Effect of Instrumentation Kinematics on Intraoperative and Post-operative Pain in Maxillary Premolars With Acute Irreversible Pulpitis
NCT ID: NCT07250399
Last Updated: 2025-11-26
Study Results
Results pending
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.
Recruitment Status
RECRUITING
Clinical Phase
NA
Total Enrollment
56 participants
Study Classification
INTERVENTIONAL
Study Start Date
2025-10-15
Study Completion Date
2027-05-10
Brief Summary
Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.
Post-endodontic pain refers to the discomfort experienced following endodontic procedures. The incidence of post-operative pain is reported to be 25-40% regardless of the pulp and periradicular condition. It has been shown that pain prevalence declined from 40% in the first 48 h after treatment to 11% 7 days post-treatment. The mechanisms behind post-endodontic pain are complex and multifactorial that include host-dependent factors such as host immunity and preoperative pain history as well as operator-related factors such as chemical, mechanical or bacterial injury that occurs during endodontic procedure. A major contributor to this pain is the extrusion of infected debris as dentin chips, microorganisms, and the remnants of pulp tissue to the periradicular area. The intensity of pain is directly proportional to the extent of tissue injury caused.
During root canal preparation, a variety of materials including dentin debris, pulp remnants, microorganisms, endotoxins, and irrigating solutions may be extruded into the periapical tissues, potentially leading to inflammation, increased vascular permeability, oedema, nerve compression and postoperative pain. Studies suggest that apical extrusion is affected by file systems, file kinematics and instrumentation techniques used during root canal preparation .
Rotary systems vary in the amount of debris they extrude due to variations in cross-sectional design, flute depth, cutting blade, kinematics, taper, file sequence, tip size and cutting efficiency. Both rotary and reciprocating NiTi files are effective in reducing endotoxins and bacterial by-products from infected root canals. NiTi files enhance biomechanical preparation and canal centering and exhibit greater resistance to cycle fatigue due to their super elasticity and
greater flexibility. However, the extent of periapical inflammation may differ among NiTi systems due to variations in the amounts of extruded irritantsEdgeOne Fire reciprocating system (EdgeEndo, Albuquerque, New Mexico, USA) features a parallelogram cross-section having two cutting edges and an off-center design. these endodontic instruments are treated with a proprietary heat process called FireWire™, that it is claimed to provide high flexibility and a negligible restoring force. It operates using alternating cutting and releasing angles through a reciprocating motion; with an exchange in the direction of rotation.
Jizai rotary file systems (JZ) (MANI, Tochigi, Japan) is a recently developed NiTi rotary system made of a proprietary heat-treated NiTi alloy. JZ system exhibits bending deformation indicating that it is not purely austenitic but contains R-phase and/or martensite at room or body temperature. It has an off-center quasi-rectangular cross-section with a radial land on one of the short sides. According to the manufacturer, this cross-sectional design produces low screw-in forces owing to the radial land and provides wide spaces for debris removal. EdgeOne Fire reciprocating system (EdgeEndo, Albuquerque, New Mexico, USA) features a parallelogram cross-section having two cutting edges and an off-center design. these endodontic instruments are treated with a proprietary heat process called FireWire™, that it is claimed to provide high flexibility and a negligible restoring force. It operates using alternating cutting and releasing angles through a reciprocating motion; with an exchange in the direction of rotation.
Jizai rotary file systems (JZ) (MANI, Tochigi, Japan) is a recently developed NiTi rotary system made of a proprietary heat-treated NiTi alloy. JZ system exhibits bending deformation indicating that it is not purely austenitic but contains R-phase and/or martensite at room or body temperature. It has an off-center quasi-rectangular cross-section with a radial land on one of the short sides. According to the manufacturer, this cross-sectional design produces low screw-in forces owing to the radial land and provides wide spaces for debris removal.A systematic review of the literature suggested that debris extrusion is influenced by instrument kinematics . However, evidence is still conflicting and sometimes even contradicting regarding the association of kinematics with debris extrusion and post-operative pain.
