Escalation vs. Induction Therapy Strategy in Patients With Early-Onset MS After Age 50

NCT ID: NCT07313462

Last Updated: 2026-01-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

830 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-02-07

Study Completion Date

2026-02-28

Brief Summary

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The objective of this study is to evaluate the risk of inflammatory disease activity by retrospectively comparing two therapeutic strategies (escalation group and induction group). The investigators also aim to identify factors associated with inflammatory relapse and treatment-related complications.

Detailed Description

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Conditions

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Multiple Sclerosis (MS)

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

RETROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Patients with RRMS onset after age 50
* Patients who started their first disease-modifying therapy within 2 years of the first symptoms
* Patients Treated with moderately effective disease-modifying antirheumatic drugs (DMARDs) (teriflunomide, dimethyl fumarate or diroximel fumarate, glatiramer acetate, interferon beta, peginterferon)
* Patient treated with highly effective DMARDs (fingolimod, ponesimod, natalizumab, rituximab, ocrelizumab, ofatumumab, cladribine)

Exclusion Criteria

\- Patients with early progressive MS
Minimum Eligible Age

50 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University Hospital, Strasbourg, France

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Centre d'Investigation Clinique - CHU de Strasbourg - France

Strasbourg, , France

Site Status RECRUITING

Countries

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France

Central Contacts

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Nicolas Collongues, MD

Role: CONTACT

33 3.88.12.87.33

Facility Contacts

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Nicolas Collongues, MD

Role: primary

33 3.88.12.87.33

Other Identifiers

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9535

Identifier Type: -

Identifier Source: org_study_id

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