Biomarker Study for Prediction of aGVHD

NCT ID: NCT03614143

Last Updated: 2018-08-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

250 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-12-31

Study Completion Date

2020-07-31

Brief Summary

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This is a prospective study in patients receiving allogeneic stem cell transplantation. The blood samples on Day-14, -7, 0 and every 7 days until D100 were collected together with clinical data. In the final analysis, cytokines and biomarkers analysis will be carried out and compared between patients in No aGVHD and grade II-IV aGVHD.

Detailed Description

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This is a prospective study, observation study in patients receiving allogeneic stem cell transplantation in 4 BMT centers in Shanghai. The blood samples (on Day-14, -7, 0 and every 7 days until D100) and clinical data will be collected. In the final analysis, a panel of cytokines and biomarkers analysis of serial blood samples will be carried out and compared between patients with no aGVHD and grade II-IV aGVHD.

Conditions

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aGVHD

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* all patients undergoing allogeneic stem cel transplantation
* with informed consent
* patients survived without aGVHD or relapse and patients with development of grade II-IV aGVHD

Exclusion Criteria

* patients with blood sample and clinical data not available
Minimum Eligible Age

16 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Shanghai Jiao Tong University School of Medicine

OTHER

Sponsor Role lead

Responsible Party

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Jiong HU

Deputy director, department of hematology, Rui Jin Hospital

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Jiong HU, M.D.

Role: PRINCIPAL_INVESTIGATOR

Ruijin Hospital

Locations

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Blood & Marrow Transplantation Center, RuiJin Hospital

Shanghai, Shanghai Municipality, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Jiong HU, M.D.

Role: CONTACT

86-21-64370045 ext. 601818

Facility Contacts

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Jiong HU, M.D.,

Role: primary

86-21-64370045

Ling Wang, M.D.,

Role: backup

86-21-64370045

Other Identifiers

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SHTG-001

Identifier Type: -

Identifier Source: org_study_id

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