During root canal preparation, a variety of materials including dentin debris, pulp remnants, microorganisms, endotoxins, and irrigating solutions may be extruded into the periapical tissues, potentially leading to inflammation, increased vascular permeability, oedema, nerve compression and postoperative pain. Studies suggest that apical extrusion is affected by file systems, file kinematics and instrumentation techniques used during root canal preparation .
Rotary systems vary in the amount of debris they extrude due to variations in cross-sectional design, flute depth, cutting blade, kinematics, taper, file sequence, tip size and cutting efficiency. Both rotary and reciprocating NiTi files are effective in reducing endotoxins and bacterial by-products from infected root canals. NiTi files enhance biomechanical preparation and canal centering and exhibit greater resistance to cycle fatigue due to their super elasticity and
greater flexibility. However, the extent of periapical inflammation may differ among NiTi systems due to variations in the amounts of extruded irritantsEdgeOne Fire reciprocating system (EdgeEndo, Albuquerque, New Mexico, USA) features a parallelogram cross-section having two cutting edges and an off-center design. these endodontic instruments are treated with a proprietary heat process called FireWire™, that it is claimed to provide high flexibility and a negligible restoring force. It operates using alternating cutting and releasing angles through a reciprocating motion; with an exchange in the direction of rotation.
Jizai rotary file systems (JZ) (MANI, Tochigi, Japan) is a recently developed NiTi rotary system made of a proprietary heat-treated NiTi alloy. JZ system exhibits bending deformation indicating that it is not purely austenitic but contains R-phase and/or martensite at room or body temperature. It has an off-center quasi-rectangular cross-section with a radial land on one of the short sides. According to the manufacturer, this cross-sectional design produces low screw-in forces owing to the radial land and provides wide spaces for debris removal. EdgeOne Fire reciprocating system (EdgeEndo, Albuquerque, New Mexico, USA) features a parallelogram cross-section having two cutting edges and an off-center design. these endodontic instruments are treated with a proprietary heat process called FireWire™, that it is claimed to provide high flexibility and a negligible restoring force. It operates using alternating cutting and releasing angles through a reciprocating motion; with an exchange in the direction of rotation.
Jizai rotary file systems (JZ) (MANI, Tochigi, Japan) is a recently developed NiTi rotary system made of a proprietary heat-treated NiTi alloy. JZ system exhibits bending deformation indicating that it is not purely austenitic but contains R-phase and/or martensite at room or body temperature. It has an off-center quasi-rectangular cross-section with a radial land on one of the short sides. According to the manufacturer, this cross-sectional design produces low screw-in forces owing to the radial land and provides wide spaces for debris removal.A systematic review of the literature suggested that debris extrusion is influenced by instrument kinematics . However, evidence is still conflicting and sometimes even contradicting regarding the association of kinematics with debris extrusion and post-operative pain.
Related Clinical Trials
Explore similar clinical trials based on study characteristics and research focus.
Can Instrumentation Kinematics Affect Post Operative Pain and Substance P Levels? A Randomized Controlled Trial
NCT06081335
Pain, Postoperative
Irreversible Pulpitis
Apical Periodontitis
COMPLETED
NA
Postoperative Pain Assessment After Canal Preparation by Different NiTi File Systems
NCT06286995
Post Operative Pain
Inflammation
COMPLETED
NA
Comparison Between M-Pro and ProTaper Next
NCT03692039
Symptomatic Irreversible Pulpitis
COMPLETED
NA
Postoperative Pain and Bacterial Reduction in Oval Canals After Instrumentation With Different Noval Rotary Files Systems
NCT07019792
Bacterial Count Reduction in Oval Canal After Rotary Instrumentation With Different Systems
Post-operative Pain After Rotary Instrumentation of Oval Canal With Different Systems
ACTIVE_NOT_RECRUITING
NA
Effect of Different Modalities of Cryotherapy on Post-Operative Pain in Patients With Symptomatic Irreversible Pulpitis
NCT06304259
Endodontic Disease
Endodontically Treated Teeth
COMPLETED
NA
Detailed Description
Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.
1. Trial design:
This study will be a parallel randomized controlled trial a. It is written in accordance with the Preferred Reporting Items for Randomized Trial in Endodontics (PRIRATE) 2020 guidelines .
2. Participants:
Patients of age range between 20 and 50 years old from the outpatient clinic of Endodontic Department, Faculty of Dental Medicine for Girls, Al-Azhar University will participate in this study. These patients have maxillary premolar teeth with symptomatic pulpitis. Patients will be informed about all the study's procedures. They will be included in the study after fulfilling the inclusion criteria and sign an informed consent . The Visual Analog Scale (VAS) will be explained to all participants utilizing visual, verbal and numerical methods to ensure complete understanding. Training on its use will be provided after their recruitment and before randomization to ensure that participants are familiar with the scale before pretreatment pain assessment.
3. Sample size calculation:
Sample size calculation was performed using G\*Power version 3.1.9.7 based on the results of a previous study (Kherlakian et al.) . A power analysis was designed to have adequate power to apply a two-sided statistical test to reject the null hypothesis that there is no difference between groups. By adopting an alpha level of (0.05) and a beta of (0.2), i.e. power = 80% and an effect size (d) of (0.826). The predicted sample size (n) was (50), i.e., 25 subjects per group. This number is increased to 28 subjects per group to compensate for a drop-out rate of 10%.
Criteria of patient selection:
Inclusion Criteria:
1. Maxillary first and second bi-rooted premolar teeth having type I root canal.
2. Patients have mature teeth with closed apex.
3. Teeth with prolonged response to the pulp tests.
4. Spontaneous pain (preoperative visual analog scale score )4-6).
5. Teeth with normal periapical appearance.
6. Restorable teeth.
7. Patients who will be able to understand the informed consent form and pain recording scales used in the study will be included.
Exclusion Criteria:
1. Patients with apical periodontitis.
2. Patients who received analgesics or anti-inflammatory drugs in the last 12 hours and
antibiotics for the last 1 month.
3. Presence of multiple teeth that require treatment.
4. Systemic disease.
5. Physical or mental disability.
6. Teeth with calcified root canal, root resorption and tooth mobility.
7. The presence of additional roots or canal variations from maxillary premolar anatomy.
8. Patient unable to tolerate comple¬tion of root canal treatment in a single visit.
Proper diagnosis of the case including patient history, clinical examination, thermal pulp tests and preoperative periapical radiograph will be obtained.
Symptomatic pulpitis will be diagnosed clinically based on positive response to pulp sensibility tests and the presence of spontaneous provoked pain that lasts longer than 30 s. Patients will be asked to record their pretreatment pain level using Visual Analogue Scale (VAS).
Randomization and blinding
Fifty-six patients will be divided randomly into two groups (28 patients in each group) using simple randomization procedure using random number generator. https://www.random.org/ based on the type of file system used.
Both patient and statistician will be blinded to group allocation.
Treatment protocol:
Local anesthesia will be achieved using 2 mL of 4% articaine and 1:100000 epinephrine (Ultracaine DS Fort; Hoechst- Marion Roussel, Frankfurt, Germany). Access cavity will be prepared under strict aseptic condition and rubber dam isolation using diamond round bur and Endo Z bur (Dentsply, Maillfer, Switzerland). The working length will be determined using an electronic apex locator (EAL) and will be confirmed using periapical radiograph. Glide path preparation will be performed manually up to sizes #20K file.
Subsequently, two groups will be formed according to the predetermined group numbers based on the file system to be used in root canal preparation and the operator will be informed with the study group at this phase.
Group I reciprocating system (EdgeOne Fire group):
Root canal preparation will be completed using EdgeOne Fire reciprocating system (Albuquerque, NM, USA) up to size (35/0.04). Files will be operated at reciprocating motion, where the angle of reciprocation will be set at 150° counterclockwise (CCW) and 30° clockwise (CW).
Group II rotary system (JZ file group):
Root canal preparation will be completed using JZ file system up to size (35/0.04). The files will be operated at 300 rpm and 2 Ncm torque.
The files will be operated passively using an endodontic motor Motopex endodontic motor (Woodpecker, Guilian, China). After each file use, the root canal will be irrigated with 5ml of freshly prepared 2.5% sodium hypochlorite (NaOCl) solution (Alex. Deteregents and Chemical Co., Egypt) for 1 minute using a 30-gauge Navi-Tip flexible irrigating needle (Navi-Tip, Ultradent product, South Jourdan, UT). The needle will be inserted into the root canal 2 mm short of the working length without binding. 5 ml of 17% EDTA (Colgate Oral Care Company, Waverly, Australia) for 1 min will be used for smear layer removal following saline separation. 5 ml of saline solution will be used for final irrigation of the root canal to neutralize all the previously used irrigants.
Finally, the root canal system will be obturated using ADSEAL resin-based sealer (Meta Biomed Co, Cheongju, Korea) and gutta-percha (Dentsply Maillefer, Switzerland) with cold lateral condensation method after being completely dried using paper points of comparable size to the master cone. A final coronal restoration with direct composite filling (Filtek Bulk Fill,3M ESPE, USA) will be performed in the same visit.
The patients will be notified about the possible development of pain and given the VAS form to record the pain level. In this scale, the level of pain is specified by using numbers between 0 and 10; no pain (0), mild pain (1-3), moderate pain (4-6) and severe pain (7-10). Ibuprofen 400 mg will be prescribed to patients to be taken only when needed. The VAS scores will be recorded at 6, 12, 24, 48, ,72 h and 1 week as well as analgesic intake.
Intraoperative and postoperative pain and analgesic intake assessment:
* The evaluation of intraoperative pain will be conducted immediately after root canal preparation with each of the instrumentation kinematics using Visual Analog Scale (VAS). In each group, the patients will be asked to specify the level of pain for the buccal and palatal canals separately. The average of two values reported by the patient will be taken and then accepted as VAS value.
* Postoperative pain will be recorded after 6,12,24,48,72 hours and 1 week of the treatment using Visual Analog Scale (VAS).
* Analgesic intake will also be recorded.
Statistical Analysis Data will be collected and statistically analyzed.
This study will be a parallel randomized controlled trial a. It is written in accordance with the Preferred Reporting Items for Randomized Trial in Endodontics (PRIRATE) 2020 guidelines .
2. Participants:
Patients of age range between 20 and 50 years old from the outpatient clinic of Endodontic Department, Faculty of Dental Medicine for Girls, Al-Azhar University will participate in this study. These patients have maxillary premolar teeth with symptomatic pulpitis. Patients will be informed about all the study's procedures. They will be included in the study after fulfilling the inclusion criteria and sign an informed consent . The Visual Analog Scale (VAS) will be explained to all participants utilizing visual, verbal and numerical methods to ensure complete understanding. Training on its use will be provided after their recruitment and before randomization to ensure that participants are familiar with the scale before pretreatment pain assessment.
3. Sample size calculation:
Sample size calculation was performed using G\*Power version 3.1.9.7 based on the results of a previous study (Kherlakian et al.) . A power analysis was designed to have adequate power to apply a two-sided statistical test to reject the null hypothesis that there is no difference between groups. By adopting an alpha level of (0.05) and a beta of (0.2), i.e. power = 80% and an effect size (d) of (0.826). The predicted sample size (n) was (50), i.e., 25 subjects per group. This number is increased to 28 subjects per group to compensate for a drop-out rate of 10%.
Criteria of patient selection:
Inclusion Criteria:
1. Maxillary first and second bi-rooted premolar teeth having type I root canal.
2. Patients have mature teeth with closed apex.
3. Teeth with prolonged response to the pulp tests.
4. Spontaneous pain (preoperative visual analog scale score )4-6).
5. Teeth with normal periapical appearance.
6. Restorable teeth.
7. Patients who will be able to understand the informed consent form and pain recording scales used in the study will be included.
Exclusion Criteria:
1. Patients with apical periodontitis.
2. Patients who received analgesics or anti-inflammatory drugs in the last 12 hours and
antibiotics for the last 1 month.
