The Effect of a Continuous 1-Hour Time Delay on Circadian Rhythms

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-12-20

Study Completion Date

2027-08-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The purpose of this study is to investigate whether the experience of a daily time delay can affect our internal circadian rhythm.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Circadian Rhythms and Time Perception in Healthy Adults During Constant Wakefulness

NCT07294781

Sleep Deprivation Circadian Rhythm Healthy Volunteers +1 more

RECRUITING NA

Experimental Manipulation of Sleep and Circadian Rhythms and the Role Played on Reward Function in Teens

NCT04792697

Delayed Sleep Phase Syndrome

RECRUITING NA

Pathophysiology of Circadian Rhythm Delayed Sleep Wake Phase Disorder

NCT06471374

Delayed Sleep Phase Syndrome Delayed Sleep Phase

RECRUITING NA

Effects of Morningness on Night Split Shift Performance

NCT06440434

Shift-work Disorder

ACTIVE_NOT_RECRUITING NA

Biomarkers for Circadian Timing in Healthy Adults

NCT03956745

Sleep Wake Disorders Sleep Disorders, Circadian Rhythm Sleep Disorders, Intrinsic +10 more

TERMINATED

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Circadian Rhythms Time Perception Sleep

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

SINGLE_GROUP

Participating couples will need to live in this environment for 5 consecutive days. By lottery draw, you as a couple will either be exposed to a fixed daily routine, where all activities occur at the same time every day, or a daily time delay of 1 hour, where all activities will be delayed by one hour.

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Open-label, single-group basic science study; no masking used.

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Fixed daily routine

All activities occur at the same time every day. During the five days, participants will have to complete various daily tests and also be asked to provide 8 saliva samples during days 1, 3, and 5

Group Type EXPERIMENTAL

Fixed daily routine

Intervention Type BEHAVIORAL

All activities occur at the same time every day

Daily time delay of 1 hour

All activities will be delayed by one hour. During the five days, participants will have to complete various daily tests and also be asked to provide 8 saliva samples during days 1, 3, and 5

Group Type EXPERIMENTAL

Daily time delay

Intervention Type BEHAVIORAL

All activities will be delayed by one hour per day over a 5 day period.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Fixed daily routine

All activities occur at the same time every day

Intervention Type BEHAVIORAL

Daily time delay

All activities will be delayed by one hour per day over a 5 day period.

Intervention Type BEHAVIORAL

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Healthy adults aged 23-45 years
* Part of a heterosexual, cohabiting couple willing to participate together in a five-day in-laboratory study
* Completion of at least upper-secondary education
* Maintain a regular sleep-wake schedule
* Habitual sleep timing within a normative range (non-extreme chronotype), assessed using the Morningness-Eveningness Questionnaire (MEQ) or the Munich Chronotype Questionnaire (MCTQ)
* Both partners fall within the acceptable chronotype range to ensure aligned sleep-wake patterns
* Low seasonality scores on the Seasonal Pattern Assessment Questionnaire (SPAQ)
* Free from underlying sleep or mood disorders

Exclusion Criteria

* Engages in night-shift work or maintains an irregular work or sleep schedule
* International travel involving a time-zone change of more than two hours within the past two months, or anticipated travel before study completion
* Diagnosed neurological, psychiatric, or sleep disorder (e.g., insomnia, sleep apnea, bipolar disorder)
* High risk of sleep apnea, defined as a Berlin Questionnaire score \>2 (Lauritzen et al., 2018)
* Use of medications known to affect sleep, alertness, melatonin secretion, or circadian timing
* Unable or unwilling to comply with behavioral restrictions, including refraining from electronic devices displaying time cues unless clocks are removed and devices are disconnected from Wi-Fi
* Unable or unwilling to comply with consumption restrictions, including abstaining from caffeine, alcohol, and melatonin-rich foods during the study
* Extreme chronotype, defined as a habitual midsleep time outside 03:00-05:00 on the MCTQ or classification as an extreme morning or extreme evening type on the MEQ
* Daily caffeine consumption exceeding 400 mg (approximately 4-5 cups of coffee)
* Current smoker or smoking within the past six months

Minimum Eligible Age

23 Years

Maximum Eligible Age

45 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes