Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
90 participants
OBSERVATIONAL
2015-09-30
2016-07-01
Brief Summary
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The main question it aims to answer is:
1. Do children infected with Hepatitis C have a higher incidence of Insulin resistance compared to healthy controls of same age and gender?
2. Is Insulin resistance occurence affected by HCV viral load, blood transfusion frequency, or metabolic factors? Researchers will compare hepatitis c infected children who are either thalassemic or survivors of childhood malignant to healthy age and sex matched controls.
Participants will be subjected to:
* standardized Questionnaires,
* physical examination and
* laboratory investigations including liver functions (ALT, AST, Alkaline phosphatase), Prothrombin time, serum ferritin level, albumin, fasting glucose, fasting insulin level and Insulin resistance assessment by HOMA IR calculation.
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Detailed Description
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Conditions
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Study Design
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CASE_CONTROL
CROSS_SECTIONAL
Study Groups
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Patient group included 60 hepatitis C infected children and adolescents
The patient group included 30 thalassemic patients and 30 malignancy survivors
No interventions assigned to this group
Control group of 30 age and sex matched healthy children and adolescents
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* autoimmune hepatitis,
* primary biliary cirrhosis (PBC),
* sclerosing cholangitis,
* haemochromatosis,
* α1-antitrypsin deficiency,
* Wilson's disease,
* patients with obesity (BMI \> 25), or
* Type 2 DM.
3 Years
18 Years
ALL
Yes
Sponsors
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Ain Shams University
OTHER
Responsible Party
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Locations
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Pediatric hematology and Oncology clinic, Children's Hospital, Ain Shams university
Cairo, , Egypt
Countries
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Other Identifiers
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Pediatric Protocol
Identifier Type: OTHER
Identifier Source: secondary_id
FMASU MSO 15/2025
Identifier Type: -
Identifier Source: org_study_id
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