3. Presence of multiple teeth that require treatment.
4. Systemic disease.
5. Physical or mental disability.
6. Teeth with calcified root canal, root resorption and tooth mobility.
7. The presence of additional roots or canal variations from maxillary premolar anatomy.
8. Patient unable to tolerate comple¬tion of root canal treatment in a single visit.
Proper diagnosis of the case including patient history, clinical examination, thermal pulp tests and preoperative periapical radiograph will be obtained.
Symptomatic pulpitis will be diagnosed clinically based on positive response to pulp sensibility tests and the presence of spontaneous provoked pain that lasts longer than 30 s. Patients will be asked to record their pretreatment pain level using Visual Analogue Scale (VAS).
Randomization and blinding
Fifty-six patients will be divided randomly into two groups (28 patients in each group) using simple randomization procedure using random number generator. https://www.random.org/ based on the type of file system used.
Both patient and statistician will be blinded to group allocation.
Treatment protocol:
Local anesthesia will be achieved using 2 mL of 4% articaine and 1:100000 epinephrine (Ultracaine DS Fort; Hoechst- Marion Roussel, Frankfurt, Germany). Access cavity will be prepared under strict aseptic condition and rubber dam isolation using diamond round bur and Endo Z bur (Dentsply, Maillfer, Switzerland). The working length will be determined using an electronic apex locator (EAL) and will be confirmed using periapical radiograph. Glide path preparation will be performed manually up to sizes #20K file.
Subsequently, two groups will be formed according to the predetermined group numbers based on the file system to be used in root canal preparation and the operator will be informed with the study group at this phase.
Group I reciprocating system (EdgeOne Fire group):
Root canal preparation will be completed using EdgeOne Fire reciprocating system (Albuquerque, NM, USA) up to size (35/0.04). Files will be operated at reciprocating motion, where the angle of reciprocation will be set at 150° counterclockwise (CCW) and 30° clockwise (CW).
Group II rotary system (JZ file group):
Root canal preparation will be completed using JZ file system up to size (35/0.04). The files will be operated at 300 rpm and 2 Ncm torque.
The files will be operated passively using an endodontic motor Motopex endodontic motor (Woodpecker, Guilian, China). After each file use, the root canal will be irrigated with 5ml of freshly prepared 2.5% sodium hypochlorite (NaOCl) solution (Alex. Deteregents and Chemical Co., Egypt) for 1 minute using a 30-gauge Navi-Tip flexible irrigating needle (Navi-Tip, Ultradent product, South Jourdan, UT). The needle will be inserted into the root canal 2 mm short of the working length without binding. 5 ml of 17% EDTA (Colgate Oral Care Company, Waverly, Australia) for 1 min will be used for smear layer removal following saline separation. 5 ml of saline solution will be used for final irrigation of the root canal to neutralize all the previously used irrigants.
Finally, the root canal system will be obturated using ADSEAL resin-based sealer (Meta Biomed Co, Cheongju, Korea) and gutta-percha (Dentsply Maillefer, Switzerland) with cold lateral condensation method after being completely dried using paper points of comparable size to the master cone. A final coronal restoration with direct composite filling (Filtek Bulk Fill,3M ESPE, USA) will be performed in the same visit.
The patients will be notified about the possible development of pain and given the VAS form to record the pain level. In this scale, the level of pain is specified by using numbers between 0 and 10; no pain (0), mild pain (1-3), moderate pain (4-6) and severe pain (7-10). Ibuprofen 400 mg will be prescribed to patients to be taken only when needed. The VAS scores will be recorded at 6, 12, 24, 48, ,72 h and 1 week as well as analgesic intake.
Intraoperative and postoperative pain and analgesic intake assessment:
* The evaluation of intraoperative pain will be conducted immediately after root canal preparation with each of the instrumentation kinematics using Visual Analog Scale (VAS). In each group, the patients will be asked to specify the level of pain for the buccal and palatal canals separately. The average of two values reported by the patient will be taken and then accepted as VAS value.
