Atezolizumab Plus Bevacizumab in First Line NSCLC Patients

NCT ID: NCT03836066

Last Updated: 2025-12-04

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE2
• Total Enrollment: 41 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2019-05-15
• Study Completion Date: 2024-10-21

Brief Summary

This is a multi-center phase II clinical trial of atezolizumab in combination with bevacizumab as first line treatment for locally advanced or metastasic high-intermediate tumour mutation burden selected NSCLC patients. 102 patients will be enrolled in this trial to examine the efficacy of this combination measured by progression free survival according to response evaluation Criteria in solid tumours (RECIST) version 1.1.

Detailed Description

Chemotherapy-naïve patients high-intermediate TMB (TMB≥10 mutations/MB) and with locally advanced or metastatic non-squamous non-small cell lung cancer patients will be selected. Enroled patientswill receive 1200 mg of atezolizumab and 15mg/Kg of Avastin® (bevacizumab) administered by IV infusion every 21 days (+/- 3 days).

The treatment will start within 1-5 days from enrolment. Atezolizumab may continue beyond disease progression per RECIST v1.1 until loss of clinical benefit, unacceptable toxicity, patient or physician decision to discontinue , or death. Bevacizumab will be administered until progression disease, unacceptable toxicity, patient or physician decision to discontinue or death.

For all patients, tumour response data collection will continue until disease progression, even if the patient stops study treatment prior to disease progression.

The primary endpoint is to evaluate the efficacy of Atezolizumab in combination with Bevacizumab as measured by Progression Free Survival according to RECIST Version 1.1.

PFS after enrolment is defined as the time from enrolment to the first occurrence of disease progression or death from any cause, whichever occurs first.

Patient accrual is expected to be completed within 1.5 years excluding a run-in-period of 46 months. Treatment and follow-up are expected to extend the study duration to a total of 4.5 years. Patients will be followed 1.5 years after the end of treatment independently of the cause of end of treatment. The study will end once survival follow-up has concluded.

Conditions

Non Small Cell Lung Cancer

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Experimental: Atezolizumab plus Bevacizumab arm

1 group, Atezolizumab 1200mb + Bevacizumab 15 mg/kg (IV),every 21 days.

Group Type: EXPERIMENTAL

Atezolizumab-Bevacizumab

Intervention Type: DRUG

Atezoluzumab 1200 mg + Bevacizumab 15 mg / kg

Interventions

Atezolizumab-Bevacizumab

Atezoluzumab 1200 mg + Bevacizumab 15 mg / kg

Intervention Type: DRUG

Other Intervention Names

Tecentriq-Avastin

Eligibility Criteria

Inclusion Criteria

1. Male or female, aged ≥ 18 years old

2. ECOG performance status of 0 or 1.

3. Histologically or cytologically confirmed, Stage IIIB or IV non-squamous NSCLC according to 8th version of the International Association for the Study of Lung Cancer Staging Manual in Thoracic Oncology

4. No prior treatment for Stage IIIB or IV non-squamous NSCLC.

5. Patients who have received prior neo-adjuvant, adjuvant chemotherapy, radiotherapy, or chemo-radiotherapy with curative intent for non-metastatic disease must have experienced a treatment-free interval of at least 6 months from randomization since the last chemotherapy, radiotherapy, or chemo-radiotherapy.

6. Patients with a treated asymptomatic CNS metastasis are eligible, provided they meet all of the following criteria:

1. Only supratentorial and cerebellar metastases allowed (i.e., no metastases to midbrain, pons, medulla or spinal cord).

2. No ongoing requirement for corticosteroids as therapy for CNS disease.

3. No stereotactic radiation within 7 days or whole-brain radiation within 14 days prior to randomization.

4. No evidence of interim progression between the completion of CNS-directed therapy and the screening radiographic study. Patients with new asymptomatic CNS metastases detected at the screening scan must receive radiation therapy and/or surgery for CNS metastases. Following treatment, these patients may then be eligible without the need for an additional brain scan prior to inclusion, if all other criteria are met.

7. Patients with high-intermediate Tumour Mutational Burden analysed by Foundation Medicine (≥10 mutations/ MB) performed by a Foundation Medicine laboratory on previously obtained archival tumour tissue or tissue obtained from a biopsy at prescreening (sample must fulfil minimal sample requirements of 20% tumour cellularity and a minimum surface of 25mm2).

