Ultra-early Chest CT for SAP Prediction

NCT ID: NCT07321275

Last Updated: 2026-02-05

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

1000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2026-01-15

Study Completion Date

2026-03-15

Brief Summary

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Stroke-associated pneumonia (SAP) is a common and serious complication after acute ischaemic stroke (AIS). Existing scores rely mainly on clinical variables, and the added prognostic value of inflammatory markers and early chest CT findings remains uncertain. We developed and externally validated an early multimodal model combining clinical severity, inflammation, and chest CT abnormalities, and explored risk-stratified associations between prophylactic antibiotics and SAP.

Detailed Description

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Conditions

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Acute Ischaemic Stroke Stroke-associated Pneumonia

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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Development (Derivation) cohort

No interventions assigned to this group

External validation cohort

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

1. patients aged ≥18 years;
2. Admitted to a participating stroke centre with neuroimaging-confirmed acute ischaemic stroke ;
3. Had chest CT performed within 24 hours of stroke onset.

Exclusion Criteria

1. Pneumonia;
2. Chest CT images unavailable or incomplete for assessment;
3. Insufficient clinical documentation to ascertain stroke-associated pneumonia occurrence within 7 days after stroke onset
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Capital Medical University

OTHER

Sponsor Role lead

Responsible Party

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Ji Xunming,MD,PhD

Professor of Neurology, Xuanwu Hospital, Capital Medical University

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Suzhou Municipal Hospital of Anhui Province

Suzhou, Anhui, China

Site Status RECRUITING

Rongcheng County People's Hospital

Baoding, Hebei, China

Site Status RECRUITING

Ningjin County People's Hospital

Fenghuang, Hebei, China

Site Status RECRUITING

The Second Hospital of Hebei Medical University,

Shijiazhuang, Hebei, China

Site Status RECRUITING

Central Hospital of Xiangtan

Xiangtan, Hunan, China

Site Status RECRUITING

First Affiliated Hospital of Soochow University

Suzhou, Jiangsu, China

Site Status RECRUITING

Shihezi People's Hospital,

Shihezi, Xinjiang, China

Site Status RECRUITING

Xuanwu Hospita

Beijing, , China

Site Status RECRUITING

Countries

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China

Central Contacts

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Xunming Ji, PhD/MD

Role: CONTACT

01083198962

Chuanjie Wu, MD

Role: CONTACT

01083199439

Facility Contacts

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Zhengfei Ma

Role: primary

18905572919

Mengge Zhang

Role: primary

Fei Gu

Role: primary

Xue Fang

Role: primary

Naren Ya

Role: primary

Chuanjie Wu, MD

Role: primary

01083199439

Xunming Ji, PhD/MD

Role: backup

01083198962

Other Identifiers

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SENTRY

Identifier Type: -

Identifier Source: org_study_id

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