* Postoperative pain will be recorded after 6,12,24,48,72 hours and 1 week of the treatment using Visual Analog Scale (VAS).
* Analgesic intake will also be recorded.
Statistical Analysis Data will be collected and statistically analyzed.
Conditions
See the medical conditions and disease areas that this research is targeting or investigating.
the Effect of Instrumentation Kinematics on Intraoperative and Post-operative Pain
Study Design
Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.
Allocation Method
RANDOMIZED
Intervention Model
PARALLEL
Primary Study Purpose
TREATMENT
Blinding Strategy
DOUBLE
Participants
Outcome Assessors
Study Groups
Review each arm or cohort in the study, along with the interventions and objectives associated with them.
Group I reciprocating system (EdgeOne Fire group)
Root canal preparation will be completed using EdgeOne Fire reciprocating system (Albuquerque, NM, USA) up to size (35/0.04). Files will be operated at reciprocating motion, where the angle of reciprocation will be set at 150° counterclockwise (CCW) and 30° clockwise (CW).
Group Type
EXPERIMENTAL
EdgeOne Fire reciprocating system
Intervention Type
DEVICE
Files will be operated at reciprocating motion, where the angle of reciprocation will be set at 150° counterclockwise (CCW) and 30° clockwise (CW)
Group II rotary system (JZ file group)
Root canal preparation will be completed using JZ file system up to size (35/0.04). The files will be operated at 300 rpm and 2 Ncm torque.
Group Type
EXPERIMENTAL
JZ file system
Intervention Type
DEVICE
The files will be operated at 300 rpm and 2 Ncm torque
Interventions
Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.
EdgeOne Fire reciprocating system
Files will be operated at reciprocating motion, where the angle of reciprocation will be set at 150° counterclockwise (CCW) and 30° clockwise (CW)
Intervention Type
DEVICE
JZ file system
The files will be operated at 300 rpm and 2 Ncm torque
Intervention Type
DEVICE
Eligibility Criteria
Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.
Inclusion Criteria
* Maxillary first and second bi-rooted premolar teeth having type I root canal.
* have mature teeth with closed apex.
* Teeth with prolonged response to the pulp tests.
* Spontaneous pain (preoperative visual analog scale score )4-6).
* Teeth with normal periapical appearance.
* Restorable teeth.
* Patients who will be able to understand the informed consent form and pain recording scales used in the study will be included.
* have mature teeth with closed apex.
* Teeth with prolonged response to the pulp tests.
* Spontaneous pain (preoperative visual analog scale score )4-6).
* Teeth with normal periapical appearance.
* Restorable teeth.
* Patients who will be able to understand the informed consent form and pain recording scales used in the study will be included.
Exclusion Criteria
\-
Minimum Eligible Age
20 Years
Maximum Eligible Age
50 Years
Eligible Sex
ALL
Accepts Healthy Volunteers
No
Sponsors
Meet the organizations funding or collaborating on the study and learn about their roles.
Al-Azhar University
OTHER
Sponsor Role
lead
Responsible Party
Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.
Sabah Morad Sobhy
Endodontic department, al azhar university. principal investigator
Responsibility Role
PRINCIPAL_INVESTIGATOR
Principal Investigators
Learn about the lead researchers overseeing the trial and their institutional affiliations.
Sabah M Sobhy, PHD
Role: PRINCIPAL_INVESTIGATOR
Al-Azhar University
Locations
Explore where the study is taking place and check the recruitment status at each participating site.
from the outpatient clinic of Endodontic Department, Faculty of Dental Medicine for Girls, Al-Azhar University
Cairo, , Egypt
Site Status
RECRUITING
Countries
Review the countries where the study has at least one active or historical site.
Egypt
Central Contacts
Reach out to these primary contacts for questions about participation or study logistics.
Facility Contacts
Find local site contact details for specific facilities participating in the trial.
References
Explore related publications, articles, or registry entries linked to this study.
