Effect of TCC Cocktail Combined With TACE Versus TACE Alone on Survival in uHCC Patients

NCT ID: NCT07321613

Last Updated: 2026-01-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

545 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-05-01

Study Completion Date

2025-06-01

Brief Summary

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This is a multicenter, retrospective cohort study that aims to evaluate the efficacy and safety of a triple-drug cocktail (TCC), consisting of Thalidomide, Carmofur, and Compound Mylabris Capsules (CMC), in combination with conventional Transarterial Chemoembolization (TACE) for the treatment of patients with unresectable Hepatocellular Carcinoma (HCC).

Detailed Description

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Conditions

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Hepatocellular Cancer (HCC)

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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TACE+cocktail

Patients in the TACE+cocktail group received TACE and took the combined oral medications daily, which consisted of thalidomide tablets, carmofur tablets , and compound mylabris capsule.

Thalidomide (50mg)

Intervention Type DRUG

Thalidomide tablets (Changzhou Pharmaceutical Factory, 50 mg qn)

carmofur

Intervention Type DRUG

carmofur tablets (Qilu Pharmaceutical, 100 mg, tid)

compound mylabris capsule

Intervention Type DRUG

CMC (Guizhou Yibai Pharmaceutical Co., Ltd, 750 mg, bid)

TACE

Intervention Type PROCEDURE

received initial treatment with traditional TACE by well-trained and experienced physicians

TACE only

Patients in the TACE only group received only TACE treatment.

TACE

Intervention Type PROCEDURE

received initial treatment with traditional TACE by well-trained and experienced physicians

Interventions

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Thalidomide (50mg)

Thalidomide tablets (Changzhou Pharmaceutical Factory, 50 mg qn)

Intervention Type DRUG

carmofur

carmofur tablets (Qilu Pharmaceutical, 100 mg, tid)

Intervention Type DRUG

compound mylabris capsule

CMC (Guizhou Yibai Pharmaceutical Co., Ltd, 750 mg, bid)

Intervention Type DRUG

TACE

received initial treatment with traditional TACE by well-trained and experienced physicians

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* patients who met the HCC diagnostic criteria according to the Guidelines for Diagnosis and Treatment of Primary Liver Cancer in China.
* patients underwent conventional TACE.
* availability of complete medical records for data extraction and follow-up.

Exclusion Criteria

* a history of previous or synchronous treatment for tumors such as radio frequency ablation (RFA) or systemic chemotherapy.
* poor liver functions (Child-Pugh class C).
* accompanying other life-threatening diseases.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Shanghai Zhongshan Hospital

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Zhongshan Hospital, Fudan University

Shanghai, , China

Site Status

Countries

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China

Other Identifiers

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20251111101713560

Identifier Type: -

Identifier Source: org_study_id

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