A Study Of Corticosteroid On Postoperative Pain After Ureteroscopy For Urinary Calculi

NCT ID: NCT07223580

Last Updated: 2026-02-03

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

PHASE4

Total Enrollment

90 participants

Study Classification

INTERVENTIONAL

Study Start Date

2026-01-23

Study Completion Date

2027-12-01

Brief Summary

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The purpose of this research is to evaluate if corticosteroid (prednisone) after ureteroscopy and placement of the stent will help alleviate postoperative pain control in addition to other normal postoperative pain medications

Detailed Description

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Conditions

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Ureteroscopy Post Operative Pain

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Caregivers Investigators

Study Groups

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Standard of care plus Corticosteroid

Participants will receive standard of care postoperative ureteroscopy medication, with the addition of prednisone 25 mg.

Group Type EXPERIMENTAL

Corticosteroid

Intervention Type DRUG

In addition to the standard of care postoperative ureteroscopy medication, participants will be given prednisone 25 mg orally, once a day for 5 days post-surgery.

Standard of Care

Participants will receive standard of care postoperative ureteroscopy medication, with the addition of a placebo pill.

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type OTHER

In addition to the standard of care postoperative ureteroscopy medication, participants will be given a placebo pill orally, once a day for 5 days post-surgery.

Interventions

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Corticosteroid

In addition to the standard of care postoperative ureteroscopy medication, participants will be given prednisone 25 mg orally, once a day for 5 days post-surgery.

Intervention Type DRUG

Placebo

In addition to the standard of care postoperative ureteroscopy medication, participants will be given a placebo pill orally, once a day for 5 days post-surgery.

Intervention Type OTHER

Other Intervention Names

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Prednisone

Eligibility Criteria

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Inclusion Criteria

* Patients who are diagnosed with kidney or ureteral stones confirmed on imaging (CT of the abdomen or pelvis) and who elect for definitive treatment via ureteroscopy with placement of ureteral stent.
* Age 18 years or older
* Patients of either gender
* Patients of all ethnic backgrounds
* Cable of giving informed consent
* Capable and willing to fulfill the requirements of the study.

Exclusion Criteria

* History of chronic pain
* Chronic use of opioids or other pain medication (\>12 weeks)
* Known allergies to corticosteroids.
* Known or suspected pregnancy
* Inability to give informed consent or unable to meet requirements of the study for any reason.
* Bilateral ureteroscopy
* Current Corticosteroid Use
* Diabetic patients who are insulin dependent
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Mayo Clinic

OTHER

Sponsor Role lead

Responsible Party

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Karen L. Stern

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Karen L. Stern, MD

Role: PRINCIPAL_INVESTIGATOR

Mayo Clinic

Locations

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Mayo Clinic in Arizona

Scottsdale, Arizona, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Rev V. Vilasan Shylaja

Role: CONTACT

480-574-1466

Facility Contacts

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Rev V. Vilasan Shylaja

Role: primary

480-574-1466

Related Links

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Other Identifiers

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25-003416

Identifier Type: -

Identifier Source: org_study_id

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