Ahmad MZ, Sadaf D, MacBain MM, Merdad KA. Effect of mode of rotation on apical extrusion of debris with four different single-file endodontic instrumentation systems: Systematic review and meta-analysis. Aust Endod J. 2022 Apr;48(1):202-218. doi: 10.1111/aej.12612. Epub 2022 Mar 7.
Reference Type
BACKGROUND
Pak JG, White SN. Pain prevalence and severity before, during, and after root canal treatment: a systematic review. J Endod. 2011 Apr;37(4):429-38. doi: 10.1016/j.joen.2010.12.016.
Reference Type
BACKGROUND
Other Identifiers
Review additional registry numbers or institutional identifiers associated with this trial.
P-PD-25-32
Identifier Type: -
Identifier Source: org_study_id
More Related Trials
Additional clinical trials that may be relevant based on similarity analysis.
Postoperative Pain Assessment After Using Different Kinematics
NCT04277520
COMPLETED
NA
Pain Intensity After Root Canal Instrumentation
NCT04216940
COMPLETED
NA
Post-Operative Pain Evaluation After Using Different Single-file Root Canal Preparation System: A Randomized Clinical Study
NCT06207019
COMPLETED
NA
The Impact Of Different Final Irrigation Activation Techniques On Postoperative Pain
NCT06501703
COMPLETED
NA
Comparison of Postoperative Pain After Instrumentation in Different Visits With Different Single File Systems.
NCT04767399
UNKNOWN
NA
Post Operative Pain of Partial Pulpotomy Using a Bioceramic Material in Patients With Symptomatic Irreversible Pulpitis
NCT05956613
COMPLETED
EARLY_PHASE1
Effect Of XP Endo Finisher Versus Ultrasonic Activated Irrigation On Post-operative Pain In Endodontic Treatment of Symptomatic Irreversible Pulpitis
NCT03096587
UNKNOWN
NA
Postoperative Pain After Using Reciprocating Motion With Reciproc Files Versus Adaptive Motion With Twisted File Adaptive
NCT03338322
UNKNOWN
NA
Effect of TruNatomy and HyFlex EDM Instrumentation on Postoperative Pain
NCT05289973
UNKNOWN
NA
Effect of Apical Enlargement to Different Preparation Sizes and Tapers on Pain and Bacterial Reduction in Necrotic Pulp
NCT05620147
UNKNOWN
NA
Effect of Sonic Activation of Irrigant on Post Operative Pain After Root Canal Treatment
NCT07062419
COMPLETED
NA
3D Instrumentation Versus Rotary Instrumentation
NCT03285334
UNKNOWN
NA
Postoperative Pain After Pulpotomy in Children Using Calcium Silicate Cements With and Without Laser Therapy
NCT07290049
RECRUITING
NA
Comparison Between Reciproc and Protaper Next
NCT02946099
COMPLETED
NA
Postoperative Pain Following Treatment of Asymptomatic Necrotic Mandibular Molars in Single Visit Using Wave-one Reciprocating Instruments Versus One-Shape Rotary Instruments
NCT03301259
UNKNOWN
NA
Postoperative Pain of Root Canal Therapy With Three Techniques
NCT02442388
COMPLETED
NA
Evaluating Postoperative Pain and Antibacterial Effect of Ultrasonic and 980 nm Diode Laser Combination
NCT07041736
RECRUITING
NA
Effect of Submucosal Cryotherapy on Postoperative Endodontic Pain
NCT06090500
COMPLETED
NA
Occlusal Reduction Effect on Postendodontic Pain
NCT04186897
COMPLETED
NA
Comparison of Post-Operative Pain Occurrence After Single Visit Root Canal Treatment
NCT06777381
ENROLLING_BY_INVITATION
NA
Assessment of Post-operative Pain After Different Instrumentation Techniques in Pulpectomy Treatment of Primary Molars
NCT06256250
ACTIVE_NOT_RECRUITING
NA
Postoperative Pain After Using NiTi Instruments
NCT04700995
COMPLETED
NA
Comparative Evaluation of Post-endodontic Pain Using Two Rotary Instrumentation Systems
NCT02621034
COMPLETED
NA