The Coronary Artery Calcium and Troponins in Rheumatoid Arthritis (CAT-RA) Study

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

120 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-09-04

Study Completion Date

2028-03-04

Brief Summary

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Individuals with rheumatoid arthritis (RA) have up to 2x the risk of having a heart attack compared to someone without RA. The goal of this study is to identify biomarkers that can help us do a better job of identifying individuals at risk before they develop symptoms of heart disease and start preventative treatment earlier.

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Detailed Description

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The objective of this study is to test the utility of high sensitivity cardiac troponin (hs-cTn) and coronary artery calcium (CAC) in risk stratifying patients with rheumatoid arthritis (RA) who may benefit from lipid lowering therapy. The population of interest are individuals who would not otherwise be recommended for therapy based on general population risk calculators for heart disease risk.

Conditions

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Rheumatoid Arthritis (RA Atherosclerotic Cardiovascular Disease (ASCVD)

Study Design

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Observational Model Type

COHORT

Study Time Perspective

CROSS_SECTIONAL

Interventions

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high sensitivity cardiac troponin

Blood measurement of high sensitivity cardiac troponin

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* RA diagnosed by a rheumatologist
* Age 40- 79
* ≥1 ASCVD risk factor including prediabetes, hypertension, BMI \>30, current or history of cigarette smoking

Exclusion Criteria

* Patients on a statin or with a contraindication to statin, on a cholesterol absorption inhibitor, or on a PCSK9 inhibitor
* Patients with diabetes mellitus
* Pregnancy

Minimum Eligible Age

35 Years

Maximum Eligible Age

79 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No