Improving Care and Mental Well-Being for Adults With Heart Failure

NCT ID: NCT07313657

Last Updated: 2026-01-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

7300 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-09-26

Study Completion Date

2026-11-30

Brief Summary

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Heart failure is a high-risk, chronic condition that impacts patients' mental health. Approximately 50% of heart failure patients experience comorbid mental health conditions, such as stress, depression and anxiety, which affect their day-to-day lives. Despite this interconnection, the integration of mental health awareness and support into cardiac care remains limited. To address this gap, the FRAME (Foundation, Recognition, Awareness, Management, Engagement) intervention was co-designed by researchers, healthcare providers, health system decisionmakers, and patient partners. This pilot study evaluates the feasibility of implementing the FRAME intervention in pilot clinical sites within two health regions in Ontario, Canada, including team-based family medicine clinics, cardiac rehabilitation/specialist clinics, and emergency departments. Utilizing a pretest-posttest hybrid 1 model intervention design, this study evaluates process indicators and patient-focused outcomes through surveys and semi-structured qualitative interviews. Findings from this study will inform a future large scale cohort study and scalable integration of the FRAME tool into existing cardiac care pathways to enhance mental health awareness and support among heart failure patients.

Detailed Description

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Conditions

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Heart Failure Mental Health Stress Anxiety Depression

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Hybrid Type 1 effectiveness- implementation design, which is well-suited to for evaluating interventions in real-world healthcare settings where both clinical outcomes and implementation processes are focus areas. This design evaluates the effectiveness of an intervention while also collecting formative data to understand it's implementation context, where we determine its feasibility, acceptability, barriers and facilitators to uptake to support future trials. The primary aim of Hybrid Type 1 would be to determine whether an intervention is effective in improving targeted outcomes. In our study, the aim of this design would be to determine whether the intervention is effective in improving our outcome measures.
Primary Study Purpose

HEALTH_SERVICES_RESEARCH

Blinding Strategy

NONE

Study Groups

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FRAME Intervention

Every participant who completed the intake survey for baseline data collection will receive the FRAME intervention via email in January 2026.

Group Type OTHER

Heart Failure and Mental Health Intervention (FRAME)

Intervention Type OTHER

Foundation, Recognition, Awareness, Management and Engagement (FRAME) is a multi-component, co-designed web tool created in collaboration with patient partners, caregivers, healthcare providers, and Archipel and Great River Ontario Health Teams. It is designed to improve recognition, awareness, management and support for mental health in patients with heart failure. There are three different versions: one for healthcare providers, one for caregivers and one for patients. The intervention includes educational material about heart failure and mental health, conversational support to help facilitate discussions about mental health, self-management activity maps (e.g., tips about nutrition and exercise), asset maps (i.e., displaying available resources), and the provider-facing discussion tool to help initiate conversations about mental health and guide referrals or supports. FRAME was developed through a co-design process informed by the lived experiences of community partners.

Interventions

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Heart Failure and Mental Health Intervention (FRAME)

Foundation, Recognition, Awareness, Management and Engagement (FRAME) is a multi-component, co-designed web tool created in collaboration with patient partners, caregivers, healthcare providers, and Archipel and Great River Ontario Health Teams. It is designed to improve recognition, awareness, management and support for mental health in patients with heart failure. There are three different versions: one for healthcare providers, one for caregivers and one for patients. The intervention includes educational material about heart failure and mental health, conversational support to help facilitate discussions about mental health, self-management activity maps (e.g., tips about nutrition and exercise), asset maps (i.e., displaying available resources), and the provider-facing discussion tool to help initiate conversations about mental health and guide referrals or supports. FRAME was developed through a co-design process informed by the lived experiences of community partners.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

For Patients (Surveys and Optional Interviews):

* Patients at risk of heart failure (e.g., irregular heartbeat, coronary artery disease, a past heart attack, high blood pressure that is being treated, cardiomyopathy), or with a self-reported/documented diagnosis of heart failure OR on the following list of medications :

* Angiotensin receptor-neprilysin inhibitors (ARNI), called sacubitril-valsartan
* Angiotensin converting enzyme inhibitors (ACEi), called "prils"
* Angiotensin-receptor blockers (ARBs), called "sartans"
* Beta-blockers, called "lols"
* Mineralocorticoid receptor antagonists (MRAs)
* Sodium-glucose co-transporter-2 (SGLT2) inhibitors, called "flozins"
* Receiving care at one of the participating pilot test sites or if they found their way to the tool website
* Willing and able to provide informed consent and name, email address and phone number for follow-up contact (for survey and interview)

Caregivers (Optional interviews):

* Caregivers who support adult(s) with heart failure.

Exclusion Criteria

* Inability to provide informed consent (e.g., due to cognitive impairment or language barriers without translated support)
* Participants who do not have access to the internet will not be able to use the web-tool.

For Healthcare Providers

* Providers that are not involved in the care of heart failure patients
Minimum Eligible Age

40 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Canadian Institutes of Health Research (CIHR)

OTHER_GOV

Sponsor Role collaborator

Bruyère Health Research Institute.

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Seaway Valley Community Health Centre (Cardiac Rehab Program)

Cornwall, Ontario, Canada

Site Status RECRUITING

Centre de Santé Communautaire de l'Estrie

Limoges, Ontario, Canada

Site Status ACTIVE_NOT_RECRUITING

Orleans Cardiopulmonary Clinic

Orléans, Ontario, Canada

Site Status RECRUITING

Bruyère Health Research Institute

Ottawa, Ontario, Canada

Site Status NOT_YET_RECRUITING

Byward Family Health Team

Ottawa, Ontario, Canada

Site Status NOT_YET_RECRUITING

Montfort Hospital, and associated Aline-Chrétien Rehabilitation Clinic

Ottawa, Ontario, Canada

Site Status ACTIVE_NOT_RECRUITING

Ste-Anne Medical Clinic

Ottawa, Ontario, Canada

Site Status ACTIVE_NOT_RECRUITING

University of Ottawa Heart Institute

Ottawa, Ontario, Canada

Site Status ACTIVE_NOT_RECRUITING

Winchester Memorial Hospital

Winchester, Ontario, Canada

Site Status RECRUITING

Countries

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Canada

Central Contacts

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Krystal Kehoe MacLeod, PhD

Role: CONTACT

613-862-4314

Facility Contacts

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Krystal Kehoe MacLeod Principal Investigator

Role: primary

613-862-4314

Provided Documents

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Document Type: Study Protocol and Statistical Analysis Plan

View Document

Document Type: Informed Consent Form

View Document

Related Links

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https://www.ccaeresearch.ca/brain-heart-interconnectome/

Project Background and Information from the Research Team conducting this study

https://www.uottawa.ca/research-innovation/bhi/research/theme-4-innovative-health-systems-tailored-models-care

Project Background and Information from the Brain-Heart Interconnectome at the University of Ottawa

Other Identifiers

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M16-25-028

Identifier Type: -

Identifier Source: org_study_id

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