8. Measurable disease, as defined by RECIST v1.1. Previously irradiated lesions can only be considered as measurable disease if disease progression has been unequivocally documented at that site since radiation and the previously irradiated lesion is not the only site of disease.

9. Adequate hematologic and organ function defined by the following laboratory results obtained within 14 days prior to randomization:

Neutrophils ≥ 1500 cells/μL without granulocyte colony-stimulating factor support.

• Lymphocyte count ≥ 500/μL.
• Platelet count ≥ 100,000/μL without transfusion.
• Haemoglobin ≥ 9.0 g/dL. Patients may be transfused to meet this criterion.
• INR or aPTT ≤ 1.5 × upper limit of normal (ULN). This applies only to patients who are not receiving therapeutic anticoagulation; patients receiving therapeutic anticoagulation should be on a stable dose.
• AST, ALT, and alkaline phosphatase ≤ 2.5 × ULN, with the following exceptions: Patients with documented liver metastases: AST and/or ALT ≤ 5 × ULN. Patients with documented liver or bone metastases: alkaline phosphatase ≤ 5 × ULN.
• Serum bilirubin ≤ 1.25 × ULN. Patients with known Gilbert disease who have serum bilirubin level ≤ 3 × ULN may be enrolled.
• Serum creatinine ≤ 1.5 × ULN or creatinine clearance of ≥45ml/min (based on the Cockcroft Gault formula).

10. All patients are notified of the investigational nature of this study and signed a written informed consent in accordance with institutional and national guidelines, including the Declaration of Helsinki prior to any trial-related intervention.

11. For female patients of childbearing potential, agreement (by patient and/or partner) to use a highly effective form(s) of contraception that results in a low failure rate (< 1% per year) when used consistently and correctly, and to continue its use for 5 months after the last dose of Atezolizumab and/or 6 months after the last dose of Bevacizumab, whichever is later. Such methods include: combined (oestrogen and progestogen containing) hormonal contraception, progestogen-only hormonal contraception associated with inhibition of ovulation together with another additional barrier method always containing a spermicide, intrauterine device (IUD): intrauterine hormone-releasing system (IUS), bilateral tubal occlusion, vasectomized partner (on the understanding that this is the only one partner during the whole study duration), and sexual abstinence.

12. For male patients with female partners of childbearing potential, agreement (by patient and/or partner) to use a highly effective form(s) of contraception that results in a low failure rate [< 1% per year] when used consistently and correctly, and to continue its use for 6 months after the last dose of Bevacizumab. Male patients should not donate sperm during this study and for at least 6 months after the last dose of Bevacizumab.

13. Oral contraception should always be combined with an additional contraceptive method because of a potential interaction with the study drugs. The same rules are valid for male patients involved in this clinical study if they have a partner of childbirth potential. Male patients must always use a condom.

14. Women who are not postmenopausal (≥ 12 months of non-therapy-induced amenorrhea) or surgically sterile must have a negative serum pregnancy test result within 14 days prior to initiation of study drug.

Exclusion Criteria

1. Patients with a sensitizing mutation in the epidermal growth factor receptor (EGFR) gene.

2. Patients with an anaplastic lymphoma kinase (ALK) fusion oncogene.

3. Patients with an STK-1 Ligand alteration.

4. Patients with MDM2 amplification.

5. Patients with ROS1 translocations.

6. Active or untreated CNS metastases as determined by CT or magnetic resonance imaging (MRI) evaluation during screening and prior radiographic assessments.

7. Spinal cord compression not definitively treated with surgery and/or radiation or previously diagnosed and treated spinal cord compression without evidence that disease has been clinically stable for > 2 weeks prior to randomization.

8. Leptomeningeal disease.

9. Uncontrolled tumour-related pain. Patients requiring pain medication must be on a stable regimen at study entry. Symptomatic lesions amenable to palliative radiotherapy (e.g., bone metastases or metastases causing nerve impingement) should be treated prior to initiation of study drug. Patients should be recovered from the effects of radiation. There is no required minimum recovery period. Asymptomatic metastatic lesions whose further growth would likely cause functional deficits or intractable pain (e.g., epidural metastasis that is not currently associated with spinal cord compression) should be considered for locoregional therapy, if appropriate, prior to initiation of study drug.

