Determining the Benefits of Exercise on Cardiovascular Risk in PTSD
NCT ID: NCT07260032
Last Updated: 2025-12-02
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
10 participants
INTERVENTIONAL
2025-02-01
2027-01-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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NA
SINGLE_GROUP
TREATMENT
NONE
Study Groups
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Exercise
Exercise
The exercise program will consist of specifically designed activities to place a gradually increasing workload on the cardiovascular system.
Interventions
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Exercise
The exercise program will consist of specifically designed activities to place a gradually increasing workload on the cardiovascular system.
Eligibility Criteria
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Inclusion Criteria
* Trauma exposure
* PTSD symptoms
* Subclinical atherosclerotic CVD (e.g., coronary, cerebrovascular, or peripheral arterial plaque or calcifications on imaging), clinical atherosclerotic CVD (e.g., myocardial infarction or revascularization), or increased risk for atherosclerotic CVD (i.e., \>2 of hypertension, diabetes mellitus, hyperlipidemia, and active smoking)
* Ability to understand and sign informed consent
Exclusion Criteria
* Use of certain CVD medications (e.g., beta-blockers, high-intensity statins \[e.g., rosuvastatin 20/40 mg and atorvastatin 40/80 mg\], PCSK-9 inhibitors)
* Psychiatric or cardiovascular medication change within 4 weeks (i.e., stable regimen is allowed)
* Unstable blood pressure or cardiac arrhythmia
* Currently in a supervised or graduated exercise program
* Neurological or systemic inflammatory disease/current systemic anti-inflammatory therapy
* Moderate/severe alcohol/substance use disorder
* Current mania/psychosis
* Weight \>300 lbs.
* Claustrophobia
* Pregnancy
* Metal implants
* Uncontrolled hyperglycemia (HgbA1c\>7.5%)
* Subjects who have had significant radiation exposure as part of research (\>2 nuclear tests, computed tomography images, or fluoroscopic procedures) during the preceding 12-months
18 Years
65 Years
ALL
No
Sponsors
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Massachusetts General Hospital
OTHER
Responsible Party
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Antonia V. Seligowski, PhD
Assistant Professor
Locations
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Massachusetts General Hospital
Boston, Massachusetts, United States
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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2024P003032
Identifier Type: -
Identifier Source: org_study_id
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