TRIM25 in Septic Patients

NCT ID: NCT07320638

Last Updated: 2026-01-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ENROLLING_BY_INVITATION

Total Enrollment

65 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-12-10

Study Completion Date

2026-07-01

Brief Summary

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Sepsis is a life-threatening condition caused by the body's overwhelming response to infection, which can lead to organ damage and failure. The goal of this observational study is to better understand the underlying biological changes that occur in patients with sepsis compared to those who do not have the condition.

We will collect peripheral blood samples from patients diagnosed with sepsis and from non-sepsis control participants. From these samples, we will isolate peripheral blood mononuclear cells (PBMCs) and serum.

We will then analyze these components to measure the activity of specific genes and the levels of key inflammatory factors (cytokines).

The information we gather will help researchers identify molecular and inflammatory markers associated with sepsis. This knowledge is crucial for developing new and more effective methods for diagnosing and treating this critical illness.

Detailed Description

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Conditions

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Sepsis

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Non-sepsis patients

Sepsis patients

Gene and Inflammatory Marker Analysis in Sepsis

Intervention Type DIAGNOSTIC_TEST

1.Sepsis Group:

1. SOFA score \>=2;
2. Aged 18-70 years male and female;
3. Hospitalization. 2.Non-sepsis Group:

(1) Healthy adults; (2) Aged 18-70 years male and female.

Interventions

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Gene and Inflammatory Marker Analysis in Sepsis

1.Sepsis Group:

1. SOFA score \>=2;
2. Aged 18-70 years male and female;
3. Hospitalization. 2.Non-sepsis Group:

(1) Healthy adults; (2) Aged 18-70 years male and female.

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* 1\. SOFA score \>=2; 2. Aged 18-70 years male and female; 3. Hospitalization.

Exclusion Criteria

* 1\. Immune system disease, such as HIV; 2. Disease that possibly affect the function of immune system, such as tumor and chronic viral infection; 3. Patients that treated with massive cortical hormone (\>200mg/d) or immunosuppressant; 4. Pregnant or lactation women.
Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Ruijin Hospital

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Shanghai JiaoTong University School of Medicine

Shanghai, , China

Site Status

Countries

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China

Other Identifiers

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81900073

Identifier Type: OTHER_GRANT

Identifier Source: secondary_id

Sepsis-2021-278

Identifier Type: -

Identifier Source: org_study_id

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