Enhanced Recovery After Uvulopalatoplasty

NCT ID: NCT07246694

Last Updated: 2025-12-05

Basic Information

• Recruitment Status: NOT_YET_RECRUITING
• Clinical Phase: NA
• Total Enrollment: 80 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2025-12-31
• Study Completion Date: 2026-12-31

Brief Summary

Obstructive sleep apnea is a prevalent condition often treated surgically with palatoplasty, which improves airway patency and reduces apneic events. However, postoperative pain and airway discomfort following palatoplasty can be significant, leading to delayed oral intake, increased opioid consumption, and prolonged recovery. Combining an ultrasound-guided glossopharyngeal nerve block with topical airway anesthesia may provide synergistic analgesia and support a safer recovery profile.

Detailed Description

Obstructive sleep apnea is a prevalent condition often treated surgically with palatoplasty, which improves airway patency and reduces apneic events. However, postoperative pain and airway discomfort following palatoplasty can be significant, leading to delayed oral intake, increased opioid consumption, and prolonged recovery. Enhanced Recovery After Surgery protocols aim to accelerate functional recovery and reduce perioperative morbidity. Combining an ultrasound-guided glossopharyngeal nerve block with topical airway anesthesia may provide effective analgesia and support a smoother recovery profile.

Conditions

Analgesia; Recovery, Psychological

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: DOUBLE

Study Groups

Group I

The patient will receive the ultrasound-guided glossopharyngeal nerve block combined with topical airway anesthesia.

Group Type: ACTIVE_COMPARATOR

Glossopharyngeal nerve block

Intervention Type: PROCEDURE

Glossopharyngeal nerve block using ultrasound guidance after induction of general anesthesia plus topical anesthesia before surgical incision.

Group c

The patient will receive the standard multimodal analgesia.

Group Type: ACTIVE_COMPARATOR

Standard multimodal analgesia

Intervention Type: OTHER

The patient will receive intravenous fentanyl and non opioids analgesics (acetaminophen and non-steroidal anti-inflammatory drugs) with general anesthesia.

Interventions

Glossopharyngeal nerve block

Glossopharyngeal nerve block using ultrasound guidance after induction of general anesthesia plus topical anesthesia before surgical incision.

Intervention Type: PROCEDURE

Standard multimodal analgesia

The patient will receive intravenous fentanyl and non opioids analgesics (acetaminophen and non-steroidal anti-inflammatory drugs) with general anesthesia.

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Confirmed diagnosis of moderate to severe obstructive sleep apnea.
• Patients scheduled for elective palatoplasty under general anesthesia.
• American Society of Anesthesiologists Physical Status class I and II.

Exclusion Criteria

• Patients with chronic opioid use.
• Advanced hepatic, renal, cardiovascular, and neurologic diseases.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 65 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Zagazig University

OTHER_GOV

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Fatma Mahmoud Ahmed, MD

Role: PRINCIPAL_INVESTIGATOR

Department of Anesthesia, Intensive Care & Pain Management, Zagazig University

Alshaimaa Abdelfattah Kamel, MD

Role: STUDY_DIRECTOR

Department of Anesthesia, Intensive Care & Pain Management, Zagazig University

Osama Yehia Khalifa, MD

Role: STUDY_DIRECTOR

Department of Anesthesia, Intensive Care & Pain Management, Zagazig University

Locations

Zagazig university hospital

Zagazig, Al-Sharkia, Egypt

Countries

Egypt

Central Contacts

Mohamed

Role: CONTACT

mgaber200098@gmail.com

011118851696

Osama Yehia, MD

Role: CONTACT

01007579438

Facility Contacts

Mohamed Gaber, MD

Role: primary

mgaber200098@gmail.com

01118851696

Other Identifiers

Uvulopalatoplasty Analgesia

Identifier Type: -

Identifier Source: org_study_id