Revascularization of Young Immature Permenant Teeth Using Different Types of Intra Canal Medication

NCT ID: NCT07236567

Last Updated: 2025-11-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Clinical Phase

NA

Total Enrollment

45 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-12-01

Study Completion Date

2027-11-01

Brief Summary

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Evaluation of the Effect of Grape Seed Extract, Glycyrrhizin Compared to Triple Antibiotic Paste as Intra Canal Medication in Revascularization of Necrotic Permanent Immature Teeth in Children: A Randomized Clinical Trial

Detailed Description

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Digital count of e.faecalis before and after application of different type of intra canal medication

Conditions

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Traumatic Teeth Necrotic Teeth

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Group a

Revascularization with triple antibiotic paste as intracanal medication

Group Type ACTIVE_COMPARATOR

Triple Antibiotic Paste

Intervention Type DRUG

Trple antibiotic paste Left for one week

Group b

Revascularization with grape seed extract as intra canal medication

Group Type EXPERIMENTAL

Grape Seed Extract

Intervention Type DRUG

Grape seed extract in form of hydrogel with concentration 6.5 % left in canal for one week

Group c

Revascularization with glycyrrhizin as intracanal medication

Group Type EXPERIMENTAL

Glycyrrhizin

Intervention Type DRUG

Glycyrrhizin hydrogel 50 micrograms in 1 milligram left in canal for one week

Interventions

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Grape Seed Extract

Grape seed extract in form of hydrogel with concentration 6.5 % left in canal for one week

Intervention Type DRUG

Glycyrrhizin

Glycyrrhizin hydrogel 50 micrograms in 1 milligram left in canal for one week

Intervention Type DRUG

Triple Antibiotic Paste

Trple antibiotic paste Left for one week

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Healthy children aged from 7-13 years old.
* Patient with necrotic pulp.
* Open apex.

Exclusion Criteria

* Teeth with root fractures.
* Presence of root resorptions.
* Presence of periodontal pockets.
* Developmental anomalies.
* Tooth with class III mobility
Minimum Eligible Age

7 Years

Maximum Eligible Age

13 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Al-Azhar University

OTHER

Sponsor Role lead

Responsible Party

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Mohamed Khalifa

Doctor of dental medicine

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Al-Azhar University faculty of dental medicine

Cairo, , Egypt

Site Status

Countries

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Egypt

Central Contacts

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Mohamed Khalifa

Role: CONTACT

+2010 69978846

References

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Evaluation of the Effect of Grape Seed Extract, Glycyrrhizin Compared to Triple Antibiotic Paste as Intra Canal Medication in Revascularization of Necrotic Permanent Immature Teeth in Children: A Randomized Clinical Trial

Reference Type BACKGROUND

Other Identifiers

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Revascularization

Identifier Type: -

Identifier Source: org_study_id

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