10. Uncontrolled pleural effusion, pericardial effusion, or ascites requiring recurrent drainage procedures (once monthly or more frequently). Patients with indwelling catheters (e.g., PleurX®) are allowed.

11. Uncontrolled or symptomatic hypercalcemia (> 1.5 mmol/L ionized calcium or Ca > 12 mg/dL or corrected serum calcium > ULN).

12. Malignancies other than NSCLC within 5 years prior to randomization, with the exception of those with a negligible risk of metastasis or death (e.g., expected 5-year OS > 90%) treated with expected curative outcome (such as adequately treated carcinoma in situ of the cervix, basal or squamous-cell skin cancer, localized prostate cancer treated surgically with curative intent, ductal carcinoma in situ treated surgically with curative intent).

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Fundación GECP

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Mariano Provencio, MD

Role: PRINCIPAL_INVESTIGATOR

Hospital Universitario Puerta de Hierro

Locations

Hospital Clínico Universitario de Santiago

Santiago de Compostela, A Coruña, Spain

Hospital General de Alicante

Alicante, Alicante, Spain

Hospital General Universitario de Elche

Elche, Alicante, Spain

ICO Badalona

Badalona, Barcelona, Spain

Hospital Clínic de Barcelona

Barcelona, Barcelona, Spain

Hospital de la Santa Creu i Sant Pau

Barcelona, Barcelona, Spain

Consorci Sanitari de Terrassa

Terrassa, Barcelona, Spain

Consorcio Hospitalario Provincial de Castelló

Castelló, Castelló, Spain

Hospital Universitario Reina Sofía

Córdoba, Córdoba, Spain

Complejo Hospitalario de Jaén

Jaén, Jaén, Spain

Complejo Hospitalario Universitario A Coruña

A Coruña, La Coruña, Spain

Hospital Universitario Lucus Augusti

Lugo, Lugo, Spain

Hospital La Princesa

Madrid, Madrid, Spain

Hospital Clínico San Carlos

Madrid, Madrid, Spain

Hospital Universitario Fundación Jiménez Díaz

Madrid, Madrid, Spain

Hospital Puerta de Hierro

Majadahonda, Madrid, Spain

Hospital Universitario Son Espases

Palma de Mallorca, Mallorca, Spain

Hospital Universitario Son Llàtzer

Palma de Mallorca, Mallorca, Spain

Hospital General Universitario de Málaga

Málaga, Málaga, Spain

Complexo Hospitalario Universitario de Vigo

Vigo, Pontevedra, Spain

Complejo Hospitalario de Toledo

Toledo, Toledo, Spain

Hospital Universitari i Politécnic La Fe

Valencia, Valencia, Spain

Hospital Clínico Universitario de Valencia

Valencia, Valencia, Spain

Hospital General de Valencia

Valencia, Valencia, Spain

Hospital Clínico Universitario de Valladolid

Valladolid, Valladolid, Spain

Countries

Spain

References

Provencio M, Ortega AL, Coves-Sarto J, Calvo V, Marse-Fabregat R, Domine M, Guirado M, Carcereny E, Fernandez N, Alvarez R, Blanco R, Leon-Mateos L, Sanchez-Torres JM, Sullivan IG, Cobo M, Sanchez-Hernandez A, Massuti B, Sierra-Rodero B, Martinez-Toledo C, Serna-Blasco R, Romero A, Cruz-Bermudez A. Atezolizumab Plus Bevacizumab as First-line Treatment for Patients With Metastatic Nonsquamous Non-Small Cell Lung Cancer With High Tumor Mutation Burden: A Nonrandomized Controlled Trial. JAMA Oncol. 2023 Mar 1;9(3):344-353. doi: 10.1001/jamaoncol.2022.5959.

Reference Type: DERIVED

PMID: 36520426 (View on PubMed)

Provided Documents

Document Type: Study Protocol and Statistical Analysis Plan

View Document

Related Links

http://www.gecp.org

Web page of the sponsor where users can find more information about Fundación GECP studies

Other Identifiers

2018-004654-17

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

GECP 18/03_TELMA

Identifier Type: -

Identifier Source: org_study_id