A Study to Evaluate Patient-Reported Satisfaction, Effectiveness, and Safety of Atezolizumab in Participants Treated in Routine Clinical Practice
NCT ID: NCT07284121
Last Updated: 2026-01-07
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
700 participants
OBSERVATIONAL
2025-07-17
2028-12-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Cohort 1: Early Non-small Cell Lung Cancer (NSCLC)
Participants diagnosed with early-stage NSCLC following complete resection and platinum-based chemotherapy with Programmed Cell-Death Ligand 1 (PD-L1) expression of \>= 50% on Tumor Cell (TC).
Atezolizumab
Atezolizumab will be administered at the discretion of the treating physician and independently of participation in this study.
Cohort 2: Metastatic NSCLC
Participants diagnosed with metastatic NSCLC with PD-L1 expression of \>= 50% on TC who have not received prior systemic therapy for metastatic disease.
Atezolizumab
Atezolizumab will be administered at the discretion of the treating physician and independently of participation in this study.
Cohort 3: Extensive stage small cell lung cancer (ES-SCLC)
Participants diagnosed with ES-SCLC who have not previously been treated.
Atezolizumab
Atezolizumab will be administered at the discretion of the treating physician and independently of participation in this study.
Cohort 4: Hepatocellular Carcinoma (HCC)
Participants diagnosed with advanced or unresectable HCC who have not received prior systemic therapy.
Atezolizumab
Atezolizumab will be administered at the discretion of the treating physician and independently of participation in this study.
Interventions
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Atezolizumab
Atezolizumab will be administered at the discretion of the treating physician and independently of participation in this study.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Early stage NSCLC following complete resection and platinum-based chemotherapy with a high risk of recurrence and PD-L1 expression on ≥ 50% of TC and with no EGFR-mutant or ALK-positive NSCLC
* Metastatic stage NSCLC with PD-L1 expression on ≥ 50% TC or ≥ 10% tumor infiltrating immune cells (IC) and with no EGFR-mutant or ALK-positive NSCLC not previously treated
* Extensive-stage small cell lung cancer (ES-SCLC) not previously treated
* Advanced or unresectable HCC not previously treated with systemic therapy
* Should not have received \> 4 prior cycles of IV Atezolizumab
Exclusion Criteria
* Receiving concomitant systemic anticancer therapy at the time of initiation of Atezolizumab or an Atezolizumab-containing regimen for treatment of the same disease, as per label
* Receiving treatment with Atezolizumab as part of a clinical trial, pre-approval access program, compassionate use program, expanded use program, post-trial access program, or continued access program
* Unwilling to complete questionnaires related to treatment satisfaction and treatment-related quality of life
18 Years
ALL
No
Sponsors
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Hoffmann-La Roche
INDUSTRY
Responsible Party
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Principal Investigators
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Clinical Trials
Role: STUDY_DIRECTOR
Hoffmann-La Roche
Locations
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Landesklinikum Krems
Krems, , Austria
Ordensklinikum Linz Elisabethinen
Linz, , Austria
Krankenhaus Nord - Klinik Floridsdorf
Vienna, , Austria
Klinikum Wels-Grieskirchen
Wels, , Austria
CHU UCL Mont-Godinne
Mont-godinne, , Belgium
Multiprofile Hospital for Active Treatment Uni Hospital
Panagyurishte, , Bulgaria
Complex Oncological Center-Ruse EOOD
Rousse, , Bulgaria
UMHAT "Sv. Ivan Rilski", EAD
Sofia, , Bulgaria
MBAL Serdika EOOD
Sofia, , Bulgaria
MHAT SofiaMed
Sofia, , Bulgaria
Presidio Ospedaliero Vito Fazzi
Lecce, Apulia, Italy
AORN Ospedali dei Colli Ospedale Monaldi
Napoli, Campania, Italy
Az. Osp. Cardarelli
Napoli, Campania, Italy
A.O. Universitaria Policlinico Di Modena
Modena, Emilia-Romagna, Italy
Ospedale Provinciale Santa Maria Delle Croci
Ravenna, Emilia-Romagna, Italy
Policlinico Universitario Agostino Gemelli
Rome, Lazio, Italy
Università Campus Bio-Medico di Roma
Rome, Lazio, Italy
