie@ihcams.ac.cn

861088324577

Ling Hui Xia, MD

Role: primary

linghuixia@hust.edu.cn

861088324577

Other Identifiers

2025-z259

Identifier Type: -

Identifier Source: org_study_id