Characterization of Skin and Facial Fat Pad Thickness Changes Following Microneedling Radiofrequency With and Without Topical Poly-L-Lactic Acid for Facial Rejuvenation
NCT ID: NCT07261527
Last Updated: 2025-12-03
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.
NOT_YET_RECRUITING
NA
30 participants
INTERVENTIONAL
2025-11-24
2027-11-30
Brief Summary
Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.
Related Clinical Trials
Explore similar clinical trials based on study characteristics and research focus.
Clinical Assessment of Skin Tightening and Contour Change of Submental Tissue Using Bipolar Radiofrequency Microneedling
NCT04477187
Radio Frequency Microneedling for Suprapatellar Skin
NCT03507036
Split Face Study of the Effects of Micro Needling With and Without Platelet Rich Plasma
NCT04219293
Lifting and Tightening of the Face and Neck Following an Increased Density Treatment
NCT01519206
A Pilot Study on the Use of Platelet Rich Plasma (PRP) for Facial and Hand Skin Rejuvenation
NCT03647917
Detailed Description
Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.
Conditions
See the medical conditions and disease areas that this research is targeting or investigating.
Study Design
Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.
RANDOMIZED
PARALLEL
TREATMENT
SINGLE
Study Groups
Review each arm or cohort in the study, along with the interventions and objectives associated with them.
microneedling radiofrequency (RF)
microneedling RF treatment
Participants will undergo two microneedling RF treatment sessions, 4-6 weeks apart
no treatment
No interventions assigned to this group
microneedling RF treatment with topical poly-L-lactic acid (PLLA)
microneedling RF treatment
Participants will undergo two microneedling RF treatment sessions, 4-6 weeks apart
PLLA
Participants will undergo two microneedling RF treatment sessions, 4-6 weeks apart followed by PLLA application after each treatment
microneedling RF treatment with placebo
microneedling RF treatment
Participants will undergo two microneedling RF treatment sessions, 4-6 weeks apart
Sterile Water as control
Participants will undergo two microneedling RF treatment sessions, 4-6 weeks apart followed by sterile water application after each treatment
Interventions
Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.
microneedling RF treatment
Participants will undergo two microneedling RF treatment sessions, 4-6 weeks apart
PLLA
Participants will undergo two microneedling RF treatment sessions, 4-6 weeks apart followed by PLLA application after each treatment
Sterile Water as control
Participants will undergo two microneedling RF treatment sessions, 4-6 weeks apart followed by sterile water application after each treatment
Eligibility Criteria
Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.
Inclusion Criteria
* Able and willing to provide informed consent
* Willing to comply with study procedures and follow-up visits
Exclusion Criteria
* Previous facial surgeries
* Pregnant or breastfeeding
* Active infection, dermatitis, or open lesions in the treatment area
* History of keloids or abnormal scarring
* Known allergy to poly-L-lactic acid (PLLA)- Current participation in another clinical trial involving facial aesthetic treatments
* Presence of pre-cancerous or cancerous lesions in the treatment area
* Current or planned use of glucagon-like peptide-1 receptor agonists (e.g., Ozempic, semaglutide) during the study period. Subjects on these medications will be excluded due to potential effects on facial fat and overall weight.
* HIV+ patients
* Patients on HIV medications- Patients that have eczema and rosacea
18 Years
ALL
Yes
Sponsors
Meet the organizations funding or collaborating on the study and learn about their roles.
The University of Texas Health Science Center, Houston
OTHER
Responsible Party
Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.
Ying Chen
Assistant Professor
Principal Investigators
Learn about the lead researchers overseeing the trial and their institutional affiliations.
Ying Chen, MD
Role: PRINCIPAL_INVESTIGATOR
The University of Texas Health Science Center, Houston
Locations
Explore where the study is taking place and check the recruitment status at each participating site.
The University of Texas Health Science Center at Houston
Houston, Texas, United States
Countries
Review the countries where the study has at least one active or historical site.
Central Contacts
Reach out to these primary contacts for questions about participation or study logistics.
Facility Contacts
Find local site contact details for specific facilities participating in the trial.
Other Identifiers
Review additional registry numbers or institutional identifiers associated with this trial.
HSC-MS-25-0585
Identifier Type: -
Identifier Source: org_study_id
More Related Trials
Additional clinical trials that may be relevant based on similarity analysis.