Role of CT in Tetralogy of Fallot Diagnosis

NCT ID: NCT07247435

Last Updated: 2025-11-25

Basic Information

• Recruitment Status: NOT_YET_RECRUITING
• Total Enrollment: 37 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2025-11-15
• Study Completion Date: 2028-09-15

Brief Summary

To evaluate the role of MSCT in diagnosis and surgical planning in tetralogy of Fallot cases.

Detailed Description

Role of Computed tomography (CT) : CT has become an indispensable imaging modality in the comprehensive evaluation and management of Tetralogy of Fallot (ToF). While echocardiography remains the initial diagnostic tool, CT offers unparalleled spatial resolution and the ability to generate high-quality, three-dimensional reconstructions of both intracardiac and extracardiac anatomy. This is particularly valuable for identifying associated anomalies such as major aortopulmonary collateral arteries (MAPCAs), anomalous coronary artery origins, and variations in pulmonary artery branching patterns that can significantly influence surgical decision-making. Preoperatively, CT enables precise assessment of the severity and extent of right ventricular outflow tract obstruction, ventricular septal defect morphology, and the relationship of the overriding aorta to the interventricular septum.

Overall, CT complements other imaging modalities by providing a fast, accurate, and comprehensive anatomical roadmap that guides surgical planning, informs long-term follow-up, and aids in the early detection of complications. Its role is particularly pronounced in complex and syndromic cases of ToF, where anatomical variations are more common and precise preoperative mapping is critical for successful outcomes.

Conditions

Cardiac CT TOF

Study Design

• Observational Model Type: CASE_ONLY
• Study Time Perspective: PROSPECTIVE

Interventions

Computed tomography

Radiological device

Intervention Type: DEVICE

Eligibility Criteria

Inclusion Criteria

• patients aged 1 day up to 12 years Confirmed diagnosis of tetralogy of Fallot. Patients with tetralogy of Fallot as apart from genetic syndrome.

Exclusion Criteria

• Patients with other isolated congenital heart anomalies Previously operated cases of tetralogy of Fallot.

• Maximum Eligible Age: 12 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Assiut University

OTHER

Sponsor Role: lead

Responsible Party

Benyamin Adel Abdullah Gaballah

RD

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

WAGEEH Abd el-hafeez

Role: PRINCIPAL_INVESTIGATOR

Assiut University

Central Contacts

Benyamin Gaballah

Role: CONTACT

benyaminadel99@gmail.com

01025303267

Hassan Megaly, Professor

Role: CONTACT

01006209584

References

Hoffman JI, Kaplan S. The incidence of congenital heart disease. J Am Coll Cardiol. 2002 Jun 19;39(12):1890-900. doi: 10.1016/s0735-1097(02)01886-7.

Reference Type: BACKGROUND

PMID: 12084585 (View on PubMed)

Freeman SB, Bean LH, Allen EG, Tinker SW, Locke AE, Druschel C, Hobbs CA, Romitti PA, Royle MH, Torfs CP, Dooley KJ, Sherman SL. Ethnicity, sex, and the incidence of congenital heart defects: a report from the National Down Syndrome Project. Genet Med. 2008 Mar;10(3):173-80. doi: 10.1097/GIM.0b013e3181634867.

Reference Type: BACKGROUND

PMID: 18344706 (View on PubMed)

Other Identifiers

Cardiac CT

Identifier Type: -

Identifier Source: org_study_id