IRCCS AOU San Martino - IST
Genoa, Liguria, Italy
Humanitas Gavazzeni
Bergamo, Lombardy, Italy
Fondazione IRCCS Ospedale Maggiore Policlinico
Milan, Lombardy, Italy
Ospedale Maggiore Policlinico
Milan, Lombardy, Italy
Asst Santi Paolo E Carlo
Milan, Lombardy, Italy
Ente Ecclesiastico Ospedale Generale Regionale F Miulli
Acquaviva Delle Fonti, Piedmont, Italy
A.O.U. Maggiore della Carità
Novara, Piedmont, Italy
Azienda Ospedaliero Universitaria Di Sassari
Sassari, Sardinia, Italy
Humanitas Istituto Clinico Catanese S.p.A
Misterbianco (CT), Sicily, Italy
A.O.U. Policlinico Paolo Giaccone
Palermo, Sicily, Italy
Casa di Cura La Maddalena
Palermo, Sicily, Italy
Azienda Sanitaria Territoriale Pesaro Urbino (AST PU) - Ospedale Santa Croce;UOC Oncologia - Stabilimento di Fano
Fano (PU), The Marches, Italy
Ospedale Santa Chiara
Trento, Trentino-Alto Adige, Italy
Ospedale dell'Angelo
Mestre, Veneto, Italy
Azienda Ospedaliera Universitaria Integrata Verona
Verona, Veneto, Italy
Uniwersytecki Szpital Kliniczny nr 4 w Lublinie
Lublin, , Poland
Warminsko-Mazurskie Centrum Chorób P?uc w Olsztynie
Olsztyn, , Poland
Wielkopolskie Centrum Pulmonologii i Torakochirurgii w Poznaniu
Poznan, , Poland
Wojewodzki Szpital Specjalistyczny im. Janusza Korczaka
Słupsk, , Poland
NU-MED Centrum Diagnostyki i Terapii Onkologicznej
Tomaszów Mazowiecki, , Poland
Institutul Clinic Fundeni Bucuresti
Bucharest, , Romania
Institutul Regional de Gastroenterologie si Hepatologie Prof. Dr. Octavian Fodor
Cluj-Napoca, , Romania
Spitalul Clinic Jude?ean de Urgen?? Sfântul Apostol Andrei Galati;oncology
Galati, , Romania
Institutul Regional de Oncologie Iasi
Iași, , Romania
Spitalul Municipal Ploiesti
Ploieşti, , Romania
Spitalul Judetean de Urgenta Satu Mare
Satu Mare, , Romania
Oncomed SRL
Timișoara, , Romania
Complejo Hospitalario Torrecardenas
Almería, Almeria, Spain
Hospital Son Espases
Palma de Mallorca, Balearic Islands, Spain
Hospital Sant Joan de Deu de Manresa;Servicio oncologia
Manresa, Barcelona, Spain
Hospital Universitario Puerto Real
Puerto Real, Cadiz, Spain
Complejo Hospitalario Universitario de Santiago (CHUS)
Santiago de Compostela, LA Coruna, Spain
Hospital Clínico Universitario Valladolid;servicio de digestivo
Valladolid, Madrid, Spain
Hospital Univ. Central de Asturias
Oviedo, Principality of Asturias, Spain
Hospital Univ. Central de Asturias
Oviedo, Principality of Asturias, Spain
Hospital Universitari Sant Joan de Reus
Reus, Tarragona, Spain
Complejo Hospitalario Nuestra Señora de la Candelaria
Santa Cruz de Tenerife, Tenerife, Spain
Hospital Universitario de Canarias
Santa Cruz de Tenerife, Tenerife, Spain
Hospital de Cruces
Bilbao, Vizcaya, Spain
Hospital Universitario de Cruces;servicio de digestivo
Vizcaya, Vizcaya, Spain
Hospital General de Alicante;servicio de digestivo
Alicante, , Spain
Hospital General Univ. de Alicante
Alicante, , Spain
Hospital de Badajoz
Badajoz, , Spain
Hospital Clinic I Provincial
Barcelona, , Spain
Hospital de la Santa Creu i Sant Pau
Barcelona, , Spain
Hospital General de Ciudad Real
Ciudad Real, , Spain
Hospital Universitario San Cecilio
Granada, , Spain
Hospital General Universitario de Guadalajara
Guadalajara, , Spain
Hospital General Universitario J.M Morales Meseguer
Murcia, , Spain
Hospital Virgen de Arrixaca;servicio de digestivo
Murcia, , Spain
Complejo Hospitalario de Pontevedra
Pontevedra, , Spain
Hospital Virgen del Rocio;Servicio de digestivo
Seville, , Spain
Hospital de Toledo;Servicio de digestivo
Toledo, , Spain
Hospital de Toledo;servicio de oncologia
Toledo, , Spain
Hospital Arnau de Vilanova (Valencia) Servicio de Oncologia
Valencia, , Spain
Hospital Clinico Universitario de Valladolid
Valladolid, , Spain
Hospital Universitario Miguel Servet
Zaragoza, , Spain
James Paget University Hospitals NHS Foundation Trust
Norfolk, , United Kingdom
Countries
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Central Contacts
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Reference Study ID Number: MO45893 https://forpatients.roche.com/
Role: CONTACT
Other Identifiers
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MO45893
Identifier Type: -
Identifier Source: org_study_id
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