Comparison of Compressed Continuous Suture and Conventional Suture in Pterygium Surgery

NCT ID: NCT07244276

Last Updated: 2025-11-24

Basic Information

• Recruitment Status: RECRUITING
• Clinical Phase: NA
• Total Enrollment: 40 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2024-04-02
• Study Completion Date: 2026-07-02

Brief Summary

To compare the advantages and disadvantages of continuous suture with suture and conventional Suture in primary pterygium surgery for autologous conjunctival graft fixation

Detailed Description

Pterygium is an abnormal fibrovascular tissue hyperplasia disease that occurs in the conjunctiva. The pterygium tissue can break through the limbus of the corneosclera and grow into the cornea, causing a foreign body sensation in the eyes, astigmatism, decreased vision, and even restricted eye movement. The purpose of surgical treatment for pterygium is not only to remove the diseased tissue, but more importantly, to reduce the recurrence of pterygium after surgery. Pterygium excision combined with simple autologous conjunctival transplantation is currently the most commonly used method for treating pterygium. The recurrence rate after autologous conjunctival epithelial tissue transplantation can be reduced to 5% to 30%.

As heterogenic substances, sutures can irritate the ocular surface, aggravate postoperative inflammatory reactions and conjunctival edema or hemorrhage, delay the repair of corneal wound epithelium, lead to abnormal ocular surface function, intensify postoperative discomfort, and induce hypertrophic granuloma or cysts, etc. Moreover, these adverse reactions can also induce the recurrence of pterygium (0-26%). In addition, the longer the time interval between suture removal, The greater the difficulty of removal, the more likely some of the knots may be completely buried under the conjunctiva. Therefore, in order to alleviate the adverse reactions caused by sutures and further simplify the operation of pterygium excision surgery, many attempts have been made at home and abroad to improve and innovate the method of graft fixation.

Conditions

Primary Pterygium

Study Design

• Allocation Method: NON_RANDOMIZED
• Intervention Model: FACTORIAL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Continuous suture group

Pterygium excision combined with autologous conjunctival transplantation was performed

Group Type: OTHER

Compression continuous suture with suture crimping

Intervention Type: PROCEDURE

Pterygium excision combined with autologous conjunctival transplantation was performed, and the continuous suture method with pressure lines was adopted during the operation

Intermittent suture group

Pterygium excision combined with autologous conjunctival transplantation was performed

Group Type: OTHER

Conventional Suture with suture crimping

Intervention Type: PROCEDURE

Pterygium excision combined with autologous conjunctival transplantation was performed, and the traditional suture method was adopted during the operation

Interventions

Conventional Suture with suture crimping

Pterygium excision combined with autologous conjunctival transplantation was performed, and the traditional suture method was adopted during the operation

Intervention Type: PROCEDURE

Compression continuous suture with suture crimping

Pterygium excision combined with autologous conjunctival transplantation was performed, and the continuous suture method with pressure lines was adopted during the operation

Intervention Type: PROCEDURE

Eligibility Criteria

Inclusion Criteria

1. Diagnosis of primary pterygium according to diagnostic criteria;

2. The pterygium head invades the cornea by 2-5mm;

3. The patient agrees to the surgical treatment and signs the surgical consent form.

Exclusion Criteria

1. History of previous eye surgery;

2. Have active ocular inflammatory lesions;

3. recurrent and pseudopterygium;

4. The patient refuses surgery or is unable to have regular follow-ups

• Minimum Eligible Age: 30 Years
• Maximum Eligible Age: 70 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Tianjin Eye Hospital

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Yi Zhang

Role: STUDY_DIRECTOR

Tianjin Eye Hospital

Locations

Tianjin Eye Hospital

Tianjin, Tianjin Municipality, China

Site Status: RECRUITING

Countries

China

Central Contacts

Yan Wang, director

Role: CONTACT

wangyan7143@vip.sina.com

23187165 ext. +86 022

Facility Contacts

yan wang, director

Role: primary

wangyan7143@vip.sina.com

+862227313336

Other Identifiers

zhangyi2025

Identifier Type: -

Identifier Source: org_study_id